Erythrocytes take up oxygen and release carbon dioxide

AL1A1 ADH6ADHXADH7 ADH1G ADH1B ADH4 AL1B1 Cyclin E associated events during G1/S transition FRS-mediated FGFR4 signaling ADH1A

CP2E1CP2B6 CP2A6 CP2CJCP2C8 CP2AD CP2C9 CP2D6 Pyrimidine salvageKHK TRP channels AL1A3 CP2J2Fanconi Anemia Pathway AL1A2 I23O1KMO Synthesis of bile acids and bile HYESsalts via 27-hydroxycholesterol AADATKYNUT23O Cobalamin (Cbl, vitamin B12) transport and metabolism CP3A5 ARMS-mediated activation Syndecan interactionsCP3A4 CP1A2 Tryptophan catabolism PANK3PANK2 Abacavir metabolism PANK1 Advanced glycosylation endproduct receptor signaling KCNK3 KCNK9 Loss of ALDH2proteins required for interphase microtubule organization from the centrosome XAV939 inhibits tankyrase, stabilizing AXIN Phase 2 - plateau phase KCNK2 Orc1 removal from chromatin Mineralocorticoid biosynthesis S22A6 S22ABS22AC CP26A Truncations of AMER1 destabilize the destruction complex Cytosolic sensorsPurine ribonucleoside of pathogen-associated monophosphate DNA biosynthesis ST1E1 UMPSPYRD CholineCGAT1 catabolism TPST2ST1A1 Separation ofTPH1 Sister Chromatids

Methionine INMTsalvage pathway Phase 4 - restingHPPD membrane potential Classical antibody-mediatedKCNJ4 complement activation Phase I - Functionalization of compounds KCNJ2 Cargo recognition for clathrin-mediatedBODG endocytosis ENTP3ENTP1 CP1B1 ADAL ENTP2 CD38 Costimulation by the CD28 family N-glycan trimming in the ER and Calnexin/Calreticulin cycle METK2TPMT BHMT1 PGH1 Metalloprotease DUBs Retrograde neurotrophin signalling DHSO Caspase-mediated cleavage of cytoskeletal Stimuli-sensing channelsCholesterol biosynthesis via lathosterol CP4F3 Metabolism of ingested SeMet, Sec, MeSec into H2Se BHMT2 KCNJ3KCNJ9 SC6A1 Inactivation,CP1A1 recoveryEicosanoid and ligand-bindingregulation of theTHAS receptors phototransduction cascade S6A13 Activation of E2F1 target genesKCNJ5KCNJ6 at G1/S S6A11 SL9A2 Vitamin C (ascorbate) metabolism GABA synthesis, release,ICMT reuptake and degradation COMT Acrosome Reaction FRS-mediated FGFR3 signaling Smooth Muscle Contraction ACRO DNASC6A3 replication initiation

Defective MTR causes methylmalonicDefective LFNG causes aciduria5NTD SCDO3 and homocystinuria type cblG MethylationMGMT CBR1PTGES AK1A1 COX reactions Glutamate Neurotransmitter Release Cycle SC6A9SC6A5 METH SAHHMyD88:Mal cascade initiatedSC6A2 on plasma membrane Purine salvage Vpu mediated ASAP1degradation of CD4 Synthesis of PIPs at the plasma membrane Hedgehog 'on' state Erythrocytes takeDHB2 up carbon dioxide and release oxygen EPH-EphrinMA1B1 signaling SC6A6 UD11 GGT1 UD14 ADAADK DHI1 SL9A1 HPGDS HPRT KCRM DHI2 EntryEnzymatic of Influenza degradation Virion into of dopamineHost Cell via by Endocytosis COMT ALDR Stabilization of p53 PPBN methylation DHB1 Glucocorticoid biosynthesisCBPMXPP2 AOC2AOC3EST1 Transport of the SLBP DependantUD13 Mature mRNAPPBT Glucagon-likeS15A1 Peptide-1 (GLP1) regulates insulin secretion EST2 AK1C3 Digestion of dietary carbohydrate ACATN UD18UD16 S15A2 HYEPAL3A1NQO2 Purine catabolism AOFB Polymerase switchingUDB15UD110 on the C-strand of the telomere PGDH UD2B7UD17 PTGIS TYPH Retinoid cycle disease events UPP1 Binding of TCF/LEF:CTNNB1 to target promoters LA GSTM1GSTM2 synthesis and interconversion (transamination) RNA Polymerase II Transcription Initiation And Promoter Clearance LIPP GSTA1 AAAT RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Phase 3 - rapid repolarisation TGFBR2 Kinase Domain Mutants in CP19A ENPP1 DCK 3BHS2 Late Phase of HIV Life Cycle Telomere C-strand synthesis initiation Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Endogenous sterols betaKlotho-mediated ligand binding CETP ENPP2 SO2A1 PAR14PARP4 SIA4A Viral mRNA TranslationRET4 Beta-oxidationPRC2 methylatesof pristanoyl-CoA histonesCP17A andC11B1 DNA SO2B1 PARP8 Glucuronidation VPS4B DHB4 Synthesis of active ubiquitin:PAR10PARP6 roles of E1 and E2 enzymes SIAT1 Regulation of cholesterol biosynthesis by SREBP (SREBF) PDE6D TESK1 C11B2 Viral RNP Complexes in the Host Cell Nucleus STS PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Arachidonic acid metabolism FADS2 The activation of arylsulfatases LOX12 DCMC LIPE NEUR4 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Transport of Mature mRNA Derived from an IntronlessN-Glycan Transcript antennae elongation LPHSUIS NANP HEXA S5A1Alpha-defensins GABA A (rho) receptor activation AMYPCHIA PPBI Anchoring of the basal body to theS5A2 plasma membrane AMY1 AK1BA CP24A DHB3 Cross-presentationHuR (ELAVL1) of soluble binds and exogenous stabilizes mRNA antigens (endosomes) AOFA GABR1HDACs deacetylate histones AK1C1 KITM TS101 GABR2 AK1C2 AK1C4 NEUR2 TSPO SO1A2 S27A5 JNK (c-Jun kinases) and activationNEUR3 mediated by activated TAK1 FOLR2 Ligand-gatedInterleukin-6 ion channel transportfamily signaling SO1B3 Nonsense Mediated Decay (NMD) independent of the Junction Complex (EJC) SO1B1 DigestionSHC-mediatedNGF processing cascade:FGFR4 Synthesis of IP3 and IP4 in the cytosol MHC class II antigen presentation RET signaling Josephin domainMOGT2 DUBs SC5A1 MBL2 Response to elevatedATS13 platelet cytosolicGSTO1 Ca2+ ASMGBA3GBA2 Pyrimidine biosynthesis Breakdown of the nuclear lamina Inhibition of Signaling by OverexpressedSynthesis of EGFR PIPs in the nucleus AHR SIAT6 CEGTASAH2 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se LDL clearance XCT Class C/3 (Metabotropic glutamate/pheromone receptors) ABCBB KKCC1 Transport of vitamins, nucleosides, and related molecules NRAM2 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Defective AVP causes neurohypophyseal diabetesSynthesis insipidus and processing (NDI) of ENV and VPU S40A1 Elevation of cytosolic Ca2+ levelsSC5A2 Nuclear Receptor transcription pathway BMR1ABMR1B SC5A4 DGAT2 ACVL1BMPR2 NTCPNTCP2 Glycolysis TF C1R alpha-linolenic acid (ALA) metabolism HEXB S22A1 CAH2 CREB phosphorylation through the activation of CaMKII C1S Pyrimidine catabolism AL5AP PNPHS22A2 XDH ER-PhagosomeCAH4 pathway Protein repair Metabolism of polyamines PA2GDPA2G5 ERKs are inactivated Cell-extracellularSynthesis of matrixbile acids interactions and bile salts PA2GX ReceptorClathrin-mediated Mediated endocytosisMitophagy SCD5 LX15B PA21B ERAP1ERAP2 PCFT Signaling by activated point mutantsTNNT2 of FGFR3 Acyl Acylchain chain remodelling remodelling of PG of PE DGLAABHD6 LGULLDHA MOT4MOT1 Eukaryotic Translation Termination TNNC1 Acyl chain remodellingPA2G3 of PI ABD12 LDHBFADS1 FAS Interaction between L1 and Ankyrins IRF3 mediated activation of type 1 IFN PA2GA DHB7 RecruitmentBPL1 of mitotic centrosome proteinsInlA-mediated and complexes entry of Listeria monocytogenes into host cells BGAL S27A2 CTRC UD19 Cytosolic sulfonationSYMC of small molecules ABCG2 3MG Activation of Matrix Metalloproteinases Calnexin/calreticulinApoptotic cycle execution phase Scavenging by Class A Receptors ATS1 Meiotic synapsis Sema4D induced cell migrationSYK and growth-cone collapse Reuptake of GABA Activation of CaMK IV DefectiveDefective SLCO1B1 SFTPA2 causes causes hyperbilirubinemia, idiopathicVitamin B2 pulmonary (riboflavin) Rotor fibrosis metabolism type (IPF) (HBLRR)PUR2PUR9 