DOCSLIB.ORG

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours Hellquist, Henrik; Paiva-Correia, António; Vander Poorten, Vincent; Quer, Miquel; Hernandez- Prera, Juan C; Andreasen, Simon; Zbären, Peter; Skalova, Alena; Rinaldo, Alessandra; Ferlito, Alfio Published in: Advances in Therapy DOI: 10.1007/s12325-019-01007-3 Publication date: 2019 Document version Publisher's PDF, also known as Version of record Document license: CC BY-NC Citation for published version (APA): Hellquist, H., Paiva-Correia, A., Vander Poorten, V., Quer, M., Hernandez-Prera, J. C., Andreasen, S., Zbären, P., Skalova, A., Rinaldo, A., & Ferlito, A. (2019). Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours. Advances in Therapy, 36(8), 1950-1974. https://doi.org/10.1007/s12325-019-01007-3 Download date: 01. okt.. 2021 Adv Ther (2019) 36:1950–1974 https://doi.org/10.1007/s12325-019-01007-3 ORIGINAL RESEARCH Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours Henrik Hellquist . Anto´nio Paiva-Correia . Vincent Vander Poorten . Miquel Quer . Juan C. Hernandez-Prera . Simon Andreasen . Peter Zba¨ren . Alena Skalova . Alessandra Rinaldo . Alfio Ferlito Received: May 2, 2019 / Published online: June 17, 2019 Ó The Author(s) 2019 ABSTRACT to investigate whether an accurate histological diagnosis of the 11 different types of benign Introduction: A vast increase in knowledge of epithelial salivary gland tumours is correlated to numerous aspects of malignant salivary gland any differences in their clinical behaviour. tumours has emerged during the last decade Methods: A search was performed for histolog- and, for several reasons, this has not been the ical classifications, recurrence rates and risks for case in benign epithelial salivary gland malignant transformation, treatment modali- tumours. We have performed a literature review ties, and prognosis of these tumours. The search was performed primarily through PubMed, Google Scholar, and all versions of WHO clas- Henrik Hellquist and Anto´nio Paiva-Correia contributed sifications since 1972, as well as numerous to the manuscript equally and are co-first authors. textbooks on salivary gland tumours/head and Enhanced Digital Features To view enhanced digital neck/pathology/oncology. A large number of features for this article go to https://doi.org/10.6084/ archival salivary tumours were also reviewed m9.figshare.8175251. histologically. Electronic Supplementary material The online Results: Pleomorphic adenomas carry a con- version of this article (https://doi.org/10.1007/s12325- siderable risk (5–15%) for malignant 019-01007-3) contains supplementary material, which is available to authorized users. V. Vander Poorten H. Hellquist Á A. Paiva-Correia Otorhinolaryngology-Head and Neck Surgery and Epigenetics and Human Disease Laboratory, Faro, Department of Oncology, Section Head and Neck Portugal Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium H. Hellquist Á A. Paiva-Correia Centre of Biomedical Research (CBMR) and Algarve V. Vander Poorten Á M. Quer Á P. Zba¨ren Á A. Skalova Biomedical Centre (ABC), Faro, Portugal Multidisciplinary Salivary Gland Society, Geneva, Switzerland H. Hellquist (&) Á A. Paiva-Correia Department of Biomedical Sciences and Medicine, M. Quer University of Algarve, Faro, Portugal Department of Otolaryngology, Hospital Santa Creu e-mail: [email protected] i Sant Pau, Barcelona, Spain A. Paiva-Correia J. C. Hernandez-Prera Histopathology Department, Wythenshawe Department of Anatomic Pathology, Moffitt Cancer Hospital, Manchester University NHS Foundation Center, Tampa, FL, USA Trust, Manchester, UK Adv Ther (2019) 36:1950–1974 1951 transformation but, albeit to a much lesser INTRODUCTION degree, so do basal cell adenomas and Warthin tumours, while the other eight types virtually An impressive increase in knowledge of the never develop into malignancy. Pleomorphic genetics, pathogenesis, diagnostic possibilities, adenoma has a rather high risk for recurrence clinical behavior, treatment modalities and while recurrence occurs only occasionally in prognosis of malignant salivary tumours has sialadenoma papilliferum, oncocytoma, emerged during the last decade. A similar canalicular adenoma, myoepithelioma and the development has not happened with regards to membranous type of basal cell adenoma. benign salivary neoplasms, in despite the fact Papillomas, lymphadenoma, sebaceous