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September 1st – 2nd 2016 GREAT IX INTERNATIONAL MEETING

September 5th – 6th 2016 GREAT - ITALY VII INTERNATIONAL MEETING ON EMERGENCY MEDICINE GREAT Scientific Committee Salvatore Di Somma Alexandre Mebazaa Christian Mueller

Scientific Secretariat GREAT Global Research on Acute Conditions Team www.greatnetwork.org E-mail: [email protected] [email protected] [email protected] Tel. +39.3339969125

Organizing Secretariat Fisioair S.r.l. E-mail: [email protected]| Tel. +39.06.6873034

MEETING VENUE Aula Vincenzo Parisi Scuola Superiore di Polizia ( Academy) Via Pier della Francesca, 3 - 00196 Rome

14 CME with ID n. 649-163802 have been assigned for Italian Professionals attenders

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM

THURSDAY SEPTEMBER 1st

08.45 - 09.00 Welcome Giuseppe Scandone: Director of Police Academy (Rome, Italy) Roberto Santorsa: Director of Medical Services of the State Police (Rome, Italy)

09.00 - 09.10 Introduction by S. Di Somma, C. Mueller, A. Mebazaa

09.10 - 09.30 Lecture: Epigenetic in translational research Chairperson: Giuseppe Familiari (Rome, Italy) David Brenner (San Diego, USA)

09.30 - 11.10 STATE OF THE ART AHF (15min presentation, 5min discussion) Chairpersons: Alexandre Mebazaa (Paris, France), Christian Mueller (Basel, Switzerland)

09.30 - 09.50 NT-proBNP cut-off values revisited Jim Januzzi (Boston, USA)

09.50 - 10.10 Pathophysiology of acute cardiogenic pulmonary edema Josep Masip (Barcelona, )

10.10 - 10.30 New treatments for hyperkalemia Frank Peacock (Houston, USA)

10.30 - 10.50 Phenotype presentation and pathophysiology of prediabetes and diabetes in patients with heart failure Petar Seferovic (Belgrade, Serbia)

10.50 - 11.10 How to apply the HFA guidelines in the management of the post-acute phase Giuseppe Rosano (London, UK)

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM

THURSDAY SEPTEMBER 1st

11.10 - 13.05 Joined Meeting on ACS and AHF with the ESC-ACCA (15min presentation, 5min discussion) Chairpersons: Hector Bueno (Madrid, Spain), Salvatore Di Somma (Rome, Italy)

11.10 - 11.30 Why do we need Hs Troponins Giuseppe Lippi (Verona, Italy)

11.30 - 11.50 ESC NSTE-ACS Guidelines and how to use hs-cTn in 2016 Christian Mueller (Basel, Switzerland)

11.50 - 12.10 Ruling out/in Acute coronary Syndrome Nicholas Mills (Edimburg, UK)

12.10 - 12.30 ESC-ACCA Statement: Innovations in assessing AHF and ACS Salvatore di Somma (Rome, Italy)

12.30 - 12.50 ESC HF Guideline 2016: what is new? Hector Bueno (Madrid, Spain)

12.50 - 13.05 ESC-ACCA Statement: which AHF patients are candidates for direct discharge from the ED Oscàr Miro (Barcelona, Spain)

13.05 - 14.00 Snack Lunch

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM

THURSDAY SEPTEMBER 1st

14.00 - 15.40 STATE OF THE ART Diagnosis (15min presentation, 5min discussion) Chairpersons: Jelena Celutkiene (Vilnius, Lithuania), Roland Bingisser (Basel, Switzerland)

14.00 - 14.20 Neglected and poor lab parameters Gianfranco Cervellin (Parma, Italy)

14.20 - 14.40 What’s new in stroke managment Frank Peacock (Houston, USA)

14.40 - 15.00 Use of BNP/NT- proBNP in the ambulance Michael Christ (Nürnberg, )

15.00 - 15.20 Organ dysfunction in acute heart failure Johan Lassus (Helsinki, Finnland)

15.20 - 15.40 Proneurotensin: Pathophysiology & possible clinical use Alan Maisel (San Diego, USA)

