126 (2)

J Immunol 1981; 126:393-810; ; http://www.jimmunol.org/content/126/2.citation This information is current as of October 1, 2021. Downloaded from Why The JI? Submit online.

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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. THE JOURNAL OF IMMUNOLOGY Volume 126/Number 2

Contents

CELLULAR IMMUNOLOGY

K. Kudo, A. H. Sehon, and R. J. 403 The Role of Antigen-Presenting Cells in the IgE Antibody Response. I. The Induction Schwenk of High Titer IgE Antibody Responses in IgE High-Responder and Low-Responder Mice by the Administration of Antigen-Pulsed Macrophages in the Absence of Adjuvants D. A. Hubbard, W. Y. Lee, and A. 407 Suppression of the Anti-DNP IgE Response with Tolerogenic Conjugates of DNP H. Sehon with Polyvinyl Alcohol. I. Specific Suppression of the Anti-DNP IgE Response W. Y. Lee and A. H. Sehon 41 4 Suppression of the Anti-DNP IgE Response with Tolerogenic Conjugates of DNP with Polyvinyl Alcohol. II. Induction of Hapten-Specific Suppressor T Cells J. W. Schrader 452 The in Vitro Production and Cloning of the P Cell, a Bone Marrow-Derived Null Cell That Expresses H-2 and la-Antigens, HasMast Cell-Like Granules, and Is Regulated by a Factor Released by Activated T Cells W. Borkowsky, and H. S. Law- 486 Deletion of Antigen-Specific Activity from Leukocyte Dialysates Containing Transfer rence Factor by Antigen-Coated Polystyrene Downloaded from W-Z. Wei and R. R. Lindquist 51 3 Alloimmune Cytolytic T Activity: Triggering and Expression of Killing Mechanisms in Cytolytic T Y. Cayre, A. de Sostoa, and A. E. 553 Isolation of a Subset of Inducible for Terminal Transferase Biosynthesis Silverstone M. L. Thoman, E. L. Morgan, and 632 Fc Fragment Activation of T Lymphocytes. I. Fc Fragments Trigger Lyt 1'23- T W. 0. Weigle Lymphocytes to Release a Helper -Replacing Activity G. Degiovanni and N. Schaaf-La- 641 FCS-Activated Blast T Cells Inhibit the in VitroResponse of Memory CTL Precursors http://www.jimmunol.org/ fontaine to Alloantigens by Removal of Factor(s1 from MLC Supernatant 1. Hamaoka, K. Takatsu, K. 659 Functional Characterization of the Killer-Helper Factor Responsible for the Induction Okuno, and 1. Tsuchida of Cytotoxic T Lymphocytes from Thymocytes, and Evidence for the Nature of This Factor as Distinct from T Cell-Replacing Factor (TRF) in Regards to Triggering G. M. K. Humphries 688 Evidence for Direct Control ofan inVitro, Plaque-Forming Cell Response by Quantitative Properties of Intact, Fluid, Haptenated Liposomes: A Potential Model System for Antigen Presentation by Macrophages A. Prouvost-Danon, A. Abadie, C. 699 Induction of IgE Synthesis and Potentiation of Anti-Ovalbumin IgE Antibody Re- by guest on October 1, 2021 Sapin, H. Bazin, and P. Druet sponse by HgCI, in the Rat G. D. Wetzel and J. R. Kettman 723 Activation of Murine BLymphocytes. 111. Stimulation of B Lymphocyte Clonal Growth with Lipopolysaccharide and Dextran Sulfate G. D. Marshall, Jr., G. B. Thurman, 74 1 In Vivo Generation of Suppressor T Cells by Thymosin in Congenitally Athymic J. L. Rossio, and A. L. Goldstein Nude Mice J. Schneck, 0. M. Rosen, B. Dia- 745 Modulation of Fc-Receptor Expression and Fc-Mediated Phagocytosis in Variants mond, and B. R. Bloom of a Macrophage-Like Cell Line S. M. Walker, E. L. Morgan, and 766 Regulation of the in VitroSecondary Antibody Response. II. Antigen-Induced Murine W. 0. Weigle Splenic T Cell Proliferation S. Wu and F. H. Bach 775 Helper Cells in Murine Thymus for the Generation of Primary Cytolytic T Lymphocyte (CTL) Responses in Vitro D. S. Weinberg and E. R. Unanue 794 Antigen-Presenting Function of Alveolar Macrophages: Uptake and Presentation of Listeria monocytogenes