ATS5ATS4 Stimulation of the cell death response by PAK-2p34 CAH7CAH13 Fatty acids Synthesis of 12-eicosatetraenoic acid derivatives S19A1 Acyl chain remodelling of PC CAH5A ELOV6 YAP1- and WWTR1 (TAZ)-stimulated FA9 Acyl chain remodeling of DAG and TAG GRIK2 SYTC CAH6CAH12CAH5B CP51A ARNT Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) GRIK1 CAH3CAH14 NR1H4 Antigen activates B Cell ReceptorGSTA2 (BCR) leading to generation of second messengers CBS CHL1 interactions B4GT1 HSF1 activationAmyloid fiber formation Synthesis of Leukotrienes (LT) and Eoxins (EX) Mitochondrial protein import CAH1 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB CRMPs in Sema3A signaling AMPD3 HNMT Serine SC6A4biosynthesis Acyl chain remodeling of CL NEUR1 LIPC ST14CASPE KCC4 E2AK3CLEC7A/inflammasome pathway KLK14PRSS8 Defective CSF2RB causes pulmonary surfactantChondroitin metabolism sulfate biosynthesis dysfunction 5 (SMDP5) TKT ALBU FA10 ERN1 TGM1KLK5 Transport of inorganic cations/anions and amino acids/oligopeptides L13a-mediated translational silencing of CeruloplasminPTK6 Regulates expression RTKs and Their Effectors AKT1 and DOK1 MET receptor recycling Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Class B/2 (Secretin family receptors)MGAT2 PPOXTransport of bile salts BGLRand organicGalactose acids, catabolism metal ions and amine compounds GRIK4 S28A2 PMM2 FUT8 AOC1 GRIK5 S29A1S28A3 MPI ACOD FA12FA11 TRY1CTRB1 ERG7 Chylomicron assembly S22A3 Regulation of RUNX3 expression and activity Activation of Ca-permeableNTRK3 Kainate Receptor GGPPSFPPS VTDB TTHY BMP1 Invadopodia formation Ras activation uopn Ca2+ infux through NMDA receptor DGAT1 FA7 Relaxin receptors S22A4 ACACA GTR3Hedgehog 'off'Chylomicron state clearance APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Thrombin signallingGlycogen through breakdown proteinase (glycogenolysis) activated receptors (PARs) Microtubule-dependentInsulin traffickingPLCG1 receptor ofevents connexons signalling Formationin ERBB2 from cascade signaling ofGolgi TC-NER to the Pre-Incisionplasma membrane Complex Reactions specific to the complex N-glycan synthesis pathway AbnormalNa+/Cl- conversion dependent of 2-oxoglutarate neurotransmitterAbacavir toAssemblyPeptideUnblocking 2-hydroxyglutarate transporters transmembrane chain of of elongationcollagen NMDA receptor,transportfibrils and glutamate other multimeric binding and structures activation AVR2A MGA P4HA1PPIB IRAK4 deficiency (TLR2/4) AVR2B FAAH1 CHIT1 Synthesis of Hepoxilins (HX) and TrioxilinsCDDMetal (TrX) ion AsparagineSLC transporters N-linked glycosylation CYP2E1 reactions NAMPT PGH2 KLKB1 GRM7GRM4 Regulation of APC/C activators between G1/SACLY and early anaphaseVitamin B5CBPB2 (pantothenate) metabolism Axonal growth stimulation GRIK3 GRM3 GLHA Intraflagellar transport LOX15 Arachidonate production from DAG GRM6GRM8GRM2 Highly sodium permeable acetylcholine nicotinic receptors PDK3PDK4 AGAL TPOTPOR GCYB1 Post-translational modification:KCNJ1 synthesis of GPI-anchored proteins PDK2 6PGD ASAH1 MMP16TRYB1 NRAM1 GCYA2GCYB2 RegulationACACB of PTENPDK1 localization LIPL ACEACE2 MMP24MMP17 GCYA3 KCNN3KCNN4 Mitochondrial ABC transporters CBPB1RENI BMP2 GP183 Orexin andNCEH1 neuropeptides FF and QRFP bind to their respective receptors Hyaluronan uptake and degradationGPR35 KCNN1KCNN2 FDFT GTR1 Neurexins and neuroligins Coenzyme A biosynthesisNPC1SOAT2GSTP1 Antigen processing: Ubiquitination & ProteasomeACV1B degradation B-WICH complex positively regulates rRNA expression MA2A1 SOAT1 PPIA PCSK6 IDHC LOX5 PCSK5 Hyaluronan biosynthesis and export Disinhibition of SNARE formation HCAR2 MTAP Citric acid cycle (TCA cycle) RABP2 PROC Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNATNNI3 CASR PLCB PTPRF HCAR3 HPSE ATP sensitive Potassium channels HCAR1 MTR1ALysosomalSUCR1 oligosaccharide catabolism THRB MTR1BGPR18S1PR3S1PR2 Activation of C3 and C5 IMDH1 Nicotinate metabolism CNR1CNR2 S1PR4 Synthesis of 5-eicosatetraenoicAromatic amines acids can be N-hydroxylated or N-dealkylatedGRM1 by CYP1A2 IMDH2Laminin interactions PKMTs methylate histone lysines Translocation of GLUT4 to the plasma membrane GPR55 S1PR5 SSR2SSR5 GRM5 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon NPY4RAGTR2 CCR7CXCR5 CCRL2CX3C1 RPOM PDE3B signalling MET Receptor Activation ELNE MMP10 PA24A APJAPELGPER1 CCR8ACKR3 ActivationMGLL of G protein gated Potassium channels ATF6ANT3 (ATF6-alpha) activates chaperoneMMP14 OPRKOPRXGALR3GALR2 CCR4CXCR6CXCR3 LDLR MMP15TRY3 S47A1S47A2 NPY1RNPY2RSSR4GALR1 CCR9 FUCO CATG ADAM9MMP11 SC5A7 NPY5RSSR1 GPR4CCR3 HEM2 Synaptic adhesion-likeS10AA molecules NPBW1 LPAR1 DHCR7 C5AR1 Prefoldin mediated transfer of substrate to CCT/TriCLKHA4 LPAR3 ECE1 C3AR PCP KLK7 Pre-NOTCH TranscriptionActivation, and myristolyation Translation of BID and translocation to mitochondria HRH3 Pentose LPAR5phosphateLPAR2 pathway (hexose monophosphate shunt) TMPS6MMP12 AT1B1 Synthesis of PCKPCD3 HRH4 Signaling by plasma membrane FGFR1 fusions CO3 Uptake and function of anthrax toxins KLK1 NMT2AT1B2 ACER1KPCD2SMS2 DRD3 RGS8 cGMP effects PPGBLRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRY2 PlateletSignaling Aggregation by activated (Plug point Formation) mutants ofAT1B3 FGFR1 Intra-Golgi traffic SPHK2KPCD1 DRD4DRD2 5HT1F5HT1D RGS12 Alpha-oxidation of phytanate ATP4BATP4A SGPL1 5HT1B BKRB1 S22A5 TranscriptionalCollagen regulation degradation of white adipocyteUPAR differentiation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 5HT5A5HT1A MCHR2 PKR1UR2RTRFR CXCR4 MMP8 MMP7 P2RX5P2RX3 ABCB6 Highly calcium permeable postsynaptic nicotinic5HT1E acetylcholine receptors NMUR1NMUR2 CCKARBRS3NTR2 KNG1 Lysine catabolism MMP13MMP1 P2RX4P2RX2 NOS1 RL3R2 Fructose catabolism BKRB2 NMBR PPARDRXRGRXRB RL3R1 PAR2EDNRB Dopamine Neurotransmitter Release Cycle P2RY4 ACM4 NTR1EDNRAMTLR CYH2 NEP LEG1 GRP78 PLGF PLD2 Serotonin and melatonin biosynthesis P2Y14 CholesterolKISSR GRPRbiosynthesis via desmosterolPPB1 CXCR1 SYUA AMPN AA1R CholesterolGHSR biosynthesis BACE1 Acetylcholine Neurotransmitter Release Cycle OXER1 CXCR2 PAR1 Collagen biosynthesis and modifyingDisplacement enzymes of DNA glycosylase by APEX1 VGFR3 HIV TranscriptionAA3R Initiation HRH1 mTOR signalling CPT1B MAOX FURIN DAG and IP3 signaling ACM5 LYAGARGI1 Sodium/Proton exchangers KCMB1 GPR17 CAH9 RegulationACM1 of activated PAK-2p34SIR5 by proteasomeRXRA mediated degradation KLK2 Degradation of GLI2 by the proteasomePLMN Role of second messengers in netrin-1 signalingPLD1 PE2R3 5HT2A5HT2BKCMA1 SIR3SIR4 Regulation of innate immune responses to cytosolic DNA PD2R2 5HT2C GNRHR LDL remodeling MA2B1 Signaling by moderate kinase activity BRAF mutants Ion homeostasis Regulation of TP53 Degradation EGFR Transactivation by Gastrin EBP MANBA P2RX1 Vasopressin-like receptors ADA12 ALR Oxygen-dependentGPBAR proline hydroxylation of Hypoxia-inducibleLT4R1 Factor Alpha TRFE BMP4 CD1DSH21A Netrin mediated repulsion signals NR1D1 (REV-ERBA) represses gene expression P2Y10CLTR2 Intestinal hexose absorption NCOA1 PSN1 UROK PADI4PADI3 AT1A2 Lectin pathway of complement activation P2RY6CLTR1LT4R2 PAR4 NR4A2 MTP ADAM8 AT1A3AT1A4 Activation