ade- that a few of these are precursors to the malig- noma, cystadenoma, basal cell adenoma (solid, nant variants. The current 4th World Health trabecular and tubular subtypes) very rarely, if Organization (WHO) classification of 2017 ever, recur. defines 11 different types of benign epithelial Conclusions: A correct histopathological diag- salivary tumours (some of them with subclassi- nosis of these tumours is necessary due to (1) fications), 4 non-neoplastic epithelial lesions (1 preventing confusion with malignant salivary of which future studies possibly may give evi- gland tumours; (2) only one (pleomorphic dence that it may be a neoplasm–sclerosing adenoma) has a considerable risk for malignant polycystic adenosis), 3 benign soft tissue transformation, but all four histological types lesions/tumours, and 22 carcinomas [1]. This is of basal cell adenoma can occasionally develop to be compared to the 1st WHO edition of 1972 into malignancy, as does Warthin tumour; (3) that comprised just two adenomas (pleomor- sialadenoma papilliferum, oncocytoma, phic and monomorphic adenoma), two canalicular adenoma, myoepithelioma and tumours (acinic cell tumour ad mucoepider- Warthin tumour only occasionally recur; while moid tumour) and five carcinomas [adenoid (4) intraductal and inverted papilloma, lym- cystic carcinoma, adenocarcinoma, epidermoid phadenoma, sebaceous adenoma, cystadenoma, carcinoma, undifferentiated carcinoma and basal cell adenoma (apart from the membra- carcinoma in pleomorphic adenoma (PA)] [2]. A nous type) virtually never recur. No biomarker modified classification was proposed by Seifert was found to be relevant for predicting recur- et al. in 1990 [3] that led to the publication of rence or potential malignant development. the 2nd WHO classification in 1991 by which Guidelines for appropriate treatment strategies time the two recognisable benign tumour enti- are given. ties had risen to nine (two of which had sub- classifications) [4]. With the continuous Keywords: Benign salivary gland tumours; increase of knowledge, and a wider use of Biomarkers; Malignant transformation; immunohistochemistry and molecular tech- PubMed; Recurrence; Salivary gland niques, the separate entities have been better neoplasms; Treatment modalities characterized and more widely accepted. Sali- vary gland tumours were included in the 3rd and 4th editions of WHO classifications of head S. Andreasen A. Skalova Department of Otorhinolaryngology Head and Neck Department of Pathology, Charles University, Surgery and Audiology, Rigshospitalet, Faculty of Medicine in Plzen, Plzenˇ, Czech Republic Copenhagen, Denmark A. Rinaldo S. Andreasen University of Udine School of Medicine, Udine, Italy Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, A. Ferlito Køge, Denmark Coordinator of the International Head and Neck Scientific Group, Padua, Italy P. Zba¨ren Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital, Bern, Switzerland 1952 Adv Ther (2019) 36:1950–1974 and neck tumours (2005 and 2017, respectively) Table 1 2017 WHO classification of benign epithelial instead of being published in separate books salivary gland tumours (from El-Naggar et al. [1]) [1, 5]. The histological identification of PA, Warthin tumour (WT) and, to a certain extent Pleomorphic adenoma myoepithelioma myoepithelioma (MYO), is usually relatively Basal cell adenoma (membranous, solid, trabecular and straightforward, but the classification of some tubular types; often mixtures thereof) Warthin of the other eight benign tumours can on tumour occasion be rather difficult, primarily due to their rareness in a routine pathology laboratory Oncocytoma set-up. Many may perhaps agree with Zarbo Lymphadenoma (sebaceous and non-sebaceous et al. in their statement related to less common lymphadenoma) cystadenoma benign salivary gland tumours ‘‘To wit, we believe it does not matter what these tumours Sialadenoma papilliferum are called as long as they are recognized and Ductal papilloma (intraductal and inverted ductal designated benign and the adequacy of excision papilloma) Sebaceous adenoma is noted’’ [6]. However, it appears that some of the benign salivary gland tumours do have a Canalicular adenoma tendency to recur, others have a very low ten- dency, while yet some others do not recur at all. Compliance with Ethics Guidelines A few are known to develop into malignant neoplasms, while in others malignant transfor- This article is based on previously conducted mation is extremely rare, or has not yet even studies and does not contain any studies with been reported. Therefore, the aims of this study human participants or animals performed by were to investigate via a search in the medical any of the authors. The studies involved fully literature, whether the study of any biomarker complied with the ethical standard of the hos- and a correct histological subclassification pitals involved and in accordance with the would detect the risk