15.40 - 15.50 Coffee Break

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM

THURSDAY SEPTEMBER 1st

15.50 - 18.10 FELLOWS ON STAGE (10min presentation, 5min discussion) Chairpersons: Josep Masip (Barcelona, Spain), Lorenzo Paladino (New York, USA)

15.50 - 16.05 Can we diagnose/rule-out exercise-induced myocardial ischemia using biomarkers? Christian Puelacher (Basel, Switzerland)

16.05 - 16.20 Direct comparison of BNP versus NT-proBNP in the diagnosis of AHF Zaid Sabti (Basel, Switzerland)

16.20 - 16.35 Known coronary artery disease modifies the prognostic significance of mild stress-induced myocardial ischemia Nicolas Schaerli (Basel, Switzerland)

16.35 - 16.50 Biomarkers in acute HFpEF: results of the MEDIA program Lucas Van Aelst (Belgium, France)

16.50 - 17.05 Prescription and doses of RAAS inhibitors and diuretics according to severity of congestive heart failure Monika Špinarová (Brno, Czech Republic)

17.05 - 17.20 Factors Influencing the Dose of Beta Blockers in Congestive Heart Failure Patients Karel Labr (Brno, Czech Republic)

17.20 - 17.35 The significance of right ventricular stroke work index for optimizing the selection of suitable candidates for implantation of left heart support Eva Ozabalova (Brno, Czech Republic)

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM

THURSDAY SEPTEMBER 1st

17.35 - 19.05 RESEARCH UPDATE (10min presentation, 5min discussion) Chairpersons: Richard Nowak (Detroit, USA), Oscàr Miro (Barcelona, Spain)

17.35 - 17.50 Acetazolamide in AHF Wilfried Mullens, (Genk, Belgium)

17.50 - 18.05 Sleep apnea and acute myocardial infarction Ondrej Ludka (Brno, Czech Republic)

18.05 - 18.20 Baseline characteristic of FAR-NHL (FARmacology and NeuroHumoraL activation in heart failure) Lenka Špinarová (Brno, Czech Republic)

18.20 - 18.35 Penkid, plasma biomarker for diagnosis and prediction of AKI Oliver Hartmann (Berlin, Germany)

18.35 - 18.50 Bio-Adrenomedullin the new biomarker and biotarget in sepsis Joachim Struck (Berlin, Germany)

18.50 - 19.05 New technology for POCT testing Dai Saito (Tokyo, Japan)

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM FRIDAY SEPTEMBER 2nd

08.30 - 10.30 STATE OF THE ART (15min presentation, 5min discussion) Chairpersons: Mucio Tavares de Oliveira (São Paulo, Brazil), Philippe Rouet (Paris, France)

08.30 - 08.50 How to use telemedicine today Lorenzo Paladino (New York, Italy)

08.50 - 09.10 Comorbilities in acute heart failure – AHEAD score. Jindrich Spinar (Brno, Czech Republic)

09.10 - 09.30 Perioperative myocardial infarction Danielle M. Gualandro (São Paulo, Brazil)

09.30 - 09.50 Sodium in HF Wilfried Mullens (Gent, Belgium)

09.50 - 10.10 Does it make sense to combine cTn and cTnI? Noreen van der Linden (Maastricht, NL)

10.10 - 10.30 High sensitivity troponins and emergency medicine and the future and ECG triage creep: should the US guidelines be revisited Richard Nowak (Detroit, USA)

10.30 - 10.50 Cardiomiopathy in Asia Hyun Suk Yang (Seoul, Korea)

10.50 - 11.15 General assembly of the GREAT Network

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM FRIDAY SEPTEMBER 2nd

11.15 - 12.45 FELLOWS ON STAGE (10min presentation, 5min discussion) Chairpersons: Jane – Lise Samuel (Paris, France), Alain Cohen Solal (Paris, France)

11.15 - 11.30 Direct comparison of 4 hs-cTnI-based early rule-out strategies for AMI Jasper Boeddinghaus (Basel, Switzerland)

11.30 - 11.45 Penkid Utility for AKI detection in all comers in ED Rossella Marino (Rome, Italy)

11.45 - 12.00 BASEL IX: first insights Patrick Badertscher (Basel, Switzerland)

