Supplementary Figure 1. Forest plot showing the proportion of ascites in patients with tusanqi- related SOS. Supplementary Figure 2. Forest plot showing the proportion of hepatomegaly in patients with tusanqi-related SOS. Supplementary Figure 3. Forest plot showing the proportion of jaundice in patients with tusanqi- related SOS. Supplementary Figure 4. Forest plot showing the proportion of plueral effusion in patients with tusanqi-related SOS. Supplementary Figure 5. Forest plot showing the proportion of lower limbs edema in patients with tusanqi-related SOS. Supplementary Figure 6. Forest plot showing the proportion of splenomegaly in patients with tusanqi-related SOS. Supplementary Figure 7. Forest plot showing the proportion of upper gastrointestinal bleeding in patients with tusanqi-related SOS. Supplementary Figure 8. Forest plot showing the proportion of gastroesophageal varices in patients with tusanqi-related SOS. Supplementary Figure 9. Forest plot showing the proportion of hepatic encephalopathy in patients with tusanqi-related SOS. Supplementary Table 1. Exclusion of relevant studies with overlapping data

Type Excluded First of Affiliations Journals or author papers included

Zhang Yao Wu Bu Liang Fan Ying Za Zhi 2009;11(6);425-426 Excluded Ditan Hospital Junxia Affiliated to Capital Cheng Medical University Zhong Guo Gan Zang Bing Za Zhi 2012;4(4);26-28 Included Danying Wu Gan Zang Bing Za Zhi 2010;13(2);139-140 Excluded General Hospital Xiaowei of Nanjing Military Hou Command Hu Jiu 2011;25(1);178-179 Included Case Yu report Duan (4) Ren Min Jun Yi 2011;54(3);215 Excluded PLA 155 Central Hongguang Hospital, , Henan Peng Gong Neng Yu Fen Zi Yi Xue Ying Xiang Xue 2012;1(4);297-298 Included Peili Tongji Hospital Affiliated Gao Zhong Guo Zhong Xi Yi Jie He Hua Za Zhi 2006;14(6);416- Excluded to Tongji Medical Xinsheng 417 College of Huazhong Huang University of Science Lin Chuang Bing Za Zhi 2008;20(1);26-28.32 Included and Tecnology Huanjun Case Zhong Xian Dai Shi Yong Yi Xue 2010;22(7);787-788 Excluded series Jianfeng Central Hospital type I Yao Xian Dai Shi Yong Yi Xue 2012;24(8);935-936 Included (17) Lidi Chen Zhong Hua Ling Chuang Gan Ran Bing Za Zhi 2010;3(2);76-79 Excluded Huazhong Taizhou Hospital Geng Affiliated to Zhong Hua Fang She Xue Za Zhi 2009;43(3);312-314 Excluded Caizheng Medical College Chen Lin Chuang Gan Dan Bing Za Zhi 2012;28(5);376-379 Included Huazhong Fang Zhong Hua Chuan Ran Bing Za Zhi 2007;25(6);373-374 Excluded Guoping Yang Chang Zhou Shi Yong Yi Xue 2010;26(5);292-293 Excluded Miaomiao Zhang Xian Dai Zhong Xi Yi Jie He Za Zhi 2012;21(7);767-768 Excluded The Third People's Huifen Hospital of Changzhou Zhang Jie Ru Fang She Xue Za Zhi 2012;21(12);987-990 Excluded Luxi Zhang Su Zhou Da Xue Xue Bao (Yi Xue Ban) 2009;29(6);1196-1198 Excluded Weimin Yao Xian Dai Zhong Xi Yi Jie He Za Zhi 2014;23(30);3371-3372 Included Lingdi Tongji Hospital Affiliated Zhu Zhong Hua Xian Dai Hu Li Za Zhi 2008;14(15);1702-1703 Excluded to Tongji Medical Xiuqin College Huazhong University of Science Zhu Hu Li Yan Jiu 2011;25(5);1272-1273 Included and Technology Xiuqin Chuang Yi Xue 2006;26(5);86 Excluded Lixin Zhang Zhong Hua Fang She Xue Za Zhi 2006;40(3);250-254 Excluded People's Guohua Hospital Ma Zhe Jiang Lin Chuang Yi Xue 2008;10(5);593-594 Included Xinguang Xu Haibo Zhong Guo Xiang Cun Yi Yao 2010;17(9);45 Included

