SAID 2013 Literature Review
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Your Mouth on Meth
Common Ingredients in Meth Manufacturing The com mon ingredients used in making methamp hetamine and listed below are very acidic: ■ Antifreeze ■ Battery acid ■ Drain cleaner ■ Hydrochloric acid ■ Lantern fuel ■ Lye ■ Muriatic acid ■ Paint thinner ■ Red phosphorus found in the strips on match boxes ■ Over-the-counter cold medicines that contain ephedrine Mix these together and you have some caustic stuff. Meth users can go from having healthy teeth and a sparkling smile to losing their teeth in a very short time period. For most, dentures D M are the only option. D , n e l l A These dangerous chemicals can also make you h t i feel like there are bugs under your skin, causing d u J you to scratch yourself to the point that you : o t o have bleeding sores on your face, arms and legs. h p Health Care for the Homeless Clinicians' Network Your Mouth on P O Box 60427 | Nashville, TN 37206 Phone: 615 226-2292 Meth [email protected] | www.nhchc.org One Big Problem What You Can Do What You Need to Know While methamphetamine is very damaging to ■ Do not use methamphetamine or other the body and brain, it also destroys teeth. An drugs. unhealthy, unattractive mouth makes it difficult ■ If you’re already using, call the agency Meth, Speed, Ice, Chalk, Crank, Fire, Glass and to feel good about your appearance, socialize below for help getting off drugs. Crysta l are street names for the drug and find a job. ■ Instead of drinking sodas, drink plenty of metha mphetamine. -
Prevalence of Extrapyramidal Side Effects in Patients on Antipsychotics Drugs at a Tertiary Care Center
f Ps al o ych rn ia u tr o y J Kirgaval et al., J Psychiatry 2017, 20:5 Journal of Psychiatry DOI: 10.4172/2378-5756.1000419 ISSN: 2378-5756 Research Article Open Access Prevalence of Extrapyramidal Side Effects in Patients on Antipsychotics Drugs at a Tertiary Care Center5 Ramprasad Santhanakrishna Kirgaval1*, Srinivas Revanakar2 and Chidanand Srirangapattna2 1Department of Psychiatry, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India 2Department of Pharmacology, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India Abstract Background: Antipsychotic drugs are associated with adverse effects that can lead to poor medication adherence, stigma, distress and impaired quality of life. Among the various side effects of anti-psychotics extra pyramidal symptoms constitute one of the important side effects interfering with the compliance of the patients towards medication. Objective: Evaluation of extrapyramidal side effects by AIMS in patients who are on antipsychotics. Results: The extrapyramidal symptoms were more commonly seen in males (62.85%), the age of incidence of maximum in the age group of 34.28, Maximum was seen among the patients on the Risperidone (45.7%), Involvement of the extremities was common (42.85%) and 64.28% of individuals had moderate severity and 54.28% of individuals were aware of the extrapyramidal symptoms which provided mild distress. Conclusion: Extrapyramidal symptoms are one of the commonest side effect of the antipsychotics interfering with compliance of the patients towards adherence to medications, thereby decreasing the efficacy. Keywords: Extrapyramidal symptoms; Compliance; Antipsychotics; positive symptom of the psychosis but have some serious limitations AIMS. such as lack of efficacy against negative symptoms and adverse effects like extrapyramidal symptoms [7]. -
Aripiprazole Associated Rabbit's Syndrome
Journal of Xi’an Shiyou University, Natural Science Edition ISSN : 1673-064X ARIPIPRAZOLE ASSOCIATED RABBIT’S SYNDROME: A RARE CASE REPORT Mahendra Kumar R1*, Sanatkumar B Nyamagoud1, Santosh Patil B 1, AHMV Swamy 2, Abhishek M Patil 3 1 1 Department of Pharmacy Practice, KLE College of Pharmacy, Hubli (A Constituent unit of KLE Academy of Higher Education and Research, Belagavi) Karnataka, India. 1 Department of Pharmacology, KLE College of Pharmacy, Hubli (A Constituent unit of KLE Academy of Higher Education and Research, Belagavi) Karnataka, India. 