Astellas Pharma Inc. 2-5-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo 103-8411, Japan Astellas Pharma Inc

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Astellas Pharma Inc. 2-5-1, Nihonbashi-Honcho, Chuo-Ku, Tokyo 103-8411, Japan Astellas Pharma Inc ANNUAL REPORT 2016 ANNUAL REPORT 2016 For the Year Ended March 31, 2016 Astellas Pharma Inc. 2-5-1, Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan http://www.astellas.com/en/ Astellas Pharma Inc. Please direct inquiries concerning Annual Report 2016 to: Astellas Pharma Inc. Corporate Communications TEL: +81-3-3244-3202 FAX: +81-3-5201-7473 This report is printed with environmentally friendly vegetable-based inks on FSCTM-certified paper made of wood sourced from responsibly managed forests, Issued in August 2016 using a waterless printing process. Printed in Japan Contents About Astellas 1 About Astellas 2 Business Philosophy Retracing Astellas’ Steps 3 Astellas Today 5 Contribute toward Health Financial and Non-Financial Highlights 7 Raison D'être Editorial Policy 9 Contribute toward improving the health of people through Innovative Drugs around the world through the provision of innovative 2 Our Strategy 10 and reliable pharmaceutical products 1 Astellas Value Creation Process 11 • To go beyond all others in exploring and tapping the potential CEO Message Astellas is concentrating on the 13 of the life sciences. CSR-Based Management 17 innovative drug business, where Business Environment 19 • To continue tackling new challenges and creating innovative it possesses key strengths. Strategic Plan 2015-2017 pharmaceutical products. 20 We are enhancing our ability to Financial Strategy 24 • To deliver quality products along with accurate information Management Structure 25 and retain solid credibility among customers. continuously develop innovative Interview with an Outside Director 27 drugs, in conjunction with • To support healthy living for people around the world. optimizing the allocation of • To continue shining on the global pharmaceutical field. resources, in an effort to deliver 3 Performance valuable medicines to patients Mission 1. Business Review 30 worldwide. Research 31 Sustainable enhancement of enterprise value Clinical Development 32 Feature: Our Initiatives to Create Innovation 33 • Astellas will seek to enhance its enterprise value in a R&D Topics During the Year 37 sustainable manner. Review of Operations by Therapeutic Area 41 • Astellas will seek to be the company of choice among all Review of Global Operations 47 its stakeholders, including its customers, shareholders, Sales of Main Products by Region 51 employees, and the global community. Astellas will strive to gain the trust of all stakeholders and 2. Corporate Social Responsibility 52 thereby enhance its enterprise value. Overview of CSR Activities 53 CSR Activities: Results and Plans 55 Beliefs Responsible Business Activities 57 Employees 63 Our “beliefs” provide the code of conduct we prize at all times. Society 67 Astellas will always be a group of people who act upon Environment 71 these beliefs. Ethics & Compliance 75 Dialogue with Stakeholders 79 High Sense of Ethics We will always manage our business with the highest sense of ethics. 4 Corporate Governance 80 Customer Focus Corporate Governance 81 We will always seek to understand customer needs and our Messages from Outside Officers 86 focus will always be on achieving customer satisfaction. Creativity We will not be complacent and will always seek to innovate 5 Financial Information to create new value. Competitive Focus and Data 88 Our eyes will always be directed to the outside world, and 11-Year Financial Summary 89 we will continue to create better value faster. Management’s Discussion and Analysis 91 Consolidated Financial Statements 98 Astellas promises to perform its obligations toward all Investor Information 153 stakeholders by acting ethically and seeking to actively Corporate Data/Principal Subsidiaries and Affiliates 154 disclose information. Cautionary Note In this annual report, statements made with respect to current plans, estimates, strategies and beliefs and other statements that are not historical facts are forward-looking statements about the future performance of Astellas. These statements are based on management’s current assumptions and beliefs in light of the information currently available to it and involve known and unknown risks and uncertainties. A number of factors could cause actual results to differ materially from those discussed in the forward-looking statements. Such factors include, but are not limited to: (i) changes in general economic conditions and in laws and regulations relating to pharmaceutical markets, (ii) currency exchange rate fluctuations, (iii) delays in new product launches, (iv) the inability of Astellas to market existing and new products effectively, (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets, and (vi) infringements of Astellas’ intellectual property rights by third parties. Information about pharmaceutical products (including products currently in development) which is included in this annual report is not intended to constitute an advertisement or medical advice. 