CLINICAL IMMUNOLOGY

~ ~ ~~ A. Silva, M. Lopez-Botet, J.AI- 393 Enhancement of the Functional Activities of Human T Cells after Their Interaction varez, and M. 0. de Landazuri with SRBC T. J. Kunicki, N. Russell, A. T. 398 Further Studies of the Human Platelet Receptor for Quinine- and Quinidine-De- Nurden, R. H. Aster, and J. P. pendent Antibodies Caen Continued on page 4

Published monthly by The Williams & Wilkins Co., 428 E. Preston St., Baltimore, Md. 21202, USA. Subscription price $115.00 individuals, $135.00 institutions, single issue $12.00 Second class postage paid at Baltimore, Md. 21202 and at additional mailing offices. Continued from page 3 C. J. Heijnen, F. UytdeHaag, K. H. 497 Antigen-Specific Human T Cell Factors. I. T Cell Helper Factor: Biologic Properties Pot, and R. E. Ballieux F. UytdeHaag, C. J. Heijnen, K. H. 503 Antigen-Specific Human T Cell Factors. II. T Cell Suppressor Factor:Biologic Pot, and R. E. Ballieux Properties T. Hirano, T. Teranishi, H. Toba, 51 7 Human Helper T Cell Factor(s1 (ThF). I. Partial Purification and Characterization N. Sakaguchi, T. Fukukawa, and 1. Tsuyuguchi F. Gmelig-Meylingand T. A. Wald- 529 Human B Cell Activation in Vitro. Augmentation and Suppression by Monocytes of mann the Immunoglobulin Production Induced by Various B Cell Stimulants R. P. Schleimer, E. Gillespie, and 570 Release of Histamine from Human Leukocytes Stimulated with the Tumor-Promoting L. M. Lichtenstein Phorbol Diesters. I. Characterization of the Response G. J. Gleich, E. M. Zirnmermann, 575 Measurement of IgG Blocking Antibodies by Interference in the Radioallergosorbent M. C. Gleich, and J. W. Yungin- Test ger W. C. Greene, T. A. Fleisher, and 580 Suppression of Human T and B Lymphocyte Activation by Agaricus bisporus Lectin. T. A. Waldmann I. Suggestive Evidence for a Surface “Suppressor” Receptor in Human Lympho- cytes P. M. Guyre, G. R. Crabtree, J. E. 666 MLC-Conditioned Media Stimulate an Increase in Fc Receptors on Human Macro- Bodwell, and A. Munck phages J. C. Rogers and J. W. Kerstiens 703 Capping of DNA on Phytohemagglutinin-Stimulated Human 1. Garcia, R. Wolbers, and E. M. 706 Reactions between Polyribonucleotides and Low Density Lipoproteins in Sera of Tan Patients with Progressive Systemic Sclerosis Downloaded from R. P. MacDermott and M. C. Sta- 729 Further Characterization of the Human Autologous Mixed Leukocyte Reaction cey (MLR) R. S. Geha, M. E. Jonsen, 6. H. 781 MacrophageT Cell Interaction in Man: Binding of Antigen-Specific Human Prolif- Ault, E. Yunis, and M. D. Broff erating and Helper T Cells to Antigen-Pulsed Macrophages http://www.jimmunol.org/ IMMUNOCHEMISTRY

G. S. Hahn and R. N. Hamburger 459 Evolutionary Relationship of Thymopoietin to Immunoglobulins and Cellular Rec- ognition Molecules T. Kaidoh, S. Natsuume-Sakai, 463 Murine C4-Binding Protein: A Rapid Purification Method by Affinity Chromatography and M. Takahashi R. H. Zubler 557 Epitope-Specific Antibody Feedback Regulation of the Humoral Immune Response against Sheep Erythrocytes in Vitro: Specific Effects of Anti-antigen Antibody vs

Nonspecific T Cell Activities by guest on October 1, 2021 E. Linder 648 Binding of C1 q and Complement Activation by Vascular Endothelium F. D. Finkelman, S. W. Kessler, J. 680 IgD-Secreting Murine Plasmacytomas: Identification and Partial Characterization of F. Mushinski, and M. Potter Two IgD Myeloma Proteins N. J. Dobson, J. D. Lambris, and 693 Characteristics of Isolated Erythrocyte Complement Receptor Type One (CRl, C4b- G. D. Ross C3b Receptor) and CR1-Specific Antibodies M. K. Gately and E. Martz 709 T1 1 : A New Protein Marker on Activated Murine T Lymphocytes R. J. Schneider, J. P. Atkinson, V. 735 Characterization of Ligand-Binding Activity of Isolated Murine Fcy Receptor Krause, and A. Kulczycki, Jr.

