DOCSLIB.ORG

Photoaging & Skin Damage

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Photoaging & Skin Damage Use_for_Revised_OFC_Only_2006_PhotoagingSkinDamage 5/21/13 9:11 AM Page 2 PEORIA (309) 674-7546 MORTON (309) 263-7546 GALESBURG (309) 344-5777 PERU (815) 224-7400 NORMAL (309) 268-9980 CLINTON, IA (563) 242-3571 DAVENPORT, IA (563) 344-7546 SoderstromSkinInstitute.comsoderstromskininstitute.com FROMFrom YOUR Your DERMATOLOGISTDermatologist [email protected]@skinnews.com PHOTOAGING & SKIN DAMAGE Before You Worship The Sun Who’s At Risk? Today, many researchers and dermatologists Skin types that burn easily and tan rarely are believe that wrinkling and aging changes of the skin much more susceptible to the ravages of the sun on the are much more related to sun damage than to age! skin than are those that tan easily, rather than burn. Many of the signs of skin damage from the sun are Light complected, blue-eyed, red-haired people such as pictured on these pages. The decrease in the ozone Swedish, Irish, and English, are usually more suscep- layer, increasing the sun’s intensity, and the increasing tible to photo damage, and their skin shows the signs sun exposure among our population – through work, of photo damage earlier in life and in a more pro- sports, sunbathing and tanning parlors – have taken a nounced manner. Dark complexions give more protec- tremendous toll on our skin. Sun damage to the skin tion from light and the sun. ranks with other serious health dangers of smoking, alcohol, and increased cholesterol, and is being seen in younger and younger people. NO TAN IS A SAFE TAN! Table of Contents Sun Damage .............................................Pg. 1 Skin Cancer..........................................Pgs. 2-3 Mohs Micrographic Surgery ......................Pg. 4 Prevention & Protection........................Pgs. 5-6 Actual Patient of Soderstrom Skin Institute and Carl Soderstrom, W. MD. Medications ......................................... Pgs. 7-8 Increased pigment and blotchy discoloration Treatment Options................................Pg. 9-11 secondary to sun damage. SUN DAMAGE DURING LIFE Younger Older Roughness Fine Pre Cancer - Sunburn Mottled Wrinkling Deep Wrinkling Actinic Keratosis Carcinoma Suntan Hyperpigmentation (Lentigines (Sun Spots) (Cancer) Telangiectasia) 16398_01785.qxd:2006_PhotoagingSkinDamage 5/5/09 1:43 PM Page 2 16398_01785.qxd:2006_PhotoagingSkinDamage 5/5/09 1:43 PM Page 3 SKIN CANCER Over 1 million skin cancers are Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. found every year in America and 2) Squamous Cell Cancer they are the most common form Squamous cell carcinomas occur at the rate of 208,000 of cancer. Detected early, they per year and can sometimes (albeit infrequently) spread are almost always curable. Actinic Keratoses to the lymph nodes. They make up 16% of skin Precancerous sun spots cancers. Squamous cell cancers frequently develop in frequently seen with sun the sun damaged areas of the skin that have already damage on “midwestern skin.” formed precancerous actinic keratoses. Treatment of these cancers, premalignant areas, and the skin that generates these malignant conditions is advisable. ACTINIC SQUAMOUS CELL KERATOSES CANCER Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. 3) Melanoma Cancer More than 50,000 melanomas are discovered each year, which means about 1 in 74 Americans have a lifetime risk of 1) Basal Cell Carcinoma developing melanoma. They make up 4% of all skin can- Basal cell carcinomas are the most cers and if the current rate holds steady, this year one per- common form, and as we might expect, son will die each hour of melanoma. A history of sunburn is most frequently occur on sun exposed areas, significantly associated with individuals with melanomas. particularly the nose, forehead and cheeks. They account for 80% of all skin cancers It is the most serious form of skin cancer and can be found with over 140,000 new cases per year. in sun exposed areas of skin and in non-sun-exposed areas where moles have changed. Melanomas are most commonly found on men’s trunks, and women’s lower legs. BASAL CELL CARCINOMA The most effective treatment for melanoma is early surgical Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. removal, which follows early detection. Our yearly free Solar Lentigo/Sun Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. skin cancer Spots screenings have Solar lentigo consists