12.00 - 12.15 Penkid Utility in managing AKI in acute heart failure in ED Silvia Navarin (Rome, Italy)

12.15 - 12.30 Use of the modified heart score in acute chest pain Beata Morawiec (Zabcze, )

12.30 - 12.45 Can biomarkers differentiate type I from type II AMI? Thomas Nestelberger (Basel, Switzerland)

12.45 - 13.35 Snack Lunch

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Rome, Scuola Superiore di Polizia PROGRAM FRIDAY SEPTEMBER 2nd

13.35 - 15.20 FELLOWS ON STAGE (10min presentation, 5min discussion) Chairpersons: Laura Magrini (Rome, Italy), Mucio Tavares de Oliveira (São Paulo, Brazil)

13.35 - 13.50 AMiCI study Immo Weichert (Ipswich, UK)

13.50 - 14.05 Prognostic value of non-Invasive haemodynamic and fluid assessment in AHF patients in ED Giorgia Virzì (Rome, Italy)

14.05 - 14.20 PCT prognostic utility in AHF patients with or without Pneumonia Irene Lalle (Rome, Italy)

14.20 - 14.35 Role of MRI in detection of graft vasculopathy in patients after HTx pilot results Julius Godava (Brno, Czech Republic)

14.35 - 14.50 Takotsubo syndrome and hypersensitivity reaction to metals of environmental burden Marie Pavlusova (Brno, Czech Republic)

14.50 - 15.05 Superiority of Prothrombin Complex in Coumarin Poisoning Alexandre Soeiro (São Paulo, Brazil)

15.05 - 15.20 An Analysis of the GREAT football matches Katie Nowak (Detroit, USA)

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome REGISTRATION FORM Please fill in the form and send it to the Scientific Secretariat: GREAT Network E-mail: [email protected] [email protected] [email protected] Tel. +39.3339969125 Fax +39.06.68309354

LAST NAME …………………………………………………………………………… FIRST NAME ………………………………………………………………………….. TITLE ……………………………………………………………………………………… ADDRESS ………………………………………………………………………………. ZIP CODE …………….... TOWN ………………………………………………….. COUNTRY ………………………………………………………………………………. TELEPHONE …………………………………………………………………………… FAX ……………………………………………………………………………………….. EMAIL ……………………………………………………………………………………. ROLE ……………………………………………………………………………………… HOSPITAL/INSTITUTION ….…………………………………………………….. Date ………….……………………….. Signature ……………….……………

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Congress Venue: Police Academy, Via Pier della Francesca, 3 - 00196 Rome

Accommodation: Hotel Donna Laura, Lungotevere delle Armi, 21 - 00195 Rome

Police Academy – Hotel Donna Laura Police Academy – Hotel Donna Laura WALKING 1.6 km – 20 min. PUBLIC BUS Line 2 (2 stops)

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING Congress Venue: Police Academy, Via Pier della Francesca, 3 - 00196 Rome

Accommodation: Hotel Villa Glori, Via Bernardo Celentano, 11 - 00196 Rome

Police Academy – Hotel Villa Glori WALKING 550 m – 7 min.

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING

SOCIAL PROGRAM GREAT Dinner THURSDAY SEPTEMBER 1st h. 8.00 p.m. LES ETOILS ROOF GARDEN Via G. Vitelleschi, 34 - 00193 Rome Website: http://atlantehotels.com/star-eng/restaurants-near-st-peters-in-rome

A GREAT Shuttle bus will be available

NETWORKING Dinner

FRIDAY SEPTEMBER 2nd h. 8.30 p.m. CIRCOLO FUNZIONARI DELLA

Via Lungotevere Flaminio, 79/81 - 00196 Rome

Website: http://www.poliziadistato.it/articolo/view/35679

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome GREAT IX INTERNATIONAL MEETING GREAT FOOTBALL MATCH FRIDAY SEPTEMBER 2nd h. 17.00 C.O.N.I. Acqua Acetosa Center for Olympic Training Largo Giulio Onesti, 1 - 00197 Rome

After the incredible experience of the last year, we will enjoy the team spirit of GREAT with an amazing football match once again, in the beautiful Center made for the olympic sports champions.

