Glaxosmithkline Bangladesh Limited (GSK)
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Annual Report 2013
Annual Report 2013 “ Being active and having a positive outlook on life is what keeps me going every day.” Overview of 2013 “ Our performance in 2013 was defined by remarkable &R D output and further delivery of sustained financial performance for our shareholders.” Please go to page 4 for more More at gsk.com Performance highlights £26.5bn £8.0bn £7.0bn £5.2bn Group turnover Core* operating profit Total operating profit Returned to shareholders 6 112.2p 112.5p 13% Major medicines approved Core* earnings per share Total earnings per share Estimated return on R&D investment 10 6 1st 1st Potential phase III study starts in 2014/15 Potential medicines with phase III data in Access to Medicines Index Pharmaceutical company to sign AllTrials expected 2014/15 campaign for research transparency Front cover story Betty, aged 65, (pictured) has Chronic “ Health is important to me, Obstructive Pulmonary Disease (COPD). She only has 25% lung capacity. This means I try to take care of my she finds even everyday tasks difficult, but medicines and inhaled oxygen allow her to health with all the tools live as normal a life as she can. Betty’s mindset I have and do the best is to stay busy and active, so every week she goes to rehab exercise classes. that I can with it.” COPD is a disease of the lungs that leads to Betty, COPD patient, damaged airways, causing them to become North Carolina, USA narrower and making it harder for air to get in and out. 210 million people around the world are estimated to have COPD. -
Gilead and Glaxo's HIV Battle Intensifies
February 14, 2017 Gilead and Glaxo’s HIV battle intensifies Madeleine Armstrong The first phase II data with Gilead’s HIV integrase inhibitor bictegravir have set up a showdown with Glaxosmithkline/Viiv Healthcare’s marketed product dolutegravir. But Glaxo is already one step ahead with data from a two-drug combo that could reduce the side-effect burden for HIV patients. Glaxo believes that this doublet could “reshape the whole game”, the group's chief executive, Andrew Witty, said on its fourth-quarter earnings call. HIV has been one of the group’s main drivers in recent quarters as it has taken market share from Gilead, which is becoming increasingly reliant on HIV as its hepatitis C franchise slows (see tables below). Bictegravir vs dolutegravir The phase II study, presented today at the Conference on Retroviruses and Opportunistic Infections in Seattle, compared bictegravir plus emtricitabine and tenofovir alafenamide – known as FTC/TAF – with dolutegravir plus FTC/TAF in 98 treatment-naive, HIV-infected adults. Both are the latest iterations of the integrase inhibitor class, and unlike older products with the same mechanism do not require boosting – taking another drug to raise circulating levels – so have a lower risk of adverse events and drug-drug interactions. The phase II trial found similar response rates with a bictegravir-containing regimen versus a dolutegravir- containing therapy, which should boost confidence in Gilead’s compound ahead of phase III readouts expected mid-year. It found a 97% response in the bictegravir arm at 24 and 48 weeks, versus 94% at week 24 and 91% at week 48 in the dolutegravir arm, but the difference was not statistically significant. -
Pharma Pricing, Non-Profit Ties Get Increasing Scrutiny from Prosecutors
REGULATORY UPDATE REGULATORY UPDATE CONSUMER DRUGS Pediatric Rare Disease Voucher Japan Wants EMA To Stay In Digital Marketing: Health Care Brands’ Program Faces Expiration, p. 12 UK Post-Brexit, p. 15 Window Into Consumers’ Lives, p. 20 Pharma intelligence Pinkpink.pharmamedtechbi.comSheetVol. 78 / No. 38 September 19, 2016 informa Mylan NV was subpoenaed for material Pharma Pricing, Non-Profit Ties Get about the pricing of its generic doxycycline and communications with competitors. And Valeant Pharmaceuticals International Inc. is Increasing Scrutiny From Prosecutors facing several probes about its pricing and BRENDA SANDBURG [email protected] patient assistance programs (see chart, p. 5). Mylan’s doxycycline price increases were called out by Sen. Bernie Sanders, I-Vt., and Rep. Elijah Cummings, D-Md., in October 2014 when they sent letters to 14 generic drug makers about the pricing of their prod- ucts. They noted that from October 2013 to April 2014, the average price charged for a 500-count bottle of 100 mg tablets had risen from $20 to $1,829, an 8,281% increase. Mylan is now under fire for repeatedly rais- ing the price of its severe allergy treatment EpiPen (epinephrine), which has increased from about $100 for a two-pack in 2008 to more than $600. Members of Congress sent a flurry of letters to the company requesting an explanation for the price hikes. And on Sept. 6, New York Attorney Gen- Shutterstock: blvdone Shutterstock: eral Eric Schneiderman announced that his office has begun an investigation into rug makers have been unable to programs, contractual agreements with Mylan with regard to EpiPen, saying a pre- shake free of government inves- pharmacy benefit managers, support of liminary review revealed that Mylan may Dtigations of their marketing and non-profit organizations, and calculation have inserted potentially anticompetitive sales practices. -