of brown Lentigo Maligna detected many malignant spots, resembling freckles and Begins as a small brown melanomas, as cell damage on sun exposed pigmented spot that slowly well as all areas of the skin. These are extends and darkens in an forms of skin frequently caused by sun irregular fashion. These cancer, on the damage and can be treated with are early melanomas, in citizens of cen- glycolic face treatments, micro- the upper layer of skin. tral Illinois over dermabrasion, chemical peels, the last two or laser resurfacing. SOLAR LENTIGO/ decades. SUN SPOTS LENTIGO MALIGNA MELANOMA CANCER 2 3 16398_01785.qxd:2006_PhotoagingSkinDamage 5/5/09 1:43 PM Page 3 Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. 2) Squamous Cell Cancer Squamous cell carcinomas occur at the rate of 208,000 per year and can sometimes (albeit infrequently) spread to the lymph nodes. They make up 16% of skin cancers. Squamous cell cancers frequently develop in the sun damaged areas of the skin that have already formed precancerous actinic keratoses. Treatment of these cancers, premalignant areas, and the skin that generates these malignant conditions is advisable. SQUAMOUS CELL CANCER 3) Melanoma Cancer More than 50,000 melanomas are discovered each year, which means about 1 in 74 Americans have a lifetime risk of 1) Basal Cell Carcinoma developing melanoma. They make up 4% of all skin can- Basal cell carcinomas are the most cers and if the current rate holds steady, this year one per- common form, and as we might expect, son will die each hour of melanoma. A history of sunburn is most frequently occur on sun exposed areas, significantly associated with individuals with melanomas. particularly the nose, forehead and cheeks. They account for 80% of all skin cancers It is the most serious form of skin cancer and can be found with over 140,000 new cases per year. in sun exposed areas of skin and in non-sun-exposed areas where moles have changed. Melanomas are most commonly found on men’s trunks, and women’s lower legs. The most effective treatment for melanoma is early surgical Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. removal, which follows early detection. Our yearly free Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. skin cancer screenings have detected many malignant melanomas, as well as all forms of skin cancer, on the citizens of cen- tral Illinois over the last two decades. LENTIGO MALIGNA MELANOMA CANCER 3 16398_01785.qxd:2006_PhotoagingSkinDamage 5/5/09 1:43 PM Page 4 16398_01785.qxd:2006_PhotoagingSkinDamage 5/5/09 1:43 PM Page 5 Actual Patient of Soderstrom Skin Institute and Carl W. Soderstrom, MD. MOHS MICROGRAPHIC SURGERY Mild & Severe Rhytides/ Wrinkles Mohs surgery is a highly specialized treatment and pleasant. They are completely Medicare approved Mild and severe wrinkling of the upper layer for the total removal of skin cancer. This method and accredited by the Accreditation Association for of the dermis caused by sun damage. differs from all other methods of treating skin cancer Ambulatory Health Care, Inc. by the use of complete microscopic examination of all the tissues removed surgically, as well as detailed MILD RHYTIDS MODERATE RHYTIDS mapping techniques to allow the surgeon to remove all the roots and extensions of the skin cancer. TIPS........... FOR PROTECTING OURSELVES FROM SUN’S DAMAGING The procedure, performed here at Soderstrom RAYS INCLUDE: Skin Institute by a Mohs micrographic surgeon, is SUN DAMAGE AVOIDANCE & begun after the skin is injected with a local anesthetic 1. Avoiding the hot sun from 10:00am to to make it completely numb. Then the visible cancer 4:00pm. PROTECTION SAVES LIVES and a very thin layer of skin are removed with a scalpel, Sun in Moderation The prevention of damage to the skin from carefully mapped, and examined microscopically. If 2. Wearing a wide-brimmed hat. Treatment for all of the different ramifications exposure to the sun’s ultraviolet (UV) rays consists cancer is still present under the microscope, another of sun damage includes a stepwise approach, designed largely of protection. There are several ways to protect very thick layer of skin is removed from that exact 3. Wearing long-sleeved light weight the skin from this damage. location. This may be repeated to completely remove shirts and blouses. in a thoughtful manner specifically for each individual the cancer, and these are are called stages. patient. First, and most obviously, it is important