of AMPA receptors SUMOylation of transcription factors ACM3 ERR1 ERR3NR2C2HNF4AAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal NOX5 NF-kBPADI1 activation through FADD/RIP-1 pathway mediatedNOS2 AT1A1byATNG caspase-8 and -10 G alpha (12/13) signalling events NCOA2 VDRTHAESR2 TRXR2NOX4 TPA Removal of the Flap Intermediate from the C-strand P2Y12 Opioid SignallingQRFPRNPFF1 CBPN RORBTHBERR2 Post-chaperonin tubulin folding pathway Acyl chain remodelling of PS MCHR1 OX1R S1PR1 NR1H3 Gap-filling DNA repair synthesis and ligation in TC-NER MSHR NPSR1 OX2RNPFF2 MMP2 Vasopressin regulates renal water homeostasis via Aquaporins Misspliced GSK3beta mutants stabilize beta-catenin MC4R SSR3 PE2R1PF2R CCR6 P2RY1 CFAD ATF4 activates genes DDR2DDR1 MC5RMC3R O-glycosylation of TSR domain-containingPOU5F1 proteinsFPR2 (OCT4),CCR5 SOX2, NANOG repress genes relatedNR1H2 to differentiation PRTN3 CMA1 TREM1 PLPL9 GRIA2 HRH2 NK2R SRBP2CPT1A GRIA4GRIA3 DRD1 NK3R CCR1TranscriptionOPRD of the HIV genome SODC ITB7 DLG4 DRD5 5HT6R5HT4R Prolactin receptor signaling P2RY2 OXYR BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members PADI2 5HT7R FSHR P2Y11 KLK3 GLCMChromatinVitamins modifyingS37 mutants enzymes of beta-catenin aren't phosphorylatedMMP3 TSHRLSHR t(4;14) translocationsOPRM of FGFR3 STK10KPYM IKKElastic complex fibre recruitmentformation mediated by RIP1 NMDE1 V1BR QPCTPTPRBPPAP CPNS1 Ub-specific processing proteasesNMDE3NMDE4 V1ARFFAR3 The role of GTSE1 in G2/M progression after G2 checkpointGNAQ DDX3XPERMDPP2 DMPK VGFR1 RXFP2RXFP1 FFAR2 Deregulated CDK5 triggers multiple neurodegenerativeCAN1 PDIA6 pathways in Alzheimer's disease models KITH ChREBPALKBH3 activates mediated metabolic reversal gene of alkylation expression damage Vitamins B6 activationPTAFR to pyridoxal phosphate ANXA2 CREB phosphorylation through the activation of Adenylate Cyclase GRK5 Urea cycle ACM2 AGTR1Nuclear import of Rev protein MIF ITB6 PDE1C FasL/ CD95L signaling G alpha (z) signalling events GRIA1 NOD1/2 Signaling Pathway Signaling by Retinoic Acid CaMK IV-mediated phosphorylation of CREB PD2RPE2R4 LYAM1 Iron uptake and transport PE2R2 RUNX3 CCR2regulates RUNX1-mediated transcription A1AG1 Eicosanoids AA2BR Defective ABCC8 can cause hypoglycemias and hyperglycemias PLF4 CATD F13A NMDE2 Formation of tubulin folding intermediates by CCT/TriC FPR1 ENPL MMP9 Ethanol oxidation NMDZ1 PDE1A RARARARB Acetylcholine regulates insulin secretion Mitotic Prophase RARGFABP5 VACHT P2RX7 Crosslinking of collagen fibrils RAF-independent MAPK1/3 activation PDE1B PDE5A TA2R Neurotransmitter receptors and postsynaptic signal transmission ITAL ITA4 APEX1 PDE9A AA2AR RGS4 NK1R Assembly of active LPL and LIPC lipase complexes FGFR4 mutant receptor activation PDE3APDE2A Ceramide signallingPAFA PPARANR1D1 Intrinsic PathwayNorepinephrine of FibrinOrganic Clot cation Formation Neurotransmitter transport Release Cycle Dopamine clearance from the synaptic cleft CH60 PI2R PDE10PDE11 FFAR1 IL-6-type cytokine receptorSIK1 ligand interactions CATZ PLCB3 LFA3 Ligand-independentNoRC negatively caspase regulates activation rRNA expressionvia DCC IGF1R ADP signallingSynthesis through of Prostaglandins P2Y purinoceptor (PG) 1 and Thromboxanes (TX) CHLE VEGFA MUSKIntegration of provirusL1CAM interactions CALCRRAMP1 CRFR2 Golgi Cisternae Pericentriolar Stack Reorganization ACES GASR Adherens junctions interactions CALRL ADA2B PEPA5 LYAM3 VCAM1 ITB5 Phospholipase C-mediated cascade; FGFR3 Alternative complement activationTAAR1Ca2+ pathwayCALCA GRK6 SUMOylation of RNA binding proteins ADA10 ADM2ADML PDE7BPDE8B G alpha (i) signalling events ADP signalling through P2Y purinoceptor 12 Formation of the ternary complex,RORA and subsequently, the 43S complex TP4A2 LYAM2CD2 CY24B ITA5 Signaling by NOTCH3 PDE7APDE8A GLR The NLRP3 inflammasome Platelet Adhesion to exposed collagen MERTKSELPL Abasic sugar-phosphate removal viaTRAF6 the single-nucleotide mediated NF-kB activationreplacement pathway ADRB1ADRB3 Regulation of Insulin-like Growth Factor (IGF) transport and uptake byCDK19 Insulin-like Growth Factor Binding Proteins (IGFBPs) RORG DDIT3 Signaling by BRAF and RAF fusions Repression of WNT target genes GIPR ADA2A Biotin transport and metabolism CATK ATAD2 VIPR1GLP2R ADA2C ARBK2 Metabolism of Angiotensinogen to Angiotensins Trafficking and processing of endosomalICAM1 TLR FINC KCC2D CSKP PACR MED23ADA1D Metabolism of folate and pterines STF1 ITB2 ITB1 ITA2 KCC2B VIPR2 Adrenaline,noradrenaline inhibits insulin secretion NTRK2 ADA1B PTPRC KCC2GPotassium transport channels FFAR4 PYGL Role of phospholipids in phagocytosisADA1A PDIA1 DLK1 CD209 ILK Glucagon signaling in metabolic regulation V2R Carboxyterminal post-translational modifications of tubulin PAI1 E3 ubiquitin ligases ubiquitinateEarly target Phase proteins of HIV Life Cycle VWFKCC2A Netrin-1 signaling GLUC NF-kB is activated and signals survival RegulationIL8 ofLinoleic genePregnenolone expression acid (LA) bymetabolism biosynthesis Hypoxia-inducible Factor FKB1B NOS3 ITAV Activated PKN1 stimulates transcriptionDefective of AR (androgen HLCS causes receptor) multiple regulated carboxylase genes deficiencyConstitutive KLK2 MPRIand KLK3 Signaling by NOTCH1 PEST Domain Mutants Processive synthesis on the lagging strand AAK1Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ITAM NOTCH2 intracellular domain regulates transcription Cargo concentration in the ER MRP1 CATBCATL2 IAPP Calmodulin induced events RA biosynthesisCAN2 pathwayCDT1 associationDYR with the CDC6:ORC:originRK complex KSRP (KHSRP) binds and destabilizes mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationNOTC3 Activation of the mRNA upon binding of the cap-bindingTetrahydrobiopterin complex (BH4)and eIFs, MAP11synthesis,GRK7 and subsequent recycling, bindingsalvage toand 43S regulationSurfactantGRB2 metabolism events in EGFR signalingPO5F1 CARM1 CATL1 Defective CSF2RADefective causes pulmonary CFTR surfactant causes metabolism cysticFNTBMAP2 fibrosis dysfunction 4 (SMDP4) Signaling by MST1 Defective MTRR causesSORT methylmalonicDectin-2 family aciduria and homocystinuria type cblE ARBK1 CATS NOSTRIN mediatedSignaling by eNOS NODAL trafficking PARG GLP1R Synthesis, secretion, and deacylation of Ghrelin KDM4C TRXR1 Interconversion of polyaminesNANOG VGFR2 Basigin interactions DPP4 PPARG WNT ligand secretion is abrogated by the PlateletPORCN inhibitorhomeostasisActivated LGK974 NOTCH1 Transmits SignalGAK to the Nucleus GP119 LGMN eNOS activation KTHY Oxygen-dependentFIBB asparagine hydroxylation of Hypoxia-inducibleEPHA2EPHA5 EPHA1 Factor Alpha PDE3B GNAI1 XBP1(S) activates chaperone genes G6PD KCYRIR1 Regulation of TP53 Expression APC-Cdc20 mediated degradation of Nek2A EPHA4EPHA6EPHA7 BBSome-mediated cargo-targeting to cilium NICA RUNX3 regulates BCL2L11 (BIM)CNRG transcription Resolution of Abasic Sites (AP sites) ITB3 EPHA8EPHA3 NOX3 Synthesis of very long-chain fatty acyl-CoAs CATH MCL1PDE6BPDE6A MET activatesNOX1 RAS signaling CATC NOTC1 PIM1 Glutathione conjugation KGP2 KPCG NCOR1 Classical Kir channels ImportChk1/Chk2(Cds1) SFTPDof palmitoyl-CoA mediated into the inactivation