Huang Zhong Xi Yi Jie He Gan Bing Za Zhi 2011;21(5);280-281+323 Excluded Xiehe Hospital Affiliated Xiaoming to Tongji Medical college Tang Fang She Xue Shi Jian 2012;27(11);1235-1237 Excluded Huazhong University of Wenjuan Science and Technology Hua Dong Ke Ji Da Xue Shuo Shi Xue Wei Lun Wen (2013) Included Tianhe Wu Zhong Hua Gan Zang Bing Za Zhi 2013;21(8);635-636 Excluded People's Hospital Xinjun Yu Zhong Guo Xiang Cun Yi Yao 2012;19(16);62-63 Excluded Mengyong Qing Zhu Zhong Guo Chao Sheng Zhen Duan 50 Nian Ji Di Shi Yu Jie Quan Guo Chao Sheng Yi Xue Xue Shu Hui Yi 2008;260- Excluded Zidong 261 Zhang Zhe Jiang Chuang Shang Wai Ke 2009;14(1);90 Excluded Manping Zhang Zhe Jiang Zhong Xi Yi Jie He Za Zhi 2013;23(8);647-649 Included Kui Chen Zhong Guo Yi Xue Ying Xiang Xue Za Zhi 2010;18(2);154-156 Excluded Shuang General Hospital of Armed Police Forces Zhang Zhong Guo Xian Dai Pu Tong Wai Ke Jin Zhan 2014;17(3);239- Included Wei 241 Chai Wu Jing Yi Xue 2007;18(11);828-830 Excluded Peoples Liberation Army Guojun General Hospital Ding Jie Fang Jun Yi Xue Xue Bao 2013;34(1);34-36+52 Included Pengpeng Zhang Zhong Hua Yi Xue Hui Di Shi Liu Ci Quan Guo Bing Excluded The First Affiliated Yanting Gan Yan Ji Gan Bing Xue Shu Hui Yi 2013;489-490 Hospital of Nanjing Zhang Medical University Lin Chuang Gan Dan Bing Za Zhi 2013;29(12);936-939 Included Yanting Chen Zhe Jiang Da Xue Shuo Shi Xue Wei Lun Wen (2006) Excluded Hongtan Case Chen Zhong Hua Xiao Hua Za Zhi 2006;26(4);224-226 Excluded series Yipeng type II Huang 2006 Nian Zhe Jiang Sheng Chao Sheng Yi Xue Xue Shu Nian (10) Excluded The First Affiliated Zhiliang Hui 2006;60-61 Hospital of Tao Zhe Jiang Da Xue Shuo Shi Xue Wei Lun Wen (2011) Excluded University Medical Jingjing College Ying Lin Chuang Fang She Xue Za Zhi 2011;30(9);1302-1305 Excluded Shihong Jiang Zhong Guo Chao Sheng Yi Xue Za Zhi 2008;24(10);951-955 Included Tian'an Zhu Zhong Hua Xiao Hua Za Zhi 2012;32(9);620-624 Included Wanlin Lin Hai Nan Yi Xue 2011;22(15);143-144 Excluded Li The Third People's Liu Shi Yong Gan Zang Bing Za Zhi 2008;11(2);107-109 Excluded Hospital of Changzhou Jianhong Gong Zhong Xi Yi Jie He Gan Bing Za Zhi 2012;22(3);144-145 Included Jing Supplementary Table 2. Information of 56 case reports Admission First No. Journal (Year) Affiliations Provinces date of author Pts. cases Not Zhong Da Hospital Affiliated to Dongnan Jian Kang Guan Li (2014) 1 Not reported reported University

Cao Xinhuang Hospital Affiliated to Zhong Guo Yi Xue Qian Yan Za Zhi (2012) Shanghai 1 Not reported Haixia Jiaotong University Medical College

Cao Zhong Guo Fa Yi Xue Hui Fa Yi Lin Chuang City Public Security Bureau Liaoning 1 1999.12 Zhe Xue Xue Shu Yan Tao Hui (2003) Criminal Investigation Detachment

