Curriculum Vitae (short version, 4 pages)

1. FULL NAME Vincenzo Cerullo (ResearchID: B-9075-2015; ORCID: 0000-0003-4901-3796)

2. OTHER INFORMATION Citizenship: Italian Office address: Biocenter 2, Viikinkaari 5E, 00790 Helsinki, Home Address: Uimarinpolku 10C 15, 00330 Helsinki, Finland

Marital Status: Married, two children (Victor, 6 and Nicole, 2) 3. EDUCATION AND DEGREE AWARDED 23/10/1998 Master of and Pharmaceutical Chemistry (5 years), score 110/110 cum laude University of Naples “Federico II”. of the Thesis: Crellastatin A: A Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine Sponge Crella sp. Supervisors: Professors Luigi Minale and Mariavaleria D’Auria 3 Jun 1999 Board of Pharmacy 17 Jun 2004 Doctor in Biotechnology, University of L’Aquila and University of Naples “Federico II”. Title of the thesis: Development of Helper-dependent Adenoviral Vectors for gene therapy of Atherosclerosis. Supervisors: Professor Lucio Pastore and Professor Fabrizio Pane. 13 May 2011 (equivalent to adjunct professor or senior lecturer) of Experimental Virology, .

4. OTHER EDUCATION AND TRAINING, QUALIFICATIONS AND SKILLS - Pedagogy education at University of Helsinki (35ECTs) teaching in higher Education - Clinical trials development and clinical research – ASGCT

5. LINGUISTIC SKILLS Italian: mother tongue English: fluent Spanish: good Finnish: entry (second level Helsingin Aikuisopisto, training still on-going) Swedish: good (wife and son Swedish-speaking)

6. CURRENT POSITION 16/09/2012 Tenure-track associate professor Faculty of Pharmacy, Division of Pharmaceutical Biosciences, University of Helsinki 16/09/2012 Group Leader Immunovirotherapy Lab (IVTLab) at Centre for Drug Research (CDR)

7. PREVIOUS WORK EXPERIENCE and MOBILITY:

09/12-to-date Assistant Professor (Tenure-Track), Laboratory of Immunovirotherapy, Pharmaceuthical Biosciences, Faculty of Pharmacy, University of Helsinki – Finland, Europe 1 2009-2012 Senior Researcher, Cancer Gene Therapy Group, University of Helsinki, Finland Europe 2004-2008 Postdoc, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston TX USA 2001-2004 PhD student, CEINGE (Center for Genetic Engineering) and University of Naples “Federico II”, Italy, Europe 2001 Exchange PhD student, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston TX, USA 1998-2000 Research Assistant, Department of Biochemistry and Medical Biotechnology, University of Naples, Italy, Europe 1993-1998 Master Student, Department of Chemistry of the Natural Compounds, University of Naples, Italy, Europe

8. RESEARCH FUNDING, LEADERSHIP AND SUPERVISION:

MAJOR RESEARCH FUNDING GRANTS AWARDED (as PI) FP7-PEOPLE-IRG-2008 (PI) (2009-2013) (Lab expenses) 100,000.00€ University of Helsinki Postdoctoral Researcher (PI) (2010-2013) 120,000.00€ University of Helsinki Three years research grant (PI) (2013-2015) 140,000.00€ University of Helsinki Tenure-track (PI) (2012-2017) 400,000.00€ Cancer Finnish Foundation (PI) (2014) 25,000.00€ Faculty of Pharmacy (PI) (2014) 60,000.00€ Tekes - the Finnish Funding Agency for Innovation 270,000.00€ Finnish Cancer Foundation (PI) (2016-2017) 80,000.00€ NOVO Nordisk Seed (Pre-seed fund) (PI) (2016-2017) 350,000.00€ ERC-CoG grant (European Council of research) (2016-2021) 2,000,000.00€

