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Scabies in Healthcare Facilities
Scabies in Healthcare Facilities Tammra L. Morrison, RN BSN Healthcare Associated Infections Coordinator Communicable Disease Branch, Epidemiology Section December 9, 2016 Symptoms • In a person who has never had scabies: • May take 4-6 weeks for symptom onset • In a person who has had scabies in the past: • Symptoms may start in 1-4 days • May be spread PRIOR to symptom onset What to Look for • Intense itching • Especially at night • Pimple-like itchy rash • May affect entire body OR Dermatologie.md common sites: • Wrist, elbow, armpit, webbing between the fingers, nipple, penis, waist, belt-line, and buttocks • Burrows (tunnels) may be seen on the skin • Tiny raised and crooked grayish-white or skin- colored lines Transmission • Direct, prolonged, skin-to-skin contact with an infested person • Sexual partners • Household members • Quick handshake/hug will usually not spread scabies How Long Do Mites Live? • 1-2 months on a person • 48-72 hours off a person • Scabies mites will die at 122 degrees for 10 minutes Webmd.com 5 Diagnosis • Customary appearance and distribution of the rash and presence of burrows. • Confirm diagnosis: • Obtain a skin scraping to examine under a microscope for mites, eggs, or mite fecal matter • Person can still be infested even if mites, eggs, or fecal matter cannot be found • Typically fewer than 10-15 mites present on the entire body • **Crusted scabies may be thousands of mites and should be considered highly contagious** How Do You Treat Scabies? 7 Treatment • Available only by prescription • No "over-the-counter“ -
AHFS Pharmacologic-Therapeutic Classification System
AHFS Pharmacologic-Therapeutic Classification System Abacavir 48:24 - Mucolytic Agents - 382638 8:18.08.20 - HIV Nucleoside and Nucleotide Reverse Acitretin 84:92 - Skin and Mucous Membrane Agents, Abaloparatide 68:24.08 - Parathyroid Agents - 317036 Aclidinium Abatacept 12:08.08 - Antimuscarinics/Antispasmodics - 313022 92:36 - Disease-modifying Antirheumatic Drugs - Acrivastine 92:20 - Immunomodulatory Agents - 306003 4:08 - Second Generation Antihistamines - 394040 Abciximab 48:04.08 - Second Generation Antihistamines - 394040 20:12.18 - Platelet-aggregation Inhibitors - 395014 Acyclovir Abemaciclib 8:18.32 - Nucleosides and Nucleotides - 381045 10:00 - Antineoplastic Agents - 317058 84:04.06 - Antivirals - 381036 Abiraterone Adalimumab; -adaz 10:00 - Antineoplastic Agents - 311027 92:36 - Disease-modifying Antirheumatic Drugs - AbobotulinumtoxinA 56:92 - GI Drugs, Miscellaneous - 302046 92:20 - Immunomodulatory Agents - 302046 92:92 - Other Miscellaneous Therapeutic Agents - 12:20.92 - Skeletal Muscle Relaxants, Miscellaneous - Adapalene 84:92 - Skin and Mucous Membrane Agents, Acalabrutinib 10:00 - Antineoplastic Agents - 317059 Adefovir Acamprosate 8:18.32 - Nucleosides and Nucleotides - 302036 28:92 - Central Nervous System Agents, Adenosine 24:04.04.24 - Class IV Antiarrhythmics - 304010 Acarbose Adenovirus Vaccine Live Oral 68:20.02 - alpha-Glucosidase Inhibitors - 396015 80:12 - Vaccines - 315016 Acebutolol Ado-Trastuzumab 24:24 - beta-Adrenergic Blocking Agents - 387003 10:00 - Antineoplastic Agents - 313041 12:16.08.08 - Selective -
CCA Senior Care Options Formulary
