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Mindfulness and the 12 Steps
mindfulness and the 12 steps with Thérèse Jacobs-Stewart Resting the Mind • Assume a body position where your spine is straight and your body relaxed. • Allow your mind to rest for a few minutes, letting whatever happens-or doesn’t happen-be a part of the experiment. • Relax with whatever arises. • When time is up, ask yourself, “How was that?” (Don’t judge; just review what happened and how you felt.) • The only difference between meditation and the ordinary process of feeling, thinking, feeling, and sensation is the application of the “bare awareness.” Mindfulness Meditation Consciously bring awareness to your here-and-now experience with openness, interest, and self-acceptance. 1 Ways Mindfulness and Meditation Help the Therapist • Offers idea of “strengthening the heart” vs. western psychology’s concept of “self-care.” • Reduces compassion fatigue, renews energy, and counteracts burn-out. • Deepens capacity for a compassionate and non- judging presence. • Increases ability to abide with difficult emotions, offering hope and relief. • Sharpens awareness of therapist’s own reactions. Specific Brain States Correlate with Happiness Brain Activity Associated with Mindfulness Meditation 2 Meditation Changes the Circuitry of the Brain Jacobs-Stewart, Paths Are Made by Walking, 2003 “Meditation training can change the brain and forever alter our sense of well-being.” Richard Davidson Laboratory for Neuroaffective Science University of Wisconsin, Madison 3 Effects of Mindfulness on the Addictive Brain • Enhances neural plasticity. • Reduces activity in the amygdala. • Thickens the bilateral, prefrontal right-insular region of the brain. • Integrates prefrontal regulation and limbic emotion activation. • Builds new neural connections among brain cells for self-observation, optimism, and well-being. -
Reviewers Who Completed a Review During 2001
REVIEWERS LIST The constituency of the ARCHIVES comprises a “university” of often interchangeable writers and readers, students, knowledgeable practitioners, and scholars of medicine and sciences underlying the field of psychiatry. The editors are deeply grateful to the many colleagues listed here for their generous assistance in editorial critique and review. The donation of their special expertise is a necessary contribution on which the intellectual standards in the field heavily depend. Jack D. Barchas, MD Editor Larry Abel Francesc Artigas Chawki Benkelfat Evelyn Bromet James Abelson Robert Asarnow Lisa Berkman Judith S. Brook Anissa Abi-Dargham Wesson Ashford Karen Faith Berman Robert K. Brooner Howard B. Abikoff Boris Astrachan Robert Berman George W. Brown Lyn Y. Abramson Evelyn Attia Greg Berns Marty Bruce T. M. Achenbach S. Avenevoli Wade Berrettini Gerard E. Bruder Kenneth M. Adams Elizabeth Auchincloss Larry E. Beutler Maja Bucan Lawrence E.Adler David Avery Joseph Biederman Robert W. Buchanan Lenard A. Adler Thomas Babor Laura Bierut Kathleen K. Bucholz Nancy E. Adler Nadia Badawi George Bigelow Monte Buchsbaum Ralph Adolphs Alan D. Baddeley Robert Bilder Alan J. Budney George Aghajanian Lee Baer Rene Binder Stephen L. Buka W. Stewart Agras J. Michael Bailey Ray Bingham William E. Bunney Schahram Akbarian Ross J. Baldessarini Niels Birbaumer Audrey Burnam Huda Akil James C. Ballenger Boris Birmaher Barbara J. Burns Hagop S. Akiskal J. Bancroft Donald Black Terry Bush Claude Alain Karen J. Bandeen-Roche D. H. Blackwood Daniel Buysse Marigarita Alegria Deanna M. Barch Jack Blaine William Byne Georgios Alexopoulos John C. Barefoot Helen Blair Simpson Robert P. Cabaj Kimmo Alho Russell A. -
MCQ Base Clinical Pharmacology