to 4. Wearing sunscreens all year long. avoid further exposure to the sun and UVA and UVB 1. AVOIDANCE: Avoid activities in the sun from rays. This can be done by following the prevention 10:00am to 4:00pm. These are the hours of the Advantages in Mohs Surgery 5. Avoiding reflective surfaces such as guidelines below: day when the sun’s rays are the most direct and By using the detailed mapping techniques and water and snow. potentially the most damaging to the skin. complete microscopic control, the Mohs surgeon can Sun Avoidance and Protection Saves Lives! pinpoint areas involved with cancer that are otherwise 6. Minimizing sun exposure. The sun emits two types of rays that cause 2. CLOTHING: Protect exposed areas with wide invisible to the naked eye. Therefore, even the smallest damage to the skin, ultraviolet A (UVA) and ultraviolet 7.
Load more

Recommended publications
  • Glycolic Acid
    Glycolic Acid Pharmacy Compounding Advisory Committee Meeting November 3, 2016 Jane Liedtka, MD Clinical Reviewer Division of Dermatology and Dental Products, Office of Drug Evaluation III Glycolic Acid Review Team Jane Liedtka, MD, Clinical Reviewer, DDDP, ODE3 Ben Zhang, PhD, Chemistry Reviewer, OPQ Jianyong Wang, PhD, Pharmacology/Toxicology Reviewer, DDDP, ODE3 Doanh Tran, PhD., Clinical Pharmacology Team Leader, DCP3, OCP www.fda.gov 2 Nomination • Glycolic acid, 0.08% to 70%, has been nominated for inclusion on the list of bulk drug substances for use in compounding under section 503A of the Federal Food, Drug, and Cosmetic Act (FD&C Act) for topical use in the treatment of hyperpigmentation disorders and photodamaged skin www.fda.gov 3 Background • Glycolic acid is currently available in cosmetic formulations (creams, pads, and lotions) and present as excipient in some topical drug products www.fda.gov 4 Regulatory Definitions: Drugs and Cosmetics • Whether a product is a cosmetic or a drug under the law is determined by a product's intended use; different laws and regulations apply to each type of product • A drug is an article intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease or an article (other than food) that is intended to affect the structure or function of the body • A cosmetic is an article (other than soap) intended to be rubbed, poured, sprinkled, or sprayed on, introduced into, or otherwise applied to the human body for cleansing, beautifying, promoting attractiveness, or altering appearance – Regulated by CFSAN – No premarket approval of products or ingredients (except color additives) www.fda.gov 5 Cosmetic and Drug Uses of Topical Acids • Topical Acids cause exfoliation, or shedding of the skin surface.
    [Show full text]
  • Acne Treatment: Easy Ways Hospital Family Medicine Residency Program, French Camp, Calif to Improve Your Care [email protected]
    CASE c Tam T. Nguyen, MD San Joaquin General Acne treatment: Easy ways Hospital Family Medicine Residency Program, French Camp, Calif to improve your care [email protected] The author reported no For patients of any age, facial lesions can cause potential conflict of interest relevant to this article. considerable embarrassment and distress. Read on to discover what key component of acne treatment you should be using (but probably aren’t) and which dosage you can safely lower. c Practice CASE Janis S, an otherwise healthy 19-year-old, is in your recommendations office, seeking treatment for acne. She reports she has tried various over-the-counter (oTc) creams in recent months, but › Use a classification system, has seen little improvement. The acne first appeared about such as that of the American 5 years ago, and her pediatrician prescribed topical adapalene Academy of Dermatol- and doxycycline. The treatment helped, but she says her face ogy, to assess the severity never fully cleared up; over the past year, the acne has gotten of acne vulgaris. A worse. › Treat inflamma- on examination, you find several nodules and comedones tory lesions aggressively on the patient’s face, chest, and back. ms. S confides in you to prevent scarring. A that the acne—particularly on her face—kept her from going › When isotretinoin is to the senior prom. indicated, consider prescrib- ing a lower dosage (but ore than 80% of adolescents and adults develop longer duration) than the acne vulgaris at some point in their lives, and in traditional regimen. B at least 15% to 20% of cases, the acne is moderate M1 Strength of recommendation (SOR) to severe.