2 Department of Pharmacy Practice, KLE College of Pharmacy, Hubli (A Constituent unit of KLE Academy of Higher Education and Research, Belagavi) Karnataka, India 3 Department of emergency medicine, Sanjeevini Specialty Hospital and Heart Care Centre, Hubli, Karnataka, India. Abstract- II. CASE HISTORY: abbit syndrome (RS) is a rhythmic movement of the R A 47-year-old male presented to the outpatient department with mouth and lips caused by antipsychotics that resembles the complaints of tremulousness of hands, involuntary perioral rabbit munching. There is no tongue involved in the movements, with slurred speech since past 1 week. The patient movement, which is solely vertical and has a frequency of was on follow up with us on a regular basis for six months. when about 5 Hz. Long-term use of first-generation he brought up his complaints of hyper-religiosity, easy neuroleptics has been proven to cause RS, but nothing is distractibility, suppressed need for sleep, over talkativeness, over known regarding the risk of RS from newer atypical familiarity, easy irritability, uncontrollable emotional outbursts, antipsychotics. -
Oral Manifestations in Drug Users: a Review
J Clin Exp Dent. 2020;12(2):e193-200. Oral manifestations in drug users Journal section: Oral Medicine and Pathology doi:10.4317/jced.55928 Publication Types: Review https://doi.org/10.4317/jced.55928 Oral manifestations in drug users: A review Federico Cossa 1, Alessia Piastra 2, Mª Gracia Sarrion-Pérez 3, Leticia Bagán 4 1 Student of the master of Implantology at the Universidad Europea de Valencia. Graduated in Dentistry at the Universidad Europea de Valencia 2 Student of the master of Endodontics at the University of Valencia. Graduated in Dentistry at the Universidad Europea de Valencia 3 PhD, Associate Professor. Faculty of Health Sciences. Department of Dentistry. European University of Valencia. Spain 4 PhD, Titular professor. Faculty of Health Sciences. Department of Dentistry. European University of Valencia. Spain Correspondence: Universidad Europea de Valencia Paseo Alameda, 7 46010 – Valencia, Spain [email protected] Cossa F, Piastra A, Sarrion-Pérez MG, Bagán L. Oral manifestations in drug users: A review. J Clin Exp Dent. 2020;12(2):e193-200. http://www.medicinaoral.com/odo/volumenes/v12i2/jcedv12i2p193.pdf Received: 24/06/2019 Accepted: 08/01/2020 Article Number: 55928 http://www.medicinaoral.com/odo/indice.htm © Medicina Oral S. L. C.I.F. B 96689336 - eISSN: 1989-5488 eMail: [email protected] Indexed in: Pubmed Pubmed Central® (PMC) Scopus DOI® System Abstract Background: In the dental environment there is not much talk about the oral manifestations resulting from the use of drugs, because in general the issue of drugs is a very difficult subject to deal with. Therefore, the objective of this work is to understand what are the most obvious manifestations in the oral cavity and as the dentist can detect them. -
Methamphetamine Abuse and “Meth Mouth” in Europe
Med Oral Patol Oral Cir Bucal. 2015 Mar 1;20 (2):e205-10. Meth Mouth in EU Journal section: Medically compromised patients in Dentistry doi:10.4317/medoral.20204 Publication Types: Review http://dx.doi.org/doi:10.4317/medoral.20204 Methamphetamine abuse and “meth mouth” in Europe Carlo De-Carolis 1, Geraldine-A. Boyd 2, Luca Mancinelli 3, Stefano Pagano 1, Stefano Eramo 1 1 DDS. Department of Surgical and Biomedical Sciences-School of Dentistry- University of Perugia, Italy 2 Language Centre (CLA), University of Perugia, Italy 3 Geology Department, University of Dublin, Ireland Correspondence: School of Dentistry, University of Perugia Strada vicinale delle corse 60180 Perugia, Italy De-Carolis C, Boyd GA, Mancinelli L, Pagano S, Eramo S. Methamphet- [email protected] amine abuse and “meth mouth” in Europe. Med Oral Patol Oral Cir Bucal. 2015 Mar 1;20 (2):e205-10. http://www.medicinaoral.com/medoralfree01/v20i2/medoralv20i2p205.pdf Received: 28/05/2014 Article Number: 20204 http://www.medicinaoral.com/ Accepted: 16/10/2014 © Medicina Oral S. L. C.I.F. B 96689336 - pISSN 1698-4447 - eISSN: 1698-6946 eMail: [email protected] Indexed in: Science Citation Index Expanded Journal Citation Reports Index Medicus, MEDLINE, PubMed Scopus, Embase and Emcare Indice Médico Español Abstract With easy chemical synthesis from its precursor, methamphetamine (MA) is now widespread in many countries. The abuse of methamphetamine is associated with several negative effects on health, because MA is a neurotoxin and a dangerous central nervous system stimulant. It changes levels of neurotransmitters in the brain, releasing dopamine and inhibiting nor epinephrine uptake which increases sympathetic nervous system activity and can lead to cardiac arrhythmia, hypertension and tachypnea. -