MCQ Base Clinical Pharmacology Mechanism of drug action is explored by: A) pharmacokinetics B) pharmacogenetics C) pharmacoeconomics D) pharmacodynamics E) pharmacognosy Therapeutic window is the dosages of a medication (therapeutic serum concentrations ) between: A) TD50 curve and ED50 B) ED50 and T1/2 C) the amount that gives an effect (effective dose) and the amount that gives more adverse effects than desired effects D) the amount that gives minimal adverse effects and the amount that gives more adverse effects E) the amount that gives minimal effect and the amount that gives full therapeutic effect Therapeutic index is the ratio of: A) LD50 over the ED50 B) ED50over the LD50 C) bioavailability over drug dose D) apparent volume of distribution over elimination rate constant E) total clearance over nonrenal (extrarenal) clearance Therapeutic drug monitoring means: A) trough concentration under steady-state condition B) measurement of medication concentrations in blood C) the process of chemical alteration of drugs in the body D) amount of untoward effects following treatment E) development of expected desired effects Therapeutic dose is not related to: A) patient’s age B) rout of administration C) desired therapeutic effect D) organs of elimination E) treatment costs Mean therapeutic doses mentioned in manuals is obtained by the following way: A) calculation of pharmacokinetic features B) clinical investigations C) experimental investigations D) experimental data adopted for human body E) calculation of pharmacodynamic features Find -
Evidence-Based Guidelines for Treating Depressive Disorders with Antidepressants
JOP0010.1177/0269881115581093Journal of PsychopharmacologyCleare et al. 581093research-article2015 BAP Guidelines Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association Journal of Psychopharmacology 2015, Vol. 29(5) 459 –525 for Psychopharmacology guidelines © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0269881115581093 jop.sagepub.com Anthony Cleare1, CM Pariante2 and AH Young3 With expert co-authors (in alphabetical order): IM Anderson4, D Christmas5, PJ Cowen6, C Dickens7, IN Ferrier8, J Geddes9, S Gilbody10, PM Haddad11, C Katona12, G Lewis12, A Malizia13, RH McAllister-Williams14, P Ramchandani15, J Scott16, D Taylor17, R Uher18 and the members of the Consensus Meeting19 Endorsed by the British Association for Psychopharmacology Abstract A revision of the 2008 British Association for Psychopharmacology evidence-based guidelines for treating depressive disorders with antidepressants was undertaken in order to incorporate new evidence and to update the recommendations where appropriate. A consensus meeting involving experts in depressive disorders and their management was held in September 2012. Key areas in treating depression were reviewed and the strength of evidence and clinical implications were considered. The guidelines were then revised after extensive feedback from participants and interested parties. A literature review is provided which identifies the quality of evidence upon which the recommendations -
52Nd Annual Meeting
ACNP 52nd Annual Meeting Final Program December 8-12, 2013 The Westin Diplomat Resort & Spa Hollywood, Florida President: David A. Lewis, M.D. Program Committee Chair: Randy D. Blakely, Ph.D. Program Committee Co-Chair: Pat R. Levitt, Ph.D. This meeting is jointly sponsored by the Vanderbilt University School of Medicine Department of Psychiatry and the American College of Neuropsychopharmacology. Dear ACNP Members and Guests, It is a distinct pleasure to welcome you to the 2014 meeting of the American College of Neuropsychopharmacology! This 52nd annual meeting will again provide opportunities for the exercise of the College’s core values: the spirit of Collegiality, promoting in each other the best in science, training and service; participation in Community, pursuing together the goals of understanding the neurobiology of brain diseases and eliminating their burden on individuals and our society; and engaging in Celebration, taking the time to recognize and enjoy the contributions and accomplishments of our members and guests. Under the excellent leadership of Randy Blakely and Pat Levitt, the Program Committee has done a superb job in assembling an outstanding slate of scientific presentations. Based on membership feedback, the meeting schedule has been designed with the goals of achieving an optimal mix of topics and types of sessions, increasing the diversity of participating scientists and creating more time for informal interactions. The presentations will highlight both the breadth of the investigative interests of ACNP membership -