IMMUNOGENETICS AND TRANSPLANTATION

A. J. Norin, E. E. Emeson, and F. 428 Long-Term Survival of Murine Allogeneic Bone Marrow Chimeras: Effect of Anti- J. Veith lymphocyte Serum and Bone Marrow Dose J.-C. Cerottini and H. R. Mac- 490 Limiting Dilution Analysis of Alloantigen-Reactive T Lymphocytes. V. Lyt Phenotype Donald of Cytolytic T Lymphocyte Precursors Reactive against Normal and Mutant H-2 Antigens G. M. Shearer and R. P. Polisson 545 Mutual Recognition of Parental and F, Lymphocytes. 111. Parental Determinants Recognized by F1 Host Mice in Resistance to Graft-vs-Host-Associated Immu- nosuppression Map to H-2Db V. Quaranta, M. A. Pellegrino, and 548 Serologic and Immunochemical Characterization of the Specificity of Four Mono- S. Ferrone clonal Antibodies to Distinct Antigenic Determinants Expressed on Subpopula- tions of Human la-Like Antigens A. Guimezanes and A.-M. Schmitt- 563 I-Region-Restricted Long-Term Cultured T Cells with Helper Function for Thymic Verhulst Cytotoxic Precursor Cells R. P. Bocy and J. A. Kapp 603 Ir Gene Control of the Immune Response to Insulins. I. Pork Insulin Stimulates T Cell Activity in Nonresponder Mice Continued onpage 5 Continued from page 4 B.L. Hamilton, M. J. Bevan, and 621 Anti-Recipient Cytotoxic T Lymphocyte Precursors are Present in the Spleens of R. Parkman Mice with Acute Graft versus Host Disease Due to Minor Histocompatibility Antigens R. J. van de Griend, A. Astaldi, J. 636 T Lymphocyte Characteristics in Bone Marrow-Transplanted Patients. I. Changes M. Vossen, L. J. Dooren, P.T. in Biochemical Properties That Correlate with the Immunologic Reconstitution A. Schellekens, F. E. Zwaan, A. van den Ende, M. Roos, and D. Roos W. 0. Bot0 and R. E. Humphreys 759 Variation in the Synthesis of Membrane Proteins of Human T Lymphocytes during Mitogenic Activation: Recognition of a 70.000 Dalton Protein with Anti-p23,30 Heteroantiserum and a Novel 42,000 Dalton Protein withAnti-p44.12 Heteroanti- serum

IMMUNOPATHOLOGY

~~ ~ G. A. Hashim 41 9 Experimental Allergic Encephalomyelitis: Activation of Suppressor T Lymphocytes by a Modified Sequence of the T Effector Determinant D. Roos, A. A. M. Bot, M. L. J. van 433 Interaction between Human Neutrophils and Zymosan Particles: The Role of Op- Schaik, M. de Boer, and M. R. sonins and Divalent Cations Daha S. N. Vogel, L. L. Weedon, J. J. 441 Defective Fc-Mediated Phagocytosis in C3H/HeJ Macrophages. II. Correction by Downloaded from Oppenheim, and D.L. Rosen- CAMP Agonists streich M. R. Szewczuk and R. J. Camp- 472 Differential Effect of Aging on the Heterogeneity of the Immune Response to a T- bell Dependent Antigen in Systemic and Mucosal-Associated Lymphoid Tissues S. H. Zigmond and R. L. Hargrove 478 Orientation of PMN in a pH Gradient: Acid-Induced Release of a Chemotactic Factor http://www.jimmunol.org/ A. M. Dvorak, M. Lett-Brown, D. 523 Complement-Induced Degranulation of Human Basophils Thueson, and J. A. Grant H. Sano and C. Morimoto 538 Isolation ofDNA from DNA/Anti-DNA Antibody Immune Complexes in Systemic Lupus Erythematosus H. Nagura, P. D. Smith, P. K. Nak- 587 IgA in Human Bile and Liver ane, and W. R. Brown C. F. Brosnan, M. B. Bornstein, 61 4 The Effects of Macrophage Depletion on the Clinical and Pathologic Expression of and B. R. Bloom Experimental Allergic Encephalomyelitis L. C. Pontes de Carvalho, G. Wick, 750 Requirement of T Cells for the Development of Spontaneous Autoimmune Thyroiditis

