US 20140148493A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0148493 A1 Tamura et al. (43) Pub. Date: May 29, 2014

(54) AGRICULTURAL AND HORTICULTURAL Publication Classification INSECTICDE COMPOSITION AND METHOD FORUSING THE SAME (51) Int. Cl. AOIN 43/56 (2006.01) (75) Inventors: Shingo Tamura, Tokyo (JP); Takao AOIN4I/O (2006.01) Aoki, Osaka (JP); Ken Kuriyama, (52) U.S. Cl. Tokyo (JP) CPC ...... A0IN 43/56 (2013.01); A0IN 41/10 (2013.01) (73) Assignee: NIHON NOHYAKU CO.,LTD., Tokyo USPC ...... 514/406 (JP) (21) Appl. No.: 14/125,517 (57) ABSTRACT (22) PCT Fled: Jun. 28, 2012 Provided are an agricultural and horticultural insecticide composition comprising flubendiamide and tolfenpyrad as (86) PCT NO.: active ingredients; and a method for using an agricultural and S371 (c)(1), horticultural insecticide composition, comprising treating (2), (4) Date: Feb. 12, 2014 insect pests directly, treating crops potentially infested with the insect pests, or treating Surrounding soil or cultivation (30) Foreign Application Priority Data medium of the crops with an effective amount of an agricul tural and horticultural insecticide composition comprising Jun. 29, 2011 (JP) ...... 2011-144372 flubendiamide and tolfenpyrad as active ingredients. US 2014/0148493 A1 May 29, 2014

AGRICULTURAL AND HORTICULTURAL control cannot be achieved in some cases because of the kind INSECTICDE COMPOSITION AND of insect pest to be controlled, habitat characteristics, devel METHOD FOR USING THE SAME opment of insecticide resistance, etc. Under Such circum stances, the development of novel technologies for efficiently TECHNICAL FIELD controlling insect pests that have been difficult or impossible 0001. The present invention relates to an agricultural and to control is desired. horticultural insecticide composition comprising flubendia mide and tolfenpyrad as active ingredients; and a method for Solution to Problem using the same. 0011. The present inventors conducted extensive research to solve the above-described problems. As a result, the BACKGROUND ART present inventors found that a combined use of flubendiamide 0002 Flubendiamide is a commercially available com (general name) (chemical name: 3-iodo-N'-(2-mesyl-1,1- pound as an agricultural and horticultural insecticide. It is dimethylethyl)-N-(4-1,2,2,2-tetrafluoro-1-(trifluorom known that various combinations offlubendiamide or its rela ethyl)ethyl-o-tolylphthalamide), known as an agricultural tive compound and an agricultural and horticultural insecti and horticultural insecticide, and tolfenpyrad (general name) cide have a complementary effect on the insecticidal spec (chemical name: 4-chloro-3-ethyl-1-methyl-N-4-(p-toly trum and that specific combinations of them produce a loxy)benzylpyrazole-5-carboxamide), similarly known as synergistic effect (for example, see Patent Literature 1 to 5 an agricultural and horticultural insecticide, has advantages and Non Patent Literature 1). Tolfenpyrad is also a commer over a separate use of each compound. Such as remarkable cially available compound as an agricultural and horticultural synergistic effect, expansion of the range of target insect insecticide. It is also known that various combinations of pests, dose reduction, reduction of treatment frequency, etc. tolfenpyrad and an agricultural and horticultural insecticide Thus, the present invention was completed. have a complementary effect on the insecticidal spectrum and 0012 That is, the present invention relates to the follow that specific combinations of them produce a synergistic ing. effect (for example, see Patent Literature 6 and 7 and Non 1 An agricultural and horticultural insecticide composition Patent Literature 1). However, compositions comprising a comprising flubendiamide and tolfenpyrad as active ingredi combination of flubendiamide and tolfenpyrad are not entS. known, and it is not known at all that the insecticidal effect of 2 The agricultural and horticultural insecticide composition such a composition is synergistically greater than that of each according to the above 1, comprising 0.1 to 10 parts by mass compound used separately. of tolfenpyrad per part by mass of flubendiamide. 3A method for using an agricultural and horticultural insec CITATION LIST ticide composition, comprising treating insect pests directly, treating crops potentially infested with the insect pests, or Patent Literature treating Surrounding soil or cultivation medium of the crops with an effective amount of an agricultural and horticultural 0003 Patent Literature 1: JP-A 2001-131141 insecticide composition comprising flubendiamide and 0004 Patent Literature 2: WO 2002/087334 tolfenpyrad as active ingredients. 0005 Patent Literature 3: WO 2004/034786 4. A method for controlling agricultural and horticultural 0006 Patent Literature 4: WO 2005/004603 insect pests, comprising treating insect pests directly, treating 0007 Patent Literature 5: WO 2005/004604 crops potentially infested with the insect pests, or treating 0008 Patent Literature 6: JP-A 03-81266 Surrounding soil or cultivation medium of the crops with an 0009 Patent Literature 7: JP-A 2006-131516 effective amount of an optionally diluted formulation con taining flubendiamide as an active ingredient and an effective Non Patent Literature amount of an optionally diluted formulation containing tolfenpyrad as an active ingredient, the two formulations Non Patent Literature 1: being used separately but in the same period. 5. A method for controlling agricultural and horticultural The Pesticide Manual 14th Edition (British Crop Production insect pests, comprising treating insect pests directly, treating Council) crops potentially infested with the insect pests, or treating Surrounding soil or cultivation medium of the crops with an SUMMARY OF INVENTION effective amount of an optionally diluted formulation con taining flubendiamide as an active ingredient and an effective Technical Problem amount of an optionally diluted formulation containing 0010. In the production of agricultural produce, the dam tolfenpyrad as an active ingredient, the two formulations age caused by various insect pests is still large and treatment being used separately at a given interval. with various insecticides is required for control of the insect 6. A method for controlling agricultural and horticultural pests. Such insecticide treatment imposes a particularly great insect pests, comprising mixing an effective amount of a burden on farmers, and reducing the treatment operation has formulation containing flubendiamide as an active ingredient been strongly desired in terms of occupational health, in and an effective amount of a formulation containing tolfen particular the reduction of farmers workload, as well as in pyrad as an active ingredient, optionally diluting the mixture; terms of economics, in particular the reduction of production and treating insect pests directly, treating crops potentially costs of agricultural produce. To this end, various kinds of infested with the insect pests, or treating Surrounding soil or agricultural and horticultural insecticide compositions have cultivation medium of the crops with the optionally diluted been developed. However, in conventional art, effective pest mixture. US 2014/0148493 A1 May 29, 2014