Tongji Hospital Affiliated to Tongji Medical Chen 2013.1.12 Lin Chuang Xiao Hua Bing Za Zhi (2013) College of Huazhong University of 2 Shanglin Science and Technology 2013.2.27 Chen The First Hospital Affiliated to Zhejiang 2000.8.8 Zhong Hua Gan Zang Bing Za Zhi (2005) Zhejiang 2 Weixing University Medical College 2002.9.11 Cheng Beijing Ditan Hospital Affiliated to Capital 2009.5.22 Zhong Guo Gan Zang Bing Za Zhi (2012) Beijing 2 Danying Medical University 2009.6.4 2011.12.4 Cong Dang Dai Yi Xue (2014) Wendeng City People's Hospital 3 2013.2.11 Ming 2013.2.22

Dai Sir Run Run Shaw Hospital Affiliated to Zhong Hua Xiao Hua Za Zhi (2007) Zhejiang 1 Not reported ning Zhejiang University Medical College

Dong The First Hospital Affiliated to Zhejiang 2008.9.30 Zhong Hua Xian Dai Hu Li Za Zhi (2011) Zhejiang 2 Qunya University Medical College 2008.10.8 Fang Zhong Hua Lin Chuang Yi Shi Za Zhi (2013) Tongling County People's Hospital Anhui 1 Not reported Jiman 2005.12.14 Fang Zhong Ri You Hao Yi Yuan Xue Bao (2010) The -Japan Friendship Hospital Beijing 3 2006.6.12 Long 2009.7.9 Guo Shan Xi Zhong Yi (2009) University of TCM Tianjin 1 2007.4.13 Qingbo Hong Yong Gui Zhou Yi Yao (2012) Chishui City People's Hospital 1 2011 Hou Nanjing General Hospital of Nanjing 2008.3 Hu Li Yan Jiu (2011) Jiangsu 2 Yu Military Command 2009.2 Zhong Guo Ling Chuang Yi Xue Ying Xiang Za Affiliated Hospital of College of Not reported Hu Jinsong Zhejiang 2 Zhi (2014) Arts and Science Not reported Hua Renji Hospital Affiliated to Shanghai Wei Chang Bing Xue (2010) Shanghai 1 Not reported Jing Jiaotong University Medical College Tongji Hospital Affiliated to Tongji Medical 2004.12.31 Huang Lin Chuang Xiao Hua Bing Za Zhi (2008) College of Huazhong University of Hubei 3 2006.3.23 Huanjun Science and Technology 2006.10.3 Lan Zhou Da Xue Shuo Shi Xue Wei Lun Wen Lai Ruimin University Gansu 1 2012.6.12 (2013) Li PLA 302 Hospital Liver Failure Treatment Gan Zang (2010) Beijing 1 2009.4.16 Chen Research Center

Zhong Hua Hu Li Xue Hui 2009 Nian Quan Li Guo Hu Li Guan Li Xue Shu Jiao Liu Ji Zhuan Huangshi City Fifth Hospital Hubei 1 Not reported Hong Ti Jiang Zuo Hui Yi (2009)

Li Zhongshan Hospital Affiliated to Fudan 2008.6.27 Zhong Guo Ling Chuang Yi Xue (2009) Shanghai 2 Hong University 2008.12.26 The Second People's Hospital of Li Jianping Zhong Hua Gan Dan Wai Ke Za Zhi (2001) Jiangsu 1 Not reported City Chuan Ran Bing Zhen Zhi Gao Feng Lun Tan Li 2007.1.20 Ji 2007 Nian Zhe Jiang Sheng Gan Ran Bing City People's Hospital Zhejiang 2 Libo Xue, Gan Bing Xue Xue Shu Nian Hui (2007) 2007.3.8

Li Shangri Zhong Xi Yi Jie He Gan Bing Za Zhi (2007) The Second Hospital of Huangshi City Hubei 1 2006.6