Behavioral and Brain Sciences Plasticity: Implications for Opioid
Behavioral and Brain Sciences http://journals.cambridge.org/BBS Additional services for Behavioral and Brain Sciences: Email alerts: Click here Subscriptions: Click here Commercial reprints: Click here Terms of use : Click here Plasticity: Implications for opioid and other pharmacological interventions in specific pain states Anthony H. Dickenson Behavioral and Brain Sciences / Volume 20 / Issue 03 / September 1997, pp 392 403 DOI: null, Published online: 08 September 2000 Link to this article: http://journals.cambridge.org/abstract_S0140525X97241488 How to cite this article: Anthony H. Dickenson (1997). Plasticity: Implications for opioid and other pharmacological interventions in specific pain states. Behavioral and Brain Sciences,20, pp 392403 Request Permissions : Click here Downloaded from http://journals.cambridge.org/BBS, IP address: 144.82.107.43 on 10 Aug 2012 BEHAVIORAL AND BRAIN SCIENCES (1997) 20, 392±403 Printed in the United States of America Plasticity: Implications for opioid and other pharmacological interventions in specific pain states Anthony H. Dickenson Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom Electronic mail: anthony.dickenson6ucl.ac.uk Abstract: The spinal mechanisms of action of opioids under normal conditions are reasonably well understood. The spinal effects of opioids can be enhanced or reduced depending on pathology and activity in other segmental and nonsegmental pathways. This plasticity will be considered in relation to the control of different pain states using opioids. The complex and contradictory findings on the supraspinal actions of opioids are explicable in terms of heterogeneous descending pathways to different spinal targets using multiple transmitters and receptors ± therefore opioids can both increase and decrease activity in descending pathways. -
Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands
Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands By Stephanie Nicole Johnson Submitted to the graduate degree program in Medicinal Chemistry and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Masters in Science. Chairperson: Dr. Thomas E. Prisinzano Dr. Apurba Dutta Dr. Jeffrey P. Krise Date Defended: May 2, 2017 The Thesis Committee for Stephanie Nicole Johnson certifies that this is the approved version of the following thesis: Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands Chairperson: Dr. Thomas E. Prisinzano Date approved: May 4, 2017 ii Abstract The ability of ligands to differentially regulate the activity of signaling pathways coupled to a receptor potentially enables researchers to optimize therapeutically relevant efficacies, while minimizing activity at pathways that lead to adverse effects. Recent studies have demonstrated the functional selectivity of kappa opioid receptor (KOR) ligands acting at KOR expressed by rat peripheral pain sensing neurons. In addition, KOR signaling leading to antinociception and dysphoria occur via different pathways. Based on this information, it can be hypothesized that a functionally selective KOR agonist would allow researchers to optimize signaling pathways leading to antinociception while simultaneously minimizing activity towards pathways that result in dysphoria. In this study, our goal was to alter the structure of U50,488 such that efficacy was maintained for signaling pathways important for antinociception (inhibition of cAMP accumulation) and minimized for signaling pathways that reduce antinociception. Thus, several compounds based on the U50,488 scaffold were designed, synthesized, and evaluated at KORs. Selected analogues were further evaluated for inhibition of cAMP accumulation, activation of extracellular signal-regulated kinase (ERK), and inhibition of calcitonin gene- related peptide release (CGRP). -