mitochondrial of Cyclin matrix B:Cdk1 complexPKA-mediated phosphorylation of key metabolicEPH-ephrinPTN12 factorsPost-translational mediated repulsion protein of cells phosphorylation Glycosphingolipid metabolism SPHK1EPHB-mediated forwardITA2B signaling EGFR interacts with phospholipase C-gammaEPHB2 KPB1 GNAS2 InlB-mediated entry of Listeria monocytogenes into host cell KDM3A CLH1 CLC4C PHKG1 GLI proteins bind promoters of Hh responsive genes to promote transcription KDM5APHF8KDM5CKDM2ARetinoid metabolism disease events PHKG2KPBBPYGM LMNA KPB2 Xenobiotics Lysosomal glycogen catabolism APH1B CTRO SHC-mediated cascade:FGFR3 COPI-dependent Golgi-to-ER retrograde traffic Calcitonin-like ligand receptors EPHB3EPHB4 G alpha (q) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Interleukin-1 family signalingCCL2PEN2APH1AITPR1 Membrane bindingTFAP2 and(AP-2) targetting family regulates of GAG transcription proteins of cell cycle factors ADCY2ADCY4 TBX5 Cilium Assembly ADA17 EPHB6EPHB1 SignalingInhibition ofby PKR EGFR Adenylate cyclase activating pathway HDAC3 PSN2 Interleukin-3, 5 and GM-CSF signaling MATK ADCY7 ADCY5 KLF5GANAB NLRP1 Macroautophagy M3K11 RAB geranylgeranylationGRP3 PTN2 ADCY9 PDE4CPDE4A COT2 WNK3SCNNA WNT mediated activation of DVL WNT5A-dependent internalization of FZD4 Golgi Associated Vesicle Biogenesis Adenosine P1 receptors ADCY6 PDE4D WNK2ANO1SGK2Sterols are 12-hydroxylated by CYP8B1Interaction With The Zona Pellucida ITPR2 Signaling by Insulin receptorMARK3 RHO GTPases activate IQGAPsPDGFB PDE4B ASIC3SCNNB CellITPR3 surface interactions at the vascular wall FGR Signaling by FGFR3 pointSignaling mutants byin cancer Activin Adrenaline signalling through Alpha-2 adrenergic receptor SCNNGSGK3 Initiation of Nuclear Envelope Reformation ADCY1 KPCL CDK8 ARRB1 KPCE p75NTREnzymatic recruitsSignaling degradation signalling by PDGF complexes of Dopamine by monoamine oxidase ADCY3 ADCY8 DisassemblyRUNX1 regulates of the destruction transcriptionResolution complex of of Sister genes and Chromatid involved recruitment inCohesion BCR of AXINsignaling to the membrane Cytosolic tRNA aminoacylation FLT3 FABP4PLIN1 HDL assembly Cleavage of the damaged purine CSF3R MP2K2 CSK PTPRA KPCATranscriptional activation of cell cycle inhibitor p21 Role of AblCSF1R in Robo-Slit signaling MET activates RAP1 and RAC1 LIPS Transcriptional activationKDM6A of mitochondrial biogenesis KGP1 The canonical retinoidSMAD2/SMAD3:SMAD4 cycle in rods (twilight vision)heterotrimer regulates transcription HGFMET interactsNegative with TNSregulation proteins of FGFR4 signalingMET activates STAT3 FABPIFABPH Endosomal Sorting ComplexHG2A Required For Transport (ESCRT) Rev-mediatedSerotonin nuclearreceptors export of HIV RNA ANPRA NSF PRGR AsymmetricNuclear localization Pore Complex ofNLK (NPC) PCP Disassembly proteins ARP2 DPOLB RAF1 MET activates PTPN11 GALK1 ANPRB NOTCH2 ActivationNCOR2 and Transmission of Signal to the Nucleus RAB9A B2CL1 Dopamine receptorsBRAF EGFR GABA B receptor activation GATA4 CREBPLC-gamma1 phosphorylation signalling through the activation of CaMKK Serotonin G-proteinclearance activation from the synapticMET cleft TRIF-mediated programmed cell death CBP Termination of O-glycan biosynthesis Effects of PIP2 hydrolysis EGFR downregulation Uptake and function of diphtheria toxin ADRB2 Gamma-carboxylationFoldingPKN1 of actin by of CCT/TriC proteinLEG3 precursors GPVI-mediated activation cascadeTIF1A TIE2 GLI3 is processed to GLI3R by the proteasome Ca2+ activated K+ channels RetinoidNFAC1 metabolism and transport STAT6EPHA-mediatedNTRK1 growth cone collapse Platelet sensitization by LDL ConstitutiveHDA11 Signaling by NOTCH1 HD Domain Mutants Prostanoid ligand receptors Fructose biosynthesisVEGF ligand-receptor interactionsOrganic anion Interleukin-1transport processing Activation of Rac Rap1MET signalling activates PI3K/AKT signaling SIR1 HDAC9 A4 SHC1 events in EGFR signaling CRFR1 PIWI-interacting RNA (piRNA) biogenesis ConstitutiveHDA10 Signaling by NOTCH1 HD+PEST Domain Mutants ECM proteoglycans Nef and signal transduction RETMET activates PTK2 signaling PGFRBsnRNP Assembly PTH1R FOLR1 HDAC8 Uncoating of the HIV Virion FEN1 Integration ofNRP1 energy metabolismSignaling by Type 1ARL13B-mediated Insulin-like Growth Factorciliary trafficking1 Receptor of(IGF1R) INPP5E SHC-mediated cascade:FGFR1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes DYN1 PP2BA Phospholipase C-mediatedFormyl cascade; peptide FGFR4 receptors bind formyl peptides and many other ligands PGFRA FCGR activation PIP3mRNA activates Editing: AKT C tosignaling U Conversion Synthesis of PA DDAH1 TWIK related potassium channel (TREK) RAB MP2K1GEFs exchangeER Quality GTP for Control GDP onCompartment RABs (ERQC)P3C2A SHC1 events in ERBB2 signalingFGFR2 alternative splicing SF3B3 PP2BB KC1G2 NRAGE signals deathLYPA1 through JNK Signalling toFER ERK5 RASH FGF2 FGFR3 mutant receptor activationHEPS PRP4 RPGF4 Signal attenuation SynthesisLIMK2 of GDP-mannoseSialic acid metabolismPD-1 signaling KIT SHC1 events in ERBB4 signalingFGFR4 ligand bindingSignal and transduction activation by L1 Activation of anterior HOX genes in hindbrain development during RPGF3early embryogenesis ESR1 ROCK2 FAK1 Melanin biosynthesis SHC-mediated cascade:FGFR2 FGFR2bSignaling ligand bindingby FGFR2 and activationamplification mutants mRNA Capping GABA A receptor activation Hormone ligand-binding receptors ROCK1 Interleukin-12 family signalingYES ERBB2 FGFR1cSignal ligand regulatorybinding and proteinactivation family interactions PresynapticFGFR1b functionligand binding of Kainate andPTBP1 activation receptors PHOP1 PP1A KDM1A TNFs bind theirPausing physiological and recovery receptors of HIV elongation TIAM1 EPH-ephrin mediated repulsion of cells RASK FRS-mediated FGFR1Phosphate signaling bond hydrolysisFCERI by NTPDasemediated proteins NF-kB activation HATs acetylate histones BRPF3 KPCD Signalling toSTAT3 p38TYK2 via RIT andInterleukin-2 RIN family signalingCRK GRB2 events in ERBB2 signaling Frs2-mediatedPhospholipase activation C-mediated cascade:Downstream FGFR1Activated signalFGFR3 transduction point mutants of FGFR2 Regulation of IFNG signaling THIO TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling MYLKIKBKG deficiency causes anhidrotic ectodermalMAP2K dysplasia and MAPK with activation immunodeficiency G2/M(EDA-ID) DNA (via damage TLR) checkpoint Signaling by ERBB2Phenylalanine and tyrosine catabolism FGFR2 TFAP2 (AP-2) family regulatesRIR2 transcriptionTYSY of growth factorsASNS and their receptors UNC93B1 deficiency - HSE PLC beta mediated events FRS-mediatedFree fatty FGFR2 acid receptorssignaling FGFR3bSynthesis, ligand binding secretion, and activation and inactivation of Glucagon-likeSignaling by Peptide-1 FGFR1 in (GLP-1)disease RUNX3 regulates CDKN1A transcriptionSMAD2/3 Phosphorylation Motif Mutants in Cancer Energy dependent regulation of mTOR by LKB1-AMPK Triglyceride catabolism PI-3K cascade:FGFR3 Phospholipase C-mediated cascade;FGF1FGFR2c FGFR2 ligand binding andFGFR1 activation MOGS HDAC5 Platelet degranulation NADE modulates death signalling Synthesis of PIPs at the ERSignaling