Advantageous Effects of Invention 0017. The inactive carrier may be a solid or liquid carrier. Examples of the Solid carrier include natural minerals, such as 0013 The present invention relates to an agricultural and quartz, clay, kaolinite (kaolin), pyrophyllite, sericite, talc, horticultural insecticide composition comprising flubendia bentonite, acid clay, attapulgite, Zeolite and diatomite; inor mide and tolfenpyrad as active ingredients; and a method for ganic salts, such as calcium carbonate, ammonium sulfate, using the same. The agricultural and horticultural insecticide Sodium sulfate and potassium chloride; organic Solid carriers, composition and the method have advantages over a separate Such as synthetic silicic acid, synthetic silicates, starch, cel use of each compound, such as remarkable synergistic effect, lulose and plant powders (for example, sawdust, coconut expansion of the range of target insect pests, dose reduction, shell, corn cob, tobacco stalk, etc.); plastics carriers, such as reduction of treatment frequency, etc. Therefore, the present polyethylene, polypropylene and polyvinylidene chloride; invention provides a novel technology for efficiently control urea; hollow inorganic materials; hollow plastic materials; ling insect pests that have been impossible or difficult to and fumed silica (white carbon). These solid carriers may be control by conventional technologies. used alone or in a combination of two or more kinds. DESCRIPTION OF EMBODIMENTS 00.18 Examples of the liquid carrier include alcohols including monohydric alcohols, such as methanol, ethanol, 0014 Flubendiamide, which is one of the active ingredi propanol, isopropanol and butanol, and polyhydric alcohols, ents of the agricultural and horticultural insecticide compo Such as ethylene glycol, diethylene glycol, propylene glycol, sition of the present invention, can be produced according to hexylene glycol, polyethylene glycol, polypropylene glycol the production method disclosed in Patent Literature 1 etc., and glycerin; polyol compounds, such as propylene glycol but commercial formulations thereof are also available for ether, ketones, such as acetone, methyl ethyl ketone, methyl purchase. Tolfenpyrad, which is the other active ingredient, isobutyl ketone, diisobutyl ketone and cyclohexanone; ethers, can be produced according to the production method dis Such as ethyl ether, dioxane, ethylene glycol monoethyl ether, closed in Patent Literature 6, but commercial formulations dipropyl ether and tetrahydrofuran; aliphatic hydrocarbons, thereofare also available for purchase. These compounds, an Such as normal paraffin, naphthene, isoparaffin, kerosene and appropriate inactive carrier and a surfactant, and if needed an mineral oil; aromatic hydrocarbons, such as benzene, tolu adjuvant are blended in an appropriate ratio, and through the ene, Xylene, solvent naphtha and alkyl naphthalene; haloge step of dissolution, separation, Suspension, mixing, impreg nated hydrocarbons, such as dichloromethane, chloroform nation, adsorption and/or adhesion, are formulated into an and carbon tetrachloride; esters, such as ethyl acetate, diiso appropriate form for application, Such as a Suspension con propyl phthalate, dibutyl phthalate, dioctyl phthalate and centrate (flowable), an emulsifiable Suspension concentrate, dimethyl adipate; lactones, such as gamma-butyrolactone; an emulsifiable concentrate, a soluble concentrate, a wettable amides, such as dimethylformamide, diethylformamide, dim powder, a water-dispersible granule, a granule, a dust, a ethylacetamide and N-alkyl pyrrolidone (N-methyl pyrroli microcapsule, a capsule, a tablet, a jumbo and a pack. done etc.); nitriles, such as acetonitrile; Sulfur compounds, 0015 The total content of the active ingredients in the Such as dimethyl Sulfoxide; vegetable oils, such as Soybean agricultural and horticultural insecticide composition of the oil, rapeseed oil, cotton seed oil and castor oil; and water. present invention can be adjusted as needed without particu These liquid carriers may be used alone or in a combination of lar limitation, but is usually about 0.01 to 90 parts by mass. two or more kinds. For example, in the case where the agricultural and horticul tural insecticide composition is a dust or a granule, the total 0019. Examples of the adjuvant include surfactants used content of the active ingredients is preferably about 0.1 to 30 as a dispersant, a wetting agent, a spreader, a sticking/spread parts by mass, and in the case where the agricultural and ing agent, etc., binders, tackifiers, thickeners, colorants, anti horticultural insecticide composition is an emulsifiable con freezing agents, anti-caking agents, disintegrants and stabi centrate, a wettable powder, a flowable, a water-dispersible lizing agents. If needed, preservatives, plant fragments, etc. granule or the like, the total content of the active ingredients may be additionally used. These adjuvants may be used alone is preferably about 0.1 to 60 parts by mass. The blending ratio or in a combination of two or more kinds. of the active ingredients flubendiamide and tolfenpyrad in the 0020 Examples of the surfactants used as a dispersant, a agricultural and horticultural insecticide composition of the Wetting agent, a spreader, a sticking/spreading agent, etc. present invention is appropriately selected from the range of include nonionic Surfactants, such as Sorbitan fatty acid ester, 0.1 to 10 parts by mass of tolfenpyrad per part by mass of polyoxyethylene Sorbitan fatty acid ester, Sucrose fatty acid flubendiamide. ester, polyoxyethylene fatty acid ester, polyoxyethylene resin 0016. As for these active ingredients, their commercial acid ester, polyoxyethylene fatty acid diester, polyoxyethyl formulations may be used as they are. Alternatively, the active enealkyl ether, polyoxyethylene alkylaryl ether, polyoxyeth ingredients can be prepared into separate formulations or a ylene alkyl phenyl ether, polyoxyethylene dialkyl phenyl combined formulation. For the preparation of a formulation, ether, polyoxyethylene alkylphenyl ether-formaldehyde con the active ingredient(s) and an appropriate inactive carrier, densates, polyoxyethylene-polyoxypropylene block copoly and if needed an adjuvant are blended in an appropriate ratio, mers, polystyrene-polyoxyethylene block polymers, alkyl and through the step of dissolution, separation, Suspension, polyoxyethylene-polypropylene block copolymer ether, mixing, impregnation, adsorption and/or adhesion, are for polyoxyethylene alkylamine, polyoxyethylene fatty acid mulated into an appropriate form for application, Such as a amide, polyoxyethylene fatty acid bis(phenyl ether), poly Suspension concentrate (flowable), an emulsifiable Suspen alkylene benzyl phenyl ether, polyoxyalkylene styryl phenyl sion concentrate, an emulsifiable concentrate, a soluble con ether, acetylene diol, polyoxyalkylene-added acetylene diol. centrate, a wettable powder, a water-dispersible granule, a polyoxyethylene ether-type silicone, ester-type silicone, granule, a dust, a microcapsule, a capsule, a tablet, a jumbo fluoroSurfactants, polyoxyethylene castor oil and polyoxy and a pack. ethylene hydrogenated castor oil; US 2014/0148493 A1 May 29, 2014 anionic Surfactants, such as alkyl sulfates, polyoxyethylene benzophenone compounds. Examples of the preservatives alkyl ether sulfates, polyoxyethylene alkyl phenyl ether sul include potassium Sorbate and 1.2-benzothiazolin-3-one. fates, polyoxyethylene styryl phenyl ether sulfates, alkylben 0027. Further, other adjuvants including functional Zene Sulfonates, alkylaryl Sulfonates, lignoSulfonates, alkyl spreading agents, activity enhancers such as metabolic inhibi SulfoSuccinates, naphthalene Sulfonates, alkylnaphthalene tors (piperonyl butoxide etc.), antioxidants (BHT etc.) and Sulfonates, salts of naphthalenesulfonic acid-formaldehyde ultraviolet absorbers can also be used if needed. condensates, salts of alkylnaphthalenesulfonic acid-formal 0028. The “crops” for which the agricultural and horticul dehyde condensates, fatty acid salts, polycarboxylic acid tural insecticide composition of the present invention can be salts, polyacrylates, N-methyl-fatty acid sarcosinates, used is not particularly limited, and the examples include resinates, polyoxyethylene alkyl ether phosphates and poly cereals such as rice, barley, wheat, rye, oats, corn and Sor oxyethylene alkyl phenyl ether phosphates; ghum, legumes such as Soybeans, azuki beans, broad beans, cationic Surfactants including alkylamine salts, such as lauryl green peas and peanuts; fruit trees and fruits such as apples, amine hydrochloride, stearyl amine hydrochloride, oleyl mandarin oranges, oranges, lemons, limes, grapefruits, Chi amine hydrochloride, Stearyl amine acetate, Stearyl amino nese quinces, quinces, pears, European pears, Japanese pears, propyl amine acetate, alkyl trimethyl ammonium chloride grapes, blueberries, cranberries, blackberries, raspberries, and alkyl dimethylbenzalkonium chloride; and amphoteric Strawberries, peaches, Japanese plums, nectarines, Japanese Surfactants, such as amino acid-type or betaine-type ampho apricots, cherries, apricots, prunes, walnuts, hazelnuts, teric Surfactants. These Surfactants may be used alone or in a almonds, pistachio nuts, cashew nuts, macadamia nuts, combination of two or more kinds. bananas, persimmons, olives, loquats, date palms, coconut 0021 Examples of the binders or the tackifiers include palms and oil palms; vegetables such as cabbages, tomatoes, carboxymethyl cellulose and salts thereof, dextrin, soluble spinach, broccoli, lettuce, onions, Welsh onions, green pep starch, Xanthan gum, guar gum, Sucrose, polyvinyl pyrroli pers, eggplants, kohlrabi, Chinese cabbages, leaf mustard, done, gum arabic, polyvinyl alcohol, polyvinyl acetate, cauliflower, garland chrysanthemum, artichoke, asparagus, Sodium polyacrylate, polyethylene glycols with an average carrots, parsley, celery, parsnips and chard; root vegetables molecular weight of 6,000 to 20,000, polyethylene oxides Such as carrots, burdock roots, potatoes, Sweet potatoes, Japa with an average molecular weight of 100,000 to 5,000,000, nese yam, taro, Japanese radishes, lotus roots and turnips: phospholipids (for example, cephalin, lecithin, etc.), cellu crops for processing Such as cotton, hemp, paper mulberry, lose powder, dextrin, modified starch, polyaminocarboxylic oriental paperbush, rapeseeds, oil palms, Barbados nuts, acid chelating compounds, cross-linked polyvinyl pyrroli buckwheat, beet, hops, sugarcane, Sugar beet, olives, rubber, done, maleic acid-styrene copolymers, (meth)acrylic acid coffee, tobacco, mulberry and tea; gourd Such as Japanese copolymers, half esters of polyhydric alcohol polymer and pumpkins, cucumbers, Zucchini, watermelons and melons; dicarboxylic anhydride, water soluble polystyrene sul pasture grass such as orchard grass, Sorghum, timothy, clover fonates, paraffin, terpene, polyamide resins, polyacrylates, and alfalfa: polyoxyethylene, waxes, polyvinyl alkyl ether, alkylphenol lawn grass such as Japanese lawn grass, Korean lawn grass, formaldehyde condensates and synthetic resin emulsions. Bermuda grass, redtop, creeping bentgrass, colonial bent 0022. Examples of the thickeners include water soluble grass, Kentucky bluegrass, rough bluegrass, tall fescue, polymers, such as Xanthan gum, guar gum, diutan gum, car chewings fescue, creeping red fescue, annual ryegrass, peren boxymethyl cellulose, polyvinyl pyrrolidone, carboxyvinyl nial ryegrass, orchard grass and timothy grass; spice and polymers, acrylic polymers, starch derivatives and polysac aromatic crops such as lavender, rosemary, thyme, parsley, charides; and inorganic fine powders, such as high grade pepper, red pepper, Japanese horseradish, ginger, garlic, shiso, mint and basil; flowering plants such as rose, carnation, bentonite and fumed silica (white carbon). chrysanthemum, lisianthus, baby's breath, Sunflower, ger 0023 Examples of the colorants include inorganic pig bera, marigold, Salvia, petunia, Verbena, tulip, aster, gentian, ments, such as iron oxide, titanium oxide and prussian blue; lily, pansy, cyclamen, orchid, lily of the valley, lavender, and organic dyes. Such as alizarin dyes, azo dyes and metal stock, ornamental kale, primula, poinsettia, gladiolus, catt phthalocyanine dyes. leya, daisy, Verbena, cymbidium and begonia; and trees Such 0024 Examples of the antifreezing agents include poly as Japanese ash, birch, flowering dogwood, eucalyptus, hydric alcohols, such as ethylene glycol, diethylene glycol, ginkgo, lilac, maple, live oak, poplar, Chinese redbud, Chi propylene glycol and glycerin. nese Sweet gum, plane, Japanese Zelkova, Japanese Thuja, 0025. Examples of the adjuvants serving to prevent caking Momi fir, Southern Japanese hemlock, temple juniper, pine, or facilitate disintegration include polysaccharides (starch, spruce, Japanese yew, elm, buckeye, Sweet Viburnum, Bud alginic acid, mannose, galactose, etc.), polyvinyl pyrroli dhist pine, Japanese cedar, Japanese cypress, croton, Japa done, fumed silica (white carbon), ester gum, petroleum nese spindle and Japanese photinia. resin, Sodium tripolyphosphate, sodium hexametaphosphate, 0029. The “crops” include crops provided with a useful metal Stearates, cellulose powder, dextrin, methacrylate trait by a classical breeding technique and a recently copolymers, polyvinyl pyrrolidone, polyaminocarboxylic advanced gene recombination technique, for example, acid chelating compounds, Sulfonated styrene-isobutylene genetically modified crops (e.g., herbicide-tolerant crops, maleic anhydride copolymers and starch-polyacrylonitrile insect pest-resistant transgenic crops producing insecticidal graft copolymers. proteins, disease-resistant transgenic crops producing induc 0026. Examples of the stabilizing agents include desic ers of disease resistance, palatability-enhanced crops, long cants, such as Zeolite, quicklime and magnesium oxide; anti term preservable crops, high-yield crops, etc.). oxidants, such as phenolic compounds, amine compounds, 0030 Exemplary crops provided with herbicide tolerance Sulfur compounds and phosphoric acid compounds; and by a classical breeding technique include varieties of rape ultraviolet absorbers, such as Salicylic acid compounds and seed, wheat, Sunflower, rice and corn tolerant to the imida US 2014/0148493 A1 May 29, 2014

