Programme
Sunday 07 October 2012 16:00 - 17:45 Arrival and Registration ATC Registration Desk
17:45 - 19:00 BUFFET DINNER ATC Foyer
19:00 - 19:15 Welcome ATC Auditorium
19:15 - 21:30 KEYNOTE SESSION ATC Auditorium
19:15 - 20:00 Mechanisms of 3'->5' RNA degradation 1 Elena Conti Max Planck Institute of Biochemistry, Germany
Talk kindly sponsored by Open Biology
20:00 - 20:45 Involvement of Low Complexity Polypeptide Sequences in 2 the Formation of RNA Granules Steven McKnight UT Southwestern Medical Center, United States of America
20:45 - 21:30 Post-transcriptional gene regulation by small RNAs and 3 RNA binding proteins Nikolaus Rajewsky Max Delbruck Center for Molecular Medicine, Germany
21:30 - 23:00 Drinks and Poster "Sneak Preview" ATC Foyer, Helices A & B
Page 5 EMBO|EMBL Symposium The Complex Life of mRNA
Monday 08 October 2012 09:00 - 13:10 SESSION 2 - RNA Surveillance and Decay Chair: Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany ATC Auditorium
09:00 - 09:25 Viral Noncoding RNPs 4 Joan Steitz Yale University, United States of America
09:25 - 09:50 Eukaryotic mRNA Turnover 5 Roy Parker HHMI/University of Colorado Boulder, United States of America
09:50 - 10:15 Production and destruction of RNA in human nuclei 6 Torben Jensen Aarhus University, Denmark
10:15 - 10:45 COFFEE BREAK ATC Foyer
10:45 - 11:10 Tales from the Cellular Underworld: The Importance of 7 mRNA Decay Lynne Maquat University of Rochester Medical Center, United States of America
11:10 - 11:25 DHX34 activates NMD by promoting the transition from the 8 SURF to the DECID complex Nele Hug MRC HGU, IGMM, United Kingdom
11:25 - 11:50 Reining in the mRNA decay enzymes: Proteolytic control of 9 decapping Jens Lykke-Andersen University of California San Diego, United States of America
Page 6 Programme
11:50 - 12:05 Uridylation prevents the formation of aberrant mRNAs by 10 protecting deadenylated mRNA 3' ends Dominique Gagliardi CNRS-University of Strasbourg, France
12:05 - 12:30 Non-coding RNAs and mRNAs: Brothers separated at 11 birth? David Tollervey University of Edinburgh, United Kingdom
12:30 - 12:45 d4E-T: a eIF4E-binding protein that promotes 12 deadenylation-dependent decay of target mRNAs to control cell proliferation Cátia Igreja MPI for Developmental Biology Tuebingen, Germany
12:45 - 13:10 Virus-Host Interplay Leads to Widespread mRNA 13 Destruction Britt Glaunsinger University of California Berkeley, United States of America
13:10 - 16:00 LUNCH and POSTER SESSION 1 ATC Foyer and Helices A & B
16:00 - 19:20 SESSION 3 - Mechanics and Regulation of Translation Chair: Karsten Weis, University of California, Berkeley, USA ATC Auditorium
16:00 - 16:25 mRNA surveillance is driven by translation 14 Rachel Green Johns Hopkins University School of Medicine, United States of America
16:25 - 16:40 CLIP-seq of the DEAD-box RNA helicase eIF4AIII reveals 15 transcriptome-wide mapping of the exon junction complex in human Herve Le Hir IBENS, France
Page 7 EMBO|EMBL Symposium The Complex Life of mRNA
16:40 - 17:05 RNA meets metabolism: from mRNA interactomes to REM 16 networks Matthias Hentze European Molecular Biology Laboratory (EMBL), Germany
17:05 - 17:35 COFFEE BREAK ATC Foyer
17:35 - 18:00 Molecular mechanisms of ribosomal scanning and AUG 17 selection: where to begin? Alan Hinnebusch National Institutes of Health, United States of America
18:00 - 18:15 The cryo-EM structure of the UPF-EJC complex shows 18 how UPF1 is poised to unwind the 3' end of a PTC-containing mRNP Oscar Llorca Spanish National Research Council-CSIC, Spain
18:15 - 18:40 Translational Control of Higher Brain Function 19 Joel Richter University of Massachusetts Medical School, United States of America
18:40 - 18:55 Physiological Role of NMD in Neuronal Development In 20 Vivo Eleen Shum UC San Diego, United States of America
18:55 - 19:20 Crystal structures of the eukaryotic ribosome and insights 21 into the regulation and initiation of protein synthesis Nenad Ban ETH Zurich, Switzerland
19:20 - 21:00 DINNER EMBL Canteen
21:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing
Page 8 Programme
Tuesday 09 October 2012 09:00 - 12:40 SESSION 4 - Epigenetics and Transcription Chair: Lynne Elizabeth Maquat, University of Rochester, USA ATC Auditorium
09:00 - 09:25 Structure-guided dynamic transcriptome analysis 22 elucidates the mRNA life cycle Patrick Cramer Gene Center - LMU, Germany
09:25 - 09:40 Road-block termination defines a new class of cryptic 23 transcripts Domenico Libri CNRS - CGM, France
09:40 - 10:05 Chromatin and transcription regulate alternative splicing 24 Alberto Kornblihtt FCEN, University of Buenos Aires and IFIBYNE-CONICET, Argentina