Li Not Qiu Yi Wen Yao (2012) Not reported 1 Not reported Xinqiao reported 2004.12.24 Li Yuxiang Lin Chuang Gan Dan Bing Za Zhi (2006) First Hospital of Jilin 2 2005.1.24 Li The Second Hospital Affiliated to Zhejiang Zhong Hua Nei Ke Za Zhi (2005) Zhejiang 1 Not reported Zhimin university Medical College Liang Shan Dong Zhong Yi Za Zhi (2011) Xinchang County TCM Hospital Zhejiang 1 2010.6.9 Daming 2007.2 ~ Liang 2009.1 Hu Li Xue Bao (2009) Lishui City Central Hospital Zhejiang 2 Jianli 2007.2 ~ 2009.1 School of Biomedical Sciences, Faculty of Lin Journal of Hepatology Medicine, The Chinese University of Hong Hong Kong 1 Not reported Ge Kong Gulou Hospital Affiliated to Nanjing Liu Huiyan Jian Kang Bo Lan (2011) Jiangsu 1 Not reported University Medical College Lu The First Hospital Affiliated to Zhejiang Hu Li Yu Kang Fu (2013) Zhejiang 1 2012.1.12 Dan University Medical College 2005.11.1 Pan Jinhui Jiang Xi Zhong Yi Yao (2008) Xianju TCM Hospital, Taizhou Zhejiang 2 2007.11.2 Tongji Hospital Affiliated to Tongji Medical Pei Fang She Xue Shi Jian (2008) College of Huazhong University of Hubei 1 Not reported Yigang Science and Technology Gong Neng Yu Fen Zi Yi Xue Ying Xiang Xue Peng Peili PLA 155 Central Hospital, Kaifeng Henan 1 2010.2.19 (2012) Shi 2012.3.5 Jian Kang Bi Du (2012) City People's Hospital Zhejiang 2 Yunzhen 2012.1.26 Zhe Jiang Yi Xue Hui 2007 Nian Feng Shi Bing The First Hospital Affiliated to Zhejiang Sun Deben Zhejiang 1 Not reported Nian Hui (2007) University Medical College Sun Nanjing General Hospital of Nanjing Zhong Guo Yi Yuan Yao Xue Za Zhi (2011) Jiangsu 1 2009.12.14 Lingjun Military Command Sun Wei Chang Bing Xue He Gan Bing Xue Za Zhi The Second Affiliated Hospital of Xi'an 2010.12.30 2 Lu (2014) Jiaotong University 2013.5.13 Tang 2010.11.3 Zhong Guo Xiang Cun Yi Yao Za Zhi (2011) County People's Hospital Zhejiang 2 Xiaogang 2010.12.20 Tian The First Hospital Affiliated to Beijing Jia Ting Yi Yao (2014) Beijing 1 Not reported Gengshan University Wang Nanjing Hospital Affiliated to Nanjing 2011.7.20 Zhong Guo Yi Shi Za Zhi (2012) Jiangsu 2 Zhibing Medical University 2011.10.14 Wang Zhong Guo Yi Xue Gong Cheng (2013) Yuhuangding Hospital Shandong 1 Not reported Li Wang Xian Dai Yi Xue (2011) Jiangyin City Xu Xiake Hospital Jiangsu 1 Not reported Qiang 2005.7.13 Wu 2005.12.17 Zhong Hua Gan Zang Bing Za Zhi (2007) Xinchang County People's Hospital Zhejiang 4 Xinjun 2005.12.23 2006.1.12 Wu Quan Ke Yi Xue Lin Chuang Yu Jiao Yu (2012) Second Hospital of Yinzhou, Zhejiang 1 2010.12.28 Yiqun

Xiao Yujie Xu Zhou Yi Xue Yuan Xue Bao (2010) Medical College Jiangsu 1 2009.6.22