Zolinone family of ALS-inhibiting herbicides such as 0427529, EP-A-451878, WO 03/052073, etc. The toxins con imazethapyr, and Such crops are sold under the trade name of tained in Such genetically modified crops are Suitable for Clearfield (registered trademark). Also included is a variety control of pests, in particular, Coleopteran insect pests, of soybean provided with tolerance to the sulfonyl urea fam Dipteran insect pests and Lepidopteran insect pests, and due ily of ALS-inhibiting herbicides such as thifensulfuron-me to the toxins, the crops exhibit resistance to such pests. thyl by a classical breeding technique, and this is sold under the trade name of STS soybean. Also included are crops 0034 Genetically modified crops which express one or provided with tolerance to acetyl-CoA carboxylase inhibitors more of the insecticidal toxins are already known, and some Such as trione oxime herbicides and aryloxy phenoxy propi of them are commercially available. Examples of such geneti onic acid herbicides by a classical breeding technique, for cally modified crops include YieldGard (registered trade example, SR corn and the like. mark), which is a variety of corn expressing a Cry1Ab toxin; 0031 Exemplary crops provided with herbicide tolerance YieldGard Rootworm (registered trademark), which is a vari by a gene recombination technique include glyphosate-toler ety of corn expressing a Cry3Bb1 toxin; YieldGard Plus (reg ant varieties of corn, soybean, cotton, rapeseed and Sugarbeet, istered trademark), which is a variety of corn expressing and Such crops are sold under the trade names Such as Cry1Ab and Cry3Bb1 toxins; Herculex I (registered trade Roundup Ready (registered trademark) and Agrisure GT. mark), which is a variety of corn expressing a Cry1 Fa2 toxin Also included are varieties of corn, Soybean, cotton and rape and phosphinothricin N-acetyltransferase (PAT) for tolerance seed genetically engineered to be tolerant to glufosinate, and to glufosinate; NuCOTN33B (registered trademark) and such crops are sold under the trade name of LibertyLink Bollgard I (registered trademark), which are varieties of cot (registered trademark) etc. Also included is a variety of cotton ton expressing a Cry1Ac toxin; Bollgard II (registered trade genetically engineered to be tolerant to bromoxynil, and this mark), which is a variety of cotton expressing Cry1Ac and is sold under the trade name of BXN. Cry2Ab toxins; VIPCOT (registered trademark), which is a 0032 Crops provided with tolerance to acetyl-CoA car variety of cotton expressing a VIP toxin; New Leaf (registered boxylase inhibitors are described in Proc. Natl. Acad. Sci. trademark), which is a variety of potato expressing a Cry3A USA, 87, 7175-7179 (1990), and the like. Further, acetyl toxin; NatureGard (registered trademark) Agrisure (regis CoA carboxylase mutants resistant to acetyl-CoA carboxy tered trademark) GT Advantage (a GA21 glyphosate-tolerant lase inhibitors are reported in Weed Science, 53, 728-746 trait), Agrisure (registered trademark) CB Advantage (a Bt11 (2005), and the like, and by introducing the gene of such an corn borer (CB) trait); and Protecta (registered trademark). acetyl-CoA carboxylase mutant into crops by a gene recom 0035. Further, the “crops” also include crops genetically bination technique, or introducing a resistance-conferring engineered to produce selectively acting anti-pathogenic Sub mutation into acetyl-CoA carboxylase of crops, crops toler stances. Examples of the anti-pathogenic Substances include ant to acetyl-CoA carboxylase inhibitors can be engineered. PR proteins (PRPs; described in EP-A-0392225);ion channel Alternatively, by introducing a nucleic acid causing base inhibitors, such as Sodium channel inhibitors and calcium Substitution mutation into crop plant cells (a typical example channel inhibitors (for example, KP1, KP4 and KP6 toxins, of this technique is chimeraplasty technique (Gura T. 1999. which are produced in viruses, are known); Stilbene synthase; Repairing the Genome’s Spelling Mistakes. Science 285: bibenzyl synthase; chitinase; glucanase; and Substances pro 316-318.)) to allow site-specific substitution mutation in the duced by microbes, such as peptide antibiotics, heterocyclic amino acids encoded by an acetyl-CoA carboxylase gene of antibiotics and plant disease resistance-related protein factors crops, crops tolerant to acetyl-CoA carboxylase inhibitors (referred to as plant disease resistance genes and described in can be engineered. WO 03/000906). Examples of the foregoing anti-pathogenic 0033. The “crops also include crops genetically engi Substances and genetically modified crops capable of produc neered to synthesize insecticidal toxins etc. Exemplary insec ing these substances are described in EP-A-0392225, WO ticidal toxins expressed in Such genetically modified crops 95/33818, EP-A-0353191, etc. include insecticidal proteins derived from Bacillus cereus or Bacillus popilliae, Bacillus thuringiensis-derived delta-en 0036 Further, the “crops” also include crops provided dotoxins, such as Cry1Ab, Cry1Ac, Cry 1F, Cry1 Fa2. with a useful trait Such as an improved proportion of oil Cry2Ab, Cry3A, Cry3Bb1 and Cry 9C, and other insecticidal components and a higher amino acid content by a gene proteins, such as VIP1, VIP2, VIP3 and VIP3A: nematode recombination technique. Examples of Such crops include derived insecticidal proteins; toxins produced by animals, VISTIVE (registered trademark), which is a variety of soy Such as Scorpion toxins, spider toxins, bee toxins and insect bean engineered to have a reduced linolenic acid content, and specific neurotoxins; toxins of filamentous fungi, plant lec high-lysine (or high-oil) corn, which is a variety of corn tins; agglutinin; protease inhibitors, such as trypsin inhibi engineered to have an increased content of lysine or oil. tors, serine protease inhibitors, patatin, cystatin and papain 0037. Furthermore, the “crops also include stacked vari inhibitors; ribosome inactivating proteins (RIP), such as ricin, eties with a combination of two or more selected from the maize RIP, abrin, saporin and bryodin; steroid metabolizing above-described classical herbicide-tolerant traits, herbicide enzymes, such as 3-hydroxy steroid oxidase, ecdysteroid tolerant genes, insecticidal pest-resistance genes, anti-patho UDP-glucosyltransferase and cholesterol oxidase; ecdysone genic Substance-producing genes and useful traits including inhibitors; HMG-CoA reductase; ion channel inhibitors, such an improved proportion of oil components and a higher amino as sodium channel inhibitors and calcium channel inhibitors; acid content. When the agricultural and horticultural insecti juvenile hormone esterase; diuretic hormone receptors; still cide composition of the present invention is used for crops bene synthase; bibenzyl synthase; chitinase; and glucanase. modified to be tolerant to a herbicide, systematic and/or Examples of the foregoing toxins and genetically modified mixed treatment with the herbicide (for example, glyphosate crops capable of synthesizing these toxins are described in or its salts, glufosinate or its salts, dicamba or its salts, EP-A-0374753, WO 93/07278, WO 95/34656, EP-A- imazethapyr or its salts, isoxaflutole, etc.) and the agricultural US 2014/0148493 A1 May 29, 2014 and horticultural insecticide composition of the present and Such a formulation may be alternately layered. In the invention can control weeds and insect pests in an integrated application at the seeding time, the timing of the application a. may be before, at the same time as, or after seeding, or after 0038. In the use of the agricultural and horticultural insec covering with soil. In the case of paddy rice, Submerged ticide composition of the present invention, the above-de application of a granule etc. to a paddy field is often per scribed formulation(s) containing an active ingredient(s) formed. is/are optionally diluted or Suspended in water etc., and insect 0043. For field crops, such as potato, sweet potato and pests are directly treated with, or target crops potentially soybean, preferred is treatment of their seeds, cultivation infested with the insect pests, seeds of the target crops, soil or media in the vicinity of plants, or the like in the period of cultivation medium for planting the seeds, or the like are seeding to seedling culture. For plants of which the seeds are treated with the optionally diluted or suspended formulation directly sown in the field, in addition to direct seed treatment, (s) in an amount(s) effective for insect pest control according treatment of cultivation media in the vicinity of plants or the to a usual method. Examples of the treatment method include like during cultivation is preferable. Specifically, the treat spray treatment of foliage etc., treatment of nursery boxes for ment can be performed by, for example, applying a granule paddy rice, seed treatment Such as dust coating, dipping and onto Soil, or drenching soil with a formulation in a water disinfection of seeds, planting hole treatment, plant foot treat diluted or undiluted liquid form. ment, planting row treatment, drench treatment and soil 0044. In the case of culture plants to be transplanted, incorporation treatment. Also included is treatment of water examples of the treatment in the period of seeding to seedling culture media in hydroponics. culture include, in addition to direct seed treatment, drench 0039. The seed treatment may be performed in a usual treatment of nursery beds for seedlings with a formulation in manner. The exemplary methods include dipping of seeds in a liquid form; and granule application to nursery beds for a diluted or undiluted fluid of a liquid or solid formulation for seedlings. Also included are treatment of planting holes with the permeation of agrochemicals into the seeds; mixing, dust a granule; and incorporation of a granule into cultivation coating or other treatment of seeds with a liquid or Solid media in the vicinity of planting points at the time of fix formulation for the adherence of agrochemicals onto the Sur planting. faces of the seeds; monolayer or multilayer coating of seeds 0045. For the above-described treatment, a flubendiamide with a mixture of a liquid or Solid formulation and a highly single formulation and a tolfenpyrad single formulation can adhesive carrier Such as resins and polymers; and application be used after mixed with each other on site, and Such a use can of a liquid or solid formulation to the vicinity of seeds at the also produce the desired insecticidal effect. Alternatively, for same time as seeding. The term “seed' used in the seed the above-described treatment, the two single formulations treatment is, in a broad sense, synonymous with a plant body can be separately used in the same period, and Such a use can used for propagation. The examples include, in addition to a also produce the desired insecticidal effect. The term “the so-called seed, a plant body for vegetative propagation, Such same period' does not mean that treatments with the two as a bulb, a tuber, a seed potato, a discoid stem and a stem used single formulations are performed at the exact same time, and for cuttage. in the case where treatments with the two single formulations 0040. In the method of the present invention, the term are performed within a time frame of about one week, the “soil” or “cultivation medium” refers to support medium for treatments can be regarded as being performed “in the same plant cultivation and the materials are not particularly limited period.” Further, each treatment can be performed by a dif as long as plants can grow. Examples of the Support medium ferent method. Alternatively, for the above-described treat include so-called soils of various kinds, seedling mats and ment, the two single formulations can be separately used at a water, and also include sand, Vermiculite, cotton, paper, given interval, and Such a use can also produce the desired diatomite, agar, gelatinous Substances, high-molecular insecticidal effect. The interval between the treatments is not weight Substances, rock wool, glass wool, wood chip, bark particularly limited as long as the effect of the present inven and pumice. tion can be exerted, but in general, the interval is preferably 3 0041 Exemplary methods of soil application include months or less, and particularly preferably 2 months or less. application of a water-diluted or undiluted liquid or solid In this case, the first treatment may be performed with any of formulation to the vicinity of planting points, nursery beds for the active ingredients and each treatment may be performed seedlings, or the like; application of a granule to the vicinity by a different method. of planting points or nursery beds; application of a dust, a 0046. In recent years, IPM (integrated pest management) wettable powder, a water-dispersible granule, a granule or the technology using insect sex pheromones (e.g., communica like onto soil and Subsequent incorporation of the formulation tion disrupting agents against Tortricidae and Hadeninae, into the whole soil before seeding or transplanting; and appli etc.), natural enemy insects, etc. has made progress, and this cation of a dust, a wettable powder, a water-dispersible gran technology and the composition of the present invention can ule, a granule or the like to planting holes, planting rows or the be used in combination or used systematically. like before seeding or planting. 0047. The amount of the agricultural and horticultural 0042. To nursery boxes for paddy rice, for example, a dust, insecticide composition used for treatment may vary with a water-dispersible granule, a granule or the like can be various factors, for example, the purpose, the target insect applied, although the Suitable formulation may vary depend pest, the crop growing conditions, the weather, the environ ing on the application time, in other words, depending on the mental conditions, the formulation, the application method, cultivation stage such as seeding time, greening period and the application site, the application time, etc., but for planting time. In the Soil application, a formulation Such as a example, the amounts of the active ingredient compounds are dust, a water-dispersible granule, a granule or the like may be as follows: in the case of spray treatment, 1 to 200 g/ha of mixed with soil. For example, Such a formulation is incorpo flubendiamide and 10 to 500 g/ha of tolfenpyrad are applied rated into bed soil, covering soil or the whole soil. Simply, soil to target crops; and in the case of Soil treatment or drench US 2014/0148493 A1 May 29, 2014

