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Karen Ortiz Cruz, M.D Karen Ortiz Cruz, M.D. CURRICULUM VITAE Ironwood Cancer & Research Centers a division of Ironwood Physicians, PC PROFESSIONAL EXPERIENCE Ironwood Cancer & Research Centers Chandler, AZ Physician, Medical Oncology/Hematology September 2014 Waccamaw Oncology Private Practice Georgetown, SC Physician, Medical Oncology/Hematology December 2012 – June 2014 EDUCATION Post-Graduate Training: Medical University of South Carolina Charleston, SC Hematology/Oncology Fellow July 2011 – July 2014 Banner Good Samaritan Medical Center Phoenix, AZ Internal Medicine Intern/Resident June 2008 – June 2011 Education: Ross University School of Medicine Dominica, West Indies Doctor of Medicine September 2004 – June 2008 Foundation for Advanced Education in Sciences Bethesda, MD National Institutes of Health June 2002 – June 2004 University of Puerto Rico Cayey, PR Bachelor of Science August 1999 – June 2002 Major: Natural Science. Cum Laude CERTIFICATION/LICENSURE Board Certified, American Board of Internal Medicine August 2011 Board Eligible, ABIM Hematology and Medical Oncology, (certification upon completion of Fellowship in June 2014) Permanent License, South Carolina Board of Medical Examiners RESEARCH Post-Baccalaureate Research Student National Cancer Institute’s/Pediatric Oncology Branch, Bethesda, MD Preceptor Lee Helman, MD, PhD Research: Effects of CCI-779, an inhibitor of mTOR/S6Kl 4E-BPl pathway, on both primary tumor growth and metastasis tumor growth in rhabdomyosarcoma xenograft and mouse sarcoma model. 2003-2004 Post-Baccalaureate Research Student National Cancer Institute’s /Radiation Oncology Branch, Bethesda, MD Preceptor David Gius, M.D, PhD Research: Determine the function of two redox-sensitive transcriptional complex NF-κB and AP-1, which appear to be regulated by Thioredoxin Reductase and Thioredoxin. 2002-2003 Research Student Fellow University of Nebraska Medical Center- Eppley Cancer Institute, Omaha, NE Preceptor Robert Lewis, PhD Research: Construction of mice model with Kinase Suppressor of Ras (KSR) deletion. To understand cancer cells development, cell signaling, and tumorigenesis. Summer 2001 PUBLICATIONS Ortiz Cruz K, Costa J. Population Outcomes of Primary Mediastinal Large B-cell Lymphoma in the Rituximab Era. Blood 2013 122:1743. Kang Y, Ortiz Cruz K, Abbas J, Stuart R, Costa J. Outcomes of patients with multiple myeloma and renal impairment treated with bortezomib, cyclophosphamide and dexamethasone without plasma exchange. European Journal of Hematology. 2012; 89:432-434. Ortiz Cruz K, Amog-Jones G, Salvatore Joseph R.Chronic Neutrophilic Leukemia with JAK2 gene mutation. Community Oncology 2012; 9(4): 127-131. Smart DK, Ortiz KL, Mattson D, Bradbury CM, Bisht KS, Sieck LK, Brechbiel MW, Gius D. Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress. Cancer Res.2004; 64:6716-24. Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D. Geldanamycin and 17-allylamino-17- demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res.2003; 63:8984-95. ABSTRACTS/PRESENTATIONS Ortiz Cruz K, Costa, J. (2013, December). Population Outcomes of Primary Mediastinal Large B-cell Lymphoma in the Rituximab Era. Poster Presentation at: American Society of Hematology. Ortiz Cruz K, (2013, August). Population Outcomes of Primary Mediastinal Large B-cell Lymphoma in the Rituximab Era. Oral Presentation at: South Carolina Oncology Society. Ortiz Cruz, K, Costa, L, Kang, Y (2012, January). Combination of Bortezomib, Cyclophosphamide and Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma and Impaired Renal Function: Fast Improvement in Creatinine Clearance and Outcome Similar to Patients with Preserved Renal Function. Poster Presented at: Annual Research day/Medical University of South Carolina. Ortiz Cruz K, (2009, September). Extensive left sided DVT and bilateral Pulmonary embolism in a young female without previous diagnosis of May-Thurner Syndrome. Poster presented at: American College of Physicians/Annual Meeting; Tucson, AZ. Ortiz Cruz K, Sein, V, Cardello F, Dresser K, (2009, May). Isolated Left Ventricular Noncompaction: Literature Review and Example Case. Poster presented at: Annual Academic Excellence Day, Arizona College of Medicine/ASU; Phoenix, AZ. Smart DK, Ortiz KL, Mattson D, Bradbury CM, Bisht KS, Sieck LK, Brechbiel MW, Gius D. (2003, May). Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress. Poster presented at: American Association of Cancer Research 94th Annual Meeting; Washington, DC. Smart DK, Ortiz KL, Mattson D, Bradbury CM, Bisht KS, Sieck LK, Brechbiel MW, Gius D.