Programme Sunday 07 October 2012 16:00 - 17:45 Arrival and Registration ATC Registration Desk 17:45 - 19:00 BUFFET DINNER ATC Foyer 19:00 - 19:15 Welcome ATC Auditorium 19:15 - 21:30 KEYNOTE SESSION ATC Auditorium 19:15 - 20:00 Mechanisms of 3'->5' RNA degradation 1 Elena Conti Max Planck Institute of Biochemistry, Germany Talk kindly sponsored by Open Biology 20:00 - 20:45 Involvement of Low Complexity Polypeptide Sequences in 2 the Formation of RNA Granules Steven McKnight UT Southwestern Medical Center, United States of America 20:45 - 21:30 Post-transcriptional gene regulation by small RNAs and 3 RNA binding proteins Nikolaus Rajewsky Max Delbruck Center for Molecular Medicine, Germany 21:30 - 23:00 Drinks and Poster "Sneak Preview" ATC Foyer, Helices A & B Page 5 EMBO|EMBL Symposium The Complex Life of mRNA Monday 08 October 2012 09:00 - 13:10 SESSION 2 - RNA Surveillance and Decay Chair: Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany ATC Auditorium 09:00 - 09:25 Viral Noncoding RNPs 4 Joan Steitz Yale University, United States of America 09:25 - 09:50 Eukaryotic mRNA Turnover 5 Roy Parker HHMI/University of Colorado Boulder, United States of America 09:50 - 10:15 Production and destruction of RNA in human nuclei 6 Torben Jensen Aarhus University, Denmark 10:15 - 10:45 COFFEE BREAK ATC Foyer 10:45 - 11:10 Tales from the Cellular Underworld: The Importance of 7 mRNA Decay Lynne Maquat University of Rochester Medical Center, United States of America 11:10 - 11:25 DHX34 activates NMD by promoting the transition from the 8 SURF to the DECID complex Nele Hug MRC HGU, IGMM, United Kingdom 11:25 - 11:50 Reining in the mRNA decay enzymes: Proteolytic control of 9 decapping Jens Lykke-Andersen University of California San Diego, United States of America Page 6 Programme 11:50 - 12:05 Uridylation prevents the formation of aberrant mRNAs by 10 protecting deadenylated mRNA 3' ends Dominique Gagliardi CNRS-University of Strasbourg, France 12:05 - 12:30 Non-coding RNAs and mRNAs: Brothers separated at 11 birth? David Tollervey University of Edinburgh, United Kingdom 12:30 - 12:45 d4E-T: a eIF4E-binding protein that promotes 12 deadenylation-dependent decay of target mRNAs to control cell proliferation Cátia Igreja MPI for Developmental Biology Tuebingen, Germany 12:45 - 13:10 Virus-Host Interplay Leads to Widespread mRNA 13 Destruction Britt Glaunsinger University of California Berkeley, United States of America 13:10 - 16:00 LUNCH and POSTER SESSION 1 ATC Foyer and Helices A & B 16:00 - 19:20 SESSION 3 - Mechanics and Regulation of Translation Chair: Karsten Weis, University of California, Berkeley, USA ATC Auditorium 16:00 - 16:25 mRNA surveillance is driven by translation 14 Rachel Green Johns Hopkins University School of Medicine, United States of America 16:25 - 16:40 CLIP-seq of the DEAD-box RNA helicase eIF4AIII reveals 15 transcriptome-wide mapping of the exon junction complex in human Herve Le Hir IBENS, France Page 7 EMBO|EMBL Symposium The Complex Life of mRNA 16:40 - 17:05 RNA meets metabolism: from mRNA interactomes to REM 16 networks Matthias Hentze European Molecular Biology Laboratory (EMBL), Germany 17:05 - 17:35 COFFEE BREAK ATC Foyer 17:35 - 18:00 Molecular mechanisms of ribosomal scanning and AUG 17 selection: where to begin? Alan Hinnebusch National Institutes of Health, United States of America 18:00 - 18:15 The cryo-EM structure of the UPF-EJC complex shows 18 how UPF1 is poised to unwind the 3' end of a PTC-containing mRNP Oscar Llorca Spanish National Research Council-CSIC, Spain 18:15 - 18:40 Translational Control of Higher Brain Function 19 Joel Richter University of Massachusetts Medical School, United States of America 18:40 - 18:55 Physiological Role of NMD in Neuronal Development In 20 Vivo Eleen Shum UC San Diego, United States of America 18:55 - 19:20 Crystal structures of the eukaryotic ribosome and insights 21 into the regulation and initiation of protein synthesis Nenad Ban ETH Zurich, Switzerland 19:20 - 21:00 DINNER EMBL Canteen 21:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing Page 8 Programme Tuesday 09 October 2012 09:00 - 12:40 SESSION 4 - Epigenetics and Transcription Chair: Lynne Elizabeth Maquat, University of Rochester, USA ATC Auditorium 09:00 - 09:25 Structure-guided dynamic transcriptome analysis 22 elucidates the mRNA life cycle Patrick Cramer Gene Center - LMU, Germany 09:25 - 09:40 Road-block termination defines a new class of cryptic 23 transcripts Domenico Libri CNRS - CGM, France 09:40 - 10:05 Chromatin and transcription regulate alternative splicing 24 Alberto Kornblihtt FCEN, University of Buenos Aires and IFIBYNE-CONICET, Argentina 10:05 - 10:20 “Catching up” with polymerase: the mechanisms of 25 Sen1-dependent