    [Show full text]
  • PDO Thread Lift and Smoothing
    PDO Thread Li and Smoothing Pre-Care and Post-Care Instrucons Pre-Care Instrucons 2 WEEKS BEFORE: ● Avoid taking (unless medically necessary) aspirin, non-steroidal an-inflammatory medicaons such as ibuprofen, Aleve, Advil, Motrin or supplements such as St. John’s Wort, Vitamin E, Fish oil/Omega 3/Flax Seed oil or Melatonin. These agents may increase bruising and bleeding risk. Tylenol is acceptable. Please let Renew Med Spa know if you are on any medicaon, such as blood thinners, that may increase your risk of bruising and/or bleeding. 1 WEEK BEFORE: ● Avoid any topical skincare products that may irritate your skin such as glycolic acid, salicylic acid or renoic (renols) acids. ● If you have any recent skin injecon, acve acne or cold sore in the treatment area, please call our office immediately to reschedule your appointment. 1 DAY BEFORE: ● Oral Arnica should be taken to minimize risk of swelling and bruising. Take Arnica the day before your treatment. ● Please nofy Renew Med Spa or our staff if you have a history of more than 3 facial cold sores a year, as there is a risk that this procedure could cause a recurrence. You can take Valtrex, 2 grams the night before your procedure and another 2 grams 12 hours aer the procedure to prevent cold sores recurrence. DAY OF PROCEDURE: ● Local numbing medicaon will be used to maximize your comfort during the procedure. Most paents report a mild to moderate snging sensaon with numbing injecons. It is important to discuss any sensivity or allergy to Lidocaine, Novocaine or Epinephrine with your provider prior to treatment.
    [Show full text]
  • Late Stent Thrombosis After Paclitaxel-Eluting Stent Placement in a Patient with Essential Thrombocytosis
    558 Türk Kardiyol Dern Arş - Arch Turk Soc Cardiol 2010;38(8):558-560 Late stent thrombosis after paclitaxel-eluting stent placement in a patient with essential thrombocytosis Esansiyel trombositozlu bir hastada paklitaksel salınımlı stent yerleştirme sonrası gelişen geç stent trombozu Telat Keleş, M.D., Nihal Akar Bayram, M.D., Tahir Durmaz, M.D., Engin Bozkurt, M.D. Department of Cardiology, Ankara Atatürk Education and Research Hospital, Ankara We report on a case of late stent thrombosis after drug- Bu yazıda, esansiyel trombositozlu bir hastada ilaç sa- eluting stent placement in a patient with essential throm- lınımlı stent yerleştirme sonrası gelişen geç stent trom- bocytosis. A 51-year-old male patient with a three-month bozu sunuldu. Üç ay önce sol ön inen artere paklitak- history of paclitaxel-eluting stent placement to the left sel salınımlı stent yerleştirilen 51 yaşındaki erkek hasta anterior descending artery presented with a complaint şiddetli retrosternal göğüs ağrısı yakınmasıyla başvur- of severe retrosternal chest pain. A high platelet count du. İki ay öncesinde hastanın trombosit sayımı yüksek (1,063,000/mm3) was detected two months prior to (1063000/mm3) bulunmuş ve durumu esansiyel trombo- presentation, which was interpreted as essential throm- sitoz olarak yorumlanmıştı. Hasta standart ikili antitrom- bocytosis. He was on standard dual antiplatelet therapy bosit tedavi (aspirin ve klopidogrel) görmekteydi. Elekt- (aspirin and clopidogrel). The electrocardiogram showed rokardiyografide V1-V6 derivasyonlarında ST-segment ST-segment elevation in leads V1-V6. Emergent coro- yükselmesi izlendi. Acil koroner anjiyografide paklitaksel nary angiography revealed thrombotic total occlusion salınımlı stent yerinde trombotik tam tıkanıklık gözlendi. at the location of the paclitaxel-eluting stent.