treatment, 1 to 100 g/ha of flubendiamide and 5 to 300 g/ha of lis, Mamestra brassicae, Ascotis selenaria, Phtheochroides tolfenpyrad are applied onto or infiltrated into the surround clandestina, Hoshinoa adumbratana, Odonestispruni japon ing soil of target crops. ensis, Triaena intermedia, Adoxophyes Orana fasciata, Gra 0048. The agricultural and horticultural insecticide com pholita inopinata, Spilonota ocellana, Spilonota lechriaspis, position of the present invention is suitable for controlling a Illiberispruni, Argyresthia conjugella, Caloptilia Zachrysa, variety of insect pests which may damage paddy rice, Veg Archips breviplicanus, Anomis flava, Pectinophora gossyp etables, fruits, other flowering plants, etc. The insect pests to iella, Notarcha derogata, Diaphania indica, Heliothis vire be controlled are, for example, agricultural and forest pests, scens and Earias cupreoviridis, horticultural pests, stored grain pests, sanitary pests, nema species of the Order Hemiptera Such as Nezara antennata, todes, etc. The specific examples include the following: Stenotus rubrovittatus, Graphosoma rubrolineatum, Trigo species of the Order Lepidoptera Such as Parasa consocia, notylus coelestialium, Aeschynteles maculatus, Creontiades Anomis mesogona, Papilio xuthus, Matsumuraeses pallidifer; Dysdercus cingulatus, Chrysomphalus ficus, azukivora, Ostrinia Scapulalis, Spodoptera exempta, Aonidiella auranti, Graptopsaltria nigrofits cata, Blissus Hyphantria cunea, Ostrinia furnacalis, Pseudaletia sepa leucopterus, Icerya purchasi, Piezodorus hybneri, Lagynoto rata, Tinea translucens, Bactra firfiurana, Parnara guttata, mus elongatus, Thaia subrufa, Scotinophara lurida, Sitobion Marasmia exigua, Parnara guttata, Sesamia inferens, Brach ibarae, Stariodes iwasakii, Aspidiotus destructor; Taylorily mia triannulella, Monema flavescens, Trichoplusia ni, Pleu gus pallidulus, Myzus mumecola, Pseudaulacaspis pruni roptya ruralis, Cystidia couaggaria, Lampides boeticus, cola, Acyrthosiphon pisum, Anacanthocoris stricornis, Cephonodes hylas, Helicoverpa armigera, Phalerodonta Ectometopterus micantulus, Eysarcoris lewisi, manleyi, Eumeta japonica, Pieris brassicae, Malacosoma Molipteryx filginosa, Cicadella viridis, Rhopalosophum neustria testacea, rufiabdominalis, Saissetia oleae, Trialeurodes vaporari Stathmopoda masinissa, Cuphodes diospyrosella, Archips Orum, Aguriahana quercus, Lygus sp., Euceraphis punctipen xylosteanus, Agrotis segetum, Tetramoera schistaceana, nis, Andaspis kashicola, Coccus pseudomagnoliarum, Cav Papilio machaon hippocrates, Endoclyta Sinensis, Lyonetia elerius saccharivorus, Galeatus spinifrons, prunifoliella, Phyllonorycter ringoneella, Cydia kurokoi, Macrosiphoniella Sanborni, Aonidiella citrina, Halyomor Eucoenogenes aestuosa, Lobesia botrana, Latoia sinica, pha mista, Stephanitis fasciicarina, Trioza camphorae, Lep Euzophera batangensis, Phalonidia mesotypa, Spilosoma tocorisa Chinensis, Trioza quercicola, Uhlerites latius, Eryth imparilis, Glyphodes pyloalis, Olethreutes mori, Tineola bis roneura comes, Paromius exiguus, Duplaspidiotus claviger, selliella, Endoclyta excrescens, Nephotettix nigropictus, Halticiellus insularis, Perkinsiella Nemapogon granellus, Synanthedon hector; Cydia saccharicida, Psylla malivorella, pomonella, Plutella xylostella, Cnaphalocrocis medinalis, Anomoneura mori, Pseudococcus longispinis, Pseudaula Sesamia Calamistis, Scirpophaga incertulas, Pediasia teter caspis pentagona, Pulvinaria kuwacola, Apolygus lucorum, rellus, Phthorimaea operculella, Stauropus fagi persimilis, Togo hemipterus, Toxoptera aurantii, Saccharicoccus sac Etiella Zinckenella, Spodoptera exigua, Palpifer sex notata, chari, Geoica lucifiuga, Numata muiri, Comstockaspis perni Spodoptera manuritia, Scirpophaga innotata, Xestia c-ni ciosa, Unaspis citri, Aulacorthum Solani, Eysarcoris ventra grum, Spodoptera depravata, Ephestia kuehniella, Angerona lis, Bemisia argentifolii, Cicadella spectra, Aspidiotus prunaria, Clostera anastomosis, Pseudoplusia includens, hederae, Liorhyssus hyalinus, Calophya nigridorsalis, Soga Matsumuraeses falcana, Helicoverpa assulta, Autographa tella furcifera, Megoura crassicauda, Brevicoryne brassicae, nigrisigna, Agrotis ipsilon, Euproctis pseudoconspersa, Aphis glycines, Leptocorisa Oratorius, Nephotettix virescens, Adoxophyes Orana, Caloptilia theivora, Homona magn Uroeucon formosanum, Cyrtopeltis tennuis, Bemisia tabaci, anima, Lecanium persicae, Parlatoria theae, Pseudaonidia paeo Ephestia elutella, Eumeta minuscula, Clostera anachoreta, niae, Empoasca Onuki, Plautia Stali, Dysaphis tulipae, Mac Heliothis maritima, Sparganothis pilleriana, Busseola fisca, rosiphum euphorbiae, Stephanitis pyrioides, Ceroplastes Euproctis subflava, Biston robustum, Heliothis zea, Aedia ceriferus, Parlatoria camelliae, Apolygus spinolai, Nephotet leucomelas, Narosoideus flavidorsalis, Viminia rumicis, Buc tix cincticeps, Glaucias subpunctatus, Orthotylus flavospar culatrix pyrivorella, Grapholita molesta, Spullerina astau sus, Rhopalosiphum maidis, Peregrinus maidis, Eysarcoris rota, Ectomyelois pyrivOrella, Chilo suppressalis, Acrolepi parvus, Cimex lectularius, Psylla abieti, Nilaparvata lugens, opsis sapporensis, Plodia interpunctella, Hellula undalis, Psylla tobirae, Eurydema rugosum, Schizaphis piricola, Sitotroga ceralella, Spodoptera litura, a species of the family Psylla pyricola, Parlatoreopsis pyri, Stephanitis sashi, Dys Tortricidae (Eucosma aporema), Acleris comariana, micoccus wistariae, Lepholeucaspis japonica, Sappaphis Scopelodes contracus, Orgvia thyellina, Spodoptera fru piri, Lipaphis erysimi, Neotoxoptera formosana, Rhopaloso giperda, Ostrinia zaguliaevi, Naranga aenescens, Andraca phum nymphaeae, Edwardsiana rosae, Pinnaspis aspidis bipunctata, Paranthrene regalis, Acosmeryx castanea, trae, Psylla alni, Speusotettix subfusculus, Alnetoidia alneti, Phyllocnistis toparcha, Endopiza viteana, Eupoecillia Sogatella panicicola, Adelphocoris lineolatus, Dysdercus ambiguella, Anticarsia gemmatalis, Cnephasia cinereipal poecilus, Parlatoria ziziphi, Uhlerites debile, Laodelphax pana, Lymantria dispar, Dendrolimus spectabilis, Legumini striatellus, Eurydema pulchrum, Cletus trigonus, Clovia vora glycinivorella, Maruca testulalis, Matsumuraeses punctata, Empoasca sp., Coccus hesperidum, Pachybrachius phaseoli, Caloptilia Sovella, Phyllocnistis citrella, Hadvlepta luridus, Planococcus kraunhiae, Stenotus binotatus, Arbo indicata, Archips fiascocupreanus, Acanthoplusia agnata, ridia apicaris, Macrosteles fasci?ions, Dolycoris baccarum, Bambalina sp., Carposina niponensis, Conogethes punc Adelphocoris triannulatus, Viteus vitifolii, Acanthocoris sor tiferalis, Synanthedon sp., Lyonetia clerkella, didus, Leptocorisa acuta, Papilio helenus, Coliaseratepoliographus, Phalera flave Macropes obnubilus, Cletus punctiger; Riptortus clavatus, scens, species of the family Pieridae such as Pieris rapae, Paratrioza cockerelli, Aphrophora costalis, Lygus disponsi, Euproctis similis, Acrolepiopsis Suzukiella, Ostrinia nubila Lygus Saundersi, Crisicoccus pini, Empoasca abietis, Crisi US 2014/0148493 A1 May 29, 2014