A Case Study of Glaxosmithkline Plc )
)l GROWTH THROUGH MERGER: A CASE STUDY OF GLAXOSMITHKLINE PLC ) / BY JUNE WANGARI UNIVERSITY OF NAIR03J LOWER KABETE LIBRARY A MANAGEMENT RESEARCH PROJECT SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF DEGREE OF MASTER OF BUSINESS ADMINISTRATION (MBA), SCHOOL OF BUSINESS, UNIVERSITY OF NAIROBI JULY, 2008 DECLARATION I declare that this project is my original work and has never been presented for academic purposes in any other University. CANDIDATE: JUNE WANGARI DATE .(.91. This research project has been submitted for examination with my approval as the University Supervisor SIGNED. DATE. Prof. Evans Aosa Department Of Business Administration, School Of Business, University Of Nairobi 11 DEDICATION I dedicate this project to my daughter Jemima, who was born within the first year of my post graduate studies. And now that she is in kindergarten, I see that I have instilled in her the love for reading and learning and I trust that she will go very far. iii ACKNOWLEDGEMENT I thank God for seeing me through my studies as I tried to balance between my family, my work and my studies. I wish to acknowledge the contributions that were made in the course of this project by several individuals and organizations. I wish to acknowledge gratefully the following people, whose effort influenced the content and direction of this project. My first thanks go to my Supervisor Prof. Evans Aosa for his constant analytical criticism and encouragement. Thanks a lot. I wish to thank my friends for a lot of support and encouragement to me in pursuit of this goal. -
General Assembly Distr
UNITED NATIONS A General Assembly Distr. GENERAL A/HRC/11/12/Add.2 5 May 2009 Original: ENGLISH HUMAN RIGHTS COUNCIL Eleventh session Agenda item 3 PROMOTION AND PROTECTION OF ALL HUMAN RIGHTS, CIVIL, POLITICAL, ECONOMIC, SOCIAL AND CULTURAL RIGHTS, INCLUDING THE RIGHT TO DEVELOPMENT Report of the Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of health, Paul Hunt* Annex MISSION TO GLAXOSMITHKLINE** * The present report was submitted late in order to incorporate the most recent information. Paul Hunt ended his mandate as Special Rapporteur on 31 July 2008. His report is circulated as an addendum to the report of his successor, Anand Grover, who took up the mandate on 1 August 2008. ** The summary of the present report is circulated in all official languages. The report itself, annexed to the summary, is circulated as received, in the language of submission only. GE.09-13131 (E) 130509 A/HRC/11/12/Add.2 page 2 Summary The Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health visited the headquarters of GlaxoSmithKline, one of the world’s leading research-based pharmaceutical companies, in June 2008 for substantive interviews with the company’s senior management. In the Special Rapporteur’s previous reports, he examined States’ responsibilities in relation to access to medicines. However, enhancing access to medicines is a shared responsibility. The Millennium Development Goals recognize that pharmaceutical companies have a responsibility to improve access to medicines. In the present report, the Special Rapporteur outlines the responsibilities of pharmaceutical companies, including innovator, generic and biotechnology companies, with regard to the right to health in relation to access to medicines. -
Uzomis: at All Doses Compared to Those on Placebo
persistent and recurrent headache. The frequency and time to use of these additional WARNINGS treatments were also recorded. ZOMIG* (zolmitriptan) should only be used where a clear diagnosis of migraine Table 1 shows efficacy results for ZOMIG" in 5 placebo-controlled trials, 4 of which were has been established. multicenter. The percentage of patients with pain relief (grade 1/0) at 2 hours after treatment Risk of Myocardial Ischemia ami/or Infarction and Other Adverse Cardiac Events: (the primary endpoint measure) was significantly greater among patients receiving ZOMIG* 2DWB* has beMassccMedwMtmis^ chest siMfrJMkpste and 8ghtoe& UZomis: at all doses compared to those on placebo. In Study 3, which directly compared the 1 mg, which may resemble angina pectoris. Following the use of other 5-HTj 2.5 mg and 5 mg doses, there was a statistically significant greater proportion of patients with agonists, In rare cases these symptoms have been Identified as being the likely zolmitriptan tablets 2.5 mg headache response at 2 and 4 hours in the higher dose groups (2.5 mg or 5 mg) than in the result of coronary vasospasm or myocardial Ischemia. Rare cases of serious 1 mg group. There was no statistically significant difference between the 2.5 mg and 5 mg PHARMACOLOGICAL CLASSIFICATION coronary events or arrhythmia have occurred following use ot S-HTt agonists, dose groups for the primary endpoint measure of pain relief (1/0) at 2 hours, or at any other including ZOMIG*. ZOMIG* should not be given to patients who have documented 5-HTi Receptor Agonist time point measured. -