SUPERVISION OF UNDERGRADUATE STUDENTS AND MENTORED MASTER THESIS: 2008 Candidate: Matteo Ugolini; Score 110/110 cum laude; Thesis Title : Manipulating different arms of the immune system to orchestrate tumor-specific immunity and enhance tumor clearance by adenovirus-based gene therapy” 2009 Candidate: Federica Madarena; Score 106/110; Thesis Title: DC-based cancer immunotherapy 2009-2010 Candidate : Valentina Romano; Score 110/110 cum laude. Thesis Title: CpG-rich oncolytic adenoviruses to enhance tumor clearance stimulating TLR9 2011-2012 Candidate: Mari Hirvinen; Score Eximia cum laude approbatur. Thesis Title: Fcgamma receptors polymorphisms as prognostic biomarkers for oncolytic adenovirus therapy. 2014- to now Teea Sarvela (on going).

SUPERVISION OF YOUNG RESEARCHERS AND MENTORED PhD THESIS: 2007-2010 Candidate: Joao Dias; Thesis Title: Adenoviral gene therapy for advanced Head and Neck cancer. Approved with distinction by the faculty of Medicine 2012-2014 Candidate: Mariangela Garofalo; Title: Oncolytic Adenovirus loaded with L-carnosine as drug delivery system for cancer therapy 2010-present Candidate: Noora Rouvinen 2011-present Candidate: Mari Hirvinen; Title: Immunovirotherapy of cancer – Immunological boosting and personalizing of viral cancer therapeutics 2012-present Candidate: Mariangela Garofalo; Title: Role and use of L-Carnosine in cancer treatment 2012-present Candidate: Cristian Capasso; Title: Personalized cancer vaccine development 2013-present Candidate: Lukasz Kuryk; Title: Development of novel immune-boosted oncolytic adenoviruses for treatment of mesothelioma

9. TEACHING COMPETENCES: PEDAGOGICAL COMPETENCE AND TRAINING

2 2010-2013 University of Helsinki: Pedagogy I “Teaching and Learning in higher education” (YP1), Pedagogy II ”Design and implementation and assessment of teaching” (YP2), Pedagogy III “Academic Supervising” and Pedagogy IV “Assessment of learning”, Pedagogy V “Development of teaching and practical training” (YPV) (ongoing); (25 ECTs in total).

TEACHING DEVELOPMENT AT UNIVERSITY OF HELSINKI 2012, 2013, 2014 and 2015 Lecturer in the course of Biopharmaceutical II (Resp. Adyary Fallarero) 2012, 2013, 2014 and 2015 Lecturer in Adv. Biopharmaceutics (Resp. Marjo Yliperttula) 2014-to now Responsibility for the development, design, implementation and lecturing of a master level course, Advanced Immunobiology (7 credits, including theoretical and practical parts)

INVITED LECTURER AS SCIENTIFIC EXPERT (SELECTED FROM 30) 2008 Safety and toxicity of adenoviral vector, University of Helsinki, Faculty of Medicine, Haartman Institute, Finland 2010 Series of lectures on the use of adenovirus as vector for cancer gene. Department of Immunology University of Verona, Italy 2012 Adenovirus-gene therapy from bench to bedside, CEINGE and University of Naples, Italy 2012 Oncolytic viruses for Cancer gene therapy, University of , 2013 Adenovirus-gene therapy from bench to bedside, Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

10. SCIENTIFIC AWARDS AND HONORS: 1993 Scholarship at the Pharmaceutical Chemistry Department of University of Naples 1998 “Erasmus” Scholarship at “Universitat de Barcelona” Spain 1998 University of Naples, special mention and publication of the thesis 1999 Award from Società Chimica Italiana (Italian Society of Chemist) for the Master thesis 2005 Award for presentation at Cell and Gene Therapy, Galveston TX, USA 2012 “New investigator of the month” awarded by the American Society of Cell and Gene Therapy 2013 Nominated for Outstanding New Investigator Award by American Society of Gene and cell therapy 2014 Young Investigator Award at ESGCT (European Society of Gene and Cell Therapy) 2016 Young Investigator Award at American Society of Gene and Cell Therapy (ASGCT)

