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2013 Annual Report Our Mission “I know where I am, and I know where I’m going and I know I’m going to get there. I’m going to be excited and enthusiastic every day that God gives me on this earth. I am going to dream my dreams.” – jim vALVANO 1 2013 Annual Report Our Mission The V Foundation for Cancer Research is a charitable organization dedicated to saving lives by helping to find cures for cancer. The V Foundation strives to make a difference by generating extensive, passionate support for cancer research and by creating an urgent awareness among all Americans of the importance of ending the disease in all its forms. The dedicated work of our many partners, volunteers and supporters has led to many extraordinary, tangible victories in the war against cancer. Through advocacy, education, fundraising, and philanthropy, The V Foundation continues to seize every opportunity to change lives and ultimately defeat cancer. CEO Message The V Foundation has spent 21 years funding research that brings together the brightest minds working to end cancer. We are proud to present our annual report, providing a snapshot of last year’s accomplishments. During fiscal year 2013, we funded $14 million in new cancer research grants, and continue to fund previous multi- year grants. We are making important progress! This report is also a prelude to the future – a look at how to expedite this fight, to make it as effective as possible, to enlist each of you in this effort so that we can end cancer. Thank you for your help and support. No one can change the course of cancer alone. We dedicate this report to everyone working together toward this goal. Please help us continue until there is no longer a need. Susan Braun Chief Executive Officer 2013 Annual Report 2 2 013 Grants The V Foundation awards three types of grants. The V Scholar grant directly funds young investigators to help them establish their own independent laboratory research projects. The Translational grant facilitates the transition of projects from the laboratory to the patient’s beside quickly and efficiently. The Designated grants are inspired by particular areas of scientific interest and/or geographic reach. They are selected on the basis of scientific merit, as determined by our scientific advisors. V SCHOLARS Bjoern Schwer, M.D., Ph.D. Luis Carvajal-Carmona, Ph.D. Boston Children’s Hospital University of California, Davis Boston, MA Sacramento, CA Martin D. Abeloff, M.D. V Scholar Identification of Novel Breast Cancer Genes in a Neural Genome Rearrangements and Alternative Hispanic Isolate end Joining Processes in Initiation and Maintenance of Medulloblstoma Robert Doebele, M.D., Ph.D. University of Colorado School of Medicine Maximilian Diehn, M.D., Ph.D. Department of Medicine, Division of Medical Stanford Cancer Institute Oncology Stanford, CA Aurora, CO Investigating the KEAP1-NRF2 Pathway in Lung NTRK1 Gene Fusions as a Novel Oncogene Class Stem Cells and Lung Cancer and Therapeutic Target in Lung Cancer Albert Wyrick V Scholar Award Funded in Memory of Calvin Bradham with Funded by The Michael and Carole Marks support from Crown Imports Family Michael J. Emanuele, Ph.D. Rafael Bejar, M.D., Ph.D. Lineberger Comprehensive Cancer Center UCSD Moores Cancer Center University of North Carolina at Chapel Hill La Jolla, CA Chapel Hill, NC Pathogenic Mechanisms of Splicing Factor Identification of Ubiquitin Signaling Networks as Mutations in Myelodysplastic Syndromes Novel Avenues for Therapeutic Intervention Timothy F. Burns, M.D., Ph.D. Summer Gibbs, Ph.D. University of Pittsburgh Cancer Institute Oregon Health & Science University Pittsburgh, PA Portland, OR Targeting KRAS Mutant Lung Adenocarcinoma Screening of Small Molecule Fluorophores to Probe through Inhibition of TWIST 1 Pancreatic Cancer Margins in the Operating Room Supported by UNICO National in Memory of Sue Speciale 3 2013 Annual Report Peter Hammerman, M.D., Ph.D. Ryan A. Wilcox, M.D., Ph.D. Dana-Farber Cancer Institute University of Michigan Comprehensive Boston, MA Cancer Center Targeting Fibroblast Growth Factor Receptor Ann Arbor, MI Fusions in Lung and Head and Neck Cancer Role of the T-cell Transcription Factor GATA-3 in Cutaneous T-cell Lymphomas Mei Kong, Ph.D. Beckman Research Institute of the City of Hope Kris C. Wood, Ph.D. Duarte, CA Duke Cancer Institute Targeting Glutamine Metabolism and the Durham, NC B55a-p53 Survival Pathway for Lymphoma Systematic Identification of Combination Therapies Treatment Targeting the Breast Cancer Microenvironment 2013 V Foundation Wine Celebration Vounteer Christopher A. Maher, Ph.D. Grant in Honor of John and Anne Sachs Siteman Cancer Center Washington University Chunling Yi, Ph.D. St. Louis, MO Lombardi Comprehensive Cancer Center Understanding the Role of Polycomb Associated Georgetown University LncRNAs in Prostate Cancer Washington, DC 2013 Vintner Grant – Funded by The Wine Interrogating the Role of Hippo-Yap Growth Celebration Regulatory Pathway in Kidney Cancer In Honor of Fred