Load more

Recommended publications
  • 8 Benign Neoplasms and Tumor-Like Lesions Roberto Maroldi, Marco Berlucchi, Davide Farina, Davide Tomenzoli, Andrea Borghesi, and Luca Pianta
    Benign Neoplasms and Tumor-Like Lesions 107 8 Benign Neoplasms and Tumor-Like Lesions Roberto Maroldi, Marco Berlucchi, Davide Farina, Davide Tomenzoli, Andrea Borghesi, and Luca Pianta CONTENTS 8.6.6 Follow-Up 131 8.7 Juvenile Angiofi broma 131 8.1 Osteoma 107 8.7.1 Defi nition, Epidemiology, Pattern of Growth 131 8.1.1 Defi nition, Epidemiology, Pattern of Growth 107 8.7.2 Clinical and Endoscopic Findings 132 8.1.2 Clinical and Endoscopic Findings 108 8.7.3 Treatment Guidelines 132 8.1.3 Treatment Guidelines 108 8.7.4 Key Information to Be Provided by Imaging 133 8.1.4 Key Information to Be Provided by Imaging 109 8.7.5 Imaging Findings 133 8.1.5 Imaging Findings 109 8.7.6 Follow-Up 141 8.1.6 Follow-Up 110 8.8 Pyogenic Granuloma 8.2 Fibrous Dysplasia and Ossifying Fibroma 110 (Lobular Capillary Hemangioma) 145 8.2.1 Defi nition, Epidemiology, Pattern of Growth 110 8.8.1 Defi nition, Epidemiology, Pattern of Growth 145 8.2.2 Clinical and Endoscopic Findings 111 8.8.2 Treatment Guidelines 145 8.2.3 Treatment Guidelines 112 8.8.3 Key Information to Be Provided by Imaging 146 8.2.4 Key Information to Be Provided by Imaging 112 8.8.4 Imaging Findings 146 8.2.5 Imaging Findings 112 8.9 Unusual Benign Lesions 147 8.2.6 Follow-Up 114 8.9.1 Pleomorphic Adenoma (Mixed Tumor) 147 8.3 Aneurysmal Bone Cyst 114 8.9.2 Schwannoma 149 8.3.1 Defi nition, Epidemiology, Pattern of Growth 114 8.9.3 Leiomyoma 150 8.3.2 Clinical and Endoscopic Findings 115 8.9.4 Paraganglioma 151 8.3.3 Treatment Guidelines 115 References 152 8.3.4 Key Information to Be Provided
    [Show full text]
  • Immune Function of Mir-214 and Its Application Prospects As Molecular Marker
    Immune function of miR-214 and its application prospects as molecular marker Qiuyuan Wang, Yang Liu, Yiru Wu, Jie Wen and Chaolai Man College of Life Science and Technology, Harbin Normal University, Harbin, China ABSTRACT MicroRNAs are a class of evolutionary conserved non-coding small RNAs that play key regulatory roles at the post-transcriptional level. In recent years, studies have shown that miR-214 plays an important role in regulating several biological processes such as cell proliferation and differentiation, tumorigenesis, inflammation and immunity, and it has become a hotspot in the miRNA field. In this review, the regulatory functions of miR-214 in the proliferation, differentiation and functional activities of immune- related cells, such as dendritic cells, T cells and NK cells, were briefly reviewed. Also, the mechanisms of miR-214 involved in tumor immunity, inflammatory regulation and antivirus were discussed. Finally, the value and application prospects of miR-214 as a molecular marker in inflammation and tumor related diseases were analyzed briefly. We hope it can provide reference for further study on the mechanism and application of miR-214. Subjects Biochemistry, Molecular Biology, Immunology Keywords miR-214, Immune cell, Tumor immunity, Inflammation, Virus, Molecular marker INTRODUCTION MicroRNAs (miRNAs) are a kind of high conserved non-coding small RNAs in evolution that bind to the 30-untranslated region (30-UTR) of target gene mRNA and regulate gene Submitted 18 September 2020 expression at post-transcriptional level. In immune responses, miRNAs act as signal- Accepted 20 January 2021 Published 16 February 2021 regulating molecules after immune-related receptors activation, and affect the expression Corresponding author of immune-related genes, thus extensively participating in various aspects of immune Chaolai Man, [email protected] response (Bosisio et al., 2019; Mehta & Baltimore, 2016).