(2003, April). Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress. Poster presented at: National Institutes of Health Intramural Program Annual Research Festival; Bethesda, MD. Ortiz KL, Kortum RL, Razidio GL, Lewis R. (2001, September). Construction of Mice Model with Kinase Suppresor of Ras (KSR) Deletion. Poster presented at: Society for Advancement of Chicanos and Native Americans in Science; Phoenix, AZ. HONORS/AWARDS Internal Medicine Residency Program, Intern of the Month Phoenix, AZ (3/2009) Medical Scholarship, Medical Science Campus Rio Piedras, PR (2007) Society for Advancement of Chicanos and Native Americans in Science, Travel Award and Poster Presentation Phoenix, AZ (2004) Intramural Research Training Award, NIH/NCI Bethesda, MD (2002-2004) American Association of Cancer Research Travel Award and Poster Presentation Washington DC (2003) Biomedical Research student, Research Initiative for Scientific Enhancement, MBRS-RISE (2001) Scholar Honor Award by Major Cayey, PR (2000) PROFESSIONAL MEMBERSHIPS South Carolina Oncology Society (2012-Present) American Society of Clinical Oncology (2011-Present) American Society of Hematology (2011-Present) American College of Physicians (2010-Present) VOLUNTEER/COMMUNITY ACTIVITIES Resident Patient Safety Committee (2009-2010) Secretary of the Organization for Latin American Students, Medical School (2005) LANGUAGES Fluent in English and Spanish CITIZENSHIP United States CLINICAL TRIALS________________________________________________________________ Lung Cancer Trials: Novocure Protocol EF-24/Lunar: Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields) concurrent with standard of care therapies for treatment of stage 4 non- small cell lung cancer (NSCLC) following platinum failure (LUNAR) (2018- ). https://clinicaltrials.gov/ct2/show/NCT02973789?term=ef-24&rank=1 BeyondSpring Pharmaceuticals Inc. Protocol 450-0001/Dublin-3: Assessment of Docetaxel + Plinabulin Compared to Docetaxel + Placebo in Patients With Advanced NSCLC With at Least One Measurable Lung Lesion (DUBLIN-3) (2017- ). https://clinicaltrials.gov/ct2/show/NCT02504489 G1 Therapeutics Protocol G1T28-05: Phase 2 Study of Carboplatin, Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28) in Patients with Untreated Extensive- Stage Small Cell Lung Cancer (2017- ) https://clinicaltrials.gov/ct2/show/NCT03041311 Pharma Mar Protocol PM1183-C-003-14: Phase III Randomized Clinical Trial of Lurbinectedin (PM01183)/Doxorubicin (DOX) Versus Cyclophosphamide (CTX), Doxorubicin (DOX) and Vincristine (VCR) (CAV) or Topotecan as Treatment in Patients With Small-Cell Lung Cancer (SCLC) Who Failed One Prior Platinum-containing Line (ATLANTIS Trial) (2016- ) https://clinicaltrials.gov/ct2/show/NCT02566993 Eli Lilly and Company Protocol LUN 288/I6A-MC-CBBE: A Phase II Study of the Combination of LY3023414 and Necitumumab After First-Line Chemotherapy for Metastatic Squamous Non-small Cell Carcinoma of the Lung (2016-2018) https://clinicaltrials.gov/ct2/show/NCT02443337?term=I6A-MC-CBBE&rank=1 Hoffmann-La Roche Protocol GO29437: A Phase III, Open-label, Multicenter, Randomzed Study Evaluating the Efficacy and Safety of MPDL3208A (Anti-PDL-1 Antibody) in Combination with Carboplatin + Paclitaxel or MPDL3208A in Combination With Carboplatin + Nab-paclitaxel Versus Carboplatin + Nab-paclitaxel in Chemotherapy-naive Patients With Stage IV Squamous Non-small Cell Lung Cancer (2015- ) https://clinicaltrials.gov/ct2/show/NCT02367794?term=GO29437&rank=1 Hoffmann-La Roche Protocol GO29436: A Phase III, Open-Label, Randomized Study of MPDL3280A (Anti-PD-L1 Antibody) In Combination with Carboplatin + Paclitaxel With or Without Bevacizumab Compared With Carboplatin + Paclitaxel + Bevacizumab In Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (2015- ) https://clinicaltrials.gov/ct2/show/NCT02366143?term=GO29436&rank=1 BIND Therapeutics Protocol BIND-014-007: An Open Label, Multicenter, Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as a Second-Line Therapy for Patients with KRAS Mutation Positive or Squamous Cell Non-Small Cell Lung Cancer (2015-2016) https://clinicaltrials.gov/ct2/show/NCT02283320?term=BIND-014-007&rank=1 Boehringer Ingelheim Protocol 1199.128: Multicentre, Randomised, Double-blind, Phase III Trial to Investigate the Efficacy and Safety of Oral Nintedanib Plus Docetaxel Therapy Compared to Placebo Plus Docetaxel Therapy in Patients With Stage IIIB/IV or Recurrent, Adenocarcinoma Subtype Non-small Cell Lung Cancer After
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