    [Show full text]
  • 61497191.Pdf
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Repositório Institucional dos Hospitais da Universidade de Coimbra Metadata of the chapter that will be visualized online Chapter Title Phototoxic Dermatitis Copyright Year 2011 Copyright Holder Springer-Verlag Berlin Heidelberg Corresponding Author Family Name Gonçalo Particle Given Name Margarida Suffix Division/Department Clinic of Dermatology, Coimbra University Hospital Organization/University University of Coimbra Street Praceta Mota Pinto Postcode P-3000-175 City Coimbra Country Portugal Phone 351.239.400420 Fax 351.239.400490 Email [email protected] Abstract • Phototoxic dermatitis from exogenous chemicals can be polymorphic. • It is not always easy to distinguish phototoxicity from photoallergy. • Phytophotodermatitis from plants containing furocoumarins is one of the main causes of phototoxic contact dermatitis. • Topical and systemic drugs are a frequent cause of photosensitivity, often with phototoxic aspects. • The main clinical pattern of acute phototoxicity is an exaggerated sunburn. • Subacute phototoxicity from systemic drugs can present as pseudoporphyria, photoonycholysis, and dyschromia. • Exposure to phototoxic drugs can enhance skin carcinogenesis. Comp. by: GDurga Stage: Proof Chapter No.: 18 Title Name: TbOSD Page Number: 0 Date:1/11/11 Time:12:55:42 1 18 Phototoxic Dermatitis 2 Margarida Gonc¸alo Au1 3 Clinic of Dermatology, Coimbra University Hospital, University of Coimbra, Coimbra, Portugal 4 Core Messages photoallergy, both photoallergic contact dermatitis and 45 5 ● Phototoxic dermatitis from exogenous chemicals can systemic photoallergy, and autoimmunity with photosen- 46 6 be polymorphic. sitivity, as in drug-induced photosensitive lupus 47 7 ● It is not always easy to distinguish phototoxicity from erythematosus in Ro-positive patients taking terbinafine, 48 8 photoallergy.
    [Show full text]
  • May 2020 for Health Professionals Who Care for Cancer Patients
    Systemic Therapy Update Volume 23 Issue 5 May 2020 For Health Professionals Who Care for Cancer Patients Inside This Issue: Editor’s Choice Benefit Drug List New Programs: Neoadjuvant Carboplatin for Triple-Negative New: BRLACTWAC, UGUPAPA, Pegaspargase (LKNOS, Breast Cancer (BRLACTWAC) | Apalutamide for Non- LYNOS), Bevacizumab (Pediatric), IGEV (Pediatric) | Metastatic Castration-Resistant Prostate Cancer (UGUPAPA) Deleted: GIGAVEOCAP, GIGAVEOF, SMAJIFN Drug Update NEW Protocols, PPPOs and Patient Handouts Pharmacare Update – Anticoagulants | Patient Assistance BR: BRLACTWAC | GU: UGUPAPA Programs REVISED Protocols, PPPOs and Patient Handouts Drug Shortages BR: BRAJAC, BRAJACT, BRAJACTG, BRAJACTT, BRAJACTTG, New: Alemtuzumab, Anagrelide | Updated: Hydroxyurea BRAJACTW, BRAJDAC, BRAJFEC, BRAJFECD, BRAJFECDT, Cancer Drug Manual© BRAVAC, BRLAACD, BRLAACDT, BRLATACG, BRLATWAC | New: Abemaciclib, Lurbinectedin | Revised: Apalutamide, GI: GIPGEMABR | GU: UGUPABI, UGUPENZ | LK: ULKBLIN, Durvalumab, Panitumumab, Pembrolizumab ULKMDSA | SA: SAIME | SC: SCDRUGRX | SM: USMAVDAB, ST Update Editorial Board USMAVDT, USMAVTRA, USMAVVC, USMAVVEM Membership Update Resources and Contact Information Editor’s Choice New Programs Effective 01 May 2020, the BC Cancer Provincial Systemic Therapy Program has approved the following new treatment programs. The full details of these programs can be found on the BC Cancer website in the Chemotherapy Protocols section. Breast Neoadjuvant Carboplatin for Locally Advanced, Triple-Negative Breast Cancer (BRLACTWAC) — The Provincial Systemic Therapy Program has approved the addition of carboplatin to the standard taxane- anthracycline neoadjuvant chemotherapy regimens, for patients with stage II and higher triple-negative breast cancer. This regimen consists of carboplatin (given every 3 weeks) in combination with weekly paclitaxel, followed by doxorubicin-cyclophosphamide (AC given every 2 or 3 weeks). Filgrastim support is available for the dose-dense AC option.
