United States Patent (19) 11) Patent Number: 5,614,519 Hauel Et Al
USOO5614519A United States Patent (19) 11) Patent Number: 5,614,519 Hauel et al. (45) Date of Patent: Mar 25, 1997 54) (1-(2,3 OR4-N-MORPHOLINOALKYL)- 56) References Cited IMIDAZOL-4-YL)-BENIZIMIDAZOL-1- YL-METHYL-BIPHENYLS USEFUL AS U.S. PATENT DOCUMENTS ANGOTENSIN-HANTAGONSTS 3,929,814 12/1975 Narayanan et al. ................... 514/365 4,492,708 1/1985 Spitzer .................................... 548/181 75 Inventors: Norbert Hauel, Schemmerhofen; 5,171,748 12/1992 Roberts et al. ... 514/381 Berthold Narr, deceased, late of 5,189,048 2/1993 Carini et al. .... ... 514/359 Biberach, by Elisabeth Narr, legal 5,190,942 3/1993 Poss ... 548/306.1 representive; Uwe Ries, Biberch; 5,194,435 3/1993 Kees ........... ... 514/249 Jacobus C. Antonius van Meel, 5,200,422 4/1993 Olesen et al. ... 54,387 Mittelbiberach; Wolfgang Wienen, 5,28,125 6/1993 Chen et al. ..... ... 54/252 Biberach/Rissegg; Michael Entzeroth, 5,250,554 10/1993 Naka et al. ... ... 54/.381 Warthausen, all of Germany 5,254,546 10/1993 Ardecky et al. ..................... 514/325.4 FOREIGN PATENT DOCUMENTS (73) Assignee: Karl Thomae GmbH, Biberach an der 2047496 2/1992 Canada .................................. 548/254 Riss, Germany 0426021 5/1991 European Pat. Off. ... ... 548/254 0468470 1/1992 European Pat. Off. ... ... 548,254 21 Appl. No.: 457,069 0495626 7/1992 European Pat. Off. ... ... 548/252 0512314 9/1992 European Pat. Off. ... 548/306.1 22 Filed: Jun. 1, 1995 92-04343 3/1992 WIPO .................................... 548,254 Related U.S. Application Data Primary Examiner-Floyd D. Higel Attorney, Agent, or Firm-Robert P.
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