termination Odil Porrua Fuerte Centre de Genetique Moleculaire-CNRS, France 10:20 - 10:35 The mRNA-Bound Proteome and Its Global Occupancy 26 Profile on Protein-Coding Transcripts Markus Landthaler Max-Delbrück-Center for Molecular Medicine, Germany 10:35 - 11:05 COFFEE BREAK ATC Foyer 11:05 - 11:30 Ending the message in eukaryotes: Gene loops, R-loops 27 and noncoding RNA Nicholas Proudfoot University of Oxford, United Kingdom Page 9 EMBO|EMBL Symposium The Complex Life of mRNA 11:30 - 11:45 Global regulatory functions of Sen1-dependent Pol II 28 termination factors David Brow University of Wisconsin-Madison, United States of America 11:45 - 12:10 Splicing on chromatin 29 Karla Neugebauer MPI-CBG, Germany 12:10 - 12:25 Single cell analysis reveals aspects of antisense RNA 30 regulation and mode of action in PHO84 transcription repression Daniel Zenklusen Université de Montréal, Canada 12:25 - 12:40 Genome-wide measurement of RNA structure in vivo 31 Silvia Rouskin UCSF, United States of America 12:40 - 15:30 LUNCH and POSTER SESSION 2 ATC Foyer and Helices A & B 15:30 - 17:40 SESSION 5 - Pre-mRNA Processing Chair: Alberto Kornblihtt, University of Buenos Aires, Argentina ATC Auditorium 15:30 - 15:55 Processing of mRNA precursors and links to human 32 disease James Manley Columbia University, United States of America 15:55 - 16:20 TELESCRIPTING: A New Dimension to mRNA Regulation 33 Gideon Dreyfuss HHMI/University of Pennsylvania School of Medicine, United States of America Page 10 Programme 16:20 - 16:35 ELAV mediates neuronal-specific 3’ UTR extension by 34 suppressing proximal polyadenylation Valerie Hilgers UC Berkeley, United States of America 16:35 - 17:00 How competition between RNA-binding proteins for 35 overlapping binding sites controls splicing decisions Jernej Ule MRC Laboratory of Molecular Biology, United Kingdom 17:00 - 17:15 CWC22 Connects Pre-mRNA Splicing and Exon Junction 36 Complex Assembly Anna-Lena Steckelberg Institute for Genetics, University of Cologne, Germany 17:15 - 17:40 Pre-mRNA processing and mRNA metabolism 37 Melissa Moore HHMI/University of Massachusetts Medical School, United States of America 17:40 - 18:00 Pre-dinner drinks ATC Foyer 18:00 - 20:00 DINNER EMBL Canteen 20:00 - 23:00 Drinks in the ATC Foyer and Roof Top Lounge and poster viewing Page 11 EMBO|EMBL Symposium The Complex Life of mRNA Wednesday 10 October 2012 09:00 - 12:35 SESSION 6 - miRNA Function Chair: Matthias W. Hentze, EMBL Heidelberg, Germany ATC Auditorium 09:00 - 09:25 Structural insights into miRISC recruitment of the 38 CCR4-NOT complex Nahum Sonenberg McGill University, Canada 09:25 - 09:50 Function and Regulation of MicroRNAs 39 Helge Grosshans FMI, Switzerland 09:50 - 10:05 The piRNA pathway and its role in the regulation of 40 maternal mRNAs in the Drosophila early embryo Bridlin Barckmann IGH Institute of Human Genetics, France 10:05 - 10:30 Regulation of miRNA-mediated Repression and miRNA 41 Metabolism in Mammalian Cells Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland 10:30 - 11:00 COFFEE BREAK ATC Foyer 11:00 - 11:25 Biogenesis and function of PIWI-interacting RNA in 42 Drosophila Mikiko Siomi Graduate School of Science, University of Tokyo, Japan 11:25 - 11:40 miRNA-mediated regulation of the cyrano lincRNA is a 43 non-canonical pathway essential for early vertebrate development Alena Shkumatava Whitehead Institute/MIT, United States of America Page 12 Programme 11:40 - 12:05 Evolutionary plasticity of the protein interaction network 44 that regulates mRNA stability Elisa Izaurralde Max Planck Institute for Developmental Biology, Germany 12:05 - 12:20 Structure of yeast Argonaute with guide RNA 45 David Weinberg Whitehead Institute / MIT, United States of America 12:20 - 12:35 The structural biochemistry of Zucchini implicates it as a 46 nuclease in piRNA biogenesis Astrid Haase Cold Spring Harbor Laboratory, United States of America 12:35 - 15:30 LUNCH and POSTER SESSION 3 ATC Foyer and Helices A & B 15:30 - 18:30 SESSION 7 - mRNA Export and Localization Chair: Melissa J. Moore, UMass Medical School/HHMI, USA ATC Auditorium 15:30 - 15:55 Regulation of mRNA export and decay 47 Karsten Weis UC Berkeley, United States of America 15:55 - 16:10 Blastomere-specific transcriptome profiling after the first 48 embryonic division Erin Osborne Nishimura University of North Carolina, United States of America 16:10 - 16:25 Structural studies of a minimal eIF4E-Cup complex 49 Fulvia Bono Max Planck for Developmental Biology, Germany 16:25 - 16:55 COFFEE BREAK ATC Foyer Page 13 EMBO|EMBL Symposium The Complex Life of mRNA 16:55 - 17:10 The Unfolded Protein Response in Fission Yeast 50 Modulates Stability of Select mRNAs to Maintain Protein Homeostasis Philipp Kimmig UCSF,