    [Show full text]
  • Inside This Issue
    Volume 5 | Issue 1 | SkinCare Physicians | 2008 Edition 1244 Boylston Street, Chestnut Hill, MA 02467 | Phone: (617) 731-1600 | Fax: (617) 731-1601 SKINCARE PRESCRIPTION ARRIVES ! After years of exhaustive research and development, on the market, it can be confusing. To simplify SkinCare Physicians is proud to introduce our the skin care process, we have chosen the most new proprietary line of products, SKINCARE innovative and important ingredients available to PRESCRIPTION. With over 100 years of combined create a line of 8 products that our patients can use experience and expertise in skin care, the daily to care for their skin. dermatologists at SkinCare Physicians are uniquely positioned to develop this innovative product line. Unlike all the other products out there, SKINCARE The 8 products include: PRESCRIPTION is different. • Cleanser • Exfoliator The concept behind SKINCARE PRESCRIPTION is • Day Anti-Aging Moisturizer AHA with SPF 15 simple: provide a small group of carefully chosen • Night Anti-Aging Moisturizer with Retinol products that actually improve your skin, and at a • Anti-Aging Eye Cream reasonable price. Most patients use many different • Intensive Anti-Wrinkle Moisturizer (with the products, are never sure just which ones to use SkinCare Physicians special formula) when, and pay too much for them. Every day patients • Age Prevention Vitamin C Serum ask us about the products they should use to keep • Age Reversal Glycolic Acid Serum 10% their skin healthy and young looking, and because there are so many different products to choose from ( continued on page 2 ) YOUTH IN A SYRINGE: THE NEW WAY TO GET DRAMATIC RESULTS WITH FILLERS AND BOTOX INSIDE THIS ISSUE: While it may sound too good to be true, it has never lines between the eyes by combining Restylane been easier to achieve extraordinary results that can or Juvederm with Botox, creating improvement make you look younger in minutes.
    [Show full text]
  • Ultraviolet Irradiation Induces MAP Kinase Signal Transduction Cascades That Induce Ap-L-Regulated Matrix Metalloproteinases That Degrade Human Skin in Vivo
    Molecular Mechanisms of Photo aging and its Prevention by Retinoic Acid: Ultraviolet Irradiation Induces MAP Kinase Signal Transduction Cascades that Induce Ap-l-Regulated Matrix Metalloproteinases that Degrade Human Skin In Vivo GaryJ. Fisher and John J. Voorhees Department of Dennatology, University of Michigan, Ann Arbor, Michigan, U.S.A. Ultraviolet radiation from the sun damages human activated complexes of the transcription factor AP-1. skin, resulting in an old and wrinkled appearance. A In the dermis and epidermis, AP-l induces expression substantial amount of circumstantial evidence indicates of matrix metalloproteinases collagenase, 92 IDa that photoaging results in part from alterations in the gelatinase, and stromelysin, which degrade collagen and composition, organization, and structure of the colla­ other proteins that comprise the dermal extracellular genous extracellular matrix in the dermis. This paper matrix. It is hypothesized that dermal breakdown is followed by repair that, like all wound repair, is reviews the authors' investigations into the molecular imperfect. Imperfect repair yields a deficit in the struc­ mechanisms by which ultraviolet irradiation damages tural integrity of the dermis, a solar scar. Dermal the dermal extracellular matrix and provides evidence degradation followed by imperfect repair is repeated with for prevention of this damage by all-trans retinoic acid each intermittent exposure to ultraviolet irradia­ in human skin in vivo. Based on experimental evidence tion, leading to accumulation of solar scarring, and a working model is proposed whereby ultraviolet ultimately visible photoaging. All-trans retinoic acid irradiation activates growth factor and cytokine receptors acts to inhibit induction of c-Jun protein by ultraviolet on keratinocytes and dermal cells, resulting in down­ irradiation, thereby preventing increased matrix metallo­ stream signal transduction through activation of MAP proteinases and ensuing dermal damage.