membrane by FGFR2 in disease Signaling by ERBB4 ENASE RUNX1 regulates transcription of genes involved in interleukin signaling BCL2 PLEC Interleukin-35Constitutive Signaling Signalling by EGFRvIIIRole of LAT2/NTAL/LAB on Signalingcalcium mobilizationby FGFR2Signaling IIIa TM by FGFR2 fusions ELAV1 NCOA3 MEN1 SP1HSP7CInactivation of Cdc42 and Rac GRB2:SOS provides linkage to MAPKConstitutive signaling Signaling for Integrins byDownregulation AKT1 E17K in Cancer of TGF-betaCondensation receptor of signalingProphase FGF22 ActivationNOSIP ofRUNX1 the mediated pre-replicative regulates eNOS complex trafficking transcription of genes involved in differentiationThe IPAF inflammasome of HSCs SRP-dependent cotranslational protein targetingRHO to membraneGTPases activate PKNs RegulationSignaling of insulin by secretion RASSTAT1 mutants PLCG1Signaling bySignaling BMP by FGFR3 fusions in cancer Signaling by NOTCH4 Synthesis of Lipoxins (LX) KPCBRIR2B Toll Like Receptor 7/8 (TLR7/8)Cysteine Cascade formation from homocysteineLactose synthesis MYH9 JAK2 Signaling by Hippo PI4KB MDR1 FOXO3 ProcessingTCF dependentof Capped signaling -Containing in response Pre-mRNAto WNT TXKSema3A PAK dependent Axon repulsion NEP/NS2 InteractsSTA5A with the Cellular Export MachineryNegative feedback regulation of MAPK pathway CA2D2 HS90B JAK1PTN6 NegativeBCRNegative regulation regulation of activity of FGFR1 of TFAP2 signalingInsulin (AP-2) processing family transcription factors PI4KA CAC1C PI51C Interleukin-10 signaling GRB7 PI3K CascadeFGFR4 CAC1D Downregulation of ERBB2:ERBB3 signaling Recycling pathway of L1 SEMA3A-PlexinSelenocysteine repulsion synthesisPTN22 signaling by inhibiting IntegrinNegative adhesion regulatorsProcessive of DDX58/IFIH1 synthesis on thesignalingNegative C-strand regulationof the telomere of FGFR2 signalingPhysiological factors SMAD3 Peptide ligand-binding receptorsFBXL7 down-regulates AURKA during mitotic entryLIMK1 and in early mitosis PTN1 PI-3KPI-3K cascade:FGFR1 cascade:FGFR2Beta-catenin phosphorylation cascade Synthesis of PG DAP12 signaling TGFB1 Adenylate SMCA4cyclase inhibitory pathway Signaling by cytosolic FGFR1 fusion PCNA-Dependentmutants Long Patch Base Excision Repair STA5BThyroxine biosynthesis FGFR3c ligand binding and activation CREB phosphorylation HIPK1 PCP/CE pathway KAT2B FGFRL1 modulation of FGFR1 signalingHDMs demethylate histonesDNLI1 KPCZ MK01Negative regulation of FGFR3FCERI signaling mediated MAPKRecycling activation of bile acidsJAK3 and salts Signaling by Leptin Meiotic recombination BRD8 HDAC4 RAF activation FYN TYRO GCR NR4A1 FUBP2 Beta-oxidationCD4 of very long chain fatty acids Synthesis of PIPs at the early endosome membrane Gap-filling DNADNA repair methylation synthesis and ligation in GG-NER RHO GTPasesNMT1 activateDectin-1 PAKs mediated noncanonicalTECCD209 NF-kBRegulation (DC-SIGN) signaling of Glucokinase signaling by GlucokinaseP85A Regulatory Protein Synthesis of PE NGF-independantANDR TRKA activation Attachment of GPI anchor to uPARFKB1A TCF7L2 mutants don't bind CTBP RNA Polymerase I Chain Elongation HS-GAGRUNX1 degradationRUNX1 regulates and FOXP3 transcription control theof genes development involved of regulatoryin differentiation T lymphocytes of myeloid (Tregs) cells MK03Androgen biosynthesis Interleukin-4 and 13 signaling PTN11 ACTB Processing of DNA double-strand break ends CLC6ACD22FAK2 mediated BCR regulation PK3CA Pre-NOTCH Processing in the Endoplasmic ReticulumHDAC6 DepositionRAF/MAPHDAC7 of newkinase CENPA-containing cascade nucleosomes at the centromere RegulationIRAK4 deficiency of IFNA signaling (TLR5) BLK RHOA Growth hormoneTP53 regulates receptor transcriptionsignaling TRAF6 of several mediated additional inductionNLRP3 cell deathof NFkB genes and whose MAP kinasesspecificCDK13 uponroles inTLR7/8 p53-dependent or 9 activation apoptosis remain uncertain Reversible hydration of carbon dioxide FES PI3K eventsP55G in ERBB2 signaling P4K2B CATF TGFBR1 LBD Mutants in CancerFOLH1NALD2HSF1 FNTA DARPP-32 eventsPTK6LYN RegulatesEphrin signaling Cell Cycle PI-3K cascade:FGFR4 CATE HIPK2 BRD2 SCF-beta-TrCP mediated degradation of Emi1 NGF COPI-mediated anterograde transport Phosphorylation of the APC/C Signalling to RAS TGF-beta receptor signalingRCOR1TFAP2A Voltageactivates acts gated asSMADs a Potassiumtranscriptional channels repressor during retinoic acid induced cellPolo-like differentiation kinase mediated events GRP1 MAP3K8 (TPL2)-dependent MAPK1/3 activation Interferon alpha/beta signalingSHIP2 PK3C3 RON PI5P,S45 mutantsPP2A and of IER3beta-catenin RegulateKDM6B aren't PI3K/AKT phosphorylated SignalingKS6A6 POLB-Dependent Long Patch Base ExcisionNrCAM Repair interactionsRegulated proteolysis of p75NTR Interleukin-19,20,22,24,26,28SHC-relatedRegulation events of RUNX1 and triggered 29 Expressionsignaling by IGF1R and Activity P4K2A RUNX1 RHO GTPases Activate ForminsRemoval of licensing factors from origins IL2 Methylation of MeSeH for excretionNADPHActivation regeneration of RAS in B cells SMAC-mediated dissociationSMAC binds of IAP:caspase to IAPs complexes p38MAPK events Regulation of signaling by CBL Interleukin-15 signaling CAC1B TGFBR1 KD Mutants in Cancer Association of licensing factors with the pre-replicative complex RAC1RHO GTPasesRespiratory activate KTN1 electronITK transport P85B TGF-beta receptor signalingCAC1S in EMT (epithelial to mesenchymal transition)RUNX1 regulates expression of components of tightImmunoregulatory junctions interactionsVEGF between binds ato Lymphoid VEGFR leading and a tonon-Lymphoid receptor dimerization cell NCK1 HCK P3C2G RUNX3HS90AAmine Regulates ligand-binding Immune receptors ResponseRemoval and of Cell aminoterminal MigrationrRNA processingpropeptides in from theCDC42 gamma-carboxylated mitochondrion proteins Translesion synthesis by REV1 PI3K/AKT activation Vif-mediated degradationRUNX1 KAT2Aof APOBEC3G regulates estrogen receptor mediatedCAC1F transcription UFO NeddylationRegulation of HSF1-mediated heat shockDAP12 response interactions KIF5A Pre-NOTCH Processing in Golgi CA2D1 Catecholamine biosynthesis RHO GTPases Activate Rhotekin and SOS-mediatedRhophilins signalling ACHB4 CAC1G PPM1A BRD1 INSR CAC1I TBC/RABGAPs RUNX1RUNX1 interacts regulates with co-factorstranscription whose of genes precise involved effect on in RUNX1 differentiation targets isof not keratinocytes known Minus-strand TriglycerideDNA synthesis NPMbiosynthesis PK3CD LEG9 CAC1H RegulationFKBP4 of FZD by ubiquitinationDownregulation of SMAD2/3:SMAD4 transcriptional activity BRPF1 KS6A5 Miscellaneous substratesMAPK2 PI5P Regulates TP53 Acetylation PRIO EP300 KS6A1 TBK1 NCAM1 interactions Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase HS71A Creatine metabolismSCN2ASCN3APOLI AxonalPAK1 growth inhibitionGastrin-CREB (RHOA signalling activation) pathway via PKC and MAPK IRF3-mediated induction of type I IFN Loss of Nlp from mitotic centrosomes KS6A2 ROS, RNSPARP2 productionSCN4A in phagocytes PLCG2 GP1b-IX-V activation signallingLCK PK3CB Insulin effectsSignaling increased by high-kinase synthesis activity of BRAF Xylulose-5-Phosphate mutants TF7L2 ANM6 Regulation of gene