In This Section
Strategic report In this section Chairman’s statement 2 CEO’s review 4 Business overview 6 The global context 8 Our business model 12 Our strategic priorities 14 How we performed 16 Risk management 18 Grow 20 Deliver 32 Simplify 44 Our financial architecture 48 Responsible business 50 Financial review 58 Strategic report Chairman’s statement Chairman’s statement To shareholders The value of the significant changes that have been made in recent years is evidenced in our performance this year “ Since Sir Andrew became It is clear from the following pages that Through the Audit & Risk Committee, we the Group made good progress against oversee the issues and challenges faced by CEO, the company has its strategy in 2013. management, and encourage the creation of an environment in which GSK can achieve The Board believes the business is seeing returned £30 billion its strategic ambitions in a responsible and the benefits of the significant changes the sustainable manner. to shareholders.” management team has driven over recent years to deliver sustainable growth, reduce risk and I have no doubt that commercial success is enhance returns to shareholders. directly linked to operating in a responsible way and which meets the changing expectations of The notably strong performance from the society. In this respect, the company continues R&D organisation in 2013 – with six major to adopt industry-leading positions on a range new product approvals in areas including of issues. respiratory disease, HIV and cancer – is critical to the longer-term prospects of the The announcement of plans during 2013 to Group. -
On Speed: the Many Lives of Amphetamine
On Speed Nicolas Rasmussen On Speed The Many Lives of Amphetamine a New York University Press • New York and London NEW YORK UNIVERSITY PRESS New York and London www.nyupress.org © 2008 by New York University All rights reserved Library of Congress Cataloging-in-Publication Data Rasmussen, Nicolas, 1962– On speed : the many lives of amphetamine / Nicolas Rasmussen. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-0-8147-7601-8 (cl : alk. paper) ISBN-10: 0-8147-7601-9 (cl : alk. paper) 1. Amphetamines—United States—History. 2. Amphetamine abuse— United States—History. I. Title. II. Title: Many lives of amphetamine. [DNLM: 1. Amphetamines—history—United States. 2. Amphetamine-Related Disorders—history—United States. 3. History, 20th Century—United States. 4. History, 21st Century—United States. QV 102 R225o 2007] RM666.A493R37 2007 362.29'90973—dc22 2007043261 New York University Press books are printed on acid-free paper, and their binding materials are chosen for strength and durability. Manufactured in the United States of America c10987654321 p10987654321 To my parents, Laura and Norman, for teaching me to ask questions Contents Acknowledgments ix Introduction 1 1 The New Sensation 6 2 Benzedrine: The Making of a Modern Medicine 25 3 Speed and Total War 53 4 Bootleggers, Beatniks, and Benzedrine Benders 87 5 A Bromide for the Atomic Age 113 6 Amphetamine and the Go-Go Years 149 7 Amphetamine’s Decline: From Mental Medicine to Social Disease 182 8 Fast Forward: Still on Speed, 1971 to Today 222 Conclusion: The Lessons of History 255 Notes 261 List of Archival Sources 347 Index 348 About the Author 352 Illustrations appear in two groups following pages 86 and 148. -
API Written Confirmation 02-08-2021
MHRA Register of Written Confirmations For UK Active Substance Manufacturers The information published in this document was that held by the MHRA on the date of publication. Please note the site register will be updated on a Monthly basis. Date of Publication: 02/08/2021 Copyright © by the Department of Health and Social Care and MHRA, 10 South Colonnade, Canary Wharf, London E14 4PU T 020 3080 6000 – www.mhra.gov.uk NOTICES The Agency’s register is computerised. Every site and every Written Confirmation has a unique number that should be quoted when enquiries are made. NOTES FOR GUIDANCE GENERAL The Written Confirmations have been generated for UK Active Substance Manufacturing sites to support the export of Active Substances to the EEA. The Written Confirmation Number is a specific number