Commonwealth Care Alliance Senior Care Option HMO SNP 2021 List of Covered Drugs Formulary 30 Winter Street • Boston, MA 02108 PLEASE READ: THIS DOCUMENT CONTAINS INFORMATION ABOUT THE DRUGS WE COVER IN THIS PLAN This formulary was updated on 08/01/2021. For more recent information or other questions, please contact Senior Care Options Program (HMO SNP) Member Services, at 1-866-610-2273 or, for TTY users, 711, 8 a.m. – 8 p.m., 7 days a week, or visit www.commonwealthcaresco.org. HPMS Approved Formulary File Submission ID 00021589, Version Number 13 Senior Care Options Program (HMO SNP) 2021 Formulary (List of Covered Drugs) PLEASE READ: THIS DO CUMENT CONTAINS INFORMATION ABOUT THE DRUGS WE COVER IN THIS PLAN HPMS Approved Formulary File Submission ID 00021589, Version Number 13 Note to existing members: This formulary has changed since last year. Please review this document to make sure that it still contains the drugs you take. When this drug list (formulary) refers to “we,” “us”, or “our,” it means Commonwealth Care Alliance. When it refers to “plan” or “our plan,” it means 2021 Senior Care Options Program. This document includes list of the drugs (formulary) for our plan which is current as of 08/01/2021. This formulary document applies to all SCO members. For an updated formulary, please contact us. Our contact information, along with the date we last updated the formulary, appears on the front and back cover pages. You must generally use network pharmacies to use your prescription drug benefit. Benefits, formulary, pharmacy n etwork, and/or copayments/coinsurance may change on January 1, 2022, and from time to time during the year. -
Central Valley Toxicology Drug List
Chloroform ~F~ Lithium ~A~ Chlorpheniramine Loratadine Famotidine Acebutolol Chlorpromazine Lorazepam Fenoprofen Acetaminophen Cimetidine Loxapine Fentanyl Acetone Citalopram LSD (Lysergide) Fexofenadine 6-mono- Clomipramine acetylmorphine Flecainide ~M~ Clonazepam a-Hydroxyalprazolam Fluconazole Maprotiline Clonidine a-Hydroxytriazolam Flunitrazepam MDA Clorazepate Albuterol Fluoxetine MDMA Clozapine Alprazolam Fluphenazine Medazepam Cocaethylene Amantadine Flurazepam Meperidine Cocaine 7-Aminoflunitrazepam Fluvoxamine Mephobarbital Codeine Amiodarone Fosinopril Meprobamate Conine Amitriptyline Furosemide Mesoridazine Cotinine Amlodipine Methadone Cyanide ~G~ Amobarbital Methanol Cyclobenzaprine Gabapentin Amoxapine d-Methamphetamine Cyclosporine GHB d-Amphetamine l-Methamphetamine Glutethamide l-Amphetamine ~D~ Methapyrilene Guaifenesin Aprobarbital Demoxepam Methaqualone Atenolol Desalkylfurazepam ~H~ Methocarbamol Atropine Desipramine Halazepam Methylphenidate ~B~ Desmethyldoxepin Haloperidol Methyprylon Dextromethoraphan Heroin Metoclopramide Baclofen Diazepam Hexobarbital Metoprolol Barbital Digoxin Hydrocodone Mexiletine Benzoylecgonine Dihydrocodein Hydromorphone Midazolam Benzphetamine Dihydrokevain Hydroxychloroquine Mirtazapine Benztropine Diltiazem Hydroxyzine Morphine (Total/Free) Brodificoum Dimenhydrinate Bromazepam ~N~ Diphenhydramine ~I~ Bupivacaine Nafcillin Disopyramide Ibuprofen Buprenorphine Naloxone Doxapram Imipramine Bupropion Naltrexone Doxazosin Indomethacin Buspirone NAPA Doxepin Isoniazid Butabarbital Naproxen -
The New Face of Drug Abuse: Impact on Your Children, Family, and Community
The New Face of Drug Abuse: Impact on your Children, Family, and Community Patrick J. Sammon, Ph.D . [email protected] Impact of Prescription Drug Abuse: Illegal use of these drugs is responsible for multiple overdoses and fatalities Opiate addiction is blamed for causing a surge in crime: Robberies and break-ins at pharmacies Drug shoppers scamming doctors Harassments, assaults, and robberies of patients leaving drugstores Shoplifting and burglaries to support addiction Domestic violence and abuse Who’s at risk, who are the most vulnerable?: Adolescents - Sharp increase in 12 to 17 yr. olds and the 18 to 25 yr. olds Women - Increase rate of use in younger women Older adults - 17% of 60 + yr. olds may be affected by prescription drug abuse Why are Prescription Drugs so Popular? Legal, Easy to Obtain, Cheap and Safe & Non-addictive Legal: Perception that there is less legal risk than illicit drugs − Federal law does not distinguish between CI & CII drugs Easily obtainable: - From users, diverters, clinics, hospitals, Emergency Departments and practitioners and easy