expression in late stage (branching morphogenesis)KS6A3 pancreatic budSCNBA precursorSCN5ASCN1ASCN9A cells CD28 dependent PI3K/Akt signaling Synthesis of PIPs at thePI51A Golgi membrane TGFR2 RegulationHDAC2 of PAK-2p34 activity by PS-GAP/RHG10 DPOLA PKN2SCN7ASCN8A PTK6 Down-Regulation MKNK1KSYK KCJ11 SCNAA DPOD1 LRRK2 Phase 0 - rapid depolarisation RHO GTPases Activate NADPHAdrenoceptors Oxidases AXIN missense mutants destabilize the destruction complex ZAP70 SGK1RUNX3 regulates NOTCH signaling CREB phosphorylation through the activation of Ras Proton/oligopeptide cotransporters SRMS PTN13P3C2B Removal of the Flap Intermediate ANM7 CDK5 Neurotransmitter release cycle RNF mutantsG alpha show (s) enhanced signalling WNTevents signaling and proliferation HomologousActivation DNA Pairing of E2F1SMAD2/3 and Strandtarget MH2 genesExchange Domain at G1/S Mutants in Cancer PARP1 Cellular hexose transport KDM4A Translation initiationIKKE complex formation Notch-HLH transcription pathway INAR1 PI3R5 RGAP1 SMCA2 Extracellular matrix organizationPEBB Dissolution of Fibrin Clot VEGFA-VEGFR2 Pathway PK3CG PB1 Metabolism of serotonin Gap junction assembly PAK2 Class A/1 (Rhodopsin-like receptors) HDR through Single Strand Annealing (SSA) Formation of Senescence-AssociatedRIPK1-mediated Heterochromatin regulated Foci (SAHF) necrosis PAK3 RSK activation BRD7 ERBB2 Regulates Cell Motility Activation of PUMA and translocation to mitochondria MCRFKBP5 HCN channels Receptor-type tyrosine-proteinERCC6 (CSB) phosphatases and EHMT2TRPM2 (G9a) positively regulate rRNA expression Proton-coupled monocarboxylate transport PKA activation KAPCGKAPCB ANM1AAKB2FRK Integrin alphaIIb beta3Budding signaling and maturationELK1 of HIV Regulationvirion of necroptotic cell death Fatty acyl-CoA biosynthesis HIF1A AAKG2 Regulation of TLR by endogenous ligand CS/DS degradation AAPK2ANM3 ABCC9HDAC1Toll Like ReceptorNOTCH1 TLR1:TLR2 Intracellular Cascade Domain RegulatesPyruvate Transcription metabolism UBP1 PARN MK07 KIF22KIF11 KS6A4 Degradation of the extracellular matrix MRP4 DSCAM interactions Fc epsilon receptor (FCERI) signalingPAK5 KIF4A TGFR1 CD5R1 AKT phosphorylates targets in the cytosolGSK3A PAK4 Toll Like Receptor 5 (TLR5) Cascade SMO Defective ABCA3 causes pulmonaryKAPCAATF6 (ATF6-alpha)KCNJ8 surfactant metabolism activates chaperones dysfunctionCSK2B type 3 (SMDP3) Negative regulation of TCF-dependentMK14 signaling by WNTDUS3 TNR16ligand antagonists PAK6 HSF1-dependent transactivation Keratan sulfate degradation p130Cas linkage to MAPKInterconversion signaling for integrins of nucleotide di- and triphosphates KC1D HIF1N Prostacyclin signalling through prostacyclin receptor KPCT Depolymerisation of the Nuclear Lamina Downregulation of ERBB2 signaling PI42C Recruitment of NuMA to mitotic centrosomes AminoNephrin acid transportTERT family interactions acrossPTK6 the ActivatesplasmaButyrophilin membrane STAT3 (BTN) family interactions ATG4B COPII (Coat Protein 2) Mediated VesicleTBB5 Transport EZRI TLR2 PI42API42B NAAA Tat-mediated elongation of the HIV-1 transcript TollTelomere Like Receptor Extension 9 (TLR9) By Telomerase Cascade Neurotransmitter clearance ERBB2 Activates PTK6 SignalingULK1LysosomeEED Vesicle Biogenesis Translesion synthesis by POLI KIF3B PKA activation in glucagon signalling EZH2 FOXO1 Activation of BAD and translocation to mitochondria AKT1 APAF Ovarian tumor domain proteases RUNX1 regulates transcription of genes involved in WNTRegulation signaling of pyruvate dehydrogenase (PDH) complex Synthesis of PIPs at the late endosome membrane Highly calcium permeable nicotinic acetylcholine receptors KIF23 Endosomal/Vacuolar pathway IRE1alpha activates chaperonesSRCMTOR RN5A CD11ACD11B RAS signalingSUV91 downstream of NF1 loss-of-function variants SUZ12 JUN BAD CD28 co-stimulation Influenza Virus Induced Apoptosis Heme degradation CNOT6 FOS Activation of SMO BMX SENP2SENP1 RHEB ACHB2 ACHGACHD Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein betaMARK4 folding WDR5 Activation of NOXA and translocation to mitochondria Downstream TCR signaling Hh mutants that don't undergo autocatalyticACHA3ACHA4 processing are degraded by ERAD APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 CSK21RUNX3 regulates p14-ARF STAT6-mediated induction of chemokines KC1E CSK22 AAPK1 TranslesionmRNA Synthesis Splicing by POLH - Major Pathway PPP5 COPI-independent Golgi-to-ER retrograde traffic ABCC8Telomere C-strand (Lagging Strand) Synthesis AAKB1 AKT phosphorylatesKS6B2 targets in the nucleus MP2K7 Signaling by SCF-KIT ACHAACHB3 RHO GTPases activate CIT AAKG1 ACHA5 VxPx cargo-targeting to cilium Recognition of DNA damage by PCNA-containing replication complex MYCAAKG3 PTK6 RegulatesGRAB Proteins Involved in RNA Processing FCERA E2AK2 Keratan sulfate biosynthesis SUMO is proteolyticallyCCND3DNM3A processedCBX4CBX8 AKT2 AKTS1 MyD88-independent TLR3/TLR4 cascadeIRS activation TBB4B Translesion synthesis by POLK SMN Sema4D mediated inhibition of cell attachmentNegative and regulation migration of TCF-dependent signaling by PDPK1DVL-interacting proteins TLR9 ACHA7ACHA9 PPARA activates gene Lossexpression of FunctionAnchoring of FBXW7 fibril in formation Cancer and NOTCH1 SignalingTP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTP53STK11 RegulatesDCC mediated Transcription attractive of Death signaling Receptors and Ligands PTK6 TBA4A 1433G Pausing and recovery of Tat-mediated HIV elongation POLK AKT3 BTK Localization of the PINCH-ILK-PARVIN complex to focal adhesions SMAD4 MH2 Domain Mutants in Cancer PP2A-mediated dephosphorylation of key metabolicExtrinsic factors PathwayInhibition of Fibrinof replication Clot Formation initiation of damaged DNA by RB1/E2F1MK08 MP2K5 NEK2 ANM5 RFA1 MAPK3 Chylomicron remodelingTBA3C EPAS1 Other semaphorin interactions Activation of AKT2 PI3KMK13 events in ERBB4 signalingCASP3 RIOK3 Initial triggering of complement Nuclear signaling by ERBB4 MK12 Activation ofApoptotic gene expression cleavage ofby cell SREBF adhesion (SREBP) proteins PORCN RecruitmentInterleukin-7 and ATM-mediated signalingTBA1C phosphorylationAUF1TBA1A of(hnRNP repair andPLK4 D0) signaling binds proteins and at destabilizesDNA double strand mRNA breaks RIOK2 PLK2 PTK6 promotes HIF1A stabilizationMP2K4 TBB1 Rho GTPase cycle RIOK1 CCND1 ConstitutivePOLH Signaling by AberrantGLSK PI3K in Cancer PIN1 RUVB1 Toll Like Receptor TLR6:TLR2 CascadeCDK6Regulation of TNFR1M4K4 signalingMK11 ActivationActivation of of BIM BMF and and translocation translocation to to mitochondria mitochondria PNMT Formation of the HIV-1 Early ElongationTBB3TBB6 ComplexTBB4A Cytosolic iron-sulfur cluster assembly M3K5 APOBEC3G mediated resistance to HIV-1 infection Catabolism of glucuronateTY3H toDOPO xylulose-5-phosphate TBB2A Sulfur amino acid metabolismRNA Polymerase I Promoter Escape IL1B CCND2 MINK1TNIK Activation of DNA fragmentation factor Vitamin D (calciferol)AOXA metabolism TTL Polymerase switching WNT ligand biogenesis and trafficking STK26 Regulation of ornithine decarboxylase (ODC) F261 KCNE1 MPIP3 CDK-mediated phosphorylation and removalActivation of Cdc6 of the TFAP2 (AP-2) family