10:05 - 10:20 “Catching up” with polymerase: the mechanisms of 25 Sen1-dependent termination Odil Porrua Fuerte Centre de Genetique Moleculaire-CNRS, France
10:20 - 10:35 The mRNA-Bound Proteome and Its Global Occupancy 26 Profile on Protein-Coding Transcripts Markus Landthaler Max-Delbrück-Center for Molecular Medicine, Germany
10:35 - 11:05 COFFEE BREAK ATC Foyer
11:05 - 11:30 Ending the message in eukaryotes: Gene loops, R-loops 27 and noncoding RNA Nicholas Proudfoot University of Oxford, United Kingdom
Page 9 EMBO|EMBL Symposium The Complex Life of mRNA
11:30 - 11:45 Global regulatory functions of Sen1-dependent Pol II 28 termination factors David Brow University of Wisconsin-Madison, United States of America
11:45 - 12:10 Splicing on chromatin 29 Karla Neugebauer MPI-CBG, Germany
12:10 - 12:25 Single cell analysis reveals aspects of antisense RNA 30 regulation and mode of action in PHO84 transcription repression Daniel Zenklusen Université de Montréal, Canada
12:25 - 12:40 Genome-wide measurement of RNA structure in vivo 31 Silvia Rouskin UCSF, United States of America
12:40 - 15:30 LUNCH and POSTER SESSION 2 ATC Foyer and Helices A & B
15:30 - 17:40 SESSION 5 - Pre-mRNA Processing Chair: Alberto Kornblihtt, University of Buenos Aires, Argentina ATC Auditorium
15:30 - 15:55 Processing of mRNA precursors and links to human 32 disease James Manley Columbia University, United States of America
15:55 - 16:20 TELESCRIPTING: A New Dimension to mRNA Regulation 33 Gideon Dreyfuss HHMI/University of Pennsylvania School of Medicine, United States of America
Page 10 Programme
16:20 - 16:35 ELAV mediates neuronal-specific 3’ UTR extension by 34 suppressing proximal polyadenylation Valerie Hilgers UC Berkeley, United States of America
16:35 - 17:00 How competition between RNA-binding proteins for 35 overlapping binding sites controls splicing decisions Jernej Ule MRC Laboratory of Molecular Biology, United Kingdom
17:00 - 17:15 CWC22 Connects Pre-mRNA Splicing and Exon Junction 36 Complex Assembly Anna-Lena Steckelberg Institute for Genetics, University of Cologne, Germany
17:15 - 17:40 Pre-mRNA processing and mRNA metabolism 37 Melissa Moore HHMI/University of Massachusetts Medical School, United States of America
17:40 - 18:00 Pre-dinner drinks ATC Foyer
18:00 - 20:00 DINNER EMBL Canteen
20:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing
Page 11 EMBO|EMBL Symposium The Complex Life of mRNA
Wednesday 10 October 2012 09:00 - 12:35 SESSION 6 - miRNA Function Chair: Matthias W. Hentze, EMBL Heidelberg, Germany ATC Auditorium
09:00 - 09:25 Structural insights into miRISC recruitment of the 38 CCR4-NOT complex Nahum Sonenberg McGill University, Canada
09:25 - 09:50 Function and Regulation of MicroRNAs 39 Helge Grosshans FMI, Switzerland
09:50 - 10:05 The piRNA pathway and its role in the regulation of 40 maternal mRNAs in the Drosophila early embryo Bridlin Barckmann IGH Institute of Human Genetics, France
10:05 - 10:30 Regulation of miRNA-mediated Repression and miRNA 41 Metabolism in Mammalian Cells Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland
10:30 - 11:00 COFFEE BREAK ATC Foyer
11:00 - 11:25 Biogenesis and function of PIWI-interacting RNA in 42 Drosophila Mikiko Siomi Graduate School of Science, University of Tokyo, Japan
11:25 - 11:40 miRNA-mediated regulation of the cyrano lincRNA is a 43 non-canonical pathway essential for early vertebrate development Alena Shkumatava Whitehead Institute/MIT, United States of America
Page 12 Programme
11:40 - 12:05 Evolutionary plasticity of the protein interaction network 44 that regulates mRNA stability Elisa Izaurralde Max Planck Institute for Developmental Biology, Germany
12:05 - 12:20 Structure of yeast Argonaute with guide RNA 45 David Weinberg Whitehead Institute / MIT, United States of America
12:20 - 12:35 The structural biochemistry of Zucchini implicates it as a 46 nuclease in piRNA biogenesis Astrid Haase Cold Spring Harbor Laboratory, United States of America
12:35 - 15:30 LUNCH and POSTER SESSION 3 ATC Foyer and Helices A & B
15:30 - 18:30 SESSION 7 - mRNA Export and Localization Chair: Melissa J. Moore, UMass Medical School/HHMI, USA ATC Auditorium
15:30 - 15:55 Regulation of mRNA export and decay 47 Karsten Weis UC Berkeley, United States of America
15:55 - 16:10 Blastomere-specific transcriptome profiling after the first 48 embryonic division Erin Osborne Nishimura University of North Carolina, United States of America
16:10 - 16:25 Structural studies of a minimal eIF4E-Cup complex 49 Fulvia Bono Max Planck for Developmental Biology, Germany
16:25 - 16:55 COFFEE BREAK ATC Foyer
Page 13 EMBO|EMBL Symposium The Complex Life of mRNA