Statistical Analysis Plan
NCT02431702 Janssen Research & Development, LLC Statistical Analysis Plan A Prospective, Matched-Control, Randomized, Open-Label, Flexible-Dose, Study in Subjects with Recent-Onset Schizophrenia or Schizophreniform Disorder to Compare Disease Progression and Disease Modification Following Treatment with Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics Disease Recovery Evaluation and Modification (DREaM) Study Phase 3b Protocol R092670SCH3013 R092670 (paliperidone palmitate) Status: Approved Date: 6 December 2019 Prepared by: Janssen Research & Development, LLC Document No.: EDMS-ERI-201245942, 1.0 Compliance: The study described in this report was performed according to the principles of Good Clinical Practice (GCP). Confidentiality Statement The information in this document contains trade secrets and commercial information that are privileged or confidential and may not be disclosed unless such disclosure is required by applicable law or regulations. In any event, persons to whom the information is disclosed must be informed that the information is privileged or confidential and may not be further disclosed by them. These restrictions on disclosure will apply equally to all future information supplied to you that is indicated as privileged or confidential. 1 Approved, Date: 6 December 2019 NCT02431702 R092670 (paliperidone palmitate) Statistical Analysis Plan R092670SCH3013 TABLE OF CONTENTS TABLE OF CONTENTS .............................................................................................................................. -
Letters to the Editor
Letters to the Editor Internet Pharmacy Prescription complete the medication database. Of course, patients can abuse and Phentermine Overdose any medications, so collaboration between pharmacies and physicians is essential to minimize this risk. Sir: The Internet is now widely used by patients for both Dr. Takeshita reports no financial or other relationship relevant to the health information and prescription services. Yet, a MEDLINE subject matter of this letter. search in January 2002 using the phrase “Internet pharmacy” showed a total of 99 articles; nearly all were geared toward REFERENCES health care management or the general public. There are only a few published reports of bad outcome resulting from medical 1 1. Crocco AG, Villasis-Keever M, Jadad AR. Analysis of cases of information obtained from the Internet. The U.S. Food and harm associated with use of health information on the Internet. Drug Administration noted 326 Internet sites selling pharma- JAMA 2002;287:2867–2871 ceutical products.2 The exact numbers are difficult to quantify 2. Henney JE. Cyberpharmacies and the role of the US Food and Drug as Web sites are constantly changing. I report a case of overdose Administration. J Med Internet Res 2001;3:E3 with phentermine that was obtained through an Internet 3. Gardin JM, Schumacher D, Constantine G, et al. Valvular abnormali- pharmacy. ties and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. JAMA 2000;283:1703–1709 4. Koury E, Stone CK, Stapczynski JS, et al. Sympathetic overactivity Case report. Ms. A, a 20-year-old woman with a prior from fenfluramine-phentermine overdose. -
Risk Factors for Temporomandibular Disorders Among Amphetamine Users in Indonesia