allocated to each site. The Table of Contents contains a link to the relevant Written Confirmation for each company within this document. Table of Contents A NELSON AND COMPANY LIMITED AIR PRODUCTS PLC ALBUMEDIX LIMITED ALLIANCE MEDICAL RADIOPHARMACY LIMITED ALLIANCE MEDICAL RADIOPHARMACY LIMITED ALMAC SCIENCES (SCOTLAND) LIMITED ALMAC SCIENCES LIMITED APTUIT (OXFORD) LIMITED APTUIT (OXFORD) LIMITED ARC TRINOVA LIMITED BASILDON CHEMICAL COMPANY LIMITED BAXTER HEALTHCARE LIMITED BAXTER HEALTHCARE LIMITED BIO PRODUCTS LABORATORY LIMITED BSPG LABORATORIES LIMITED CATALENT MICRON TECHNOLOGIES LIMITED COURTIN & WARNER LIMITED CRODA EUROPE LIMITED CRODA EUROPE LIMITED DR REDDY'S LABORATORIES (EU) LIMITED DSM NUTRITIONAL PRODUCTS (UK) LIMITED EUROAPI UK LIMITED -
Cusip No. G8807B106 13 D/A2 Page 2 of 7
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* THERAVANCE BIOPHARMA, INC. (Name of Issuer) Ordinary Shares (Title of Class of Securities) G8807B106 (CUSIP Number) Victoria A. Whyte GlaxoSmithKline plc 980 Great West Road Brentford, Middlesex TW8 9GS England Telephone: +44 (0)208 047 5000 (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications) December 31, 2016 (Date of Event which Requires Filing of this Statement) If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐ Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent. * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act. -
Annual Report 2008 Find out More About GSK Online…
Do more, feel better, live longer Grow Deliver Simplify Annual Report 2008 Find out more about GSK online… www.gsk.com Website GlaxoSmithKline’s website www.gsk.com gives additional information on the Group. Information made available on the website does not constitute part of this Annual Report. Notice regarding limitations on Director liability under English Law Under the UK Companies Act 2006, a safe harbour limits the liability of Directors in respect of statements in and omissions from the Report of the Directors contained on pages 12 to 98. Under English law the Directors would be liable to the company (but not to any third party) if the Report of the Directors contains errors as a result of recklessness or knowing misstatement or dishonest concealment of a material fact, but would not otherwise be liable. Report of the Directors Pages 12 to 98 inclusive consist of a Report of the Directors that has been drawn up and presented in accordance with and in reliance upon English company law and the liabilities of the Directors in connection with that report shall be subject to the limitations and restrictions provided by such law. Cautionary statement regarding forward-looking statements The Group’s reports filed with or furnished to the US Securities and Exchange Commission (SEC), including this document and written information released, or oral statements made, to the public in the future by or on behalf of the Group, may contain forward-looking statements. Forward-looking statements give the Group’s current expectations or forecasts of future events. A shareholder can identify these statements by the fact that they do not relate strictly to historical or current facts. -
GCE a Level 1083/01 BUSINESS STUDIES –
GCE A level 1083/01 S15-1083-01 BUSINESS STUDIES – BS3 A.M. WEDNESDAY, 10 June 2015 2 hours 1083 010001 ADDITIONAL MATERIALS In addition to this examination paper, you will need: • a calculator; • a 12 page answer book. INSTRUCTIONS TO CANDIDATES Use black ink or black ball-point pen. Answer all the questions. Write your answers in the separate answer book provided. INFORMATION FOR CANDIDATES The number of marks is given in brackets at the end of each question. You are reminded that assessment will take into account the quality of written communication used in answers that involve extended writing in questions 4 and 5. You are reminded that questions 4 and 5 are synoptic and so will test understanding of the connections between different elements of the subject. © WJEC CBAC Ltd. AM*(S15-1083-01) 2 Study the information provided about GlaxoSmithKline plc and answer the questions that follow. BACKGROUND GlaxoSmithKline plc (GSK) is a science-led global healthcare company that researches and develops a broad range of innovative medicines and brands. It has three primary areas of business: pharmaceuticals, vaccines and consumer healthcare. Its consumer products include 5 Ribena, Macleans toothpaste, Panadol headache pills, Lucozade and Horlicks. The company can trace its history back to 1715 when Sylvanus Bevan established his pharmacy in Plough Court in London. In 1880, his descendants founded Burroughs Wellcome and Company which, eventually in 1995, merged with the Australian company Glaxo to form Glaxo Wellcome. The American branch of the business can trace its history back to 1830 when John K Smith 10 opened his first drugstore.