16:55 - 17:10 The Unfolded Protein Response in Fission Yeast 50 Modulates Stability of Select mRNAs to Maintain Protein Homeostasis Philipp Kimmig UCSF, United States of America
17:10 - 17:25 Insights into biogenesis and localization of mRNPs from in 51 vitro reconstitution experiments Dierk Niessing Helmholtz Zentrum München, Germany
17:25 - 17:50 Adaptation of the organism to its environment: fine-tuning 52 RNA localization dynamics Anne Ephrussi EMBL Heidelberg, Germany
17:50 - 18:15 Following Single mRNAs from Birth to Death: A Systems 53 Approach Robert Singer Albert Einstein College of Medicine, United States of America
18:15 - 18:30 Closing remarks ATC Auditorium
18:30 - 00:00 BANQUET DINNER and PARTY EMBL Canteen and ATC Foyer
Page 14 Posters A-Z
Adeli, Khosrow Translational Control of Apolipoprotein B mRNA via miRNAs and 54 Localization in RNA Granules
Ahmad, Mohd Hafiz Analysis of mirna Transcriptome in Normal Peripheral Blood 55 Mononuclear Cells, Chronic Myeloid Leukemia and K562 Cells
Allain, Frédéric Recognition of let-7 miRNA by the zinc knuckles of Lin28 56
Allmang, Christine The cap of selenoprotein mRNAs is hypermethylated : similarities with 57 snRNA processing
Antic, Sanja Ribosome association of the mRNA degradation machinery and the 58 miRNA effector complex in Drosophila cells
Aregger, Michael Cell-cycle-dependent phosphorylation of the RNA cap methyltransferase 59 is required for cell proliferation
Arnold, Andreas Investigating the function of Y-box binding proteins in C. elegans 60
Arribas, Laura The biological role of slicing for Arabidopsis Argonaute1 61
Asta, Francesco RUMP, a Drosophila hnRNP M homolog, elicits decay of mRNA targets 62
Attig, Jan The TIA/TIAL proteins regulate alternative polyA-site choice and thereby 63 mRNA isoform expression
Babic, Ana Transcriptome profiling at the synapse 64
Page 15 EMBO|EMBL Symposium The Complex Life of mRNA
Barbosa, Cristina An upstream open reading frame regulates the translational efficiency of 65 the human erythropoietin transcript
Bawankar, Praveen NOT10 and C2orf29 form a metazoan-specific module of the 66 CCR4–NOT complex that docks onto the N-terminal domain of NOT1
Beckmann, Benedikt M. RNA-binding proteins in posttranscriptional control: defining a eukaryotic 67 core mRNA interactome
Béthune, Julien L. Kinetic analysis reveals successive steps leading to miRNA-mediated 68 silencing in mammalian cells
Bezzi, Marco PRMT5 links alternative splicing and apoptosis in mammalian brain 69 development
Bhattacharyya, Suvendra N. Leishmania donovani downregulates miR-122 in Liver to Modulate 70 Serum Cholesterol in Parasite Infected Mouse: Mechanism and Beyond
Bieniossek, Christoph Crafting TFIID: TAF8/TAF10 complex accretion breaks symmetry in 71 human TFIID coactivator core structure
Blazquez, Lorea Inhibition of gene expression by combining RNA interference and U1 72 inhibition
Bo Eng, Cheong Molecular Cloning of Chalcone Synthase Gene from the Leaves of 73 Strobilanthes crispus
Bohmer, Marc Indian Hedgehog Signalling is regulated by the miR-15/16/195/424/497 74 family
Page 16 Posters A-Z
Bohne, Jens U1snRNP-mediated poly(A) site suppression is the molecular basis of a 75 complex immunodeficiency
Bojarska, Elzbieta Substrate specificity of yeast scavenger decapping enzyme (Dcs1) for 76 dinucleotide cap analogs
Bratu, Diana P. Loss of RNAi protein Armitage in the germline vs. soma delineates its 77 requirement during Drosophila melanogaster oocyte development
Brümmer, Anneke Modeling the binding specificity of RNA-binding proteins: the case of 78 GLD-1
Büttner, Lisa Imaging the nuclear trafficking and export of single ribosomes in vivo 79
Cano, Florencia RNA-binding E3 ubiquitin ligases regulate mRNA decay 80
Carmo Fonseca, Maria Non productive spliceosome assembly is sufficient to export unspliced 81 RNA to the cytoplasm
Carré, Clément An automiG biosensor identifies chemical compounds that inhibit miRNA 82 biogenesis or Argonaute-2 mediated silencing
Carré, Clément Human GTPases associate with RNA polymerase II to mediate its 83 nuclear import
Chen, Hung-Ta Site-specific mapping of Brf1 within the RNA polymerase III pre-initiation 84 complex
Page 17 EMBO|EMBL Symposium The Complex Life of mRNA
Chen, Ying Crystal Structure and Heterodimerization of the NOT Box Domains of 85 human NOT2 and NOT3
Chereda, Bradley Characterisation of the BCR-ABL 3’untranslated region 86
Ciminale, Vincenzo Expression kinetics and intracellular compartmentalization of HTLV-1 87 alternatively spliced mRNAs
Clayton, Christine E. An ARE-binding protein as post-transcriptional regulator of the 88 trypanosome heat-shock response