to steal Cheap: Low or no co-pay cost; may motivate people to use or sell PD’s Safer and Non-addictive: - Easily identity and less stigma than street drugs - Higher purity and less risky - Less HIV or hepatitis risk - Easier to use, no IV injecting but what about tolerance…and addiction! Commonly Misused and Abused Prescription & OTC Drugs Substance misuse is use of a drug that varies from a socially or medically accepted use. Substance abuse - any use of drugs that cause physical, psychological, economic, legal or social harm to the individual user or to others affected by the drug use's behavior. -
A Screening-Based Approach to Circumvent Tumor Microenvironment
JBXXXX10.1177/1087057113501081Journal of Biomolecular ScreeningSingh et al. 501081research-article2013 Original Research Journal of Biomolecular Screening 2014, Vol 19(1) 158 –167 A Screening-Based Approach to © 2013 Society for Laboratory Automation and Screening DOI: 10.1177/1087057113501081 Circumvent Tumor Microenvironment- jbx.sagepub.com Driven Intrinsic Resistance to BCR-ABL+ Inhibitors in Ph+ Acute Lymphoblastic Leukemia Harpreet Singh1,2, Anang A. Shelat3, Amandeep Singh4, Nidal Boulos1, Richard T. Williams1,2*, and R. Kiplin Guy2,3 Abstract Signaling by the BCR-ABL fusion kinase drives Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myelogenous leukemia (CML). Despite their clinical activity in many patients with CML, the BCR-ABL kinase inhibitors (BCR-ABL-KIs) imatinib, dasatinib, and nilotinib provide only transient leukemia reduction in patients with Ph+ ALL. While host-derived growth factors in the leukemia microenvironment have been invoked to explain this drug resistance, their relative contribution remains uncertain. Using genetically defined murine Ph+ ALL cells, we identified interleukin 7 (IL-7) as the dominant host factor that attenuates response to BCR-ABL-KIs. To identify potential combination drugs that could overcome this IL-7–dependent BCR-ABL-KI–resistant phenotype, we screened a small-molecule library including Food and Drug Administration–approved drugs. Among the validated hits, the well-tolerated antimalarial drug dihydroartemisinin (DHA) displayed potent activity in vitro and modest in vivo monotherapy activity against engineered murine BCR-ABL-KI–resistant Ph+ ALL. Strikingly, cotreatment with DHA and dasatinib in vivo strongly reduced primary leukemia burden and improved long-term survival in a murine model that faithfully captures the BCR-ABL-KI–resistant phenotype of human Ph+ ALL. -
The Alkaloid Emetine As a Promising Agent for the Induction and Enhancement of Drug-Induced Apoptosis in Leukemia Cells
737-744 26/7/07 08:26 Page 737 ONCOLOGY REPORTS 18: 737-744, 2007 737 The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells MAREN MÖLLER1, KERSTIN HERZER3, TILL WENGER2,4, INGRID HERR2 and MICHAEL WINK1 1Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364; 2Molecular OncoSurgery, Department of Surgery, University and German Cancer Research Center, Im Neuenheimer Feld 365, 69120 Heidelberg; 31st Department of Internal Medicine, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany; 4Centre d'Immunologie de Marseille-Luminy, Marseille, France Received January 8, 2007; Accepted February 20, 2007 Abstract. Emetine, a natural alkaloid from Psychotria caused mainly by two isoquinoline alkaloids, emetine and ipecacuanha, has been used in phytomedicine to induce cephaeline, having identical effects regarding the irritation of vomiting, and to treat cough and severe amoebiasis. Certain the respiratory tract (1). Nowadays, ipecac syrup is no longer data suggest the induction of apoptosis by emetine in recommended for the routine use in the management of leukemia cells. Therefore, we examined the suitability of poisoned patients (2) and recently a guideline on the use of emetine for the sensitisation of leukemia cells to apoptosis ipecac syrup was published, stating that ‘the circumstances in induced by cisplatin. In response to emetine, we found a which ipecac-induced emesis is the appropriate or desired strong reduction in viability, an induction of apoptosis and method of gastric decontamination are rare’ (3). Moreover, at caspase activity comparable to the cytotoxic effect of present there is a demand to remove ipecac from the over- cisplatin. -