Yan Jinggangshang University Affiliated Shi Yong Gan Zang Bing Za Zhi (2005) 1 Not reported Hong Hospital Yan Zhejiang Provincial Hospital of Traditional 2006.11 Zhong Xi Yi Jie He Gan Bing Za Zhi (2009) Zhejiang 2 Ying Chinese Medicine 2007.3 Yang Yi Yao Qian Yan (2012) Dali Prefecture People's Hospital Yunnan 1 2011.7.26 Bao Yang University of Chinese 2009.6.4 Xin Zhong Yi (2011) 2 Sai Medicine 2009.5.21 Zhang The Third People's Hospital of Zhenjiang 2011.10. Qi Qi Ha Er Yi Xue Yuan Xue Bao (2013) Jiangsu 2 Huamei City 2012.1 Zhang The First Bethune Hospital of Jilin Xian Dai Zhong Xi Yi Jie He Za Zhi (2011) Jilin 1 2006.5 Qianqian University Zhang Bei Jing Yi Xue (2011) Children's Hospital Affiliated to Capital Beijing 2 2008.10.27 Yanling Institute of Pediatrics Yanling Institute of Pediatrics 2009.8.29 Zhou Yao Wu Bu Liang Fan Ying Za Zhi (2012) 302 Military Hospital of China Beijing 1 2011.12.14 Yanping

Zhu Zhong Hua Yi Xue Hui Di Shi Ci Quan Guo Guangzhou General Hospital of Guangdong 1 Not reported Xiansheng Chao Sheng Yi Xue Xue Shu Hui Yi (2009) Guangzhou Military Command Supplementary Table 3. Study quality of 84 case reports First author Q1 Q2 Q3 Q4 Q5 Q6 Not reported NA Yes Yes Yes No No Cao Haixia NA Yes Yes Yes No No Cao Zhe NA Yes Yes Yes No Yes case 1 NA Yes Yes Yes Yes Yes Chen Shanglin case 2 NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Chen Weixing case 2 NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Cheng Danying case 2 NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Cong Ming case 2 NA Yes Yes Yes Yes Yes case 3 NA Yes Yes Yes Yes Yes Dai ning NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Dong Qunya case 2 NA Yes Yes Yes Yes Yes Fang Jiman NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Fang Long case 2 NA Yes Yes Yes Yes Yes case 3 NA Yes Yes Yes Yes Yes Guo Qingbo NA Yes Yes Yes Yes Yes Hong Yong NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Hou Yu case 2 NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Hu Jinsong case 2 NA Yes Yes Yes Yes Yes Hua Jing NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Huang Huanjun case 2 NA Yes Yes Yes Yes Yes case 3 NA Yes Yes Yes Yes Yes Lai Ruimin NA Yes Yes Yes Yes Yes Li Chen NA Yes Yes Yes Yes Yes Li Hong NA Yes Yes Yes Yes No case 1 NA Yes Yes Yes Yes Yes Li Hong case 2 NA Yes Yes Yes Yes Yes Li Jianping NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Li Libo case 2 NA Yes Yes Yes Yes Yes Li Shangri NA Yes Yes Yes No No Li Xinqiao NA Yes Yes Yes No No case 1 NA Yes Yes Yes Yes Yes Li Yuxiang case 2 NA Yes Yes Yes Yes Yes NA Yes Yes Yes Yes Yes Liang Daming NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Liang Jianli case 2 NA Yes Yes Yes Yes Yes Liu Huiyan NA Yes Yes Yes No No Lu Dan NA Yes Yes Yes Yes Yes Pan Jinhui case 1 NA Yes Yes Yes Yes Yes case 2 NA Yes Yes Yes Yes Yes Pei Yigang NA Yes Yes Yes No No Peng Peili NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Shi Yunzhen case 2 NA Yes Yes Yes Yes Yes Sun Deben NA Yes Yes Yes Yes Yes Sun Lingjun NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Sun Lu case 2 NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Tang Xiaogang case 2 NA Yes Yes Yes Yes Yes Tian Gengshan NA Yes Yes Yes No No case 1 NA Yes Yes Yes Yes Yes Wang Zhibing case 2 NA Yes Yes Yes Yes Yes Wang Li NA Yes Yes Yes No No Wang Qiang NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes case 2 NA Yes Yes Yes Yes Yes Wu Xinjun case 3 NA Yes Yes Yes Yes Yes case 4 NA Yes Yes Yes Yes Yes Wu Yiqun NA Yes Yes Yes Yes Yes Xiao Yujie NA Yes Yes Yes Yes No Yan Hong NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes No No Yan Ying case 2 NA Yes Yes Yes Yes Yes Yang Bao NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Yang Sai case 2 NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Zhang Huamei case 2 NA Yes Yes Yes Yes Yes Zhang Qianqian NA Yes Yes Yes Yes Yes case 1 NA Yes Yes Yes Yes Yes Zhang Yanling case 2 NA Yes Yes Yes No Yes Zhou Yanping NA Yes Yes Yes Yes Yes Zhu Xiansheng NA Yes Yes Yes Yes Yes Lin Ge NA Yes Yes Yes Yes Yes Supplementary Table 4. Information of 31 case series (type I) First No. Journal (Year) Affiliations Province Periods author Pts