Cleary, Michael Identification of mRNA decay networks in the Drosophila nervous system 89
Cook, Atlanta G. NF45 interacts with NF90, SPNR and Zfr via a conserved 90 nucleotidyltransferase fold
Cosson, Bertrand Combining analyses of 3-D structure and phylogeny reveals a new 91 partner of eIF4E
Costello, Joe A role for Puf3 in translational control following oxidative stress 92
Dallacqua, Rodrigo Differentially expressed genes in honey bee queen ovaries during 93 metamorphosis
Dargemont, Catherine mRNA journey from transcription to the nuclear pore complex: Focus on 94 histone marks and ubiquitin modifications de Lucas, Susana Deep-sequencing of RNAs associated to hStaufen 1 complexes 95 identifies conserved sequences involved in RNA-protein interaction
Page 18 Posters A-Z de Moor, Cornelia H. The role of poly(A) tail metabolism in immediate early gene expression 96
De Vito, Francesca Canonical and non-canonical regulation of c-jun transcript by miR-200 97 family members
Deneke, Carlus Linking the biochemistry of mRNA degradation to mRNA decay 98 experiments: Insights from mathematical modeling
Despic, Vladimir Study of pre-mRNA splicing during early zebrafish embryogenesis 99
Dhamija, Sonam Translational activation contributes to induction of the negative regulator 100 of inflammation, MCPIP1, by IL-1 and IL-17
Diamant, Gil DSIF Restricts NF- κB Signaling by Coordinating Elongation with mRNA 101 Processing of Negative Feedback Genes
Dikfidan, Aytac Structural and functional characterization of the polynucleotide kinase 102 Clp1
Dimitrova, Lyudmila In vitro assembly of TRanscription-EXport complex 2 (TREX-2) from 103 Chaetomium thermophilum
Dominissini, Dan Topology of the human and mouse m6A RNA methylomes 104
Donato Tanaka, Erica Multiple roles of miR-306 in honeybee Apis mellifera physiology and 105 reproduction
Duarte Pereira, Sara Characterization of NAPRT1 alternative transcripts 106
Page 19 EMBO|EMBL Symposium The Complex Life of mRNA
Dueck, Anne microRNAs associated with the different human Argonaute proteins 107
Duszczyk, Malgorzata Dead End, a protein counteracting miRNA-mediated repression of 108 tumour suppressor genes, contains non-canonical RNA binding domains
Dutertre, Martin Genome-wide analysis reveals specific patterns of alternative last exon 109 regulation by genotoxic anticancer agents
Dziembowski, Andrzej The central channel controls both exonuclease and endonuclease 110 activities of the exosome complex both in vivo and in vitro
Elek, Zsuzsanna Polymorphisms in regulatory regions of the WFS1 gene are putative risk 111 factors of diabetes mellitus
Erben, Esteban Post-transcriptional control in trypanosomatids: identification of the 112 mRNA fate modulators through a high-throughput tethering assay
Fareh, Mohamed The microvesicles enclosing the cluster miR-302-367 compromise 113 tumorigenic proprieties of Glioma Initiating Cells
Fei, Jingyi Organization of long non-coding RNAs in nuclear bodies revealed by 114 super resolution imaging
Feldbrugge, Michael Microtubule-dependent co-transport of mRNPs and endosomes in the 115 model microorganism Ustilago maydis
Fontrodona, Laura Caenorhabditis elegans to address the autosomal dominant Retinitis 116 Pigmentosa paradox for splicing related genes
Page 20 Posters A-Z
Fromm, Simon A. The structural basis of Edc3- and Scd6-mediated activation of the 117 Dcp1:Dcp2 mRNA decapping complex
Gahura, Ondrej First splicing step in Saccharomyces cerevisiae requires Prp45 118
Galeano, Federica ADAR2 editing activity inhibits glioblastoma growth through the 119 modulation of the CDC14B/Skp2/p21/p27 axis
Garmendia, Cecilia Asymmetric localization of p-bodies during the yeast cell cycle 120
Gavaldá, Sandra A new link between mRNA surveillance and genome instability mediated 121 by Trf4
Glória, Vânia At the crossroads between transcription and splicing regulation of CD6 122 exon 5 alternative splicing
Goebels, Carolin Analysis of the role of introns on gene expression in Cryptococcus 123 neoformans
Göhring, Janett In Vivo Imaging of Endogenous RNA Variants in Plant Cells 124
Gonatopoulos Pournatzis, Thomas RAM: A Novel and Essential Component of the mRNA Cap Methylation 125 Machinery
Gonzàlez-Porta, Mar Genome-wide characterization of transcript isoform predominance 126
Gorgoni, Barbara Mechanism of DAZL-mediated translational regulation during germ cell 127 development
Page 21 EMBO|EMBL Symposium The Complex Life of mRNA
Graille, Marc RNA quality control pathways dedicated to the release of ribosomes 128 stalled in translation
Graindorge, Antoine Held-Out-Wings (HOW) acts as a SXL co-repressor in msl2 mRNA 129 regulation