First Part Examination Mock Exam
FIRST PART EXAMINATION MOCK EXAM This Mock Examination is prepared to provide candidates, tutors and their Supervisors of Training with information about the way the Examiners will assess the performance of candidates in the Examination. Example questions provided are to be used as a guide only as to what may be expected. Candidates should discuss the exam with their tutors so that they may prepare appropriately for future examinations. It should be read in conjunction with the Notes to Candidates document. WRITTEN EXAM GLOSSARY OF TERMS Calculate Work out or estimate using mathematical principles Classify Divide into categories; organise, arrange Compare Examine similarities and differences Define Give the precise meaning Describe Give a detailed account of Explain Make plain, interpret, and account for Interpret Explain the meaning or significance Outline Provide a summary of the important points Relate Show a connection between Understand Appreciate the details of; comprehend 1 FIRST PART EXAMINATION MOCK EXAM SHORT ANSWER QUESTIONS MORNING PAPER (A) Start each answer on a new page and indicate the question number. It is not necessary to rewrite the question in your answer book. (B) You should aim to allocate ten minutes to answer each SAQ. (C) The questions are worth equal marks. (D) Short Answer Questions with more than one part have the proportion of marks indicated for each part. (E) Record your candidate number and each question number on the cover of each book and hand in all answer books. 2 Please answer Questions 1 and 2 in the blue answer booklet 1. Describe the anatomy of the left subclavian vein. -
(DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
pharmaceuticals Review Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact Andreia Machado Brito-da-Costa 1 , Diana Dias-da-Silva 1,2,* , Nelson G. M. Gomes 1,3 , Ricardo Jorge Dinis-Oliveira 1,2,4,* and Áurea Madureira-Carvalho 1,3 1 Department of Sciences, IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal; [email protected] (A.M.B.-d.-C.); ngomes@ff.up.pt (N.G.M.G.); [email protected] (Á.M.-C.) 2 UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 3 LAQV-REQUIMTE, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal 4 Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal * Correspondence: [email protected] (D.D.-d.-S.); [email protected] (R.J.D.-O.); Tel.: +351-224-157-216 (R.J.D.-O.) Received: 21 September 2020; Accepted: 20 October 2020; Published: 23 October 2020 Abstract: Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and bark of Banisteriopsis caapi, the plant source of harmala alkaloids. -
An Interpretationist Approach to the Thinking Mind DISSERTATION
Thought Without Language: an Interpretationist Approach to the Thinking Mind DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Michael Dean Jaworski Graduate Program in Philosophy The Ohio State University 2010 Dissertation Committee: Neil Tennant, Advisor William Taschek Ben Caplan Copyright by Michael Dean Jaworski 2010 Abstract I defend an account of thought on which non-linguistic beings can be thinkers. This result is significant in that many philosophers have claimed that the ability to think depends on the ability to use language. These opponents of my view note that our everyday understanding of our own cognitive activities qua thought bestows upon those activities the propositional structure of sentences and the inferential norms of public linguistic practice. They hold that our attributions of thought to non-linguistic beings project non-existent structure onto the cognitive activities of those beings, and assess the beings’ activities according to standards to which the beings bear no responsibility. So, despite the complex neural and behavioral activities of many non-linguistic beings, my opponents hold that those beings are not properly described as thinkers. To respond to my opponents successfully, one must not merely cite scientific and folk practices of thought attribution that permit thought to be attributed to some non- linguistic beings. My opponents’ insights might be taken to demonstrate a need to revise those practices, or to treat the attributions of thought to non-linguistic beings made within those practices as instrumentally valuable but technically false. Instead, my strategy is to acknowledge the language-like structure and norms of thought, and show that a non- linguistic being’s cognitive activities might nonetheless have that structure and be subject ii to those norms. -
