UTP18 Antibody

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Product Datasheet UTP18 Antibody Catalog No: #46702 Orders: [email protected] Description Support: [email protected] Product Name UTP18 Antibody Host Species Rabbit Clonality Polyclonal Purification Antigen affinity purification Applications IHC Species Reactivity Hu Specificity The antibody detects endogenous levels of total UTP18 protein. Immunogen Type peptide Immunogen Description Synthetic peptide corresponding to residues near the C terminal of human UTP18 Target Name UTP18 Other Names WDR50; CGI-48 Accession No. Swiss-Prot:Q9Y5J1 NCBI Gene ID:51096NCBI Protein:NP_057085 Concentration 0.2mg/ml Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage Store at -20°C Application Details Immunohistochemistry: 1: 10-50 Images The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 46702(UTP18 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200) Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 46702(UTP18 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200) Background WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. UTP18 (U3 small nucleolar RNA-associated protein 18), also known as WDR50 (WD repeat-containing protein 50), is a 556 amino acid protein that localizes to the nucleus, contains six WD repeats and is thought to be involved in the processing of pre-18S ribosomal RNA. The gene encoding UTP18 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.

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The DEAD-Box RNA Helicase-Like Utp25 Is an SSU Processome Component
Downloaded from rnajournal.cshlp.org on September 25, 2021 - Published by Cold Spring Harbor Laboratory Press The DEAD-box RNA helicase-like Utp25 is an SSU processome component J. MICHAEL CHARETTE1,2 and SUSAN J. BASERGA1,2,3 1Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA 2Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA 3Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA ABSTRACT The SSU processome is a large ribonucleoprotein complex consisting of the U3 snoRNA and at least 43 proteins. A database search, initiated in an effort to discover additional SSU processome components, identified the uncharacterized, conserved and essential yeast nucleolar protein YIL091C/UTP25 as one such candidate. The C-terminal DUF1253 motif, a domain of unknown function, displays limited sequence similarity to DEAD-box RNA helicases. In the absence of the conserved DEAD-box sequence, motif Ia is the only clearly identifiable helicase element. Since the yeast homolog is nucleolar and interacts with components of the SSU processome, we examined its role in pre-rRNA processing. Genetic depletion of Utp25 resulted in slowed growth. Northern analysis of pre-rRNA revealed an 18S rRNA maturation defect at sites A0,A1, and A2. Coimmunoprecipitation confirmed association with U3 snoRNA and with Mpp10, and with components of the t-Utp/UtpA, UtpB, and U3 snoRNP subcomplexes. Mutation of the conserved motif Ia residues resulted in no discernable temperature- sensitive or cold-sensitive growth defects, implying that this motif is dispensable for Utp25 function.
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