and 1. M. Roitt in Obese Strain (OS) Chickens by guest on October 1, 2021 D. B. Magilavy, A. Rifai, and P. H. 770 An Abnormality of Immune Complex Kinetics in Murine Lupus Plot2 R. A. F. Clark, H. F. Dvorak, and 787 Fibronectin in Delayed-Type Hypersensitivity Skin Reactions: Associations with R. B. Colvin Vessel Permeability and Endothelial Cell Activation H. D. Perez, 1. M. Goldstein, R. 0. 800 Enhancement of the Chemotactic Activity of Human C5a Des Arg by an Anionic Webster, and P. M. Henson Polypeptide ("Cochemotaxin") in Normal Serum and Plasma

TUMOR IMMUNOLOGY

S. M. Taffet and S. W. Russell 424 Macrophage-Mediated Tumor Cell Killing: Regulation of Expression of Cytolytic Activity by Prostaglandin E A. Weiss, H. R. MacDonald, J.-C. 482 Inhibition of Cytolytic T Lymphocyte Clones Reactive with Moloney Leukemia Virus- Cerottini, and K. T. Brunner Associated Antigens by Monoclonal Antibodies: A Direct Approach to the Study of H-2 Restriction J. M. Pesando, J. Ritz, H. Lazarus, 540 Fate of a Common Acute Lymphoblastic Leukemia Antigen during Modulation by K. J.Tomaselli, and S. F. Monoclonal Antibody Schlossman R. Graham Smith, V. G. Dev, and 596 Characterization of a Novel Human Pre-B Leukemia Cell Line W. A. Shannon, Jr. M.M. Zatz,B. J. Mathieson, C. 608 Separation and Characterization of Two Component Tumor Lines within the AKR Kanellopoulos-Langevin, and S. Lymphoma, AKTA-1, by Fluorescence-Activated Cell Sorting and Flow Microfluo- 0. Sharrow rometry Analysis. I. The Coexistence of slg' and slg- Sublines L. L. Lanier and N. L. Warner 626 Cell Cycle Related Heterogeneity of la Antigen Expression on a Murine B Lymphoma Cell Line: Analysis by Flow Cytometry

Continued on page 6 Continued from page 5 M. K. Robinson and E. F. Whee- 673 Identification of Macrophage-Mediated Cytolytic Activity as a Tumor Suppressive lock Mechanism during Maintenance of the L5178Y-Tumor Dormant State in DBA/2 Mice J. C. Lee, I. Horak, and J. N. lhle 715 Mechanisms in T Cell Leukemogenesis. II. T Cell Responses of Preleukemic BALB/c Mice to Moloney Leukemia Virus Antigens B. Perussia and G. Trinchieri 754 Inactivation of Cytotoxic Activity after Interaction with Target Cells

VIRAL AND MICROBIAL IMMUNOLOGY

K. L. Rosenthal and R. M. Zinker- 446 Inability of Mice to Generate Cytotoxic T Lymphocytes to Vesicular Stomatitis Virus nagel Restricted to H-2Kh or H-2Dk E. C. Jong, A. A. F. Mahmoud, and 468 Peroxidase-Mediated Toxicity to Schistosomula of Schistosomamansoni S. J. Klebanoff E. Handman, G. F. Mitchell, and J. 508 Identification and Characterization of Protein Antigens of Leishmaniatropica Iso- W. Goding lates B. J. Underdown, I. C. Roberts- 669 Giardiasis in Mice: Studies on the Characteristics of Chronic Infection in C3H/He Thomson, R. F. Anders, and G. Mice F. Mitchell T. E. Nash, M. N. Lunde, and A. 805 Analysis and Antigenic Activity of a Carbohydrate Fraction Derived from Adult Downloaded from W. Cheever Schistosoma mansoni

LETTER TO THE EDITOR

~ http://www.jimmunol.org/ H. J. Rapp 81 1

Announcements 81 2

Author Index 81 3 by guest on October 1, 2021