A GREAT Shuttle Bus will be available

2016 GREAT - IX INTERNATIONAL MEETING September 1st – 2nd, Rome WE ARE VERY THANKFUL FOR THE SUPPORT FROM

www.greatnetwork.org GREAT - ITALY VII INTERNATIONAL MEETING ON EMERGENCY MEDICINE

Acute Kidney Injury (AKI)

MONDAY SEPTEMBER 5th 2.30 – 6.00 p.m.

MEETING VENUE

Scuola Superiore di Polizia (Police Academy) Via Pier della Francesca, 3 - 00196 Rome Aula Vincenzo Parisi

2016 GREAT - ITALY VII INTERNATIONAL MEETING ON EMERGENCY MEDICINE September 5th – 6th, Rome SYMPOSIUM ON AKI IN EMERGENCY MEDICINE Aula Vincenzo Parisi PROGRAM MONDAY SEPTEMBER 5th 13.30 Welcome Lunch

Chairpersons: Salvatore Di Somma (Rome, Italy) Swee Haan Lim (Singapore) 14.30 Pathogenesis of AKI & Markers of Cellular Injury Mina Hur , Director & Professor, Department of Laboratory Medicine, Konkuk University School of Medicine Konkuk University Hospital (Seoul, Korea ) 14.50 The Challenge of AKI: the Related Prevalence, Mortality, Cost and Challenges in Acute Diseases Salvatore Di Somma, Professor of Medicine & Director Emergency Medicine Sapienza University of Rome, Sant’Andrea Hospital, President GREAT Network (Rome, Italy) 15.10 Cardio-Renal Syndrome and Clinical Implications Lori Daniels, Professor of Medicine,Cardiology Departement ,UCSD California (San Diego, USA) 15.30 The role of AKI Biomarkers: the clinical application of novel biomarkers to identify, triage and manage patients at risk of AKI in the Emergency Room Frank Peacock, Professor, Emergency Medicine Associate Chair and Research Director, Baylor College of Medicine (Houston, USA) 15.50 The Importance of AKI in Septic Patients Prabath Nanayakkara, Head section acute medicine, department of Internal Medicine, VU university medical center. (Amsterdam, The Netherlands) 16.10 The importance of early detection of AKI in ICU Lui Forni, Consultant Intensivist & Nephrologist, Royal Surrey County Hospital NHS FT Clinical investigator, Surrey Perioperative Anaesthesia Critical care collaborative Research group (SPACeR) Visiting Professor, University of Surrey (Guildford, UK) 16.30 Panel Discussion & Participant Questions Answered by Panel 17.00 Presentation of International Registry Project on AKI (B.R.A.V.A Study) All togheter 2016 GREAT - ITALY VII INTERNATIONAL MEETING ON EMERGENCY MEDICINE September 5th – 6th, Rome Symposium – Round Table

International Acamedy of Emergency Medicine: Implementations for International Cooperation on Research and Educational programs

TUESDAY SEPTEMBER 6th

SYMPOSIUM VENUE

Scuola Superiore di Polizia (Police Academy) Via Pier della Francesca, 3 - 00196 Rome Aula Vincenzo Parisi

2016 GREAT - ITALY VII INTERNATIONAL MEETING ON EMERGENCY MEDICINE September 5th – 6th, Rome SYMPOSIUM - ROUND TABLE Aula Vincenzo Parisi

PROGRAM

TUESDAY SEPTEMBER 6th 10.00 a.m. - 1.00 p.m.

Chairpersons: S. Di Somma (Rome, Italy), G. Ricevuti (Pavia, Italy)

Participants: Lisa Moreno (USA), Mauro Giordano (Italy), Swee Lim Han (Singapore), Frank Peacock (USA), Prabath Nannayakkara (The Netherlands), Lorenzo Palladino (USA), Mina Hur (Korea), Nicola Ferrara (Italy), David Brenner (USA), Daniel Migliaccio (UK), Chan Park (USA), Antoine Kazzi (Lebanon)

15 minutes each talk of proposals and 30 minutes all together for final discussion

2016 GREAT - ITALY VII INTERNATIONAL MEETING ON EMERGENCY MEDICINE September 5th – 6th, Rome