Pesquisa Brasileira em Odontopediatria e Clínica Integrada 2019; 19:e5261 DOI: http://doi.org/10.4034/PBOCI.2019.191.142 ISSN 1519-0501 ORIGINAL ARTICLE Risk Factors for Temporomandibular Disorders among Amphetamine Users in Indonesia Inge Paramitha1, Ira Tanti2, Laura S. Himawan3 1Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. 0000-0002-0072-379X 2Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. 0000-0002-0119-3153 2Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. 0000-0002-6331-5160 Author to whom correspondence should be addressed: Dr. Ira Tanti, Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya no.4, Jakarta Pusat, Jakarta 10430, Indonesia. Phone: +62 8161164801. E-mail: [email protected]. Academic Editors: Alessandro Leite Cavalcanti and Wilton Wilney Nascimento Padilha Received: 03 April 2019 / Accepted: 09 September 2019 / Published: 24 September 2019 Abstract Objective: To determine the possible risk factors for temporomandibular disorders (TMD) among amphetamine users in Indonesia. Material and Methods: This cross-sectional study involved 152 male amphetamine users, aged 18-45 years, who were undergoing rehabilitation. Data were obtained from medical records, questionnaires, and clinical examinations. Data obtained from medical records included age, gender, duration of amphetamine use, duration of rehabilitation, and psychiatric status. Collected data were analyzed using the Chi-square and logistic regression tests to identify correlations between TMD and bruxism, oral habits, tooth wear, duration of amphetamine abused, and duration of rehabilitation. Results: TMD was found in 84.2% of amphetamine users, with clicking being the most frequently reported sign (72.4%). Tooth wear (72.4%), oral habits (60.5%), and bruxism (56.6%) were also frequently found. -
Studies of Synthetic Particles and Nerve Endings on Mass
STUDIES OF SYNTHETIC PARTICLES AND NERVE ENDINGS ON MASS TRANSPORT AND KINETICS AND INHIBITION OF THE DEGLYCOSYLATED DOPAMINE TRANSPORTER By VERONICA MANLING CHIU A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY WASHINGTON STATE UNIVERSITY Department of Chemistry May 2012 To the Faculty of Washington State University: The members of the Committee appointed to examine the dissertation of VERONICA MANLING CHIU find it satisfactory and recommend that it be accepted. __________________________________ James O. Schenk, Ph.D., Chair ___________________________________ Herbert H. Hill, Jr., Ph.D. ___________________________________ Chulhee Kang, Ph.D. ___________________________________ Barbara A. Sorg, Ph.D. ii ACKNKOWLEDGEMENTS I would like to start by thanking my committee, Drs. Jim Schenk, Herb Hill, Chulhee Kang, and Barb Sorg for their support, encouragement, and guidance. I am especially grateful to my mentor as well as my friend, Dr. Jim Schenk, for the infinite support, patience, and encouragement. Jim, you allowed me to learn, think and find answers on my own, but at the same time you provided help whenever I needed it. You also encouraged me to believe who I am. You taught me how to write a scientific paper and allowed me to write in my own words. You also provided me much help with giving presentations, which I am still learning about. In addition to science knowledge, I learned a lot from you on cooking, food, American culture, and arts. I really enjoyed the time when we gathered and shared food, and of course, your food is always so tasty. I know I am going to miss it! I also enjoyed our talks, and I never met a person who has as much knowledge as you do. -
The Significance of Illicit Drug Use to Dental Practice
Article ID: WMC00455 2046-1690 The Significance Of Illicit Drug Use To Dental Practice Corresponding Author: Dr. William Maloney, clinical associate professor, New York University, 345 East 24th Street, 10010 - United States of America Submitting Author: Dr. William J Maloney, Clinical Associate Professor, New York University, 345 East 24th Street, 10010 - United States of America Article ID: WMC00455 Article Type: Original Articles Submitted on:28-Jul-2010, 04:15:06 AM GMT Published on: 28-Jul-2010, 07:20:26 AM GMT Article URL: http://www.webmedcentral.com/article_view/455 Subject Categories:DENTISTRY, DRUG ABUSE Keywords:drug abuse, dental practice, cocaine, marijuana, methampetamines, meth mouth How to cite the article:Maloney W . The Significance Of Illicit Drug Use To Dental Practice . WebmedCentral DENTISTRY, DRUG ABUSE 2010;1(7):WMC00455 WebmedCentral > Original Articles Page 1 of 7 WMC00455 Downloaded from http://www.webmedcentral.com on 22-Dec-2011, 05:49:23 AM The Significance Of Illicit Drug Use To Dental Practice Author(s): Maloney W Introduction extensively in the scientific literature to describe the devastating, yet predictable, dental effects of methamphetamine use. The buccal smooth surfaces of the teeth and the interproximal surfaces of the Dentists encounter a wide array of individuals anterior teeth are affected by decay in presenting for various professional dental services in methamphetamine users (3,5,8-14). Other oral their dental practices on a daily basis.Regardless of findings in methamphetamine users include clenching the geographic location of the dental practice or the and grinding of teeth (15), tempromandibular disorders socio-economic status of the patients, each dental (6), xerostomia, and poor oral hygiene (8). -
