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Hypoalbuminemia Predicts Intensive Care Need Among Adult Inpatients with Community Acquired Pneumonia: a Cross Sectional Study

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Hypoalbuminemia Predicts Intensive Care Need Among Adult Inpatients with Community Acquired Pneumonia: a Cross Sectional Study Original Article Hypoalbuminemia predicts intensive care need among adult inpatients with community acquired pneumonia: a cross sectional study Muhammad Adnan1, Naheed Hashmat2, Muhammad Latif3, Zahra Ali1, Tayyaba Rahat1 1 PHRC Research Center, Fatima Jinnah Medical University, Lahore, Pakistan 2 Departments of Medicine, Sir Ganga Ram Hospital, Lahore, Pakistan 3 Departments of Medicine, Akhtar Saeed Medical and Dental College, Lahore, Pakistan Abstract Introduction: Various scales helped physicians to decide the site of care of pneumonia patients, but had certain limitations. Literature review suggested that serum albumin and B/A ratio predict the site of care but more evidences were required. Therefore, the study was aimed to evaluate the role of serum albumin and B/A ratio in the prediction of intensive care need among patients with community acquired pneumonia. Methodology: The cross-sectional analytical study enrolled 134 adult inpatients with pneumonia from Sir Ganga Ram Hospital, Lahore, Pakistan during September 2014 to December 2016. Serum albumin, creatinine and urea levels were estimated; and BUN, B/A ratio and CURB- 65 scores were calculated to predict the need of ICU. Results: Overall mean age was 50 ± 21 years, and 54.5% patients were females. The patients (19.4%) who required treatment in ICU had significantly lower albumin levels (p = 0.001); elevated BUN levels (p = 0.003), B/A ratio (p = 0.001) and CURB-65 score (p = 0.038); and longer hospital stay (p = 0.002). Hypoalbuminemia showed significant association with the requirement of ICU (OR: 7.956; p = 0.001). The optimal cut-off point of serum albumin to predict ICU need was 3.4 g/dL (50% sensitivity; 89% specificity). Low serum albumin was revealed as a good predictor of requiring treatment in ICU (AUC 0.718). Conclusions: Hypoalbuminemia was a good predictor of requiring ICU treatment. Elevated B/A ratio and BUN levels showed significant association with ICU need. Serum albumin estimation before hospitalization might be used independently or additional with established criteria to decide the site of care. Key words: Blood urea nitrogen; hypoalbuminemia; hospitalization; intensive care unit; pneumonia. J Infect Dev Ctries 2018; 12(8):636-641. doi:10.3855/jidc.9971 (Received 22 November 2017 – Accepted 12 July 2018) Copyright © 2018 Adnan et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction in CURB-65 scale assessment for the presence or Community acquired pneumonia (CAP) remained absence of confusion may vary from physician to one of the major reasons for hospitalization among physician. Whereas PSI scale requires more than twenty adult patients [1]. In the United States (US), about one parameters to calculate scores that costs more time and million adult pneumonia patients get hospitalized each money. year [2]. In Pakistan, overall frequency of self-reported Few retrospective and observational studies used lifetime pneumonia was 10% [3]; and treatment cost of biochemical markers such as serum albumin, and blood hospitalization depending upon the severity of disease urea nitrogen to serum albumin (B/A) ratio to evaluate ranged from 80-598 USD [4]. Therefore, taking their role in the prediction of ICU admission [7-9]. decision about the site of care is very crucial as the Elevated B/A ratio as an independent factor had avoidable hospital admissions put significant burden on significant association with ICU need among Japanese limited resources [5,6] Infectious Diseases Society of patients with pneumonia [7]. Both, elevated B/A ratio America (IDSA) and American Thoracic Society (ATS) and low serum albumin predicted the risk of requiring recommend CURB-65 and Pneumonia Severity Index ICU treatment; however low serum albumin was a (PSI) scales for the initial assessment of severity of better predictor than B/A ratio among Turkish patients pneumonia [5]. Same recommendations have been [8]. Low serum albumin also showed significant endorsed by Pakistan Chest Society for making association with ICU admission among Spanish decision about the site of care [6]. However, there are patients [9]. certain limitations of using these scales. For example, Adnan et al. – Low albumin predicts ICU admission J Infect Dev Ctries 2018; 12(8):636-641. A review study on CAP in Pakistan included eleven by Jaffe-Reaction [13]; and serum albumin by studies published from 2003 to 2013 and reported that bromocresol green (BCG) method [14]. Blood urea most of them were observational, retrospective, clinical nitrogen (BUN) was calculated by multiplying blood and microorganisms’ specific. It was suggested that