coccus matsumotoi, Aphis craccivora, Megacopta punctatis Dacus tsuneonis, Sitodiplosis mosellana, Meromuza Simum, Eysarcoris guttiger; Lepidosaphes beckii, Diaphorina nigriventris, Anastrephaludens and Phagoletis pomonella, citri, Toxoptera citricidus, Planococcus citri, Dialeurodes species of the Order Hymenoptera such as Pristomyrmex citri, Aleurocanthus spiniferus, Pseudococcus citriculus, pungens, species of the family Bethylidae, Monomorium Zyginella citri, Pulvinaria citricola, Coccus discrepans, pharaosis, Pheidole noda, Athalia rosae, Dryocosmus Pseudaonidia duplex, Pulvinaria aurantii, Lecanium corni, kuriphilus, Formica fisca japonica, species of the Subfamily Nezara viridula, Stenodema calcaratum, Rhopalosiphum Vespinae, Athalia infimata infimata, Arge pagana, Athalia padi, Sitobion akebiae, japonica, Acromyrmex spp., Solenopsis spp., Arge mali and Schizaphis graminum, Sorhoanus tritici, Brachycaudus heli Ochetellus glaber, chrysi, Carpocoris purpureipennis, Myzus persicae, Hva species of the Order Orthoptera such as Homorocoryphus lopterus pruni, Aphis farinoseyanagicola, Metasalispopuli, lineosus, Gryllotalpa sp., Oxya hyla intricata, Oxya yezoen– Unaspis yanonensis, Mesohomotoma camphorae, Aphis spi sis, Locusta migratoria, Oxya japonica, Honorocoryphus raecola, Aphis pomi, Lepidosaphes ulmi, Psylla mali, Het jezoensis and Teleogryllus emma, erocordylus flavipes, Myzus malisuctus, Aphidonuguis mali, species of the Order Thysanoptera such as Selenothrips Orientus ishidai, Ovatus malicolens, Eriosoma lanigerum, rubrocinctus, Stenchaetothrips biformis, Haplothrips Ceroplastes rubens and Aphis gossypii; aculeatus, Ponticulothrips diospyrosi, Thrips flavus, Anapho species of the Order Coleoptera Such as Xystrocera globosa, thrips obscurus, Liothrips floridensis, Thrips simplex, Thrips Paederus fuscipes, Eucetonia roelofsi, Callosobruchus chin nigropilosus, Heliothrips haemorrhoidalis, Pseudodendro ensis, Cylas formicarius, Hypera postica, Echinocnemus thrips mori, Microcephalothrips abdominalis, Leeuwenia squameus, Oulema Oryzae, Donacia provosti, Lissorhoptrus pasanii, Litotetothrips pasaniae, Scirtothrips citri, Haplo Oryzophilus, Colasposoma dauricum, Euscepes postfascia thrips chinensis, Mycterothrips glycines, Thrips setosus, Scir tus, Epilachna varivestis, Acanthoscelides Obtectus, tothrips dorsalis, Dendrothrips minowai, Haplothrips niger, Diabrotica virgifera virgifera, In volvulus cupreus, Aula Thrips tabaci, Thrips alliorum, Thrips hawaiiensis, Haplo cophora femoralis, Bruchus pisorum, Epilachna vigintiocto thrips kurdiumovi, Chirothrips manicatus, Frankliniella intonsa, Thrips coloratus, Franklinella Occidentalis, Thrips maculata, Carpophilus dimidiatus, Cassida nebulosa, palmi, Frankliniella lilivora and Liothrips vaneeckei, Luperomorpha tunebrosa, Phyllotreta striolata, Psacothea species of the Order Acari Such as Leptotrombidium aka hilaris, Aeolesthes chrysothrix, mushi, Tetranychus ludeni, Dermacentor variabilis, Tetrany Curculio Sikkimensis, Carpophilus hemipterus, Oxycetonia chus truncatus, Ornithonyssus bacoti, Demodex canis, Tet jucunda, Diabrotica sp., Minela splendens, Sitophilus zea ranychus viennensis, Tetranychus kanzawai, species of the mais, Tribolium castaneum, Sitophilus Oryzae, Palorus sub family Ixodidae Such as Rhipicephalus sanguineus, Cheyl depressus, Melolontha japonica, Anoplophora malasiaca, etus malaccensis, Trophagus putrescentiae, Dermatopha Neatus picipes, Leptinotarsa decemlineata, Diabrotica goides farinae, Latrodectus hasseltii, Dermacentor taiwani undecimpunctata howardi, Sphenophorus venatus, Crioceris cus, Acaphylla theavagrams, Polyphagotarisonemus latus, quatuordecimpunctata, Conotrachelus menuphar, Ceutho Aculops lycopersici, Ornithonyssus Sylvairum, Tetranychus rhynchidius albOsuturalis, Phaedon brassicae, Lasioderma urticae, Eriophyes chibaensis, Sacroptes scabiei, Haema serricorne, Sitona japonicus, Adoretus tenuimaculatus, Tene physalis longicornis, Ixodes Scapularis, Trophagus similis, brio molitor, Basilepta balyi, Hypera nigrirostris, Chaetoc Cheyletus eruditus, Panonychus citri, Cheyletus moorei, nema concinna, Anomala cuprea, Heptophylla picea, Epil Brevipalpus phoenicis, Octodectes cynotis, Dermatopha achina vigintioctopunctata, Diabrotica longicornis, goides ptrenyssinus, Haemaphysalis flava, Ixodes ovatus, Eucetonia pilifera, Agriotes spp., Phyllocoptruta citri, Aculus schlechtendali, Panonychus Attagenus unicolor japonicus, Pagria signata, Anomala rufo ulmi, Amblyomma americanum and DermanySSuS gallinae; cuprea, Palorus ratzeburgii, Alphitobius laevigatus, Anthre species of the Order Isoptera such as Reticulitermes nus verbasci, Lyctus brunneus, Tribolium confilsum, miyatakei, Incisitermes minor; Coptotermes formosanus, Medythia nigrobilineata, Xvlotrechus pyrrhoderus, Epitrix Hodotermopsis japonica, Reticulitermes sp., Reticulitermes cucumeris, Tomicus piniperda, Monochamus alternatus, flaviceps amamianus, Glyptotermes kushimensis, Coptoter Popillia japonica, Epicauta gorhami, Sitophilus zeanais, mes guangzhoensis, Neotermes koshunensis, Glyptotermes Rhynchites heros, List roderes costirostris, Callosobruchus kodamai, Glyptotermes Satsumensis, Cryptotermes domesti maculatus, Phyllobius armatus, Anthonomus pomorum, cus, Odontotermes formosanus, Glyptotermes nakajimai, Linaeidea aenea and Anthonomus grandis, Pericapritermes initobei and Reticulitermes speratus, species of the Order Diptera such as Culex pipiens pallens, species of the Order Blattodea such as Periplaneta fuliginosa, Pegomya hyoscyami, Liriomyza huidobrensis, Musca domes Blattella germanica, Blatta Orientalis, Periplaneta brunnea, tica, Chlorops Oryzae, Hydrellia Sasakii, Agromyza Oryzae, Blattella lituricollis, Periplaneta japonica and Periplaneta Hydrellia griseola, Ophiomyia phaseoli, Dacus cucurbitae, annericana, Drosophila Suzuki, Rhacochlaena japonica, Muscina stabu species of the Order Siphonaptera such as Pulex irritans, lans, species of the family Phoridae such as Megaselia spi Ctenocephalides felis and Ceratophyllus gallinae, racularis, Cloginia albipunctata, Tipula aino, Phormia species of the Phylum Nematoda such as Nothotylenchus regina, Culex tritaeniorhynchus, Anopheles sinensis, Hyl acris, Aphelen.choides besseyi, Pratylenchus penetrans, emya brassicae, Asphondylia sp., Delia platura, Delia anti Meloidogyne hapla, Meloidogyne incognita, Globodera ros qua, Rhagoletis cerasi, Culex pipiens molestus Forskal, Cer to chiensis, Meloidogyne javanica, Heterodera glycines, atitis capitata, Bradysia agrestis, Pegomya cunicularia, Pratylenchus coffeae, Pratylenchus neglectus and Tilenchus Liriomyza sativae, Liriomyza bryoniae, Chromatomyia hor semipenetrans; and ticola, Liriomyza chinensis, Culex quinquefasciatus, Aedes species of the Phylum Mollusca Such as Pomacea canalicu aegypti, Aedes albopictus, Liriomyza trifolii, Dacus dorsalis, lata, Achatina fillica, Meghimatium bilineatum, Lehmannina US 2014/0148493 A1 May 29, 2014

