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Triclocarban Triclocarban sc-213106 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Triclocarban STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH0 HAZARD INSTABILITY0 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS C13-H9-Cl3-N2-O, "carbanilide, 3, 4, 4' -trichloro-", "N-(4-chlorophenyl)-N' -(3, 4-dichlorophenyl)urea", "N-(3, 4-dichlorophenyl)-N' -(4-chlorophenyl)urea", "3, 4, 4' -trichlorodiphenylurea", triclocarban, "urea, N-(4-chlorophenyl)-N' -(3, 4-dichlorophenyl)-", Cusiter, Cutisan, "ENT 26925", Genoface, Procutene, NSC-72005, Solubacter, TCC, disinfectant Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 0 Body Contact: 0 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 2 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 8 EMERGENCY OVERVIEW RISK Limited evidence of a carcinogenic effect. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-existing organ (e. g. EYE ! Although the material is not thought to be an irritant, direct contact with the eye may cause transient discomfort characterized by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. SKIN ! The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting. ! Open cuts, abraded or irritated skin should not be exposed to this material. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ! The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting. ! Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. CHRONIC HEALTH EFFECTS ! There has been concern that this material can cause cancer or mutations, but there is not enough data to make an assessment. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Triclocarban causes an alteration in gene expression in human cells that is normally seen with exposure to testosterone. In rats, exposure caused abnormally enlarged prostate glands. This is the first time an endocrine disrupter has been shown to increase the effects of hormones rather than blocking or damping their activity. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % 3,4,4'-trichlorocarbanilide 101-20-2 >98 Section 4 - FIRST AID MEASURES SWALLOWED " Immediately give a glass of water. " First aid is not generally required. If in doubt, contact a Poisons Information Center or a doctor. EYE ! If this product comes in contact with eyes: " Wash out immediately with water. " If irritation continues, seek medical attention. SKIN ! If skin or hair contact occurs: " Flush skin and hair with running water (and soap if available). " Seek medical attention in event of irritation. INHALED " If dust is inhaled, remove from contaminated area. " Encourage patient to blow nose to ensure clear passage of breathing. " If irritation or discomfort persists seek medical attention. NOTES TO PHYSICIAN ! Treat symptomatically. 2 of 8 Section 5 - FIRE FIGHTING MEASURES Vapour Pressure (mmHG): Negligible Upper Explosive Limit (%): Not available. Specific Gravity (water=1): Not available Lower Explosive Limit (%): Not available EXTINGUISHING MEDIA " Foam. " Dry chemical powder. FIRE FIGHTING " Alert Emergency Responders and tell them location and nature of hazard. " Wear breathing apparatus plus protective gloves. When any large container (including road and rail tankers) is involved in a fire, consider evacuation by 100 metres in all directions. GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS " Combustible solid which burns but propagates flame with difficulty. " Avoid generating dust, particularly clouds of dust in a confined or unventilated space as dusts may form an explosive mixture with air, and any source of ignition, i.e. flame or spark, will cause fire or explosion. Dust clouds generated by the fine grinding of the solid are a particular hazard; accumulations of fine dust may burn rapidly and fiercely if ignited. Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), hydrogen chloride, phosgene, nitrogen oxides (NOx), other pyrolysis products typical of burning organic material. FIRE INCOMPATIBILITY ! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result. PERSONAL PROTECTION Glasses: Chemical goggles. Gloves: Respirator: Particulate Section 6 - ACCIDENTAL RELEASE MEASURES MINOR SPILLS " Clean up waste regularly and abnormal spills immediately. " Avoid breathing dust and contact with skin and eyes. " Wear protective clothing, gloves, safety glasses and dust respirator. " Use dry clean up procedures and avoid generating dust. " Vacuum up or sweep up. NOTE: Vacuum cleaner must be fitted with an exhaust micro filter (HEPA type) (consider explosion-proof machines designed to be grounded during storage and use). " Dampen with water to prevent dusting before sweeping. " Place in suitable containers for disposal. Environmental hazard - contain spillage. MAJOR SPILLS ! Environmental hazard - contain spillage. Moderate hazard. " CAUTION: Advise personnel in area. " Alert Emergency Responders and tell them location and nature of hazard. Section 7 - HANDLING AND STORAGE PROCEDURE FOR HANDLING " Avoid all personal contact, including inhalation. " Wear protective clothing when risk of exposure occurs. Empty containers may contain residual dust which has the potential to accumulate following settling. Such dusts may explode in the presence of an appropriate ignition source. " Do NOT cut, drill, grind or weld such containers. " In addition ensure such activity is not performed near full, partially empty or empty containers without appropriate workplace safety authorisation or permit. RECOMMENDED STORAGE METHODS " Polyethylene or polypropylene container. " Check all containers are clearly labelled and free from leaks. 3 of 8 STORAGE REQUIREMENTS ! Observe manufacturer's storing and handling recommendations. Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION EXPOSURE CONTROLS TWA STEL STEL Peak TWA Source Material TWA ppm Peak ppm Notes mg/m# ppm mg/m# mg/m# F/CC ___________ ___________ _______ _______ _______ _______ _______ _______ _______ _______ 3,4,4'- Canada - trichlorocarbanilide Ontario (Particles (Insoluble 10 (I) Occupational or Poorly Soluble) Exposure Limits Not Otherwise) 3,4,4'- Canada - trichlorocarbanilide British (Particles (Insoluble Columbia 10 (N) or Poorly Soluble) Occupational Not Otherwise Exposure Limits Classified (PNOC)) 3,4,4'- trichlorocarbanilide Canada - (Specified (PNOS) / Ontario Particules (insolubles 3 (R) Occupational ou peu solubles) non Exposure Limits précisées par ailleurs) US - 3,4,4'- Tennessee trichlorocarbanilide Occupational (Particulates not 5 Exposure Limits otherwise regulated - Limits For Air Respirable fraction) Contaminants US - California 3,4,4'- Permissible trichlorocarbanilide Exposure Limits (Particulates not 5 (n) for Chemical otherwise regulated Contaminants Respirable fraction) Bold print identifies substances for which the Oregon Permissible 3,4,4'- Exposure US - Oregon trichlorocarbanilide Limits (PELs) Permissible (Particulates not - 10 are different Exposure Limits otherwise regulated than the (Z-1) (PNOR) (f) Total federal Dust) Limits. PNOR means “particles not otherwise regulated.” 3,4,4'- US - Michigan trichlorocarbanilide Exposure Limits (Particulates not 5 for Air otherwise regulated, Contaminants Respirable dust) US - Oregon 3,4,4'- Bold print Permissible trichlorocarbanilide identifies - 5 Exposure Limits (Particulates not substances 4 of 8 for which the Oregon Permissible Exposure Limits (PELs) are different otherwise regulated than the (Z-1) (PNOR) (f) federal Respirable Fraction) Limits. PNOR means “particles not otherwise regulated.” US - Wyoming 3,4,4'- Toxic and trichlorocarbanilide Hazardous (Particulates not Substances 5 otherwise regulated Table Z1 Limits (PNOR)(f)- for Air Respirable fraction) Contaminants 3,4,4'- Canada - See trichlorocarbanilide Prince Edward Appendix B (Particles (Insoluble Island 10 current or Poorly Soluble) Occupational TLV/BEI [NOS] Inhalable Exposure Limits
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