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may come back. If the infection worsens or should avoid driving, using machinery or VORICONAZOLE persists, consult your doctor. doing something that may be dangerous if your vision is impaired. Notify your doctor if Other NAMES: Vfend  What should you do if you FORGET a your vision changes or if bright lights are dose? bothersome. WHY is this drug prescribed? If you miss a dose voriconazole, take it as What other PRECAUTIONS should you Voriconazole is an drug. It is used soon as possible. However, if it is time for follow while using this drug? to treat a variety of fungal infections (candida, your next dose, do not double the dose, just ) in the mouth (like thrush), carry on with your regular schedule. Before starting voriconazole, please inform esophagus, lungs, blood and in other areas. your doctor if you have ever developed an What ADVERSE EFFECTS can this drug allergy to voriconazole or to similar drugs HOW should this drug be taken? cause? What should you do about them? [ (Nizoral ), (Diflucan ), (Sporanox ). Also Voriconazole is available as 50 mg and 200 Voriconazole may cause some stomach notify your doctor if you have kidney, or mg tablets. During the first days of therapy, it upset, nausea, vomiting and loss of vision problems. can also be given by intravenous (I.V.: in the appetite . Some other potential adverse veins) injections. The intravenous injections effects are abdominal pain, diarrhea, and Certain drugs can increase or decrease the will be given over a 1 to 2 hour period, likely headache . If these effects occur, please effect of voriconazole. Also, voriconazole by a nurse at the clinic. inform your doctor or pharmacist. might influence the effect of other drugs you are taking. Inform your doctor and The dose of voriconazole will depend on your Voriconazole can increase liver enzymes . pharmacist of all prescribed and non- weight and on the other drugs you are taking. This usually does not give any symptoms. prescribed drugs you are taking. As well, The usual oral dosage is 200 mg twice daily. Rarely, hepatitis (an inflammation of the liver) you should inform them of natural products This dose may need to be adjusted by your can occur. Signs of this are yellowing of the you are taking. If you wish to start a new doctor to meet your needs. eyes and skin, fever, severe nausea and / or drug or natural product, please consult with vomiting, dark urine, pale stools, fatigue, and your pharmacist before doing so. Voriconazole tablets should be taken on an abdominal pain. Consult a doctor empty stomach. Take your dose at least 1 immediately if you experience these You should NOT take the following drugs if hour before or 2 hours after a meal. symptoms. Your doctor will do regular blood your doctor has prescribed voriconazole: tests to verify your liver function. Your dosage is: (Tegretol ) Rarely, some people can develop an allergic (Sustiva ) standard dose 50 mg reaction to voriconazole. If you are allergic to Ergot derivatives [ the drug, you can develop a skin rash, hives, (Cafergot , Bellergal , Ergodryl , 200 mg tablet itching, swelling or tingling feeling in the Gravergol ), ergo-novine, mouth and throat, chest pain and dihydroergotamine (Migranal ), ____tablets (____mg) ____time(s) a day tightness, and difficulties breathing . methylergonovine (Methergine )] Please consult a doctor immediately if these Phenobarbital or symptoms appear. Pimozide (Orap ) (Biquin Durules ) intravenous infusion Changes in vision can also occur if you are (Mycobutin ) receiving voriconazole. These include Rifampin (e.g. Rifadin , Rimactane , ____mL (____mg) ____ time(s) a day changes in colour vision and a blurred vision. Rofact ) Take voriconazole for the duration of time it is These symptoms are usually mild and (Norvir ) at doses of 400 mg prescribed. If you stop it earlier, your infection temporary. If you notice vision changes, you twice daily or higher  (Rapamune ) If you have any questions or concerns St. John’s Wort about this drug or if you are experiencing adverse effects, please discuss them with Voriconazole can make your skin more your pharmacist, doctor or nurse. sensitive to the sun or sunlamps. Therefore, wear protective clothing and use a Write questions or concerns down to sunscreen with at least an SPF of 15 ensure they are addressed. whenever you are exposed to the sun. You should also avoid sunlamps. Ask your The following pharmacist is available to VORICONAZOLE pharmacist to help select a sunscreen that answer questions: protects against drug-sun reactions. Pharmacist: ______The safety of voriconazole during Telephone: ______or breastfeeding has not established. You should avoid becoming pregnant by using appropriate contraceptive methods while you are receiving voriconazole. Breastfeeding is NOT recommended if you are receiving MEDICATION voriconazole. Please discuss this with your doctor or pharmacist if this is a concern.

How should this drug be STORED? FACT SHEET

Voriconazole should be stored at room temperature in a cool (15-30 °C) dry place, protected from light and well out of the reach of children. The diluted voriconazole solution for intravenous administration should be kept in the refrigerator between 2 to 8 ° C and used within 24 hours.

If you are receiving the intravenous solution at home, about an hour before your treatment, remove a bag from the refrigerator and let it warm to room temperature. Check your bag to ensure that there are no leaks and that there are no solid particles in the solution. If so, you should not use the bag.

Ensure that the drug has not expired by Reference: Voriconazole (Vfend ) Product Monograph. Canada Inc., Kirkland, QC, 2009. Prepared by checking the expiry date (“EXP”) shown on the Ontario HIV Pharmacy Professional Specialty the outside of the package. Group, 2003. Updated 2009. Do not store in your bathroom or near the stove, as heat and moisture may cause the Additional medication fact sheets and updates may be drug to be less active. found at: www.hivclinic.ca