Integrative Analysis of the Plasma Proteome and Polygenic Risk of Cardiometabolic Diseases
bioRxiv preprint doi: https://doi.org/10.1101/2019.12.14.876474; this version posted December 19, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases Scott C. Ritchie1-5,*, Yingying Liu6,7, Samuel A. Lambert1-3,8, Shu Mei Teo1,2, Petar Scepanovic1-3, Jonathan Marten1,3,5, Sohail Zahid9,10, Mark Chaffin9, Gad Abraham1,2,11, Nicole Soranzo12, Stephen Burgess13, Brian G. Drew7,14, Sekar Kathiresan15, Anna C. Calkin6,14, Amit V. Khera9,10,16,17, John Danesh3-5,8,12,18, Adam S. Butterworth3-5,8,12,18, Michael Inouye1-5,8,11,19,* 1Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK 2Cambridge Baker Systems Genomics Initiative, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia 3British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK 4British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK 5National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK 6Lipid Metabolism & Cardiometabolic Disease Laboratory, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia
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