What Are Mouse Lemurs? in the WILD in CAPTIVITY

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What Are Mouse Lemurs? in the WILD in CAPTIVITY

Gray mouse lemurs (Microcebus murinus): A novel animal model in research Alice S.O. Hong¹, Jozeph L. Pendleton², Caitlin J. Karanewsky², Mark A. Krasnow², Megan A. Albertelli¹ ¹Department of Comparative Medicine, ²Department of Biochemistry and the Howard Hughes Medical Institute Stanford University School of Medicine, Stanford, CA What are mouse lemurs? In the WILD In CAPTIVITY • Mouse lemurs (Microcebus spp.) A wild mouse lemur in its natural • Follow the Guide for the Care and contain the smallest primates in environment in Madagascar. Use of Laboratory Animals and the world Animal Welfare Act • Prosimians (primates of the • Temperature condition: 74-80ºF Strepsirrhine group) • Humidity condition: 44-65% • Gray mouse lemur (Microcebus (dependent on season) murinus) is 80-100 grams in body weight. • Food: fruit, vegetables, primate biscuits, meal worms • ~24 species in genus • Caging: Marmoset housing cages • Cryptic species (similar (Britz & Company) morphology but different o genetics) Single housing o Group housing • Native to Madagascar in west and A captive mouse lemur resting on perch in south coast regions • Enrichment provided: its cage at Stanford University. • Hot and tropical climate o Sanded down PVC pipes Research Uses • Arboreal (live in trees) o External and cardboard nest boxes • Research in animal’s biological • Live in various environments: and physiological characteristics o Fleece blankets o Dry deciduous trees o Reproductive biology o Rain forests o Torpor, food restriction o Spiny deserts o Manipulation of photoperiod o Thornbushes o Sex differences with behavior • Eat fruits, flowers, invertebrates, o Metabolism small vertebrates, gum/sap A captive gray mouse lemur resting on a o Genetic variation researcher’s hand at Stanford University. Why mouse lemurs? • Research in translational Characteristics applications • Compared with mice: o Aging studies • Nocturnal (active at night) o Longer lifespan o Age-related neurodegenerative • Omnivorous o More closely related to diseases (ex: Alzheimer’s • Solitary foragers (search for humans disease) food resources alone) • Compared with monkeys: o Genetics • Seasonal breeders o Smaller body size Acknowledgments • Influenced by photoperiod o Shorter gestation Thanks to VSC animal care staff for helping o Longer daylight hours in o More offspring with the colony establishment and care at Stanford University. This work is supported by summer = breeding (Above) Mouse lemur in external nest box o Shorter sexual maturity the Department of Comparative Medicine, (left) and cardboard nest box (right). (Bottom) o Shorter daylight hours in MLAS program, the Vera Moulton Wall Center Mouse lemur next to food bowl on the ground for Pulmonary Vascular Disease, and HHMI. winter = torpor of its cage..

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Strengths and Weaknesses of the Gray Mouse Lemur
Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia Fabien Pifferi, Jacques Epelbaum, Fabienne Aujard To cite this version: Fabien Pifferi, Jacques Epelbaum, Fabienne Aujard. Strengths and Weaknesses of theGray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia. Frontiers in Pharmacology, Frontiers, 2019, 10, 10.3389/fphar.2019.01291. hal-02393164 HAL Id: hal-02393164 https://hal.archives-ouvertes.fr/hal-02393164 Submitted on 10 Dec 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. REVIEW published: 30 October 2019 doi: 10.3389/fphar.2019.01291 Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia Fabien Pifferi 1, Jacques Epelbaum 1,2 and Fabienne Aujard 1* 1 UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, Brunoy, France, 2 Unité Mixte de Recherche en Santé 894 INSERM, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, Paris, France Edited by: To face the load of the prevalence of Alzheimer’s disease in the aging population, Bjorn Johansson, Karolinska Institutet (KI), Sweden there is an urgent need to develop more translatable animal models with similarities to Reviewed by: humans in both the symptomatology and physiopathology of dementia.
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