and Mary Constant, Jeff and Valerie Gargiulo, Dick and Ann Grace, Fred and Sally Schweiger, and Lowell and Janet Herrero Michael Kharas, Ph.D. Memorial Sloan-Kettering Cancer Center New York, NY Understanding the MSI2 RNA Binding Protein Network in Leukemia George-Lucian Moldovan, Ph.D. Penn State Hershey Cancer Institute Hershey, PA Dysregulation of the PARI Genomic Stability Pathway in Leukemia Zeshaan Rasheed, M.D., Ph.D. The Sidney Kimmel Comprehensive Cancer Center Baltimore, MD Regulatory Effects of the Tumor Microenvironment on Stem Cell Plasticity in Pancreatic Ductal Adenocarcinoma Jatin Roper, M.D. Tufts Medical Center Boston, MA The Role of IWS1 and FGFR2 Isoform IIIc in Akt Isoform-dependent Colorectal Carcinogenesis 2013 Annual Report 4 2 013 Grants 2013 TRANSLATIONAL GRANts Nika Danial, Ph.D. John V. Heymach, M.D., Ph.D. Margaret Shipp, M.D. Varsha Gandhi, Ph.D. Jarrod Marto, Ph.D. Christine Stellrecht, Ph.D. Dana-Farber Cancer Institute Carlo Toniatti, M.D., Ph.D. Boston, MA Timothy Heffernan, Ph.D. Fueling DLBCL Proliferation and Survival: A Role The University of Texas MD Anderson Cancer for Fatty Acid Metabolism Center Houston, TX Ralph Deberardinis, M.D., Ph.D. Attacking the Specific Vulnerability of LKB1- Kemp Kernstein, M.D., Ph.D. Mutant NSCLC to Energy Depletion Using an ATP Children’s Medical Center Research Institute at Mimetic Universtiy of Texas Southwestern Dallas, TX Ite A.Laird-Offringa, Ph.D. Funded in Memory of Christopher T. Carroll Barbara Gitlitz, M.D. Translational Studies in Lung Cancer Martin W. Kast, Ph.D. Metabolism: Creating New Paradigms in Diagnosis Kimberly Siegmund, Ph.D. and Therapy Lina Wang, M.D. Michael Wong, M.D., Ph.D. Gianpietro Dotti, M.D. USC Norris Comprehensive Cancer Center Cliona Rooney, Ph.D. Los Angeles, CA Caridad Martinez, M.D. Development of Immunotherapy for Small Cell Dan L. Duncan Cancer Center at Baylor College Lung Cancer using Novel Modified Antigens of Medicine Houston, TX Daniela Matei, M.D. Prevention and Treatment of Viral Infections and Kenneth P. Nephew, Ph.D. Leukemic Relapse after Allogeneic Stem Cell Indiana University Melvin and Bren Simon Transplantation Cancer Center Indianapolis, IN Benjamin L. Ebert, M.D., Ph.D. An Epigenetic Strategy for Restoring Carboplatin Ann Mullally, M.D. Sensitivity in Ovarian Cancer William Kaelin, Jr., M.D. David Steensma, M.D. Toshi Tanuiguchi, M.D., Ph.D. Brigham and Women’s Hospital Elizabeth M. Swisher, M.D. Boston, MA Fred Hutchinson Cancer Center Identifying and Targeting Oncogenic Pathways in Seattle, WA TET2 and IDH Mutant Myeloid Malignancies Defining Genomic Scarring and Functional DNA Variants that Predict Response to PARP Inhibitors Tanja A. Gruber, M.D., Ph.D. in a Clinical Trial for Recurrent Ovarian Cancer James R. Downing, M.D. St. Jude Children’s Research Hospital Pengbo Zhou, Ph.D. Memphis, TN Leonard Salta, M.D. Funded by the 2013 Dick Vitale Gala Yao-Tseng Chen, M.D., Ph.D. In Honor of Dick and Lorraine Vitale Weill Cornell Medical College Identification of Active Compounds in Infantile New York, NY Acute Lymphoblastic Leukemia Ubiquitin Ligase as a Novel Diagnostic Marker and Therapeutic Target for Colorectal Cancer Funded by The V Foundation Wine Celebration In Honor of Steve Bornstein 5 2013 Annual Report 2013 DESIGNATED GRANts Lizi Wu, Ph.D. Amit K. Verma, M.D. Shands Cancer Center David J. Prezant, M.D. University of Florida Mayris Webber, M.P.H., Dr. P.H. Gainesville, FL Charles B. Hall, Ph.D. Regulation of Oncogenic NOTCH Signaling in Albert Einstein College of Medicine of Yeshiva Childhood Leukemia Universi-ty Funded by 2012 Dick Vitale Gala Bronx, NY In Memory of Caleb Gacobbe Early Detection of Hematologic Malignancies in New York City Firefighters Exposed to World Trade Daniel S. Wechsler, M.D., Ph.D. Center Dust after the 9/11 Attacks Duke University Medical Center Funded by The V Foundation Wine Celebration Durham, NC and Jimmy V Celebrity Golf Classic Therapeutic Targeting of Calm-AF10 Nuclear Export in Pediatric Leukemia St. Helena Hospital Funded by The Apple Gold Group Napa, CA Clinical Research Program at St. Helena Stuart Goldberg, M.D. Hospital Martin-O’Neil Cancer Center Hackensack University Medical Center Funded by The V Foundation Wine Celebration The John Theurer Cancer Center Hackensack, NJ Calvin Lee, M.D. The Use of Dynamic Single Cell Network Profile All Children’s Hospital to Predict Outcome in Newly Diagnosed Acute St. Petersburg, FL Myelogenous Leukemia (AML) BMI1’s Role in the Regulation of Myogenic Funded by Marketing Research Consultants Differentiation in Rhabdomyosarcoma In Memory of Mary Ann Ingoglia Funded by 2013 Dick Vitale Gala Victoria Belancio, Ph.D. John Cavanagh, Ph.D. Tulane University North Carolina State Jimmy V Cancer Tulane Cancer Center Therapeutics Program New Orleans, LA Raleigh, NC Line-1 Contributing to Lung Cancer in Vivo Funded by 2013 Jimmy V Celebrity Golf Classic Funded by The Kay Yow Cancer Fund In Honor of the JVCGC 20 Year Volunteers Shari Pilon-Thomas, Ph.D.
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