Salicylic Acid
Treatment Guide to Common Skin Conditions Prepared by Loren Regier, BSP, BA, Sharon Downey -www.RxFiles.ca Revised: Jan 2004 Dermatitis, Atopic Dry Skin Psoriasis Step 1 - General Treatment Measures Step 1 - General Treatment Measures Step 1 • Avoid contact with irritants or trigger factors • Use cool air humidifiers • Non-pharmacologic measures (general health issues) • Avoid wool or nylon clothing. • Lower house temperature (minimize perspiration) • Moisturizers (will not clear skin, but will ↓ itching) • Wash clothing in soap vs detergent; double rinse/vinegar • Limit use of soap to axillae, feet, and groin • Avoid frequent or prolonged bathing; twice weekly • Topical Steroids Step 2 recommended but daily bathing permitted with • Coal Tar • Colloidal oatmeal bath products adequate skin hydration therapy (apply moisturizer • Anthralin • Lanolin-free water miscible bath oil immediately afterwards) • Vitamin D3 • Intensive skin hydration therapy • Limit use of soap to axillae, feet, and groin • Topical Retinoid Therapy • “Soapless” cleansers for sensitive skin • Apply lubricating emollients such as petrolatum to • Sunshine Step 3 damp skin (e.g. after bathing) • Oral antihistamines (1st generation)for sedation & relief of • Salicylic acid itching give at bedtime +/- a daytime regimen as required Step 2 • Bath additives (tar solns, oils, oatmeal, Epsom salts) • Topical hydrocortisone (0.5%) for inflammation • Colloidal oatmeal bath products Step 2 apply od-tid; ointments more effective than creams • Water miscible bath oil • Phototherapy (UVB) may use cream during day & ointment at night • Humectants: urea, lactic acid, phospholipid • Photochemotherapy (Psoralen + UVA) Step 4 Step 3 • Combination Therapies (from Step 1 & 2 treatments) • Prescription topical corticosteroids: use lowest potency • Oral antihistamines for sedation & relief of itching steroid that is effective and wean to twice weekly. -
Dermatological Effects of Different Keratolytic Agents on Acne Vulgaris
Clin l of ica a l T n r r i u a l o s J Alodeani, J Clin Trials 2016, 6:2 Journal of Clinical Trials DOI: 10.4172/2167-0870.1000262 ISSN: 2167-0870 Research Article Open Access Dermatological Effects of Different Keratolytic Agents on Acne Vulgaris Essa Ajmi Alodeani* College of Medicine at AD-Dwadmi, Shaqra University, Saudi Arabia *Corresponding author: Essa Ajmi Alodeani, College of Medicine at AD-Dwadmi, Shaqra University, Saudi Arabia, Tel: +966 55 075 9042; E-mail: [email protected] Received date: March 24, 2016; Accepted date: April 18, 2016; Published date: April 25, 2016 Copyright: © 2016 Alodeani EA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Acne vulgaris is a chronic inflammatory skin disease; it's one of the most common skin disorders and affects mainly adolescents and young adults. Keratolytic agents are widely used in treatment of acne from several years. In this study we aimed to evaluate and compare the cutaneous response of different keratolytic agents in management of acne vulgaris. Ninety patients were selected among those attending the outpatient dermatology clinic in AD- Dwadmi hospital during the period from October 2015 to February 2016. The selected patients had different forms of acne vulgaris, papulo-pustular, comedonal and post acne scar. Three types of keratolytic agents were used, glycolic acid 50%, salicylic acid 20% and jessner solution. In papulopustular lesions, the three agents were effective with non-significant difference between them; however, there was more excellent results with jessner solution (70 % of patients) then glycolic acid (50%) and lastly salicylic acid (40%). -
Synergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and Ph Sensitive Nanocarriers
Drug Design, Development and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Synergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and pH Sensitive Nanocarriers This article was published in the following Dove Press journal: Drug Design, Development and Therapy Yonglong Jin1,* Purpose: Prodrug technology-based combination drug therapy has been exploited as Yi Wang2,* a promising treatment strategy to achieve synergistic lung cancer therapy, reduce drug Xiguang Liu1 dose, and decrease side effects. In the present study, we synthesized a pH and glutathione Jing Zhou1 (GSH) sensitive prodrug, cisplatin (CIS) and doxorubicin (DOX) conjugates (CIS-DOXp). Xintong Wang1 CIS-DOXp was loaded by nanocarriers and delivered into the tumor site. Methods: pH and GSH sensitive CIS-DOX prodrug (CIS-DOXp) was synthesized by con Hui Feng1 jugating GSH responsive CIS prodrug with pH sensitive DOX prodrug. CIS-DOXp-loaded Hong Liu2 nanocarriers (CIS-DOXp NC) were prepared using emulsification and solvent evaporation 1Department of Radiotherapy, Affiliated method. The morphology, particle size, polydispersity index (PDI) and zeta potential of nano Hospital of Qingdao University, Qingdao carriers were measured. In vitro cytotoxicity of nanocarriers and the corresponding free drugs 266000, People’s Republic of China; 2Department of Radiation Oncology, Qilu was examined using the MTT assay. In vivo anti-tumor efficiency and biodistribution behaviors Hospital of Shandong University, Jinan were evaluated on lung cancer mice models. 250012, People’s Republic of China Results: The size, PDI, zeta potential, CIS loading efficiency, and DOX loading efficiency *These authors contributed equally to of CIS-DOXp NC were 128.6 ± 3.2 nm, 0.196 ± 0.021, 15.7 ± 1.7 mV, 92.1 ± 2.1%, and 90.4 this work ± 1.8%, respectively. -
Estonian Statistics on Medicines 2016 1/41
Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole -
Ied with Great Restlessness
excessive discharge from the bowels. Subsultus tendinum plete publicity lies with Ayer; whether correctly or not, the in the terminal stage of the disease is usually accompan- quantities are all given. AYER'S rECTORAL. PRUNI-HEEOIN. ied with for which in recent cases I CHERRY great restlessness; Each auid ounce1 represents Each fluid ounce represents have found Hoffman's as recommended Wild cherry .6 grains. Wild cherry bark. anodyne, by White pine .4 White bark. a grains. pine Hare, very useful remedy. Terpin hydrate. .. .4 grains. Terpin hydrate.4 grains. In the later of the feeble heart's Blood root .2 grains. Blood root. stage typhoid fever, Heroin ( !).1/6 grain. Heroin .1/6 grain. action calls for and one must instruct the Grindella rohusta. .4 grains. Ammon muriate. .16 grains. support; Senega .4 grains. Spikenard. nurse relative to the necessary stimulants to sustain the Rio Ipecac .2 grains. Glycerin. circulation. the urine is loaded Glycerin. Solvents. During convalescence Alcohol .80 m. etc. with the bacillus. in 5- Syrup. typhoid Hexamethylenamin Water. three times a well diluted with grain doses, repeated day, If Ayer's "shotgun" Pectoral ought "to be considered obso- and continued for a week or ten will water, days, destroy lete, what shall we say of Pruni-Heroin? If a pre- the bacillus in urine. physician the scribe Pruni-Heroin and condemn Ayer's to a patient who has taken Ayer's, what will the patient think of the advice if he learns the of composition Pruni-Heroin? _ Expectorants in the Pharmocopeia. THE PHYSICIAN AND THE PHARMACOPEIA.