urea level (mg/dL) to 0.47 and B/A ratio by dividing more comprehensive studies were essentially required BUN over serum albumin level. to revise the in-practice treatment guidelines for adult Pakistani patients with CAP [10]. A recent nationwide CURB-65 scale study from Pakistan reported 39.7% disagreement It was used to measure the severity of community between physician’s decisions regarding the site of care acquired pneumonia. It included five parameters i.e. age and the recommendations of CURB-65 scale [11]. ≥ 65 years; blood urea (≥ 20 mg/dL); respiratory rate (≥ Limited data on severity and prognosis of 30 breaths per minute); low blood pressure (SBP ≤ 90 community acquired pneumonia from Pakistan and mmHg, DBP ≤ 60 mmHg); and confusion (present). other studies on the prediction of ICU requirement Each positive parameter had been assigned with one suggested evaluating the role of serum albumin and B/A score, and none was given to negative parameter. As per ratio in the prediction of ICU admission among adult interpretation of CURB-65 scale, the patients who score CAP patients. 0-1 should be treated as outpatient; who score 2 require short hospital stay; who score 3 require indoor Methodology treatment; and who score 4-5 require intensive care Bioethical Clearance [15]. Ethical approval was obtained from the Institutional Ethical Review Board, Fatima Jinnah Medical Statistical Analysis University/ Sir Ganga Ram Hospital, Lahore on 30th Data were entered and analyzed by using Statistical September 2014 (No.1177 I.E.R.B). Informed written Package for Social Sciences (SPSS) version 20. consent was also obtained from all participants. Qualitative and quantitative variables were described by using number (percentage) and mean ± standard Study Design, Setting and Duration deviation, respectively. Comparison of variant The cross-sectional analytical study was carried out characteristics underlying study was discussed by using at Sir Ganga Ram Hospital, Lahore; and data was t-test and chi square test. Odds ratios were calculated to collected from September 2014 to December 2016. measure the risk of ICU admission. Receiver’s operative characteristics (ROC) curve was used to Sampling Technique and Inclusion Criteria predict the need of ICU. Youden index was used to find Total 134 newly admitted CAP patients who were optimal cut-off points. P-value ≤ 0.05 was considered not taking antibiotics for last 14 days were selected by significant. convenient sampling method. Other inclusion criteria were adult (≥ 18 years) and of both genders. Results CAP diagnosis depended upon history of high grade Mean age of 134 CAP patients was 50 ± 21 years. fever with pleuritic chest pain, shortness of breath and Frequency of males and females was 45.5% and 54.5%, cough. Laboratory findings included infiltration on respectively. Mean family income was 222 ± 162 USD chest X-ray; Leucocytosis, and sputum examination. per month. Assessment of household arrangements The patients with fever, dehydration, confusion, showed that 43.4% patients were residing with 7-20 and positive chest X-ray were admitted in the ward. family members; 11.9% patients were living in a single While those who required support on ventilator were room house; 22.4% patients had no separate kitchen; admitted in the ICU. CURB-65 score had also been and 16.4% patients were using wooden stove for considered for ICU admissions. cooking purposes. Frequencies of current and passive CAP patients who had chronic kidney disease, cigarette smokers were 29.1% and 38.1%, respectively. advanced liver disease, sepsis, or who were on Comorbidities included hypertension 10.6%, chronic immunosuppressive drugs were excluded from the obstructive pulmonary disease (COPD) 9.1%, and study. tuberculosis 6.1%. Occurrence rates of bronchial and lobar pneumonia were 59.7% and 40.3%, respectively. Lab Investigations While reoccurrence rate of pneumonia within 1 year Blood urea was estimated by Glutamate was 14.9%. dehydrogenase (GLDH) method [12]; serum creatinine 637 Adnan et al. – Low albumin predicts ICU admission J Infect Dev Ctries 2018; 12(8):636-641. Table 1. Comparison of ICU versus Ward Patients. ICU* Ward P value (n = 26) (n = 108) Age (years) 51.0 ± 20.0 50.1 ± 20.9 0.828 Hospital Stay (days) 6.6 ± 4.4 4.4 ± 2.8 0.002 Body Mass Index (Kg/m2) 21.5 ± 3.8 23.5 ± 5.5 0.094 Systolic blood pressure (mmHg) 117.6 ± 17.9 123.2 ± 21.8 0.226 Diastolic blood pressure (mmHg) 70.1 ± 11.1 76.1 ± 12.8 0.030 Serum creatinine level (mg/dL) 3.8 ± 3.9 1.7 ± 1.0 0.001 Blood urea nitrogen (mg/dL) 41.3 ± 29.1 22.4 ± 13.0 0.003 Serum albumin level (g/dL) 3.0 ± 0.4 3.5 ± 0.7 0.001 BUN* over albumin ratio (mg/g) 14.0 ± 10.1 6.7 ± 3.9 0.001 CURB-65 score 1.7 ± 1.2 1.2 ± 1.0 0.038 *ICU: Intensive Care Unit; BUN: Blood Urea Nitrogen. Total 19.4% patients were admitted in the ICU and CURB-65 scale was 38.8%. There were 36.6% patients 80.6% patients in the ward.
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