valentiana, Limacus flavus and Acusta despecta Sieboldiana. hydroxyisoxazole, hydroxyisoxazole-potassium, binapacryl, Other agricultural and horticultural insect pests to be con biphenyl, piperalin, hymexaZol, pyraoxystrobin, pyracar trolled are, for example, Tuta absoluta and the like. bolid, pyraclostrobin, pyrazophos, pyrametostrobin, pyri 0049. The agricultural and horticultural insecticide com ofenone, pyridinitril, pyrifenox, position of the present invention can be used simultaneously pyribencarb, pyrimethanil, pyroxychlor, pyroxyfur, pyro with agricultural and horticultural microbicides, agricultural quilon, VincloZolin, ferbam, famoxadone, fenapanil, fenami and horticultural insecticides, agricultural and horticultural done, fenaminosulf, fenarimol, fenitropan, fenoxanil, ferim herbicides, synergists, phytotoxicity reducers, etc. for control Zone, fentin, fenpiclonil, fenpyraZamine, fenbuconazole, of diseases/insect pests, weeds, etc. which may spread in the fenfuram, fempropidin, fempropimorph, fenhexamid, phtha application period of the composition of the present inven lide, buthiobate, butylamine, bupirimate, fuberidazole, blas tion, enhanced effects and reduced phytotoxicity to crops. ticidin-S, furametpyr, furalaxyl, fluacrypyrim, fluaZinam, flu Non-limiting examples of typical compounds used as the oxastrobin, fluotrimazole, fluopicolide, fluopyram, agricultural and horticultural microbicides, the agricultural fluoroimide, furcarbanil, fluxapyroxad, fluquinconazole, fur and horticultural insecticides, the agricultural and horticul conazole, furconazole-cis, fludioxonil, flusilaZole, flusulfa tural herbicides, the synergists or the phytotoxicity reducers mide, flutianil, flutolanil, flutriafol, furfural, furmecyclox, are listed below. flumetover, flumorph, produinazid, prochloraz, procymi 0050 Examples of the agricultural and horticultural done, prothiocarb, microbicides include aureofungin, azaconazole, azithiram, prothioconazole, propamocarb, propiconazole, propineb, acypetacs, acibenzolar, acibenzolar-S-methyl, azoxystrobin, furophanate, probenazole, bromuconazole, hexachlorobuta anilazine, amisulbrom, ampropylfos. ametoctradin, allyl diene, hexaconazole, hexylthiofos, bethoxazin, benalaxyl, alcohol, aldimorph, amobam, isotianil, isovaledione, isopy benalaxyl-M, benodanil, benomyl, pefurazoate, benquinox, razam, isofetamid, isoprothiolane, ipconazole, iprodione, penconazole, benzamorf, pencycuron, benzohydroxamic iprovalicarb, iprobenfos, imazalil, iminoctadine, iminocta acid, bentaluron, benthiazole, benthiavalicarb, benthiavali dine-albesilate, iminoctadine-triacetate, imibenconazole, carb-isopropyl, penthiopyrad, penflufen, boscalid, phos uniconazole, uniconazole-P. echlomeZole, edifenphos, eta diphen, fosetyl, fosetyl-Al, polyoxins, polyoxorim, polycar conazole, ethaboxam, ethirimol, etem, ethoxyquin, etridiaz bamate, folpet, formaldehyde, machine oil, maneb, ole, enestroburin, epoxiconazole, oxadixyl, oxycarboxin, mancoZeb, mandipropamid, mycloZolin, myclobutanil, mil copper-8-quinolinolate, Oxytetracycline, copper-oxinate, diomycin, milineb, mecarbinzid, methasulfocarb, metaZOXo Oxpoconazole, Oxpoconazole-fumarate, oxolinic acid, lon, metam, metam-sodium, metalaxyl, metalaxyl-M, meti octhillinone, ofurace, orysastrobin, metam-Sodium, ram, methyl isothiocyanate, meptylidinocap, metconazole, kasugamycin, carbamorph, carpropamid, carbendazim, car metSulfovax, methfuroxam, metominostrobin, metrafenone, boxin, carvone, quinaZamid, quinacetol, quinoxyfen, chi mepanipyrim, mefenoxam, meptylidinocap, mepronil, mebe nomethionat, quinomethionate, captafol, captan, kiralaxyl, nil, iodomethane, rabenzazole, benzalkonium chloride, inor quinconazole, quintoZene, guaZatine, cufraneb, cuprobam, ganic microbicides such as basic copper chloride, basic cop glyodin, griseofulvin, climbazole, cresol, kresoxim-methyl, per Sulfate and silver, Sodium hypochlorite, cupric hydroxide, chloZolinate, clotrimazole, chlobenthiaZone, chlorani wettable Sulfur, calcium polysulfide, potassium hydrogen formethan, chloranil, chlorquinox, chloropicrin, chlorfena carbonate, Sodium hydrogen carbonate, Sulfur, copper Sulfate Zole, chlorodinitronaphthalene, chlorothalonil, chloroneb, anhydride, nickel dimethyldithiocarbamate, oxine copper, salicylanilide, Zarilamid, cyaZofamid, diethyl pyrocarbonate, Zinc sulfate and copper Sulfate pentahydrate. diethofencarb, cyclafuramid, diclocymet, dichloZoline, 0051 Examples of the agricultural and horticultural insec diclobutrazol, dichlofluanid, cycloheximide, diclomezine, ticides include 3.5-xylyl methylcarbamate (XMC), crystal dicloran, dichlorophen, dichlone, disulfiram, ditalimfos, line protein toxins produced by Bacillus thuringiensis such as dithianon, diniconazole, Bacillus thuringiensis aizawai, Bacillus thuringiensis israe diniconazole-M, Zineb, dinocap, dinocton, dinosulfon, dinot lensis, Bacillus thuringiensis japonensis, Bacillus thuring erbon, dinobuton, dinopenton, dipyrithione, diphenylamine, iensis kurstaki and Bacillus thuringiensis tenebrionis, difenoconazole, cyflufenamid, diflumetorim, cyproconazole, BPMC, Bt toxin-derived insecticidal compounds, CPCBS cyprodinil, cyprofuram, cypendazole, Simeconazole, dime (chlorfenson), DCIP (dichlorodiisopropyl ether), D-D (1,3- thirimol, dimethomorph, cymoxanil, dimoxystrobin, methyl dichloropropene), DDT, NAC, O-4-dimethylsulfamoylphe bromide, Ziram, silthiofam, Streptomycin, spiroxamine, Sul nyl O.O-diethyl phosphorothioate (DSP), O-ethyl O-4-nitro tropen, sedaxane, Zoxamide, dazomet, thiadiazin, tiadinil, phenyl phenylphosphonothioate (EPN), thiadifluor, thiabendazole, tioxymid, thioquinox, thiochlor tripropylisocyanurate (TPIC), acrinathrin, azadirachtin, azin femphim, thiophanate, thiophanate-methyl, thicyofen, thi phos-methyl, acequinocyl, acetamiprid, acetoprole, aceph fluZamide, thiram, decafentin, tecnaZene, tecloftalam, teco ate, abamectin, afidopyropen, avermectin-B, amidoflumet, ram, tetraconazole, debacarb, dehydroacetic acid, amitraz, alanycarb, aldicarb, aldoxycarb, aldrin, alpha-en tebuconazole, tebufloquin, dodicin, dodine, dosulfan, alpha-cypermethrin, albendazole, allethrin, isaZo dodecyl benzensulfonate bis-ethylene diamine copper(II) fos, isoamidofos, isoxathion, isofenphos, isoprocarb (MIPC), (DBEDC), dodemorph, drazoxolon, triadimenol, triadime ivermectin, imicyafos, imidacloprid, imiprothrin, indoxac fon, triazbutil, triazoxide, triamiphos, triarimol, trichlamide, arb, esfenvalerate, ethiofencarb, ethion, ethiprole, etoxazole, tricyclazole, triticonazole, tridemorph, tributyltin oxide, tri ethofenproX, ethoprophos, etrimfos, emamectin, emamectin flumizole, trifloxystrobin, triforine, tolylfluanid, tolclofos benzoate, endosulfan, empenthrin, oxamyl, Oxydemeton-me methyl, tolprocarb, natamycin, nabam, nitrostyrene, thyl, oxydeprofos (ESP), oxibendazole, oxfendazole, potas nitrothal-isopropyl, nuarimol, copper nonylphenol Sulfonate, sium oleate, sodium oleate, cadusafos, cartap, carbaryl, halacrinate, validamycin, Valifenalate, harpin protein, biX carbosulfan, carbofuran, gamma-cyhalothrin, Xylylcarb, afen, picoxystrobin, picobenzamide, bithionol, bitertanol, quinalphos, kinoprene, chinomethionat, cloethocarb, US 2014/0148493 A1 May 29, 2014