11. Additional Academic merits - Participation as Pre-examiner of Doctoral Theses (5) - Participation as appointed Doctoral examinations at European School of Molecular Medicine (SEMM) (4) - Organizing Committee for the European Society of Gene and Cell therapy meeting 2015 - 2014-on Strategy planning group member for the Faculty of Pharmacy, University of Helsinki - 2015-on Responsible for the international Master program in Biopharmacy University of Helsinki- University of Padova ------2012 ASGCT - Abstract Reviewer for the “Adenovirus and other DNA viruses” category 2013-2016 ASGCT – Committee Rosters “Immune response to gene and cell therapy” 2014 ASGCT - Abstract Reviewer for the “Cancer-Immunotherapy” category 2015 ASGCT - Abstract Reviewer for the “Cancer-Oncolytic Viruses” category 2015 ESGCT – Local committee organizer and member for the event in Helsinki

PATENTS AND INVENTIONS 1. Title: “Antigen specific immunosuppression by dendritic cell therapy” Patent No. : US20080311140 2. Title: “Adenoviral vectors and methods and uses related thereto” Patent No. : Finnish patent office 20095466 3. Title: “Non-Ad5 adenoviral vectors and methods and uses related thereto” 3 Patent No. : Finnish patent office 20095751 4. Title: Ad5D24-CD40L-family, Finnish Patent pending, application #20105988 5. Title: Ad5D24-CTLA4-family, Finnish Patent pending, application #20105991 6. Title: VVDD-CD40L-family, Finnish patent pending, application #20115914 7. Title: VVDD-CD40L-family, US patent pending, application #61/535429 8. "Novel therapeutic vectors", Finnish application #20116181 and US application #61/563,634 9. "Novel therapeutic vectors", US application #61/563,634 10. “Personalised peptide-coated viruses – PeptiCrad, international patent: PCT/EP2015/060903

12. POSITION OF TRUST • Editor-in-chief of "Tumor Immunology and Immunotherapy" - Biomedicines • Editorial Board of Biomedicines • Editorial Board of Molecular Therapy Oncolytics • Editorial Board of the Journal of Molecular Cytotherapy • Editorial Board of PlosOne • Editorial Board of American Journal of Cancer Research and Clinical Oncology • Guest Editor of Biomedicines for the special issue “Gene therapy for cancer treatment” • Grant Reviewer for: American Institute for cancer Research (AICR), The Welcome Trust UK, and Swiss National Science Foundation • Board Member of the Immune Response to Gene and Cell Therapy Committee of ASGCT • Abstract evaluator for ASGCT 2012, 2013, 2014 and 2015 and ESGCT 2015 • Ad hoc reviewer for: Molecular Therapy, Human Gene Therapy, Gene Therapy, Cancer Research, Clinical Cancer Research, International Journal of Cancer, Journal of Gene Medicine, PlosOne, among others • Evaluator for an the Italian professorship; selected from 1700 applicants by ANVUR (2013)

13. MEMBERSHIPS OF SCIENTIFIC SOCIETIES Finnish Society of Gene Therapy, American Society of Gene and Cell Therapy, European Society of Gene and Cell Therapy, Society for Immunotherapy of Cancer (SITC)

14. MAJOR ONGOING COLLABORATIONS International: Dotti Giampietro (Texas Children Hospital), Masataka Suzuki (Center for Gene and Cell Therapy (CGCT) Houston TX), Brendan Lee (Baylor College of Medicine, Houston TX), Luigi Buonaguro (Ospedale Pascale, Napoles, Italy), Gennaro Piccialli (Naples, Italy), Davide Melisi (Verona, Italy) National: Akseli Hemminki, Markku Varjosalo and Dario Greco (Universty of Helsinki), Ari Hinkkanen (University of Eastern Finland).

15. SCIENTIFIC AND SOCIETAL IMPACT OF RESEARCH

Summary Table Total peer-reviewed articles (already accepted and indexed) 68 Total articles in submission not yet accepted at the time of deadline 5 First Authorship 9 Second Authorship 6 Last and/or corresponding authorship 17 h index 22 Total citations 1416 Patents and Invention 11 Book Chapters 5 Invited Oral presentation at International Meetings 18

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