    [Show full text]
  • Genitourinary Pathology (Including Renal Tumors)
    LABORATORY INVESTIGATION THE BASIC AND TRANSLATIONAL PATHOLOGY RESEARCH JOURNAL LI VOLUME 99 | SUPPLEMENT 1 | MARCH 2019 2019 ABSTRACTS GENITOURINARY PATHOLOGY (INCLUDING RENAL TUMORS) (776-992) MARCH 16-21, 2019 PLATF OR M & 2 01 9 ABSTRACTS P OSTER PRESENTATI ONS EDUCATI ON C O M MITTEE Jason L. Hornick , C h air Ja mes R. Cook R h o n d a K. Y a nti s s, Chair, Abstract Revie w Board S ar a h M. Dr y and Assign ment Co m mittee Willi a m C. F a q ui n Laura W. La mps , Chair, C ME Subco m mittee C ar ol F. F ar v er St e v e n D. Billi n g s , Interactive Microscopy Subco m mittee Y uri F e d ori w Shree G. Shar ma , Infor matics Subco m mittee Meera R. Ha meed R aj a R. S e et h al a , Short Course Coordinator Mi c h ell e S. Hir s c h Il a n W ei nr e b , Subco m mittee for Unique Live Course Offerings Laksh mi Priya Kunju D a vi d B. K a mi n s k y ( Ex- Of ici o) A n n a M ari e M ulli g a n Aleodor ( Doru) Andea Ri s h P ai Zubair Baloch Vi nita Parkas h Olca Bast urk A nil P ar w a ni Gregory R. Bean , Pat h ol o gist-i n- Trai ni n g D e e p a P atil D a ni el J.
    [Show full text]
  • Poster: Publikace 2008
    Publikované Práce lékařů Šiklova Patologicko – anatomického ústavu a bioPtické laboratoře s.r.o. za rok 2008 Časopisy s „impact“ faktorem syringofibroadenoma associated with well-differentiated squamous cell 28. Kuroda N., Katto K., Yamaguchi T., Kawada T., ImamuraY., Hes O., Michal M., 42. Vazmitel M., Spagnolo D.V., Němcová J., Michal M., Kazakov D.V.: 1. Alvarado-Cabrero I., Perez-Montiel D.M., Hes, O.: Multicystic urothelial carcinoma. Am J Dermatopathol, 30, 572-574, 2008. Shuin T., Lee G.H.: Chromophobe renal cell carcinoma: Diagnostic ancillary Hidradenoma papilliferum with a ductal carcinoma in situ component. Case report and review of the literature. Am J Dermatopathol, 30, 392-394, 2008. carcinoma of the bladder with gland-like lumina and with signet-ring cells. 17. Kacerovska D., Michal M., Kreuzberg B., Mukensnabl P., Kazakov DV.: application of imprint cytology and fluorescencein situ hybridization of Acral calcified vascular leiomyoma of the skin: a rare clinicopathological chromosomes 10 and 21 in two cases of typical and eosinophilic variants. 43. Vazmitel M., Michal M., Kazakov D.V.: Merkel cell carcinoma with a A case report. Diagn Pathol, 3, 36, 2008. follicular lymphocytic infiltrate: report of two cases. Am J Dermatopathol, 2. Beneš Z., Chlumská A., Antoš Z., Kohout P., Sequens R.: Detection of variant of cutaneous vascular leiomyomas: report of 3 cases. J Amer Acad Med Mol Morphol, 41, 227-232, 2008. 29. Kuroda N., Kato K., Tamura M., Shiotsu T., Hes O., Michal M., Hagashima 30, 389-391, 2008. carcinoma by means of endoscopic cytoscopy in the area of ulcerative colitis. Dermatology, 59,1000-1004, 2008.