of transcription factors Gamma carboxylation,Cam-PDE hypusine 1 activation formationTBB2B and arylsulfataseTBB8 activation RHO GTPases Activate ROCKs EHMT2Transferrin endocytosis and recycling MK09MK10 TBA1B CFTR DNA Damage/Telomere Stress Induced Senescence MGMT-mediated DNA damage reversalTBA3E Activation of the phototransduction cascade Common Pathway of FibrinLysosphingolipid LCAPClot Formation and LPA receptors PLK3 UHRF1 Gap junction degradation TLR8TLR7 p75NTRInteractions negatively of Tat withregulates host cellular cell cycle proteins via SC1 POU5F1 (OCT4),Binding SOX2, and NANOG entry of HIVactivate virion genes related to proliferation TLR3 deficiency - HSE PAOX Insulin receptorInhibition recyclingPP2AA of voltageDYRK2 gated Ca2+SUMO channels is transferred via Gbeta/gamma fromDNMT1 DNM3BE1 tosubunits E2 (UBE2I, UBC9) vRNP Assembly WNT3 Mitotic Prometaphase CTNB1 MPIP2 SAE2SUMOylationSAE1NUAK1 of DNA damage response and repair proteins TNFA Formation of a pool of freeM3K8 40S subunits CENPE Glyoxylate metabolism and degradationTraffickingInhibition of GluR2-containing of TSC complex AMPA formation receptors by PKB HXK4 ABL1 Toll Like Receptor 4 (TLR4) Cascade TerminationRegulation of translesion of TP53 DNA Activity synthesis throughEHMT1 Association with Co-factorsCyclin A:Cdk2-associated events at S phase entry Activation of caspases through apoptosome-mediated cleavage Negative regulation of the PI3K/AKTXPO1 network Mitochondrial tRNA aminoacylationReversal of alkylation damage by DNA dioxygenasesDimerization of procaspase-8 OGT1 CDC7DBF4A Aflatoxin activationS100B and detoxification mRNA Splicing - Minor Pathway CASP8 activity is inhibited Striated Muscle Contraction MDM2 IRAK2Muscarinic mediated acetylcholine activation of receptors TAK1 complex MoleculesFormation associated of the cornified with envelopeelastic fibres Resolution of D-loop Structures through Holliday Junction Intermediates Glutathione synthesis and recycling CDK4 P53 PRKDCDual Incision in GG-NER OXDA HXK1 ABC3A OXDD F263 CNOT7 Glycoprotein hormones Regulation of Complement cascade F262 SUMO is conjugated to E1Regulation (UBA2:SAE1) of TP53 Activity through Phosphorylation EF2K TAU WNT3A TRAIL signaling RAD52 KS6B1 RNA Polymerase III Abortive And Retractive Initiation TP53 Regulates Transcription of Genes Involved in G1 RegulationCellSUV92 CycleLMBL1 Arrestof TP53 Activity through Acetylation CASP6 MyD88 deficiency (TLR2/4) PKA-mediatedKMT5CSETD7 phosphorylationSUMO2Nef of MediatedCREB CD4 Down-regulationSUMO1 IMA1 Sensing of DNA SERADouble Strand Breaks BIRC5 Plus-strand DNA synthesis SETB1 Nonsense MediatedPTK6MITF Expression Decay (NMD) enhanced by BAZ2AtheHDL Exon remodeling JunctionKCNQ3 Complex (EJC) MP2K3 NS1 Mediated Effects on Host Pathways CDK1 TOP2A ISG15 antiviral mechanismTERA DOT1L Activation of NIMAE2F1 Kinases NEK9, NEK6, NEK7 KCNQ2 CASP1 TRAF3 deficiency - HSE MAPK3 (ERK1) activation Activation of PPARGC1A (PGC-1alpha) by phosphorylation RNATP53 Polymerase Regulates III TranscriptionMetabolic Genes Termination Mismatch repairRUNX3 (MMR) regulatesdirected by WNT MSH2:MSH3 signaling (MutSbeta) SMYD2 Regulation of FormationTP53 Activity of HIV through elongationOther Methylation interleukin complex insignaling the absence of HIV Tat Branched-chainCASP7 amino acid catabolism S33 Chemokinemutants of receptors beta-catenin bind chemokinesaren'tCdc20:Phospho-APC/C phosphorylated mediated degradation of Cyclin A ATR TNFR1-induced NFkappaB signaling pathway Synthesis, secretion, and inactivation of Glucose-dependent InsulinotropicKMT2A PolypeptideActivationKCNQ1 (GIP) of ATR in UBC9response to replicationDetoxification stress of Reactive Oxygen Species AMPK inhibits PLK1chREBP transcriptional activation activity TOP1 RUNX3 regulates BetaYAP1-mediated defensinsWEE1 transcription MAPK5 MDM4 DPOLL MajorTGFBR2 pathwayThe MSIof rRNAAIM2 Frameshift processinginflammasome Mutants in theABL2 innucleolus Cancer and cytosol Dual incision in TC-NER TOP2B SUMOylation of DNA replication proteinsTYDP2DPOLM CASP2 TAOK1APC truncation mutants haveCCNB1 impaired AXIN binding KMT5ATranscription of E2F targets under negative control by p107 (RBL1) and p130TYDP1 (RBL2) in complex with HDAC1 Deactivation of the beta-catenin transactivating complexTRAF6 mediated induction of TAK1IRAK4 complex PhosphorylationMitochondrial transcription of proteins initiation involvedMitotic in G1/S Metaphase/Anaphase transition by active Cyclin Transition E:Cdk2 complexes GSK3B MASTL Facilitates Mitotic Progression TNR1A p53-Dependent G1 DNA CASP9Damage ResponseM3K1 INCEphospho-PLA2 pathway AutodegradationtRNA of processing the E3 in the ubiquitinnucleus ligase COP1 Recognition and association of DNA glycosylase with site containing an affected purine HCN1 Antimicrobial peptides CDN1A KAT5 EYA2 Ligand-dependent caspase activation HCN4 CCNB2Defective SLCO1B3Regulation causes SUMOylationof gene hyperbilirubinemia, expression of chromatin in beta organizationcellsRotor type proteins(HBLRR) Signaling by FGFR4 in disease STK24 GTP hydrolysis and joining of the 60S ribosomal subunit CCNE1 Cyclin D associated events in G1 MyD88 deficiency (TLR5) G2/MCondensation Checkpoints of Prometaphase Chromosomes HDR through Homologous Recombination (HRR)LATS2STK4 DAPK3 Negative regulation of MET activity DVL3 CHK1TP53 Regulates Transcription of CaspaseRAGE ActivatorsSTK3LATS1 and Caspases Signalling to STAT3 DAPK2 DVL1 PMYT1 Phase 1 - inactivation of fast Na+ channelsSpry regulation of FGF signalingNFKB1BRCA1 NFG and proNGFTNFR1-mediated binds to p75NTR ceramide production SIRT1 negatively regulates rRNA Expression DAPK1 MPIP1 RPA1 SeMet incorporation intoMP2K6 proteins BCAT2BCAT1 MAPK6/MAPK4Presynaptic depolarization signaling and calcium channel opening Negative regulation of MAPK pathway CTLA4 inhibitory signalingG beta:gamma signalling through PI3Kgamma activated TAK1 mediates p38 MAPK activation AURKB GCKR KC1APPME1 HSPB1 Nitric oxide stimulates guanylate cyclase BMAL1:CLOCK,NPAS2Tristetraprolin activates(TTP,TRKA ZFP36) activation circadian binds by gene andNGF destabilizes expression mRNA AKT-mediated inactivationALKB3 Activation of FOXO1A of NF-kappaB in B cells E2F-enabled inhibition of pre-replication complex formationWRN RNA Polymerase II Pre-transcription Events RORA activates gene expression DYR1A RB NSD2 IRS-related events triggered by IGF1RTLR4 IRAK1 AcetylationARY1 NRIF signals cell death from the nucleus TP53 Regulates TranscriptionFormationCCNE2 of DNA of Incision Repair GenesComplexSIR6 in GG-NERFormationG2 Phaseof RNABLM Pol II elongation complex HCD2 Cyclin A/B1/B2 associated events during G2/M transitionTranscriptionalTP53B regulation of pluripotent stem cells KPCI PresynapticCHK2 phase of homologous DNA pairing andInterleukin strand exchange receptor SHC signaling SFRP1 NEK6NEK9 AURKA Regulation of actin dynamics for phagocytic cup formation ATM RAD51 mTORC1-mediated signalling NEK7 Integrin cell surface interactions Phosphorylation of Emi1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain DNA CDK2Damage RecognitionResolution in GG-NER of AP sites viaHIV the elongation multiple-nucleotide