Gray, Nicola K. Extensive and complex post-translational modification of poly(A)-binding 130 protein (PABP) 1 may regulate its multi-functionality
Gregersen, Lea Haarup Transcriptome-wide analysis of the RNA binding pattern of the RNA 131 helicase MOV10
Gribling-Burrer, Anne-Sophie Assembly of selenoprotein mRNPs: potential role of the Survival of Motor 132 Neurons (SMN) and methylosome complexes involved in sn(o)RNP biogenesis
Grosswendt, Stefanie Transcriptome-wide identification of miRNA binding sites in C. elegans 133
Gruber, Andreas R. Cleavage Factor Im as a key regulator of 3’ UTR length 134
Grund, Kerstin Stress-dependent 3’end processing regulates the expression of two key 135 proteases for coagulation, F2 and Urokinase
Grzybowska, Ewa New insight into HAX-1 functions: nucleocytoplasmic shuttling, 136 involvement in mRNA processing, nuclear export and P-body localization
Guidugli Lazzarini, Karina Rosa Gene expression profiles associated with behavioral maturation of Apis 137 mellifera workers
Page 22 Posters A-Z
Guimarães, Beatriz Gomes Activity of Trypanosoma brucei exosome component Rrp6 and its 138 partner EAP3 towards different RNA substrates
Hafner, Markus Nucleocytoplasmic transport of mRNAs by Exportin 5 139
Hallegger, Martina miRNA profile of Dopamine neurons derived from induced pluripotent 140 stem cells
Hammarskjold, Marie-Louise A conserved mechanism for expression of proteins from mRNAs with 141 retained introns
Handler, Dominik Idenification of novel piRNA factors by an tissue specific transcriptome 142 wide RNAi screen in Drosophila melanogaster
Hashimoto, Yoshifumi Translation termination factor eRF3 is targeted for caspase-mediated 143 proteolytic cleavage and degradation during DNA damage-induced apoptosis
Hausser, Jean Integration of low- and high-throughput data sets reveals the kinetics of 144 miRNA-dependent gene regulation
Helwak, Aleksandra Mapping the human miRNA interactome by CLASH reveals frequent 145 non-canonical binding
Heras, Sara R. The Microprocessor controls the activity of mammalian LINE-1 146 retrotransposon
Hermesh, Orit The link of mRNA localization to the ER 147
Hett, Anne Studying the fate of aberrantly spliced human pre-mRNAs 148
Page 23 EMBO|EMBL Symposium The Complex Life of mRNA
Hlevnjak, Mario Structural and functional enrichment analysis of the distribution of mRNA 149 pyrimidine content versus protein polar requirement sequence profiles
Hofmann, Ilse (Presenter: Regina Fischer-Keso) Plakophilin 3 regulates the mRNA stability of plakophilin 2 150
Holmes, Rebecca K. Crosslinking reveals unexpected roles for the yeast SR protein Npl3 in 151 RNA metabolism
Hornyik, Csaba Exploring the miRNA transcriptome of a tuber bearing crop, potato 152
Horos, Rastislav Dynamic responses of the hepatocytic mRNA interactome to metabolic 153 reprogramming
Jalinot, Pierre Role of INT6/EIF3E in histone mRNA translation 154
Jambor, Helena A systematic exploration of RNA localization in Drosophila ovaries: 155 Finding novel partners of the maternal determinants
Jonas, Stefanie Structural insight into the role of SMG5–SMG7 heterodimerization for 156 nonsense-mediated mRNA decay
Joo, Chirlmin Single-Molecule Approach to MicroRNA Protein Complexes 157
Jopling, Catherine L. Transcription, splicing and processing of exonic microRNAs 158
Juli, Giada Inhibition of translation elongation in response to ribosomal stress 159
Page 24 Posters A-Z
Kaminski, Tim Regulation of RNAP II during stable elongation under induced stress 160
Karousis, Evangelos D. A rapid and straightforward approach for the isolation, cloning and 161 expression analysis of subtle alternative transcript isoforms
Kellner, Julian NM Structure – Function studies of the RNA helicase DDX1 162
Kershaw, Chris The La-motif containing protein Slf1 is involved in the translation 163 regulation of mRNAs destined for mitochondria
Kesarwani, Anil K. Feedback and salt stress regulation of nonsense-mediated decay factors 164 in Arabidopsis
Kim, Hajin Dynamics of the Mitochondrial Transcription Pre-Initiation Complex 165
Kim, Tae Don Human microRNA-27a* targets Prf1 and GzmB expression to regulate 166 NK cell cytotoxicity
Klinge, Sebastian Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex 167 with Initiation Factor 6
Köhn, Marcel The non-coding Y3-RNA promotes histone-mRNA 3'-processing 168
Kolowerzo, Agnieszka Functional analysis of poly(A) RNA present in Cajal bodies 169
Kong, Ka-Yiu Edwin Yeast TRAMP complex facilitates splicing factor recruitment and 170 contributes to optimal splicing efficiency
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Kramer, Susanne Simpler P-bodies? Insights into RNA granules formation in 171 trypanosomes.