Cai 2010~ Zhong Guo Shi Yong Yi Yao (2013) Jieyang People's Hospital Guangdong 10 Shaolong 2012

Zhe Jiang Sheng Zhong Xi Yi Jie He Xue Hui Chen Xiao Hua Zhuan Ye Di Ba Ci Xue Shu Nian Hui The First Affiliated Hospital of Zhejiang 1996.1~ Zhejiang 20 Hongtan Ji Sheng Zhong Xi Yi Jie He Xiao Hua Xi Ji University Medical College 2006.9 Bing Xin Jin Zhan Xue Xi Ban (2007)

Chen Taizhou Hospital Affiliated to Wenzhou 1998.1~ Lin Chuang Gan Dan Bing Za Zhi (2012) Zhejiang 45 Huazhong Medical College 2011.5

Zhongshan Hospital Affiliated to Fudan 2006.1~ Gao Hong Journal of Digestive Diseases (2012) Shanghai 5 University 2010.8

Nanjing Drum Tower Hospital, The Affiliated 2008.6~ Gu Chao Zhong Hua Xiao Hua Za Zhi (2010) Jiangsu 7 Hospital of Nanjing University Medical School 2010.5

2011.9~ Guo Wei Zhong Hua Ling Chuang Yi Shi Za Zhi (2012) Air Force General Hospital of PLA Beijing 5 2012.3

2006~ Hu Zhibin Zhong Guo CT He MRI Za Zhi (2011) Yingcheng People's Hospital Hubei 5 2011

Huang 2004.8~ Xian Dai Zhong Xi Yi Jie He Za Zhi (2009) Yangzhou Hongquan Hospital Jiangsu 8 Jiguo 2008.4

Xinchang County Hospital of Traditional 2008.1~ Jin Ruijun Yi Xue Ying Xiang Xue Za Zhi (2014) Zhejiang 16 Chinese Medicine 2013.5

Li Affiliated Hospital of Medical College of 2005.6~ Zhong Guo Xian Dai Yi Sheng (2012) Guangdong 12 Liangping Jiaying University 2012.6

Ma 1996.12~ Zhe Jiang Lin Chuang Yi Xue (2008) Xianju County People's Hospital Zhejiang 16 Xinguang 2006.12

2008.1~ Qiao Yan Dang Dai Hu Shi (2014) The First People's Hospital of Yancheng Jiangsu 6 2013.6

Wu An Hui Yi Ke Da Xue Bo Shi Xue Wei Lun 2007.3~ Anhui Medical University Anhui 10 Xingwang Wen (2012) 2010.2

2005.1~ Xu Haibo Zhong Guo Xiang Cun Yi Yao (2010) Xianju County People's Hospital Zhejiang 14 2009.12

Xu 2003.1~ Lin Chuang Hui Cui (2007) The First Hospital of 6 Meimei 2007.1

Xu Zhong Hua Wei Zhong Zheng Yi Xue Za Zhi Wuyi County Hospital of Traditional Chinese 2006.1~ Zhejiang 42 Xiaojun (2010) Medicine 2009.12

Xue The First Affiliated Hospital of Nanjing 2006~ Jiang Su Yi Yao (2014) Jiangsu 5 Xinquan Medical University 2014

Yang 2011.7~ Shi Yong Fang She Xue Za Zhi (2014) The First People's Hospital of Jiujiang Jiangxi 4 Chunjing 2013.6

Yang The First Affiliated Hospital of 2000.7~ Yi Xue Ying Xiang Xue Za Zhi (2010) Jiangsu 32 Jianjun University 2009.11