arrestTRAF6 and mediated patchrecovery replacement IRF7 activation pathway TICAM1 deficiency - HSE Tat-mediated HIV elongation arrest and recovery Resolution of AP sites via the single-nucleotide replacement pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation G beta:gammaPhosphorylation signalling throughof CD3 andPLC TCRbeta zeta chains MyD88 cascade initiated on plasma membrane CCNA1P2Y receptors ASF1A TR10A TF65 UBP7 TR10B NIK-->noncanonical NF-kB signaling Retrograde transport atFTO the Trans-Golgi-Network MAPK1 (ERK2) activationCCNA2 MK06 Ribosomal scanning and start codon recognition MyD88 dependent cascade initiatedApoptotic on endosome cleavage of cellular proteins MK04 CLEC7A (Dectin-1) signaling TLR5 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant KCNH2 T41 mutants of beta-catenin aren't phosphorylated TNF signaling TLR3 CC14A NOD1NOD2 The NLRP1 inflammasome RIPK2 VLDL assembly TP53 Regulates TranscriptionUCH proteinases of Genes Involved in G2 Cell Cycle Arrest GLI2 BAP1 RNA Pol II CTD phosphorylationRNA Polymerase and interaction I PromoterS27A4 with Opening CE during HIV infection TNFR2Thromboxane non-canonicalTie2 signalling Signaling throughNF-kBTransport TP pathway Transportreceptor of gamma-carboxylatedToll of nucleosides Like Receptor and 3 protein(TLR3) freeIF4E purine Cascadeprecursors and pyrimidine from the basesendoplasmic across thereticulum plasma to membrane the Golgi apparatus Senescence-Associated Secretory Phenotype (SASP)AXIN2 RNA Pol II CTDTranslocation phosphorylation of ZAP-70 and to interaction Immunological with CE synapse Transport of organic anions GLI1 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A UBE2N Nonhomologous End-Joining (NHEJ) Gluconeogenesis FACE2 Regulation of PLK1 Activity at G2/M XIAPTransition SMG1 IDE CASP8Leukotriene receptors Generation of second messenger molecules UBP2 CDK7 KCNA3 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Trafficking of AMPA receptors KCNA1 TRAF3-dependent IRF activation pathway KCNQ4KCNA5M3K7 CCNH MRP2ABCB5 Digestion of dietary lipid MRP7ABCCB CDK9CCNT1 Transport of the SLBP independentCarnitine Mature synthesis mRNA PERK regulates gene expressionNFKB2 Regulation of signaling by NODAL Reelin signalling pathwaySphingolipidFormation ofde the novo Editosome biosynthesis ABC-family proteins mediated transport KCND3 Mitotic Telophase/Cytokinesis Factors involved in megakaryocyteSCF(Skp2)-mediated development EstrogenandFibronectin platelet biosynthesis degradation matrix production formation of p27/p21 SUFU RIP-mediatedFormation of theNFkB EarlyIRAK3 activation Elongation via ZBP1 Complex RIPK1 tRNA processingVEGFR2 inPECAM1 mediated the mitochondrion interactions vascular permeability Downstream signaling of activated FGFR1 TNF receptorFormation superfamily ofRMTs the beta-catenin:TCF methylate(TNFSF)Ion transportmembers histone transactivating arginines mediatingby P-type non-canonical ATPases complex NF-kB pathway G3P IkBA variant leads to EDA-ID Ion influx/effluxTAK1Formation at activates host-pathogen ofNFkB apoptosome byinterface phosphorylation and activation of IKKs complex Activation of the AP-1 family of transcription factors TPIS Hydrolysis of LPC FormationRNAParadoxical Polymerase of annularInteraction activation II gapPromoter junctions between of EscapeRAF PHLDA1 signaling and by kinase AURKA inactive BRAF EAA3 UCHL1 TAB1Formation of HIV-1 elongation complexPAOs oxidise Histaminecontaining polyamines HIV-1receptors to Tat amines RSSA GRB7 events in ERBB2 signaling Assembly Of The HIV Virion Tachykinin receptors bind tachykinins TRPA1 Synthesis of 15-eicosatetraenoic acid derivatives RHO GTPases regulate CFTR trafficking TNF10 TRPV1TRPM8RHO GTPases Activate WASPs and WAVEs Regulation of PTEN gene transcription IKBA IKKB PABP1 TRPV3 MRP5 Ubiquitin-dependent degradation of Cyclin D1 RIPK3 TRPM6TRPV4 Kinesins EAA1 HSP90 chaperone cycle for steroid hormone receptors (SHR) TNKS2 BIRC2IKBKB deficiency causes SCID Transcription-Coupled Nucleotide Excision RepairEAA2 (TC-NER) TNKS1 IKKA IRAK1 recruits IKK complex Non-integrin membrane-ECM interactionsAssociation of TriC/CCTTransport with target of fatty proteins acids during biosynthesis Regulation of RAS by GAPs RNA Polymerase I TranscriptionRegulation Termination of KIT signaling IF4H WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FCERI mediated Ca+2 mobilization RNA PolymeraseHistidine II Transcription catabolismNeutrophil Initiation degranulation RNA Polymerase II Transcription Elongation SENP8 Transcription RNAof RNAE2F Polymerase polymerasetargets under I TranscriptionII transcribesnegative control InitiationsnRNA by genesDREAM complex Scavenging by Class F Receptors RNA Polymerase II HIV Promoter Escape TAF1 Degradation ofGeneric GLI1 Transcription by the proteasome Pathway CLEC7A (Dectin-1) induces NFAT activationMALT1 TAF1L KEAP1 BIRC3 Hydroxycarboxylic acid-binding receptors DCAM Degradation of RUNX1DVL regulates genes involved in megakaryocyte differentiationRBTN2 and platelet function HDR through MMEJ (alt-NHEJ)Attenuation phase NCAM signalingDegradation for neurite out-growth of AXIN Interferon gamma signaling M3K14 UBA1 Aryl hydrocarbon receptor signalling PSB7Regulation of PTEN stability and activity ASGR1 Oncogene Induced Senescence Tight junction interactions PSA5PSB1PSA2Activation of Na-permeable kainate receptors M3K3 Metabolism of ingested MeSeO2H into MeSeH CD28 dependent Vav1TWIK-releated pathway acid-sensitive K+ERK/MAPK channel targets(TASK) HedgehogOxidative ligand Stress biogenesis Induced SenescenceType I hemidesmosome assembly EGLN1Defective B3GALTL causes Peters-plusPSB9 syndrome (PpS) PSB8 APC/C:Cdc20EGLN3 mediated degradationPSA7 of SecurinPSB4 tRNA modification DDX1in the mitochondrion ULK3 EGLN2 PSA6 PSB3VLDLR internalisation and degradation SPSB2 PSA7LPSB6 Degradation of beta-catenin by the destruction complexPSB10 VHL PSB11AutodegradationPSA1PSD10 TNFR1-induced of Cdh1 by proapoptotic Cdh1:APC/C signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective TPR may confer susceptibility towards thyroidPSB5 papillary carcinomaPSA4Regulation (TPC)Deadenylation by c-FLIP of mRNA DCOR PSB2PSA3 Fatty Acids bound to GPR40Heme (FFAR1) biosynthesis regulate insulin secretion UBA5 Nicotinamide salvaging G0 and Early G1 CDC6 association with the ORC:origin complex GEMI APC/C:Cdc20 mediated degradation of Cyclin B Regulation of lipid metabolism byAstrocytic Peroxisome Glutamate-Glutamine proliferator-activated Uptake receptor And alpha Metabolism (PPARalpha) Glucagon-type ligand receptors Scavenging ofAURKA heme Activation from plasma by TPX2 VEGFR2 mediatedCDO cell in proliferationmyogenesis QCR7 TRAP1 Cross-presentation of particulate exogenous antigens (phagosomes) G6PCG6PT1 Release of Hh-Np from the secreting cell F16P1MDHC Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

NQO1

MDHM CLC4KMRC1 Circadian Clock

5HT3E5HT3BGLRA2 5HT3A5HT3CGLRA1 G2/M DNA5HT3D replication checkpoint GBRR1 GBRR3GBRR2

LGI-ADAM interactions GBRA1GBRA6 GBRG3GBRB1GBRA4 GBRTGBRA3 GBRB2GBRA2GBRA5 GBRG2GBRB3 GAB1 signalosome Neurophilin interactions with VEGF and VEGFR