Kubitscheck, Ulrich Nuclear Export of single native mRNA 172
Kuhlmann, Sonja Structural basis for the molecular recognition of polyadenosine RNA by 173 the Zn fingers of Nab2
Kumakura, Naoyoshi Assessment of plant RNA exosome as a viral resistance factor 174
Lanctôt, Christian Transcriptional pulsing of RNA polymerase I-dependent transgene 175 expression in living cells
Lange, Sita J. Global or local? Predicting secondary structure and accessibility in 176 mRNAs
Larivière, Laurent Structure of the Mediator head module 177
Lazzaretti, Daniela Structural and functional characterization of eIF1A nuclear export 178 pathway
Le Gallic, Lionel Altered metabolism in Psoriasis leads to HuR mediated stabilization of 179 selective mRNAs
Limousin, Taran miRNAs can inhibit translation initiation independently of PABP/eIF4G 180 interaction
Linero, Florencia Natalia Translational strategy of New World arenavirus: The viral nucleoprotein 181 as a translation initiation factor
Page 26 Posters A-Z
Lloyd, James PB SMG1 is an ancient nonsense-mediated mRNA decay effector that has 182 been lost from multiple lineages
Löber, Jana Regulation of Nonsense-Mediated mRNA Decay by Cellular Stress 183
Loedige, Inga The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of 184 mRNA function
Longman, Dasa DHX34 and NAG/NBAS act in concert with core NMD factors to regulate 185 common endogenous RNA targets in humans, zebrafish and C. elegans
Lyons, Shawn M. The C-terminal tail of Lsm4 is required for efficient histone mRNA 186 degradation
Mackereth, Cameron D. Nucleic-acid binding by splicing factor Sup-12 and isoform control in 187 nematode muscle
Magler, Iris Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism 188 for UTP selectivity
Majewska, Aneta Differences in expression of inflammatory genes (Tnfa and Mcp-1) and 189 their histone H3 acetylation in the liver of young and old hyperphagic obese mice
Makino, Debora L. The Crystal Structure of a Yeast 11-Subunit Exosome Complex Bound to 190 RNA
Manojlovic, Zarko Translation regulation of type I collagen mRNAs; a silent mechanism of 191 fibrogenesis
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Martinho, Rui G. Defining the requirements for efficient gene expression during early 192 embryonic development
Maryan, Natalia Lack of evidence for transcriptional ripple effect in the neighbourhood of 193 mitogen activated genes
Maslovskaja, Julia AIRE-regulated gene expression mainly occurs on transcriptional level 194 and is promoter-independent
Mathys, Hansruedi Multitude of protein sequence elements and protein-protein interactions 195 involved in miRNA-mediated repression in metazoa
Mattioli, Chiara Antagonistic role of spliceosome and microprocessor complex on 196 processing of Splice site Overlapping (SO) pri-miRNAs
Mauxion, Fabienne H. The conserved C2ORF29 protein is a bona fide subunit of the 197 CCR4-NOT complex
Meignin, Carine Sensing viral RNAs by the innate immune system in drosophila 198
Meinel, Dominik Cotranscriptional recruitment of mRNA export adaptors to genes: a 199 genome-wide view
Mercier, Blandine Translation-dependent mRNA decay: a key regulator of gene expression 200 in T cells?
Michaud, Morgane Cytosolic mRNA trafficking to plant mitochondria 201
Mikl, Martin The mRNA splicing regulator SPK-1 is required for cell polarity in one-cell 202 C. elegans embryos
Page 28 Posters A-Z
Militti, Cristina Drosophila UNR regulates dosage compensation complex assembly by 203 acting as an RNA chaperone on roX2 noncoding RNA
Mircsof, Dennis The Role of NOPS proteins in regulating inhibitory synapse function 204
Mocquet, Vincent HTLV-1 Tax protein inhibits NMD by interacting with INT6/EIF3E and 205 UPF1
Moda, Livia Maria Differential nutrition, mRNA expression and brain mophogenesis: the 206 honeybee model
Modic, Miha The role of TDP-43 in Controlling the Selection of Alternative 207 Polyadenylation Sites
Morales, Julia Translational control during sea urchin early development 208
Moran, Yehu The roles and mode of action of microRNAs in the sea anemone 209 Nematostella vectensis
Moreira, Alex Gene Punctuation: alternative polyadenylation and transcription 210 termination between closely spaced tandem genes
Mrvova, Silvia Acute lymphoblastic leukaemia cell lines have downregulated expression 211 of eIF3b
Müller-McNicoll, Michaela Novel roles for SR proteins in histone mRNA expression 212
Munschauer, Mathias Protein occupancy profiling globally maps putative cis-regulatory mRNA 213 regions
Page 29 EMBO|EMBL Symposium The Complex Life of mRNA
Muthukrishnan, Anantha Barathi Plasticity of in vivo RNA production under the control of tetA promoter in 214 individual Escherichia coli cells
Nicholson, Pamela Unravelling the mammalian nonsense-mediated mRNA decay pathway 215 by a combined tethering / knockdown approach
Niedzwiecka, Anna Biophysical properties of full length human 5’-dependent 216 3’-poly(A)-specific ribonuclease (PARN)
Nishihara, Tadashi miRNA-mediated recruitment of decapping factors to mRNA targets 217
Obermann, Diana A novel role for CELF1 in vegetal RNA localization during Xenopus laevis 218 oogenesis
Ogami, Koichi Anti-proliferative protein Tob directly regulates c-myc proto-oncogene 219 expression through cytoplasmic polyadenylation element-binding protein CPEB
Onofre, Cláudia Translational control of the human hemojuvelin via upstream open 220 reading frames
Pagani, Franco Molecular mechanism underlying splicing correction mediated by 221 Exon-Specific U1 snRNAs (ExSpeU1)
Pascual, Malena Repression at Smaug 1 mRNA silencing foci involves the miRNA 222 pathway
Passos, Geraldo A. The messenger RNAs that code peripheral tissue antigens in the thymus 223 are under two levels of control involving Aire and then microRNAs
Page 30 Posters A-Z
Pauli, Andrea Coding potential of the transcriptome during zebrafish embryogenesis 224
Petz, Michaela PDGF mediated regulation of IRES driven Laminin B1 expression during 225 cancer invasion
Pimentel, Catarina Transcriptional and post-transcriptional mechanisms controlling iron 226 storage in yeast
Pires, Camilla Valente Transcriptome analysis of Apis mellifera haploid embryos males 227
Plotnikova, Aleksandra The decapping activator HPat a novel factor interacting with the miRNA 228 effector complex
Polyansky, Anton A. Evidence for the stereo-chemical origins of the genetic code and direct 229 complementary interactions between proteins and cognate mRNAs obtained from the analysis of protein-RNA complexes
Provenzani, Alessandro The RNA binding protein HuR is involved in the insurgence of drug 230 resistance mechanism to doxorubicin in breast cancer cells.