    [Show full text]
  • Photodermatoses  Update Knowledge and Treatment of Photodermatoses  Discuss Vitamin D Levels in Photodermatoses
    Ashley Feneran, DO Jenifer Lloyd, DO University Hospitals Regional Hospitals AMERICAN OSTEOPATHIC COLLEGE OF DERMATOLOGY Objectives Review key points of several photodermatoses Update knowledge and treatment of photodermatoses Discuss vitamin D levels in photodermatoses Types of photodermatoses Immunologically mediated disorders Defective DNA repair disorders Photoaggravated dermatoses Chemical- and drug-induced photosensitivity Types of photodermatoses Immunologically mediated disorders Polymorphous light eruption Actinic prurigo Hydroa vacciniforme Chronic actinic dermatitis Solar urticaria Polymorphous light eruption (PMLE) Most common form of idiopathic photodermatitis Possibly due to delayed-type hypersensitivity reaction to an endogenous cutaneous photo- induced antigen Presents within minutes to hours of UV exposure and lasts several days Pathology Superficial and deep lymphocytic infiltrate Marked papillary dermal edema PMLE Treatment Topical or oral corticosteroids High SPF Restriction of UV exposure Hardening – natural, NBUVB, PUVA Antimalarial PMLE updates Study suggests topical vitamin D analogue used prophylactically may provide therapeutic benefit in PMLE Gruber-Wackernagel A, Bambach FJ, Legat A, et al. Br J Dermatol, 2011. PMLE updates Study seeks to further elucidate the pathogenesis of PMLE Found a decrease in Langerhans cells and an increase in mast cell density in lesional skin Wolf P, Gruber-Wackernagel A, Bambach I, et al. Exp Dermatol, 2014. Actinic prurigo Similar to PMLE Common in native
    [Show full text]
  • Far-Infrared Suppresses Skin Photoaging in Ultraviolet B-Exposed Fibroblasts and Hairless Mice
    RESEARCH ARTICLE Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice Hui-Wen Chiu1,2, Cheng-Hsien Chen1,3,4, Yi-Jie Chen1, Yung-Ho Hsu1,4* 1 Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei, Taiwan, 2 Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3 Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, 4 Department of Internal Medicine, School of Medicine, College of a1111111111 Medicine, Taipei Medical University, Taipei, Taiwan a1111111111 [email protected] a1111111111 * a1111111111 a1111111111 Abstract Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human OPEN ACCESS skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to Citation: Chiu H-W, Chen C-H, Chen Y-J, Hsu Y-H block the epidermal hyperproliferative response to UVB and may play a crucial role in pre- (2017) Far-infrared suppresses skin photoaging in venting skin photoaging. In the present study, we investigated whether far-infrared (FIR) ultraviolet B-exposed fibroblasts and hairless mice. PLoS ONE 12(3): e0174042. https://doi.org/ therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibro- 10.1371/journal.pone.0174042 blasts and SKH-1 hairless mice. We found that FIR treatment significantly increased procol- Editor: Ying-Jan Wang, National Cheng Kung lagen type I through the induction of the TGF-β/Smad axis. Furthermore, UVB significantly University, TAIWAN enhanced the expression of matrix metalloproteinase-1 (MMP-1) and MMP-9.