1 Astellas Pharma Inc. ANNUAL REPORT 2016 Astellas Pharma Inc. ANNUAL REPORT 2016 2 Contents About Astellas 1 About Astellas 2 Business Philosophy Retracing Astellas’ Steps 3 Astellas Today 5 Contribute toward Health Financial and Non-Financial Highlights 7 Raison D'être Editorial Policy 9 Contribute toward improving the health of people through Innovative Drugs around the world through the provision of innovative 2 Our Strategy 10 and reliable pharmaceutical products 1 Astellas Value Creation Process 11 • To go beyond all others in exploring and tapping the potential CEO Message Astellas is concentrating on the 13 of the life sciences. CSR-Based Management 17 innovative drug business, where Business Environment 19 • To continue tackling new challenges and creating innovative it possesses key strengths. Strategic Plan 2015-2017 pharmaceutical products. 20 We are enhancing our ability to Financial Strategy 24 • To deliver quality products along with accurate information Management Structure 25 and retain solid credibility among customers. continuously develop innovative Interview with an Outside Director 27 drugs, in conjunction with • To support healthy living for people around the world. optimizing the allocation of • To continue shining on the global pharmaceutical field. resources, in an effort to deliver 3 Performance valuable medicines to patients Mission 1. Business Review 30 worldwide. Research 31 Sustainable enhancement of enterprise value Clinical Development 32 Feature: Our Initiatives to Create Innovation 33 • Astellas will seek to enhance its enterprise value in a R&D Topics During the Year 37 sustainable manner. Review of Operations by Therapeutic Area 41 • Astellas will seek to be the company of choice among all Review of Global Operations 47 its stakeholders, including its customers, shareholders, Sales of Main Products by Region 51 employees, and the global community. Astellas will strive to gain the trust of all stakeholders and 2. Corporate Social Responsibility 52 thereby enhance its enterprise value. Overview of CSR Activities 53 CSR Activities: Results and Plans 55 Beliefs Responsible Business Activities 57 Employees 63 Our “beliefs” provide the code of conduct we prize at all times. Society 67 Astellas will always be a group of people who act upon Environment 71 these beliefs. Ethics & Compliance 75 Dialogue with Stakeholders 79 High Sense of Ethics We will always manage our business with the highest sense of ethics. 4 Corporate Governance 80 Customer Focus Corporate Governance 81 We will always seek to understand customer needs and our Messages from Outside Officers 86 focus will always be on achieving customer satisfaction. Creativity We will not be complacent and will always seek to innovate 5 Financial Information to create new value. Competitive Focus and Data 88 Our eyes will always be directed to the outside world, and 11-Year Financial Summary 89 we will continue to create better value faster. Management’s Discussion and Analysis 91 Consolidated Financial Statements 98 Astellas promises to perform its obligations toward all Investor Information 153 stakeholders by acting ethically and seeking to actively Corporate Data/Principal Subsidiaries and Affiliates 154 disclose information. Cautionary Note In this annual report, statements made with respect to current plans, estimates, strategies and beliefs and other statements that are not historical facts are forward-looking statements about the future performance of Astellas. These statements are based on management’s current assumptions and beliefs in light of the information currently available to it and involve known and unknown risks and uncertainties. A number of factors could cause actual results to differ materially from those discussed in the forward-looking statements. Such factors include, but are not limited to: (i) changes in general economic conditions and in laws and regulations relating to pharmaceutical markets, (ii) currency exchange rate fluctuations, (iii) delays in new product launches, (iv) the inability of Astellas to market existing and new products effectively, (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets, and (vi) infringements of Astellas’ intellectual property rights by third parties. Information about pharmaceutical products (including products currently in development) which is included in this annual report is not intended to constitute an advertisement or medical advice. 1 Astellas Pharma
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