clothianidin, clofentezine, chromafenozide, chlorantranilip nil, aclonifen, azafenidin, acifluorfen, aZiprotryne, azimsul role, chlorethoxyfos, chlordimeform, chlordane, chlorpyri furon, asulam, acetochlor, atrazine, atraton, anisuron, anilo fos, chlorpyrifos-methyl, chlorphenapyr, chlorfenson, chlor fos, aviglycine, abscisic acid, amicarbazone, amidosulfuron, fenvinphos, chlorfluaZuron, chlorobenzilate, chlorobenzoate, amitrole, aminocyclopyrachlor, aminopyralid, amibuzin, kelthane (dicofol), salithion, cyanophos (CYAP), diafenthi amiprophos-methyl, ametridione, ametryn, alachlor, alli uron, diamidafos, cyantraniliprole, theta-cypermethrin, dochlor, alloxydim, alorac, iofensulfuron, isouron, isocarba dienochlor, cyenopyrafen, dioxabenzofos, diofenolan, mid, isoxachlortole, isoxapyrifop, isoxaflutole, isoxaben, iso sigma-cypermethrin, dichlofenthion (ECP), cycloprothrin, cil, isonoruron, isoproturon, isopropalin, isopolinate, disulfoton, dinotefuran, cyhalothrin, cyphenothrin, isomethiozin, inabenfide, ipazine, ipfencarbaZone, iprymi cyfluthrin, diflubenzuron, cyflumetofen, diflovidazin, dam, imaZaquin, imaZapic, imazapyr, imaZamethapyr. cyhexatin, cypermethrin, dimethylvinphos, dimethoate, imazamethabenZ, imazamethabenZ-methyl, imaZamox, dimefluthrin, Silafluofen, cyromazine, spinetoram, spinosad, imazethapyr, imaZoSulfuron, indaziflam, indanofan, indole spirodiclofen, spirotetramat, spiromesifen, Sulfluramid, Sul butyric acid, uniconazole-Peglinazine, esprocarb, ethamet profos, Sulfoxaflor, Zeta-cypermethrin, diazinon, sulfuron, ethametsulfuron-methyl, ethal fluralin, ethiolate, tau-fluvalinate, dazomet, thiacloprid, thiamethoxam, thiodi ethychloZate-ethyl, ethidimuron, etinofen, ethephon, ethox carb, thiocyclam, thiosultap, thiosultap-sodium, thionazin, ySulfuron, ethoxyfen, etnipromid, ethofumesate, etobenza thiometon, deet, dieldrin, tetrachlorvinphos, tetradifon, tet nid, epronaz, erbon, endothal, oxadiazon, oxadiargyl, oxazi ramethylfluthrin, tetramethrin, tebupirimfos, tebufenozide, clomefone, Oxasulfuron, oxapyrazon, oxyfluorfen, ory Zalin, tebufenpyrad, tefluthrin, teflubenzuron, demeton-S-methyl, orthosulfamuron, orbencarb, cafenstrole, cambendichlor, temephos, deltamethrin, terbufos, tralopyril, tralomethrin, carbasulam, carfentraZone, carfentraZone-ethyl, karbutilate, transfluthrin, triaZamate, triaZuron, trichlamide, trichlorphon carbetamide, carboxazole, quizalofop, quizalofop-P, quizalo (DEP), triflumuron, tolfenpyrad, naled (BRP), nithiazine, fop-ethyl, Xylachlor, quinoclamine, quinonamid, quinclorac, nitenpyram, novaluron, noviflumuron, hydroprene, Vanilip quinmerac, cumyluron, clacy fos, cliodinate, glyphosate, glu role, Vamidothion, parathion, parathion-methyl, halfenprox. fosinate, glufosinate-P, credazine, clethodim, cloxyfonac, halofenozide, clodinafop, clodinafop-propargyl, clopyralid, cloproxydim, bistrifluron, bisultap, hydramethylnon, hydroxy propyl cloprop, clofop, clomaZone, chlomethoxynil, chlomethoxy starch, binapacryl, bifenazate, bifenthrin, pyflubumide, fen, clomeprop, chloraZifop, chlorazine, chloranocryl, pymetrozine, pyraclofos, pyrafluprole, pyridafenthion, chloramben, cloranSulam, pyridaben, pyridalyl, pyrifluquinazon, pyriprole, pyriproxy cloransulam-methyl, chloridazon, chlorimuron, chlorimu fen, pirimicarb, pyrimidifen, pirimiphos-methyl, pyrethrins, ron-ethyl, chlorsulfuron, chlorthal, chlorthiamid, chlortolu fipronil, fenaZaquin, fenamiphos, phenisobromolate, feni ron, chlornitrofen, chlorfenac, chlorfenprop, chlorbufam, trothion (MEP), fenoxycarb, fenothiocarb, phenothrin, chlorflurazole, chlorflurenol, chlorprocarb, chlorpropham, fenobucarb, fensulfothion, fenthion (MPP), phenthoate chlorbromuron, chlormeduat, chloreturon, chloroxynil. (PAP), fenvalerate, fenpyroximate, fempropathrin, fenbenda chloroXuron, chlorotoluron, chloropon, saflufenacil, cyana Zole, butathiofos, buprofezin, furathiocarb, prallethrin, flu Zine, cyanatryn, di-allate, diuron, diethamquat, dicamba, acrypyrim, fluaZinam, fluaZuron, cycluron, cycloate, cycloxydim, dicloSulam, cyclosulfamu fluensulfone, flucycloxuron, flucythrinate, fluvalinate, ron, dichlorprop, dichlorprop-P, dichlobenil, diclofop, diclo flupyradifurone, flupyrazofos, flufiprole, flufenerim, fop-methyl, dichlormate, dichloralurea, diguat, cisanilide, flufenoxuron, flufenzine, flufenprox, fluproxyfen, flubro disul, Siduron, dithiopyr, dinitramine, cinidon-ethyl, cythrinate, flumethrin, flurimfen, prothiofos, protrifenbute, dinosam, cinosulfuron, dinoseb, dinoterb, dinofenate, dino flonicamid, propaphos, propargite (BPPS), profluthrin, pro prop, cyhalofop-butyl, diphenamid, difenoXuron, difeno poxur (PHC), flometoquin, bromopropylate, beta-cyfluthrin, penten, difenZoquat, cybutryne, cyprazine, cyprazole, hexaflumuron, hexythiazox, heptenophos, permethrin, ben diflufenican, diflufenZopyr, dipropetryn, cypromid, cyper clothiaz, bendiocarb, benSultap, benzoximate, benfuracarb, quat, gibberellin, Simazine, dimidazon, dimexano, dimeth phoxim, phosalone, fosthiazate, fosthietan, phosphamidon, achlor, dimethametryn, dimethenamid, simetryn, simeton, phosphocarb, phosmet (PMP), polynactins, formetanate, for dimepiperate, dimefuron, cinmethylin, Swep, Sulglycapin, mothion, phorate, machine oil, Sulcotrione, Sulfallate, SulfentraZone, Sulfo Sulfuron, Sulfo malathion, milbemycin, milbemycin-A, milbemectin, mecar meturon, Sulfometuron-methyl, secbumeton, Sethoxydim, bam, mesulfenfos, methomyl, metaldehyde, metaflumizone, Sebuthylazine, terbacil, daimuron, dazomet, dalapon, thiaz methamidophos, metam-ammonium, metam-Sodium, afluron, thiazopyr, thiencarbazone, thiencarbazone-methyl, methiocarb, methidathion (DMTP), methylisothiocyanate, tiocarbazil, tioclorim, thiobencarb, thidiazimin, thidiaZuron, methylneodecanamide, methylparathion, metoxadiaZone, thifensulfuron, thifensulfuron-methyl, desmedipham, desm methoxychlor, methoxyfenozide, metofluthrin, methoprene, etryn, tetrafluron, thenylchlor, tebutam, tebuthiuron, terbu metolcarb, meperfluthrin, mevinphos, monocrotophos, meton, tepraloxydim, tefuryltrione, tembotrione, delachlor, monosultap, lambda-cyhalothrin, ryanodine, lufenuron, res terbacil, terbucarb, terbuchlor, terbuthylazine, terbutryn, methrin, lepimectin, rotenone, levamisole hydrochloride, toprameZone, tralkoxydim, triaziflam, triasulfuron, triafa fenbutatin oxide, morantel tartarate, methyl bromide, tricy mone, tri-allate, trietazine, tricamba, triclopyr, tridiphane, clohexyltin hydroxide (cyhexatin), calcium cyanamide, cal tritac, tritosulfuron, triflusulfuron, triflusulfuron-methyl, tri cium polysulfide, Sulfur and nicotine-Sulfate. fluralin, trifloxysulfuron, tripropindan, 0052 Examples of the agricultural and horticultural her tribenuron, tribenuron-methyl, trifop, trifopsime, trimeturon, bicides include 1-naphthylacetamide, 2.4-PA, 2.3.6-TBA, naptalam, naproanilide, napropamide, nicosulfuron, nitralin, 2,4,5-T 2,4,5-TB, 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 3,4- nitrofen, nitrofluorfen, nipyraclofen, neburon, norflurazon, DA, 3,4-DB, 3,4-DP, 4-CPA (4-chlorophenoxyacetic acid), noruron, barban, paclobutraZol, paraquat, parafluron, haloxy 4-CPB, 4-CPP, MCP, MCPA, MCPA-thioethyl, MCPB, ioxy dine, haloxyfop, haloxyfop-P, haloxyfop-methyl, halosafen, US 2014/0148493 A1 May 29, 2014 halosulfuron, halosulfuron-methyl, bilanafos, picloram, oxabetrinil, allidochlor, isoxadifen-ethyl, cyprosulfamide, picolinafen, bicyclopyrone, bispyribac, bispyribac-Sodium, fluxofenim and 1.8-naphthalic anhydride. pydanon, pinoxaden, bifenox, piperophos, hymexaZol, pyra clonil, pyrasulfotole, pyrazoxyfen, pyrazosulfuron, pyrazo Sulfuron-ethyl, pyrazolate, bilanafos, pyraflufen-ethyl, pyri EXAMPLES clor, pyridafol. pyrithiobac, pyrithiobac-Sodium, pyridate, pyriftalid, pyribu 0055. Hereinafter, representative Examples and Test ticarb, pyribenzoxim, pyrimisulfan, primisulfuron, pyrimino Examples in connection with the present invention are shown, bac-methyl, pyroxasulfone, pyroxSulam, fenasulam, phen but the present invention is not limited thereto. In Examples, isopham, fenuron, fenoxasulfone, fenoxaprop, fenoxaprop-P, the “part(s) means a part(s) by mass. fenoxaprop-ethyl, phenothiol, fenoprop, phenobenzuron, fenthiaprop, fenteracol, fentraZamide, phenmedipham, phen Formulation Example 1 medipham-ethyl, butachlor, butafenacil, butamifos, buthi uron, buthidazole, butylate, buturon, butenachlor, butroxy dim, butralin, butroxydim, flaZaSulfuron, flamprop, Emulsifiable Concentrate furyloxyfen, prynachlor, primisulfuron-methyl, fluazifop, fluazifop-P, fluazifop-butyl, 0056 fluaZolate, fluroxypyr, fluothiuron, fluometuron, fluorogly cofen, flurochloridone, fluorodifen, fluoronitrofen, fluoromi dine, flucarbazone, flucarbazone-sodium, fluchloralin, fluc Flubendiamide 5 parts etosulfuron, fluthiacet, fluthiacet-methyl, flupyrsulfuron, Tolfenpyrad 10 parts flufenacet, flufenican, flufenpyr, flupropacil, flupropanate, Xylene 65 parts flupoxam, flumioxazin, flumiclorac, flumiclorac-pentyl, flu N-methyl pyrrollidone 10 parts mipropyn, flumeZin, flumetSulam, fluridone, flurtamone, Mixture of polyoxyethylene nonylphenyl ether 10 parts fluroxypyr, pretilachlor, proxan, proglinazine, procyazine, prodiamine, prosulfalin, proSulfuron, and calcium alkylbenzene Sulfonate prosulfocarb, propaquizafop, propachlor, propazine, propa nil, propyZamide, propisochlor, prohydrojasmon, propyrisul furon, propham, profluazol, profluralin, prohexadione-cal 0057 The above ingredients are mixed and dissolved uni cium, propoxycarbazone, propoxycarbazone-sodium, formly to give an emulsifiable concentrate. profoxydim, bromacil, brompyrazon, prometryn, prometon, bromoxynil, bromofenoxim, bromobutide, bromobonil, flo Formulation Example 2 rasulam, hexachloroacetone, hexazinone, pethoxamid, bena Zolin, penoXSulam, pebulate, beflubutamid, Vernolate, per Dust fluidone, bencarbazone, benzadox, benzipram, benzylaminopurine, benzthiaZuron, benzfendizone, ben Sulide, benSulfuron-methyl, benzoylprop, 0.058 benzobicyclon, benzofenap, benzofluor, bentaZone, pen tanochlor, benthiocarb, pendimethalin, pentoxazone, benflu Flubendiamide 3 parts ralin, benfuresate, fosamine, fomesafen, foramsulfuron, Tolfenpyrad 10 parts forchlorfenuron, maleic hydrazide, mecoprop, mecoprop-P, Clay powder 72 parts medinoterb, mesosulfuron, mesosulfuron-methyl, mesotri Diatomite powder 15 parts one, mesoprazine, methoprotryne, metaZachlor, methazole, metazosulfuron, methabenzthiazuron, metamitron, metami fop, metam, methalpropalin, methiuron, methioZolin, 0059. The above ingredients are uniformly mixed and then methiobencarb, methyldymron, metoxuron, metoSulam, met pulverized to give a dust. Sulfuron, metSulfuron-methyl, metflurazon, metobromuron, metobenzuron, methometon, metolachlor, metribuzin, mepi quat-chloride, mefenacet, mefluidide, monalide, monisou Formulation Example 3 ron, monuron, monochloroacetic acid, monolinuron, moli nate, morfamquat, iodosulfuron, iodosulfuron-methyl Granule Sodium, iodobonil, iodomethane, lactofen, linuron, rimsulfuron, lenacil, rhodethanil, calcium peroxide and 0060 methyl bromide. 0053 Examples of the synergists include piperonylbutox ide, sesamex, sulfoxide, N-(2-ethylhexyl)-8,9,10-trinorborn Flubendiamide 1 part 5-ene-2,3-dicarboximide (MGK 264), N-declyimidazole, Tolfenpyrad 2 parts WARF-antiresistant, TBPT, TPP, IBP PSCP methyl iodide, Mixture of bentonite powder and clay powder 92 parts t-phenylbutenone, diethyl maleate, DMC, FDMC, ETP and Calcium lignoSulfonate 5 parts ETN. 0054 Examples of the phytotoxicity reducers include benoxacor, cloquintocet-mexyl, cyometrinil, daimuron, 0061 The above ingredients are uniformly mixed. After dichlormid, cyprosulfamide, fenchlorazole-ethyl, fenclorim, addition of an appropriate Volume of water, the mixture is flurazole, fluxofenim, furilazole, mefenpyr-diethyl, MG191, kneaded, granulated and dried to give a granule. US 2014/0148493 A1 May 29, 2014 11

