UNIVERSITY OF AARHUS GRADUATE SCHOOL OF HEALTH SCIENCES PhD Day 15 January 2010 2 Welcome It is our pleasure to welcome students, faculty, and guests to the PhD Day 2010. We warmly thank all those who have taken the time to participate and help make the PhD Day a leading event in the training of our graduate students. The world of science is by nature global and to go international is a key ambition of the PhD programme in Denmark. Aarhus Graduate School of Health Sciences acknowledges that internationalisation is a very important aspect of science, not least for the individual PhD student. One way to support internationalisation is by networking. The theme of the PhD Day 2010 is thus INTERNATIONAL NETWORKING. Nine PhD students coming from USA, England, Sweden, Switzerland, and France will spend a day with PhD students from Aarhus. They were invited by the respective Graduate Programmes and we trust that this day of science related as well as social activities will lead to new contacts, further networking and new collaborations across borders. As is evident from the abstracts presented in this programme book the Aarhus Graduate School of Health Sciences provides a vibrant scientific environment ready to meet new challenges and offering many opportunities. The PhD students are central to research and research environments and the Organizing Committee is satisfied that this book shows the commitment and high quality research done at our Faculty. The Organizing Committee and the Faculty of Health Sciences are confident that the PhD Day 2010 will be a success and we cordially welcome all participants. Troels Staehelin Jensen Lise Wogensen Bach Chairman, Organizing Committe Vice‐Head, Aarhus Graduate School of Health Sciences Søren Mogensen Dean, Faculty of Health Sciences Aarhus University 3 4 Contents Welcome 3 Information 6 Program 7 The Skou Lecture 9 Aarhus Graduate School of Health Sciences 10 International office 11 The PhD Association 12 Association of Pregaduate Medical Research 13 The Student Counsellor 14 Library of Health Sciences 15 SunQnet - a network for female scientists 16 Sponsors 17 Session chairmen 18 Free communication program Session overview - Fogh Nielsen Prize 19 - oral 19 - posters 20 Abstracts 37 Index 234 5 Information Practical information: Lunch will be held in the Lake Auditorium Building Posters will be shown in the Lake Auditorium Building; the Bartholin Building teaching wing room and auditoria 1 ‐ 4; and the Victor Albeck Building. Posters should be hung between 15.00 and 16.00 on 14 January or 7.15‐8.00 on 15 January. All posters must be taken down immediately after the closing of the conference. Oral presenters for sessions O1‐O4 must meet in the auditorium concerned between 07.30 and 08.00 to put their PowerPoint presentation onto the auditorium hard disk. Organizing committee: Gunna Christiansen, Institute of Medical Microbiology & Immunology Helene Nørrelund, Department of Endocrinology and Diabetes Iben Møller Jønsson, PhD student, Department of Paediatrics Jens Cosedis Nielsen, Department of Cardiological Medicine B Kimmo Jensen, Institute of Physiology and Biophysics Lise Wogensen Bach, Research Laboratory for Biochemical Pathology Maciej Bogdan Maniecki, PhD student, Department of Clinical Biochemistry Michael Mulvany, Head Graduate School of Health Sciences Niels Trolle Andersen, Department of Biostatistics, Institute of Public Health Thomas Vorup‐Jensen, Institute of Medical Microbiology & Immunology Troels Staehelin Jensen (chairman), Department of Neurology and Danish Pain Research Center Troels Thim, PhD Student, Department of Cardiological Medicine B Vivi Schlünssen, Department of Environmental and Occupational Medicine, Institute of Public Health Tanja Hansen, PhD Administration Prize committee: Chairman, Jens Chr. Djurhuus Co‐chairman, Helene Nørrelund Secretariat: Inge Haislund Andersen, Forskeruddannelsen, The Faculty of Health Sciences, Vennelyst Boulevard 9, 8000 Aarhus C. [email protected] 6 Graduate School of Health Sciences, Aarhus University PHD DAY 15 JANUARY 2010 International networking Sessions held in Auditorium 1 in the Lake Auditorium unless otherwise indicated 14 January 15.00 – 16.00 Set up posters 15 January 7.15 – 8.00 Set up posters Welcome 8.15 Søren Mogensen, Dean of Faculty 8.20 Maciej Maniecki, Chairman of the PhD Association 8.25 Troels S. Jensen, Chairman of the Organizing Committee – today’s programme 8.30 Jonathan Webb, University of Oxford: “Establishing a dynamic doctoral program. A PhD student’s perspective” Poster session 9.15 Poster visits part one (two chairmen per group of 10 posters) and coffee P01‐P13: Lake Auditorium, P14‐P28: Bartholin Building, P29‐P36: Victor Albeck Building (all odd numbered sessions) Oral communications 10.45 Parallel sessions (6 presentations, each presentation 10+5 min.) Session O1 Chairmen: Raben Rosenberg & Ebba Nexø Aud. 1 Session O2 Chairmen: Bente Jespersen & Christian Aalkjær Aud. 2 Session O3 Chairmen: Leif Mosekilde & Lise Wogensen Bach Aud. 3 Session O4 Chairmen: Jens Overgaard & Jytte Banner Lundemose Aud. 4 12.15 Lunch 7 Poster session 13.00 Poster visits part two (two chairmen per group of 10 posters) and coffee P01‐P13: Lake Auditorium, P14‐P28: Bartholin Building, P29‐P36: Victor Albeck Building (all even numbered sessions). 