Quintas, Ana Deciphering the RNA-binding mechanism of African swine fever virus 231 g5R protein
Ramundo, Silvia Conditional repression of plastid gene expression reveals the complex 232 life of some mRNAs in the chloroplast
Rashpa, Ravish Elucidating the role of Cap binding proteins in BicD dependent 233 localization processes
Page 31 EMBO|EMBL Symposium The Complex Life of mRNA
Rayson, Samantha Conserved peptide upstream open reading frames as targets of 234 nonsense-mediated mRNA decay
Ribas, Lluís (Presenter: Eva Novoa) A new mechanism for genome-wide control of gene expression levels 235
Rodriguez-Navarro, Susana TREX-2 mRNA export complex and SAGA dependent deubiquitylation 236
Rösel, Tanja U1C-dependent alternative splicing regulation: RNA-Seq analysis reveals 237 U1C/U1-70K cross-regulation
Rota, Rossella Notch3-dependent myomiRs regulation in Rhabdomyosarcoma 238
Roudko, Vladimir Recruitment of Ccr4-Caf1 to the Not complex is required for efficient 239 mRNA deadenylation in vivo
Roux, Milena The role of Arabidopsis PAT1 in plant innate immunity 240
Roy, Rahul Spatial organization of RNA polymerase II and spliceosome revealed by 241 super-resolution imaging of mammalian cell nucleus
Rybak, Agnieszka In vivo Dicer targets 242
Sakakibara, Iori The Six1-Linc-MYH axis regulates muscle fiber phenotype 243
Sato, Ryosuke Analyses of underlying relationship between the subcellular localization 244 and stimulatory activity on cap-dependent translation of RNA-binding protein HuD
Page 32 Posters A-Z
Savelyeva, Anna Transfection of human cells by artificial RNA-nucleophosmin 1 245 complexes
Sawh, Ahilya N. A Truncated Dicer Tilts the Balance of RNAi Pathways 246
Schaal, Heiner U1 in tug of war: The choice between two closely spaced, identical 247 splice sites is controlled by outside-positioned splicing regulatory elements
Schamberger, Anita Experimental validation of human mirtrons: functional microRNAs can be 248 produced simultaneously from both arms in a flanking exon-independent manner
Scheiffele, Peter Dynamic regulation of synaptic adhesion complexes by alternative 249 splicing
Scherrer, Klaus The Gene and Genon Concept allows Functional and 250 Information-theoretic Analysis of Gene Expression
Schmid, Tobias Inflammatory conditions induce IRES-dependent translation of cyp24A1 251
Schüler, Markus Analyzing transcriptome-wide protein occupancy profiling 252
Schüler, Markus doRiNA: A database of RNA interactions in post-transcriptional 253 regulation
Schwartz, Schraga Exploring the 5th base of mRNA: Transcriptome wide mapping of the 254 mamalian N6-methyladenosine landscape
Schwarz, Juliane A System Analysis of Translation in Stem Cells 255
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Seibt, Julie Sleep-dependent mRNA translation consolidates cortical plasticity in 256 vivo
Sellier, Chantal Fox proteins chase MBNL1 from CCUG aggregates: an explanation to 257 the lesser severity of DM2 ?
Serpeloni, Mariana mRNA transcription/export pathway in parasites: are they using the 258 same way?