DEPARTMENT INSTRUCTIONAL REPORT-FINAL RUN DATE: 8/8/2008 University of Wisconsin-Madison Office of the Registrar RUN TIME: 9:43:37AM
DEPARTMENT INSTRUCTIONAL REPORT-FINAL RUN DATE: 8/8/2008 University of Wisconsin-Madison Office of the Registrar RUN TIME: 9:43:37AM SUBJECT: AGRICULTURAL AND APPLIED ECONOMICS (108) TERM: 1086 FACILITY_ID COMB_ENRL ENRL_TOT EMPLID INSTRUCTOR ROLE/NAME AGRICULTURALALS AND APPLIED ECONOMICS ACC 306 LEC 001 1 09:00 - 12:00 M T W R 0140 1185 49 6 0000875079 MICHAEL JOHNSON DJJ 399 IND 086 1 - 2 0000933523 PAUL MITCHELL ECC 875 SEM 001 2 13:00 - 16:00 M T W R F 0464 0B30 13 0002601604 MARVIN JOHNSON ECC 875 SEM 001 1 08:30 - 11:30 M T W R F 0464 0B30 13 0002601604 MARVIN JOHNSON DHH 990 IND 063 1 - 9 0000226384 MICHAEL CARTER DHH 990 IND 064 1 - 1 0002600175 THOMAS COX DHH 990 IND 073 1 - 3 0002601457 IAN COXHEAD DHH 990 IND 078 1 - 3 0002602152 T FORTENBERY DHH 990 IND 079 1 - 1 0002600972 STEVEN DELLER DHH 990 IND 080 1 - 3 0002602096 BRADFORD BARHAM DHH 990 IND 082 1 - 2 0000125075 JEREMY FOLTZ DHH 990 IND 083 1 - 6 0003374884 KYLE STIEGERT DHH 990 IND 086 1 - 1 0000933523 PAUL MITCHELL DHH 990 IND 087 1 - 3 0004111956 DAVID LEWIS DHH 990 IND 089 1 - 1 0001459007 SHI GUANMING DHH 990 IND 090 1 - 1 0001016452 BRENT HUETH DHH 999 IND 085 1 - 1 0003088634 BRIAN GOULD PAGE NUMBER: 1 OF 1 DEPARTMENT INSTRUCTIONAL REPORT-FINAL RUN DATE: 8/8/2008 University of Wisconsin-Madison Office of the Registrar RUN TIME: 9:44:48AM SUBJECT: BIOLOGICAL SYSTEMS ENGINEERING (112) TERM: 1086 FACILITY_ID COMB_ENRL ENRL_TOT EMPLID INSTRUCTOR ROLE/NAME BIOLOGICAL SYSTEMS ENGINEERING DHH 399 IND 010 1 - 2 0000693634 DAVID BOHNHOFF DHH 399 IND 014 1 - 2 0000664097 -
Safety Alert: Risks Associated with Ophthalmic Anesthetics
WRHA Pharmacy Program Health Sciences Centre MS-189 820 Sherbrook St. Winnipeg, Manitoba R3A 1R9 CANADA TEL: 204-787-7183 Fax: 204-787-3195 FAX: 204-787-3195 Safety Alert: Risks associated with Ophthalmic Anesthetics The self-administration of ophthalmic anesthetics by patients for the relief of eye pain should be avoided and they should not be given to patients to take home for pain relief. Vision threatening complications of topical anesthetic abuse are common. There is no indication for the use of ophthalmic anesthetics except for diagnostic and short term therapeutic purposes (the removal of a foreign body or ocular surgery) and therefore, these products should only be used under a physician’s supervision. Eye trauma resulting in a corneal abrasion (epithelial injury) is a common complaint in the Emergency department (1). A superficial corneal injury can cause intense pain causing a patient to seek medical help or immediate relief from available over the counter remedies. In Canada, only two topical ophthalmic anesthetic drugs are available commercially as single entities, proparacaine (proxymetacaine) and tetracaine (available in bottle and minim forms). Benoxinate (oxybuprocaine) is only available in combination with fluorescein (3). Lidocaine is also used in ophthalmic surgical procedures however, it is not available in the Canadian market as an ophthalmic preparation. Topical ophthalmic anesthetics function by blocking nerve conduction when applied to the cornea and conjunctiva. The ocular surface is innervated by the multiple branches of the trigeminal nerve. The cornea is supplied by the long and short ciliary nerves, the nasociliary nerve and the lacrimal nerve (4). Topical anesthetics reduce sodium permeability preventing generation and conduction of nerve impulses, increasing excitation threshold, and slowing the nerve impulse propagation.