14.00 Poster viewing Skou Lecture Chaired by Søren Mogensen, Dean of Faculty 14.30 Nobel Laureate Timothy Hunt: y“M Way into the Cell Cycle” Fogh Nielsen prize competition Chaired by Søren Moestrup & Iben Møller Jønsson 15.15 PhD student Anna Krarup Keller 15.30 PhD student Anne Nyholm Holdensen 15.45 PhD student Casper Bindzus Foldager Closing remarks 16.00 Lise Wogensen Bach, Vice‐Head of Graduate School Social programme 18.00 Dinner and presentation of prizes in ‘Stakladen’ Festive speech by Jane Skov, PhD 22.00 Band and dance 8 The Skou Lecture Tim Hunt is a ‘Principal Scientist’ (note, not THE principal scientist) at Cancer Research UK, Clare Hall Laboratories, in South Mimms, Herts (15 miles north of central London). Dr Hunt was born in 1943 and grew up in Oxford, but went up to Cambridge to read Natural Sciences in 1961. He did his Ph.D. in the Department of Biochemistry on “The Synthesis of Haemoglobin”. He spent almost 30 years altogether in Cambridge, mostly working on the control of protein synthesis, with spells in the USA; he was a postdoctoral Fellow at the Albert Einstein College of Medicine in 1968-70 and he spent summers at the Marine Biological Laboratory, Woods Hole from 1977 until 1985, teaching and doing research. In 1982, he discovered cyclins, which turned out to be “Key Regulator(s) of the Cell Cycle”. This discovery led to a share of the Nobel Prize in Physiology or Medicine in 2001, together with Lee Hartwell and Paul Nurse. Dr Hunt has helped write two books: together with Andrew Murray, he wrote “The Cell Cycle: An Introduction”, and with John Wilson composed “Molecular Biology of the Cell: A Problems Approach” to accompany the textbook by Alberts et al. The latest edition of The Problems Book has just been published (2008). Apart from researching, writing and lecturing, Dr Hunt finds himself on numerous scientific advisory panels. He was a member of the EMBO panel that reviewed Cell and Molecular Biology in Austria and chaired the EMBO review panel for the French “Genopole” system. He was on the Scientific Advisory Board of the IMP in Vienna, and is a member of the advisory board of laboratories in Barcelona, Dundee, London, Madrid, Mishima, Oxford and Trieste. He chaired the Life Sciences Panel for selection of European Young Investigators under the aegis of the European Science Foundation, and is chairman of the council of EMBO. He actively promoted the idea of the European Research Council by lobbying commissioners and MPs in Brussels. Dr Hunt is a Fellow of the Royal Society, a Fellow of the Academy of Medical Sciences, a Foreign Associate of the National Academy of Sciences of the USA, a Member of EMBO, a Foreign Member of the American Academy of Arts and Sciences and a Member of Academia Europaea. He was knighted in June 2006. He is married to Mary Collins, who is Professor of Infection and Immunity at University College London. They have two children, Celia (13) and Agnes (9). 9 Aarhus Graduate School of Health Sciences The Aarhus Graduate School of Health Sciences was established in 1996, and was based on a tradition of providing quality postgraduate courses started in the 1970s. The Graduate School has currently 500 PhD students enrolled, with 170 enrolled in 2009. The Graduate School is part of the Faculty of Health Sciences, which has four broad divisions: biomedical sciences, clinical sciences, public health and odontology. The Faculty has a total of about 400 professors and associate professors, with the clinical faculty members having joint appointments in the Aarhus University Hospital. The Graduate School has established eleven graduate programmes (forskeruddannelsesprogrammer) of high scientific quality which cover the whole range of the Graduate Schoolʹs activities. The University of Aarhus Graduate School of Health Sciences provides PhD training in all aspects of health sciences from basic research to the clinic. The integrated approach ensures that the overall aim of improving patient health care is obtained in a multidisciplinary manner without fragmentation of the research training process. Furthermore, this approach ensures a uniform quality of the PhD training program. The Graduate School is led by a Head and vice‐Head who are advised by the elected PhD Committee. The Graduate School Heads are assisted by the PhD administrator and the staff of the PhD office. The Graduate School holds about 80 courses each year, of which some are core courses taken by all PhD students, while the majority of courses are elective taken according to the needs of the particular PhD student. The Graduate School Heads are responsible for monitoring the quality of the courses and initiating new courses as required in collaboration with the graduate programmes.