Original Article Brainstem Injury Associated with Supratentorial Lesions Is Revealed by Electronystagmography of the Cold Caloric Reflex Test
Am J Transl Res 2017;9(5):2119-2131 www.ajtr.org /ISSN:1943-8141/AJTR0046971 Original Article Brainstem injury associated with supratentorial lesions is revealed by electronystagmography of the cold caloric reflex test Qizhi Fu1, Zhiguo Qi2, Ruirui Yang3, Ke Cheng4, Yongtao Yang4, Peng Xie5 1Department of Neurology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China; 2Department of Neurology, The First Affiliated Hospital of JiamusiU ni- versity, Jiamusi, China; 3Department of Neurology, The Shandong Provincial Hospital, Jinan, China; 4Institute of Neuroscience, Chongqing Medical University, Chongqing, China; 5Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Received December 20, 2016; Accepted March 22, 2017; Epub May 15, 2017; Published May 30, 2017 Abstract: To explore the brainstem injury associated with supratentorial lesions, we conducted analysis of ICP levels and detected ENG parameters by using the cold caloric reflex test and histopathological examinations of the brain- stem. Rat model of intracerebral hemorrhage was well-established in the study of supratentorial lesions of varying severities (n=210). Intracerebral pressure monitoring and electronystagmography of the cold caloric reflex test were simultaneously performed in animals. Apoptotic, immunohistochemical, and histopathological changes in different segments of the brainstem were investigated at various time intervals. Electronystagmography parameters were analyzed by cold caloric reflex test. The result showed that the increase of intracerebral pressure was correlated with lesion severity including elevating levels and rostral-caudal progression of neuronal apoptosis, demyelination, N-methyl-D-aspartate cell receptor down-regulation (r=0.815), and histopathological changes.
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