AHEC Course Listing Use the Search Function to Look for a Course
AHEC Course Listing Use the search function to look for a course. Multidisciplinary Approach to Complex Restorative Dentistry Faculty: Ryan Cook, DDS, MS Time: 3 hrs Complex treatment plans require a multidisciplinary team approach to maximize therapeutic outcomes. Treating patients utilizing a multidisciplinary approach not only optimizes patient care, but also enhances a clinician’s diagnostic skills. This presentation will review the fundamentals of a multidisciplinary approach and illustrates how state of the art technology can supplement these fundamentals resulting in clinical excellence. Multiple and single unit restorations will be discussed from the treatment planning phase to final restoration in a step by step fashion that allows for easy assimilation into everyday practice. Target Audience: D, H, A AGD: Academy of General Dentistry Codes: Course Objectives: 1. Understanding restorative options in fixed prosthodontics and implant dentistry 2. How diagnosis, treatment planning and initial patient presentation effects: a. Final abutment selection b. Cost c. Esthetics d. Implant selection and location e. Occlusal scheme f. Type of final restoration g. Periodontal- Restorative Interface 3. Simplifying impression techniques 4. Ortho-Perio- Restorative factors that influence treatment outcomes 5. Understand the importance of treatment sequencing in multidisciplinary care. 6. Understanding how digital dentistry enhances communication. Teeth or Implants: An Evidence Based Approach to Treatment Planning Faculty: Ibrahim Duqum, BDS, MS Time: 1.5-2 hrs Should I restore this tooth or extract it and replace it with a dental implant? This is a frequent question that dentists encounter on daily basis when evaluating broken and compromised teeth that require root canal therapy, post and core foundations and external coverage restorations. -
A Report of Rabbit Syndrome Who Benefited from Sigma 1 Agonist Fluvoxamine
Case Report https://doi.org/10.9758/cpn.2019.17.1.134 pISSN 1738-1088 / eISSN 2093-4327 Clinical Psychopharmacology and Neuroscience 2019;17(1):134-138 Copyrightⓒ 2019, Korean College of Neuropsychopharmacology A Report of Rabbit Syndrome Who Benefited from Sigma 1 Agonist Fluvoxamine Yakup Albayrak, Murat Beyazyüz, Özlem Abbak, Ece Altındağ Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey Rabbit Syndrome is an uncommon side effect of antipsychotic treatment. Although it is usually associated with typical antipsychotics, it can also be related to atypical antipsychotics. Anticholinergics are the most accepted treatment ap- proach in treating Rabbit Syndrome. Fluvoxamine is a member of selective serotonin reuptake inhibitors and it is a potent agonist of sigma 1 receptors. In this article, we report a Rabbit Syndrome case who has benefited from fluvox- amine, in terms of both depressive disorder and Rabbit Syndrome; and present the data on the effects of sigma 1 agonist fluvoxamine on numerous movement disorders. KEY WORDS: Rabbit syndrome; Sigma receptors; Side effect; Fluvoxamine. INTRODUCTION Although all SSRIs share the same mechanism of action by means of the serotonergic system, their effects on sigma 1 Fluvoxamine is a selective serotonin reuptake inhibitor receptors vary. Among these drugs, fluvoxamine exerts (SSRI) which is used for the treatment of depressive dis- the most potent agonistic activity on sigma 1 receptors.3,11) order and obsessive compulsive disorder.1,2) Besides its ef- There have been experimental studies which demon- fect on the serotonergic system, it was well established strated the effects of fluvoxamine as a potent sigma 1 re- that fluvoxamine is a potent sigma 1 chaperone receptor ceptor agonist.