    [Show full text]
  • A Case Report of Nasal Adenoid Cystic Carcinoma Rahim H1*, Bencheikh R2, Gliti MA1, Harmouch A3, Benbouzid MA2, Essakali L2
    Saudi Journal of Medical and Pharmaceutical Sciences Abbreviated Key Title: Saudi J Med Pharm Sci ISSN 2413-4929 (Print) |ISSN 2413-4910 (Online) Scholars Middle East Publishers, Dubai, United Arab Emirates Journal homepage: https://saudijournals.com Case Report A Case Report of Nasal Adenoid Cystic Carcinoma Rahim H1*, Bencheikh R2, Gliti MA1, Harmouch A3, Benbouzid MA2, Essakali L2 1Resident physician in otorhinolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Ibn Sina University Hospital, Faculty of Medicine, Mohammed V University, Rabat, Morocco 2Professor of otorhinolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Ibn Sina University Hospital, Faculty of Medicine, Mohammed V University, Rabat, Morocco 3Professor of Anatomopathology, Ibn Sina University Hospital, Faculty of Medicine, Mohammed V University, Rabat, Morocco DOI: 10.36348/sjmps.2020.v06i11.007 | Received: 22.08.2020 | Accepted: 29.08.2020 | Published: 28.11.2020 *Corresponding author: Rahim Hanaa Abstract The adenoid cystic carcinoma is a rare tumor in the region of the head and neck, it's the common malignant tumor of the salivary glands. Its location in the nasal cavity is exceptional. We report in our study a case of adenoid cystic carcinoma of the nasal cavity of a 68-year-old patient who presents nasal symptoms. The CT- scan shows a tissue process in the right nasal cavity, the endoscopy showed a process in the right nasal cavity extending to the lower cornet. The histology confirmed the adenoid cystic carcinoma. The surgical treatment consisted on the excision of the entire tumor followed by radiation therapy. Keywords: Adenoid cystic carcinoma – nasal cavity. Copyright © 2020 The Author(s): This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY-NC 4.0) which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited.
    [Show full text]
  • Tumors in the Kidney (Pdf)
    Systemicist Pathology.. Lecture # 8 Title :Tumors In The Kidney Done by: Dema Mhmd Khdier A man may die, nations may rise and fall…….But an idea lives on Classification PRIMARY **Benign: 1)Papillary adenoma (in the cortex). 2)Oncocytoma 3)Medullary fibroma (interstitial cell T) **Malignant: 1)Renal cell carcinoma (most common): •Clear cell renal cell carcinoma. •Papillary renal cell carcinoma. •Chromophobe renal cell carcinoma. 2) Nephroblastoma (Wilms tumor). 3) Urothelial carcinoma of renal pelvis. SECONDARY **Benign renal tumors** _ Angiomyolipoma: Consists of vessels, smooth muscles & fat. Seen in 25-50% of patients with (Tuberous Sclerosis). **Malignant renal tumors** 1)Renal cell carcinoma (RCC) Tumors are derived from the renal tubular epithelium. • Most cases are sporadic. • 2-3% of all visceral cancers. ~85% of all renal cancer. • M:F = 2:1. Commonly 60-70 years. Risk factors 1) Smoking (most significant), obesity, HTN. 2)Unopposed estrogen Rx 3)Cadmium, petroleum products & heavy metals. 4)CRF & acquired cystic disease** (30 folds ) 5)Familial (4%) most are AD: _Von Hippel-Lindau (VHL) syndrome _Hereditary clear cell carcinoma _Hereditary papillary carcinoma Morphology of RCC Grossly: ▫ Mainly arise in cortex > polar & spherical. ▫ May extend into renal vein. ▫ Orange – yellow OR tan–brown, variegated tumor with hemorrhagic, necrotic & cystic areas. Classified according to the histological picture: 1)Clear cell carcinoma (70-80%). 2)Papillary carcinoma (10-15%). 3)Chromophobe renal carcinoma (5%). 4)Sarcomatoid carcinoma. A. Clear cell carcinoma • Most common RCC subtype. • Arise from proximal convoluted tubules. • Majority are sporadic & unilateral. • Familial forms, associated with germ-line mutation of the VHL tumor suppressor gene on 3p: *von Hippel-Lindau: rare tumor of adrenal gland tissue.