    [Show full text]
  • Urticaria from Wikipedia, the Free Encyclopedia Jump To: Navigation, Search "Hives" Redirects Here
    Urticaria From Wikipedia, the free encyclopedia Jump to: navigation, search "Hives" redirects here. For other uses, see Hive. Urticaria Classification and external resourcesICD-10L50.ICD- 9708DiseasesDB13606MedlinePlus000845eMedicineemerg/628 MeSHD014581Urtic aria (or hives) is a skin condition, commonly caused by an allergic reaction, that is characterized by raised red skin wheals (welts). It is also known as nettle rash or uredo. Wheals from urticaria can appear anywhere on the body, including the face, lips, tongue, throat, and ears. The wheals may vary in size from about 5 mm (0.2 inches) in diameter to the size of a dinner plate; they typically itch severely, sting, or burn, and often have a pale border. Urticaria is generally caused by direct contact with an allergenic substance, or an immune response to food or some other allergen, but can also appear for other reasons, notably emotional stress. The rash can be triggered by quite innocent events, such as mere rubbing or exposure to cold. Contents [hide] * 1 Pathophysiology * 2 Differential diagnosis * 3 Types * 4 Related conditions * 5 Treatment and management o 5.1 Histamine antagonists o 5.2 Other o 5.3 Dietary * 6 See also * 7 References * 8 External links [edit] Pathophysiology Allergic urticaria on the shin induced by an antibiotic The skin lesions of urticarial disease are caused by an inflammatory reaction in the skin, causing leakage of capillaries in the dermis, and resulting in an edema which persists until the interstitial fluid is absorbed into the surrounding cells. Urticarial disease is thought to be caused by the release of histamine and other mediators of inflammation (cytokines) from cells in the skin.
    [Show full text]
  • Dear Editor, Photo-Onycholysis Due to Tetracyclines
    Dear EditOr, Photo-onycholysis Due to Tetracyclines: a Case Report (Tetrasiklin Kulammma Baglz Fotoonikolizis: Olgu Sunumu) Mehmet Kose Assist. Prof.1 M.D. Department of Pediatrics Erciyes University Medical Faculty Photo-onycholysis refers to separation of the nail plate from the nail bed after [email protected] exposure to ultraviolet light. Drug induced photo-onycholysis is seen most commonly with tetracycline. Harun Y1lmaz M.D. Department of Pediatrics A-12-years old boy was admitted to our pediatric department because of fever and Erciyes University Medical Faculty arthralgia. He was diagnosed as Brucellosis and treated with rifampin (20 mglkg/24hr) Kaz•m Ozum and tetracycline (30mg/kg/24hr in 3 divided oral doses). Seven days later pinkish­ Prof., M.D. purple discoloration and onycholysis developed on his fingernails. Two weeks later Department of Pediatrics Erciyes University Medical Faculty his fingernails darkened to a purple-black color and onycholysis became evident [email protected] (Picture 1). He was admitted again. Toenails were normal. Tetracycline was discontinued after 14 days of treatment and trimethoprim- sulfamethoxizole was Selim Kurtoglu Prof., M.D. added to therapy. Two months later, the nail changes resolved spontaneously. Department of Pedi atrics Erciyes University Medica l Facu lty Photosensitivity is a well-recognized complication of tetracyclines. Photo-onycholysis selimk@e rciyes.edu.tr has been observed with many of the tetracyclines usually appearing more than 2 weeks commencing drug administration (I, 2). It was first described by Segal as photosensitivity fo llowed by discoloration of the nails and onycholysis (3). Tetracyclines were reported to cause pseudoporphyria, cutaneous pigmentation, erythema multiforme, toxic epidermal necrolysis, Steven-Johnson Syndrome, fixed drug eruptions, pruritis, urticaria and vasculitis (2, 4).
    [Show full text]