Formulation Example 4 intervals, 8 times in total. In plots of Plutella xylostella or Spodoptera litura, 20 plants per plot were chosen at random, Wettable Powder the number of surviving larvae was measured before the agrochemical treatment, at 4 days after the 5th agrochemical 0062 treatment and at 4 days after the 6th agrochemical treatment. With reference to the number of larvae before the agrochemi cal treatment, the control effect was calculated according to Flubendiamide 5 parts the formula shown below. In addition, the expected value for Tolfenpyrad 15 parts Kaolin and synthetic high-dispersion silicic 75 parts the control effect of the mixed use was calculated according to acid Colby's equation shown below. When the control effect of the Mixture of polyoxyethylene nonylphenyl ether 5 parts mixed use is Superior to the expected value, the mixed use is and calcium alkylbenzene Sulfonate regarded as having not a mere additive effect but a synergistic effect. As for plots of Spodoptera exigua, the calculation was 0063. The above ingredients are uniformly mixed and then performed based on the measurements at 4 days after the 7th pulverized to give a wettable powder. agrochemical treatment and at 4 days after the 8th agrochemi cal treatment. Formulation Example 5 Control effect=100-{(TaxCb)/(TbxCa)}x100 Flowable 0067 Ta the number of larvae after the agrochemical treatment in a treatment plot 0.064 0068 Tb=the number of larvae before the agrochemical treatment in a treatment plot 0069 Ca=the number of larvae after the agrochemical Flubendiamide 5 parts treatment in a non-treatment plot Tolfenpyrad 25 parts 0070 Cb-the number of larvae before the agrochemical Sorpol 3105 (manufactured by Toho Chemical 5 parts Industry Co., Ltd. Japan) treatment in a non-treatment plot Propylene glycol 5 parts Rhodopol 23 (manufactured by Rhone-Poulenc 2 parts Colby's Equation S.A.) Water 58 parts (0071 E(expected value)=(X+Y)-(X-Y7100) 0065. The above ingredients are uniformly mixed and then 0072 X=the control effect of flubendiamide alone dispersed in water to give a flowable. (0073 Y—the control effect of tolfenpyrad alone Test Example 1 0074 The results are shown in Tables 1 to 3. In each table, 4DAT5, 4DAT6, 4DAT7 and 4DAT8 areas defined below, and Tests of Insecticidal Effect on Plutella xylostella, the a. i. Stands for active ingredient. Spodoptera exigua and Spodoptera litura (0075 4DAT5: the measurement at 4 days after the 5th 0066. In an experimental Chinese kale (Brassica oleracea agrochemical treatment var. acephala) field (sized 4 mx5 m and planted with 800 0076 4DAT6 the measurement at 4 days after the 6th plants per plot), foliar application was conducted with a agrochemical treatment water-diluted agrochemical Solution (anamount equivalent to (0077 4DAT7 the measurement at 4 days after the 7th 750 L/ha) containing a predetermined dose of a flubendia agrochemical treatment mide 20% water-dispersible granule and/or a predetermined (0078 4DAT8 the measurement at 4 days after the 8th dose of a tolfenpyrad 15% emulsifiable concentrate at 4-day agrochemical treatment TABLE 1

Control effect on Plutella xylostella

Number of larvae per plant

Dose Before Control effect (%) Expected value (%)

Test agrochemical (ga.i./ha) treatment 4DATS 4DAT6 4DATS 4DAT6 4DATS 4DAT6

Flubendiamide 11.3 2.76 O.OS O.O2 91.9 96.2 67.2 87.4 Tolfenpyrad 60 Flubendiamide 11.3 2.3 O.24 O.13 53.5 70.O Tolfenpyrad 60 2.4 O.38 O.19 29.4 58.0 Non-treatment 2.81 O.63 O.S3 US 2014/0148493 A1 May 29, 2014 12

TABLE 2 Control effect on Spodoptera exigua Number of larvae per plant Dose Before Control effect (%). Expected value (% Test agrochemical (ga.i./ha) treatment 4DAT7 4DAT8 4DAT7 4DAT8 4DAT7 4DAT8 Flubendiamide 11.3 1.32 O.O1 O.O1 84.5 93.O 37.6 62.2 Tolfenpyrad 60 Flubendiamide 11.3 O.98 O.O3 O.04 37.6 62.2 Tolfenpyrad 60 1.08 O.O6 O.13 O O Non-treatment 1.02 O.OS O.11

TABLE 3 Control effect on Spodoptera litura Number of larvae per plant Dose Before Control effect (%). Expected value (% Test agrochemical (ga.i./ha) treatment 4DAT5 4DAT6 4DAT5 4DAT6 4DAT5 4DAT6 Flubendiamide 11.3 O.33 O.13 O.04 66.6 90.8 3.9 37.8 Tolfenpyrad 60 Flubendiamide 11.3 O.38 O.43 O.31 3.9 37.8 Tolfenpyrad 60 O.11 O.25 O.S3 O O Non-treatment O.45 O.S3 O.S9

0079. In each test, the control effect observed in the mixed taining flubendiamide as an active ingredient and an effective treatment plot was greater than the expected effect (expected amount of an optionally diluted formulation containing value) calculated from the effect observed in the flubendia tolfenpyrad as an active ingredient, the two formulations mide treatment plot and the effect observed in the tolfenpyrad being used separately but in the same period. treatment plot. 5. A method for controlling agricultural and horticultural 1. An agricultural and horticultural insecticide composi insect pests, comprising treating insect pests directly, treating tion comprising flubendiamide and tolfenpyrad as active crops potentially infested with the insect pests, or treating ingredients. Surrounding soil or cultivation medium of the crops with an 2. The agricultural and horticultural insecticide composi effective amount of an optionally diluted formulation con tion according to claim 1, comprising 0.1 to 10 parts by mass taining flubendiamide as an active ingredient and an effective of tolfenpyrad per part by mass of flubendiamide. amount of an optionally diluted formulation containing 3. A method for using an agricultural and horticultural tolfenpyrad as an active ingredient, the two formulations insecticide composition, comprising treating insect pests being used separately at a given interval. directly, treating crops potentially infested with the insect 6. A method for controlling agricultural and horticultural pests, or treating Surrounding soil or cultivation medium of insect pests, comprising mixing an effective amount of a the crops with an effective amount of an agricultural and formulation containing flubendiamide as an active ingredient horticultural insecticide composition comprising flubendia and an effective amount of a formulation containing tolfen mide and tolfenpyrad as active ingredients. pyrad as an active ingredient, optionally diluting the mixture; 4. A method for controlling agricultural and horticultural and treating insect pests directly, treating crops potentially insect pests, comprising treating insect pests directly, treating infested with the insect pests, or treating Surrounding soil or crops potentially infested with the insect pests, or treating cultivation medium of the crops with the optionally diluted Surrounding soil or cultivation medium of the crops with an mixture. effective amount of an optionally diluted formulation con