The Second Xiangya Hospital of Central 2005.1~ Yang Li Gan Zang (2009) Hunan 6 South University 2008.12

2004.6~ Yao Lidi Xian Dai Shi Yong Yi Xue (2012) Huzhou Central Hospital Zhejiang 17 2010.1

Yao 2005.1~ Xian Dai Zhong Xi Yi Jie He Za Zhi (2014) The Third People's Hospital of Changzhou Jiangsu 16 Lingdi 2012.12 Xiehe Hospital Affiliated to Tongji Medical Hua Dong Ke Ji Da Xue Shuo Shi Xue Wei 2010.4~ Ye Tianhe College Huazhong University of Science and Hubei 20 Lun Wen (2013) 2012.7 Technology Lishui Hospital of Traditional Chinese 2006.10~ Ye Yuzhu Hu Xiu Za Zhi (2013) Zhejiang 4 Medicine 2012.5

Zhong Guo Yi Xue Ying Xiang Xue Za Zhi Zhongshan Hospital Affiliated to Fudan Shanghai; 2002.11~ Yu Shun 6 (2013) University; Fujian Provincial Hospital Fujian 2012.2 2005.2~ Zhang Kui Zhe Jiang Zhong Xi Yi Jie He Za Zhi (2013) Xinchang County People's Hospital Zhejiang 18 2012.6

Zhang Xianju County Hospital of Traditional Chinese 2002.6~ Zhe Jiang Zhong Yi Za Zhi (2007) Zhejiang 17 Zhiqin Medicine 2007.3

Zhong The First Affiliated Hospital of 2008.1~ Jiang Xi Yi Yao (2012) Jiangxi 5 Lan University 2011.10.

The First Affiliated Hospital of Zhejiang 2009.8~ Zhou Hua Korean Journal of Radiology (2014) Zhejiang 16 University Medical College 2011.2

Zhu The China-Japan Friendship Hospital Ministry 2005 ~ Lin Chuang Fang She Xue Za Zhi (2011) Beijing 3 Xianjin of Health 2009 Tongji Hospital Affiliated to Tongji Medical Zhu 2004.12~ Hu Li Yan Jiu (2011) College Huazhong University of Science and Hubei 6 Xiuqin 2009.12 Technology Supplementary Table 5. Quality of 31 case series (type I) First author Q1 Q2 Q3 Q4 Q5 Q6 Cai Shaolong No Yes Yes Yes Yes Yes Chen Huazhong No Yes Yes Yes Yes Yes Gao Hong No Yes Yes Yes No Yes Gu Chao No Yes Yes Yes Yes Yes Guo Wei No Yes Yes Yes Yes Yes Hu Zhibin No Yes Yes Yes Yes Yes Huang Jiguo No Yes Yes Yes Yes Yes Ma Xinguang No Yes Yes Yes Yes Yes Qiao Yan No Yes Yes Yes Yes Yes Xu Haibo No Yes Yes Yes Yes Yes Xu Meimei No Yes Yes Yes Yes Yes Xu Xiaojun No Yes Yes Yes Yes Yes Yang Chunjing No Yes Yes Yes Yes Yes Yang Li No Yes Yes Yes Yes Yes Yao Lingdi No Yes Yes Yes Yes Yes Ye Tianhe No Yes Yes Yes Yes Yes Ye Yuzhu No Yes Yes Yes Yes Yes Zhang Zhiqin No Yes Yes Yes Yes Yes Zhong Lan No Yes Yes Yes Yes Yes Zhu Xiuqin No Yes Yes Yes Yes Yes Supplementary Table 6. Information of 19 case series (type II) First Journal (Year) Affiliations Province Periods author

Ding Jie Fang Jun Yi Xue Yuan Xue Bao 2003.8~ Peoples Liberation Army General Hospital Beijing Pengpeng (2013) 2012.5

Gong Zhong Xi Yi Jie He Gan Bing Za Zhi 2005.1~ The Third People's Hospital of Changzhou Jiangsu Jing (2012) 2010.7

Gu Qi Qi Ha Er Yi Xue Yuan Xue Bao 1999.1~ Xianju County People's Hospital Zhejiang Meichun (2004) 2003.5