    [Show full text]
  • A034047-100 Top Secrets.Qxd 5/18/06 2:32 PM Page 1
    A034047-100 Top Secrets.qxd 5/18/06 2:32 PM Page 1 TOP 100 SECRETS These secrets are 100 of the top board alerts. They summarize the concepts, principles, and most salient details of CT body scans. 1. Computed tomography (CT) differs from conventional radiography by forming a cross-sectional image, eliminating the superimposition of structures that occurs in plain film imaging because of compression of three-dimensional body structures onto the two-dimensional recording system. 2. The sensitivity of CT to subtle differences in x-ray attenuation is at least a factor of 10 higher than normally achieved by film screen recording systems because of the virtual elimination of scatter. 3. Radiation doses in CT range from 15–50 mGy, depending on exam type. In general, these doses are at least 10 times higher than in radiographic exams. 4. Always seek to optimize scan parameters to minimize patient dose consistent with diagnostic image quality: Minimize mAs, minimize kVp, maximize pitch, maximize slice thickness, and maximize collimator setting. 5. When scanning children, be sure to use pediatric protocols, not adult protocols. In pediatric protocols the CT scan parameters should be reduced so that radiation doses are optimized according to patient size. 6. Pregnant women should be scanned only if there is adequate justification to avoid unnecessary fetal irradiation. 7. Many of the side effects of contrast media are entirely or mainly due to high osmolality. The other causes of side effects due to contrast media are chemotoxicity (allergic-like symptoms), ion toxicity (interference with cellular function), and those caused by a high dose.
    [Show full text]
  • Title Inverted Papilloma of the Renal Pelvis Associated with Renal Cell
    Inverted papilloma of the renal pelvis associated with renal cell Title carcinoma: a case report Ueda, Takeshi; Akimoto, Susumu; Shimazaki, Jun; Matsuzaki, Author(s) Masaru; Nagao, Kouichi Citation 泌尿器科紀要 (1992), 38(5): 561-563 Issue Date 1992-05 URL http://hdl.handle.net/2433/117552 Right Type Departmental Bulletin Paper Textversion publisher Kyoto University Acta Urol. Jpn. 38: 561-563, 1992 561 INVERTED PAPILLOMA OF THE RENAL PELVIS ASSOCIATED WITH RENAL CELL CARCINOMA: A CASE REPORT Takeshi U eda, Susumu Akimoto, J un Shimazaki, Masaru Matsuzaki* and Kouichi Nagao* From the Department of Urology, School of Medicine, Chiba University and Pathology, School of Medicine, Teikyo University, Ichihara Hospital Twenty-one cases of inverted papilloma of the renal pelvis have been described in the litera­ ture. A 71-year-old man was admitted to our hospital to examine a right renal mass. We diagnosed a right renal tumor on the basis of the findings from excretory urogram (IVP), computerized tomog­ raphy (CT) and magnetic resonance imaging (MRI). Surgical material revealed an inverted pap­ illoma in the renal pelvis. We report on the first case of an invested papilloma of the renal pelvis associated with renal cell carcinoma. (Acta Uro!. Jpn. 38: 561-563, 1992) Key words: Inverted papilloma, Renal pelvis, Renal cell carcinoma this was again demonstrated by MRI. Se­ INTRODUCTION lective arteriography showed a marked Since Potts!) reported the first case of an neovascularity in the identical portion of inverted papilloma of the urinary bladder, the kidney as mentioned above we diag­ more than 200 cases have been reported. nosed a right renal tumor.
    [Show full text]
  • Upper Urinary Tract Inverted Papillomas: Report of 10 Cases
    ONCOLOGY LETTERS 4: 71-74, 2012 Upper urinary tract inverted papillomas: Report of 10 cases JIN-DAN LUO, PING WANG, JUN CHEN, BEN LIU, SHUO WANG, BO-HUA SHEN and LI-PING XIE Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China Received February 21, 2012; Accepted April 20, 2012 DOI: 10.3892/ol.2012.706 Abstract. The aim of the study was to review the clinical at The First Affiliated Hospital of Zhejiang University, China, features and treatments of 10 (9 males and 1 female; age range, and reviewed the clinical syndromes, diagnostic procedures, 61-73 years; median age, 67 years) upper urinary tract inverted treatment approaches and follow-up study results of each papilloma (IP) cases between 1995 and 2010. The clinical patient. syndromes, diagnostic procedures, treatments and results of the follow-up were evaluated. The results showed that the site Patients and methods of tumor development was the ureter in 6 cases and the renal pelvis in 4 cases. It was also identified that 7 tumors devel- The present study included 10 pa tients who had been hospital- oped on the left side and 3 developed on the right side of the ized in our Department of Urology between 1995 and 2010 as ureter and renal pelvis, respectively. A nephroureterectomy was a result of IP within the upper urinary tract. Of the 10 patients, performed in the first 6 cases, while a partial ureterectomy was 9 were male and 1 was female (age range, 61-73 years; median, performed in 3 cases and a local resection was performed endo- 67 years).