Sesma, Ane RBP35 is a novel auxiliary protein of the polyadenylation machinery of 259 filamentous fungi
Shahbabian, Karen Coordinated assembly of localization and translational control factors on 260 mRNA during transcription
Shalem, Ophir H. Measurements of the impact of 3' end sequences on gene expression 261 reveal wide range and sequence dependent effects
Shao, Ada An NMD-microRNA Regulatory Circuit in the Brain 262
Sharbati, Soroush Intestinal Salmonella Typhimurium infection leads to miR-29a induced 263 Caveolin 2 regulation
Sharma, Varun Kumar The microRNA regulatory network in T-cells transformed by human T-cell 264 leukemia virus type 1
Shcherbata, Halyna Drosophila microRNA-9a canalizes the process of muscle attachment 265 assembly via downregulation of Dystroglycan
Shcherbata, Halyna The miR-310s complex regulates cell differentiation and proliferation in 266 Drosophila
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Shcherbata, Halyna R. Steroid-induced microRNA let-7 acts as a spatio-temporal code for 267 neuronal cell fate in the developing Drosophila brain
Siebrasse, Jan-Peter Single Molecule Kinetics of the RNA Helicase Dbp5 268
Singh, Kusum K. Two functional MAGOH genes contribute to exon junction complex 269 composition and nonsense-mediated decay
Singhania, Richa Post-transcriptional and translational control of siRNA-generated mRNA 270 cleavage fragments
Slobodin, Boris The COPI coat complex and two cis-acting motifs govern the 271 intracellular localization of OXA1 mRNA and its contribution to mitochondrial function
Smolinski, Dariusz J. Correlation between mRNA metabolism and formation of Cajal bodies 272 and cytoplasmic snRNP-rich bodies
Sperling, Joseph Genome-wide activation of latent donor splice sites in stress and disease 273
Sperling, Ruth A network of interactions within the supraspliceosome 274
Spiró, Zoltán Characterization of lin-5 mRNA localization in C. elegans embryos 275
Stepanov, Grigoriy Artificial Box C/D RNAs Affect pre-mRNA Maturation in Human Cells 276
Page 35 EMBO|EMBL Symposium The Complex Life of mRNA
Stevens, Stewart G. Translation efficiency in human cells – the poor correlation between 277 mRNA and protein levels for many genes indicates widespread translational control
Stöhr, Nadine IGF2BP1 - A post-transcriptional ‘driver’ of tumor cell migration 278
Sträßer, Katja The phosphoproteome of ribosomes and two specific roles in translation 279
Subasic, Deni A switch in microRNA target regulation in C. elegans: from translational 280 inhibition to mRNA degradation in miR-58 family mutants
Sugiyama, Tomoyasu Selective Elimination of Meiotic mRNAs in Vegetative Fission Yeast 281
Sun, Mai Comparative Dynamic Transcriptome Analysis (cDTA) reveals mutual 282 feedback between mRNA synthesis and degradation
Susor, Andrej EJC component Magoh, is essential for processing of specific 283 transcripts in the mammalian oocyte
Swida-Barteczka, Aleksandra Plant miRNAs originated from the 3’UTR of protein coding genes 284
Syntichaki, Popi The role of mRNA metabolism factors in the lifespan and stress response 285 of Caenorhabditis elegans
Takeuchi-Tomita, Nono Role of the N-terminal extension on the activity of mammalian 286 mitochondrial ribosome recycling factor: implication for the role of GTP-hydrolysis in ribosome recycling
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Tamura, Teruko Interaction of THOC5, a member of mRNA export complex with its target 287 mRNA: CA/UG trinucleotide repeats directly bind to putative helical structure domain of THOC5
Tantale, Katjana HIV-1 transcription in live cells with single polymerase sensitivity 288
Tantale, Katjana 3’end cleavage buffers transcriptional noise 289
Tatomer, Deirdre C. Mutation of flash affects both histone locus body structure and histone 290 pre-mRNA processing: separation of function mutations define regions required for discrete roles
Tebaldi, Toma Triomics: comparison between transcriptome, translatome and 291 proteome variations
Teoh, Peik Lin The WAR complex controls the efficiency of FOS splicing 292
Theil, Kathrin 5' UTR-mediated translational repression by the RNA binding protein 293 GLD-1
Tiedje, Christopher The p38/MK2-driven exchange of TTP by HuR regulates LPS-induced 294 translation initiation of AU-rich element containing mRNAs
Tomasetto, Catherine L. Perispeckles are major assembly sites for the exon junction core 295 complex
Tran, Doan Duy Hai THOC5, a member of the mRNA export complex, is essential for 296 hematopoiesis in vivo and is required for M-CSF induced macrophage differentiation, thereby playing a key role in the mRNA export of M-CSF inducible genes
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Twyffels, Laure Competitive interplay between the cytoplasmic role of dTIS11 in 297 ARE-mediated decay and its Transportin-dependent nuclear import
Ubby, Ifeoma Regulation of TMEM16A Alternative Splicing 298
Urban, Marc Small RNA pathways in female gamete specification in Arabidopsis 299 thaliana
Valasek, Leos Yeast Translation Begins and Ends with Translation Initiation Factor 3 300 (eIF3)
Vanacova, Stepanka A Phosphoserine-Proline Switch in RNAP II CTD Controls Binding of an 301 RNA Processing Factor
Vindry, Caroline dTIS11-dependent polysomal deadenylation is the key step in AU-Rich 302 Element-mediated mRNA decay in Drosophila cells
Vlatakis, Ioannis C. Enhancer of RNA interference -1-like-1: one more player in the RNA 303 processing game of the chloroplast
Wagner, Jasmin Intracellular microRNA licalization and trafficking 304
Wang, Shao-Win Pdc1 functions in the assembly of P-bodies in Schizosaccharomyces 305 pombe
Wang, Zhen Mapping the transcriptome-wide exon junction complex binding sites 306 using 2-step iCLIP of eIF4A3
Weill, Laure Musashi: a new layer in the combinatorial CPE code 307
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Wellner, Juliane Germ cell specific RNA stabilization in Xenopus embryos 308
Winkler, Sebastiaan The anti-proliferative activity of BTG/TOB proteins is mediated via the 309 Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4 Not complex
Wippich, Frank DYRK3 couples mTORC1 signaling to mRNA granule turnover 310
Wong, Justin J-L An atlas of differential mRNA regulation by miRNAs in stem and 311 committed myeloid cells
Wurth, Laurence A role of the conserved RNA-binding protein UNR in cancer progression 312
Zagrovic, Bojan Sequence Signatures of Direct Complementarity between mRNAs and 313 Cognate Proteins on Multiple Levels
Zielonka, Elisabeth Responses of mRNA interactome and RNA-regulons to genotoxic stress 314
Zirkel, Anne M. IGF2BP1 promotes mesenchymal cell properties by enhancing the 315 LEF1-dependent expression of fibronectin
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