Guo Da Lian Yi Ke Da Xue Shuo Shi Xue 2011.9~ Air Force General Hospital, PLA Beijing Wei Wei Lun Wen (2013) 2012.12

Jiang Zhong Guo Chao Sheng Yi Xue Za Zhi The First Affiliated Hospital of Zhejiang 2000.8~ Zhejiang Tian'an (2008) University Medical College 2007.9

Li 2011.8~ Zhong Guo CT He MRI Za Zhi (2014) Affiliated Hospital of Xuzhou Medical College Jiangsu Zeng 2014.2

Li Di Er Shi Yi Ci Quan Guo Zhong Xi Yi Affiliated Hospital of Medical 2010.2~ Guizhou Hong Jie He Gan Bing Xue Shu Hui Yi (2012) College 2012.3 Xiehe Hospital Affiliated to Tongji Medical Li 2010.1~ Hu Li Xue Za Zhi (2013) college Huazhong University of Science and Hubei Ling 2013.1 Technology Li 2009.4~ Hu Shi Jin Xiu Za Zhi (2014) Taizhou People's Hospital Jiangsu Xiaoqin 2013.5

Li Lin Chuang Gan Dan Bing Za Zhi The First Affiliated Hospital of Anhui Medical 2007.6~ Anhui Yang (2011) University 2010.2

Li Drum Tower Hospital Affiliated to Nanjing 2005.6~ Zhong Guo Lin Chuang Yan Jiu (2012) Jiangsu Yujiang University Medical School 2011.6

Li Beijing Youan Hospital, Capital Medical 2009.4~ Ci Gong Zheng Cheng Xiang (2011) Beijing Yunfang University 2011.8

Wang 2009.10~ Shou Du Yi Ke Da Xue Xue Bao (2014) Peking University People's Hospital Beijing Junyao 2014.8

Zhong Hua Zhong Yi Yao Xue Hui Xun Not Quan Guo Di Shi Si Ci Gan Dan Bing The Sixth People's Hospital of Zhejiang Yunhao reported Xue Shu Hui Yi (2010)

Zhang 2006.2~ Yi Xue Ying Xiang Xue Za Zhi (2012) Sanmen People's Hospital Zhejiang Genhua 2010.3

Zhang 2007.10~ Shi Yong Yi Xue Za Zhi (2011) Lishui People's Hospital Zhejiang Jingjing 2010.5

Zhang Zhong Guo Xian Dai Pu Tong Wai Ke 2005.9~ General Hospital of Armed Police Forces Beijing Wei Jin Zhan (2014) 2011.12

Zhang Lin Chuang Gan Dan Bing Za Zhi The First Affiliated Hospital of Nanjing 2008.8~ Jiangsu Yanting (2013) Medical University 2013.5

Zhu The First Affiliated Hospital of Zhejiang 2008.8~ Zhong Hua Xiao Hua Za Zhi (2012) Zhejiang Wanlin University Medical College 2011.8 Supplementary Table 7. Quality of 19 case series (type II) First author Q1 Q2 Q3 Q4 Q5 Q6 Ding Pengpeng No Yes Yes Yes Yes Yes Gong Jing No Yes Yes Yes Yes Yes Gu Meichun No No Yes Yes No No Guo Wei No Yes Yes Yes No No Jiang Tian'an No Yes No Yes No No Li Zeng No Yes No Yes No No Li Hong No No Yes No No No Li Ling No Yes Yes Yes Yes Yes Li Xiaoqin No Yes Yes No Yes Yes Li Yang No Yes Yes Yes Yes Yes Li Yujiang No Yes Yes Yes Yes Yes Li Yunfang No Yes Yes Yes Yes No Wang Junyao No Yes Yes Yes Yes Yes Xun Yunhao No Yes Yes Yes Yes Yes Zhang Genhua No Yes No Yes No No Zhang Jingjing No Yes No Yes Yes Yes Zhang Wei No Yes Yes Yes Yes Yes Zhang Yanting No Yes Yes Yes Yes Yes Zhu Wanlin No Yes Yes Yes Yes Yes