    [Show full text]
  • Title Acta Urologica Japonica Vol. 35, 1989 Author(S)
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Kyoto University Research Information Repository Title Acta Urologica Japonica Vol. 35, 1989 Author(s) Citation 泌尿器科紀要 (1989), 35(12): xii-xxvii Issue Date 1989-12 URL http://hdl.handle.net/2433/116762 Right Type Others Textversion publisher Kyoto University xll Acta Urologica Japonica Vol. 35, 1989 Vol. 35, No. 1January 1989 Study on Urinary (3-Glucuronidaseand Alkaline Phosphatase Activities as Indicators of CDDP Renal Toxicity ...............T. Takahashi et al.••• I Transurethral Ureterolithotripsy under Hydraulic Ureteral Dilatation .................................................................................Y. Mori et al.••• 7 Significanceof Isoantigen in the Managemantof the Urinary Bladder Tumor —A Basic Study of ABO Isoantigen in Step Sections of Entire Bladder—.................................................................................T. Ogawa et al.••• 13 An Experimental Study on Bladder Carcinogenesisin Dogs by N-Butyl-N-(4-Hydroxybutyl)Nitrosamine (BBN) and its Urinary Metabolites ............................................................S. Morishita et al.••• 27 A New Clinical Trial Intravesical Chemotherapywith Instillation of Peplomycin Preparation Emulsion in Hydroxypropylcellulosum —PreliminaryStudy of Patients with Bladder Tumor—.........M. Asakawa et al.••• 39 Studies of the New Parameter Based Urinary Flow Rate Curve in Benign Prostatic Hypertrophy ......................................................C. Haraguchi•••
    [Show full text]
  • Comprehensive Inherited Cancer Precision Panel Overview
    Comprehensive Inherited Cancer Precision Panel Overview Hereditary cancer syndromes are encountered in all medical specialties. Although they account for about 5% of all malignancies, it is of special importance to identify these patients because, unlike patients with sporadic cancers, they require special, long-term care as their predisposition can cause them to develop certain tumors at a relatively early age. These cancers can arise in the lungs, kidneys, liver, pancreas, skin, eyes, heart. Most hereditary cancers are associated with a “germline mutation” that will be present in every cell of the human body. Identification of patients at risk of inherited cancer susceptibility is dependent upon the ability to characterize genes and alterations associated with increased cancer risk as well as gathering a detailed personal and family history aiding in the identification of the mode of inheritance as well as other family members at risk of suffering from this susceptibility. Most hereditary cancer syndromes follow an autosomal dominant inheritance, and the penetrance is high. The Igenomix Comprehensive Inherited Cancer Precision Panel provides a comprehensive analysis of the most common hereditary cancer syndromes using next-generation sequencing (NGS) to fully understand the spectrum of relevant cancer predisposition genes. Indications The Igenomix Comprehensive Inherited Caner Precision Panel is indicated as a screening and diagnostic test in those cases where there are: ‐ Multiple relatives on the same side of the family with the same or related forms of cancer ‐ Cancer at an early age ‐ Early presentation of an aggressive cancer type ‐ Multiple primary cancers in an individual 1 Clinical Utility The clinical utility of this panel is: ‐ Early and accurate genetic diagnosis allowing the most appropriate clinical management of a patient with personal or family history suggestive of a hereditary cancer syndrome.
    [Show full text]
  • Q35;Ql3) Breakpoint
    PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/25861 Please be advised that this information was generated on 2021-09-25 and may be subject to change. ELSEVIER Fine Mapping of the Human Renal Oncocytoma- Associated Translocation (5;ll)(q35;ql3) Breakpoint Richard J. Sinke, Trynie Dijkhuizen, Bert Janssen, Daniël Olde Weghuis, Gérard Merkx, Eva van den Berg, Ed Schuuring, Aurelia M. Meloni, Bauke de Jong, and Ad Geurts van Kessel ABSTRACT: Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;ll)(q35;ql3) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;ll)-positive renal oncocytomas and a panel of soma tic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band llql3 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCLl locus. © Elsevier Science Inc., 1997 INTRODUCTION cytogenetic anomaly in at least 3 independent cases and, as such, should be considered as a primary change. Deletion of Oncocytomas are benign tumors that occur predominantly 3p material that occurs in the majority of renal cell carci­ in the kidney, accounting for approximately 5% of all pri­ nomas [16,17] has not been observed in renal oncocytomas. mary tumors at that site.
    [Show full text]