Prediction of Aqueous Solubility from SCRATCH
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US 2014/0116112 A1 HUMPHREY Et Al
US 201401 16112A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0116112 A1 HUMPHREY et al. (43) Pub. Date: May 1, 2014 (54) METHODS FOR DETERMINING THE Publication Classification PRESENCE OR ABSENCE OF CONTAMINANTS IN A SAMPLE (51) Int. Cl. GOIN30/72 (2006.01) (71) Applicant: K & D LABORATORIES, INC., Lake (52) U.S. Cl. Oswego, OR (US) CPC .................................. G0IN30/7206 (2013.01) USPC ......................................................... T3/23.37 (72) Inventors: David Kent HUMPHREY, Reno, NV (US); Nicholas Joseph GEISE, Portland, OR (US) (57) ABSTRACT (73) Assignee: K & D LABORATORIES, INC., Lake Oswego, OR (US) Methods are provided for rapidly determining the presence or absence of large numbers of contaminants in a test sample, (21) Appl. No.: 13/830,388 Such as a raw material intended for use in the preparation of a nutraceutical. The disclosed methods employ gas chromatog (22) Filed: Mar 14, 2013 raphy-mass spectrometry techniques together with the spe cific use of software in combination with a database to ana Related U.S. Application Data lyze data collected after ionization of the sample and (60) Provisional application No. 61/718,607, filed on Oct. determine the presence or absence of the contaminants in the 25, 2012. sample. US 2014/01161 12 A1 May 1, 2014 METHODS FOR DETERMINING THE 0007. In one embodiment, methods for detecting the pres PRESENCE OR ABSENCE OF ence or absence of a plurality of contaminants in a sample are CONTAMINANTS IN A SAMPLE provided, such methods comprising: (a) extracting the sample with a water-miscible solvent in the presence of a high con REFERENCE TO RELATED APPLICATIONS centration of salts to provide a sample extract; (b) shaking and centrifuging the sample extract to provide a Supernatant; (c) 0001. -
Factors Influencing Pesticide Resistance in Psylla Pyricola Foerster and Susceptibility Inits Mirid
AN ABSTRACT OF THE THESIS OF: Hugo E. van de Baan for the degree ofDoctor of Philosopbv in Entomology presented on September 29, 181. Title: Factors Influencing Pesticide Resistance in Psylla pyricola Foerster and Susceptibility inits Mirid Predator, Deraeocoris brevis Knight. Redacted for Privacy Abstract approved: Factors influencing pesticide susceptibility and resistance were studied in Psylla pyricola Foerster, and its mirid predator, Deraeocoris brevis Knight in the Rogue River Valley, Oregon. Factors studied were at the biochemical, life history, and population ecology levels. Studies on detoxification enzymes showed that glutathione S-transferase and cytochrome P-450 monooxygenase activities were ca. 1.6-fold higherin susceptible R. brevis than in susceptible pear psylla, however, esterase activity was ca. 5-fold lower. Esterase activity was ca. 18-fold higher in resistant pear psylla than in susceptible D. brevis, however, glutathione S-transferase and cytochrome P-450 monooxygenase activities were similar. Esterases seem to be a major factor conferring insecticideresistance in P. Pvricola. Although the detoxification capacities of P. rivricola and D. brevis were quite similar, pear psylla has developed resistance to many insecticides in the Rogue River Valley, whereas D. brevis has remained susceptible. Biochemical factors may be important in determining the potential of resistance development, however, they are less important in determining the rate at which resistance develops. Computer simulation studies showed that life history and ecological factors are probably of greater importancein determining the rate at which resistance develops in P. pvricola and D. brevis. High fecundity and low immigration of susceptible individuals into selected populations appear to be major factors contributing to rapid resistance development in pear psylla compared with D. -
Lambda Cyhalothrin Elicited Dose Response Toxicity On
TOXICOLOGY AND FORENSIC MEDICINE http://dx.doi.org/10.17140/TFMOJ-1-107 Open Journal Research Lambda Cyhalothrin Elicited Dose *Corresponding author Response Toxicity on Haematological, Sujata Maiti Choudhury, PhD Department of Human Physiology with Community Health Hepatic, Gonadal and Lipid Metabolic Vidyasagar University Midnapore, West Bengal, India Biomarkers in Rat and Possible Modulatory Tel. + 9474444646 Fax: + 3222 275 329 Role of Taurine E-mail: [email protected]; [email protected] Rini Ghosh, MSc; Tuhina Das, MSc; Anurag Paramanik, MSc; Sujata Maiti Choudhury, Volume 1 : Issue 2 PhD* Article Ref. #: 1000TFMOJ1107 Department of Human Physiology with Community Health, Vidyasagar University, Midnapore Article History 721102, West Bengal, India Received: September 10th, 2016 Accepted: October 5th, 2016 Published: October 6th, 2016 ABSTRACT Extensive application of pesticides is usually accompanied with serious problems of pollution Citation and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used Ghosh R, Das T, Paramanik A, Maiti in agriculture, home pest control and protection of foodstuff. This study designed to evalu- Choudhury S. Lambda cyhalothrin elicited dose response toxicity on hae- ate the dose dependent haematological, hepatic and gonadal toxicity of LCT at different dose matological, hepatic, gonadal and lipid levels in Wistar rat. Investigations were also done to find out the toxic effect of lambda cyha- metabolic biomarkers in rat and possi- lothrin on lipid metabolism in female rat and its amelioration by taurine. Rats were exposed ble modulatory role of taurine. Toxicol to different doses of lambda cyhalothrin over a period of 14 consecutive days. Exposure to Forensic Med Open J. -
Polystyrene Microplastics Do Not Affect Juvenile Brown Trout (Salmo Trutta F
Schmieg et al. Environ Sci Eur (2020) 32:49 https://doi.org/10.1186/s12302-020-00327-4 RESEARCH Open Access Polystyrene microplastics do not afect juvenile brown trout (Salmo trutta f. fario) or modulate efects of the pesticide methiocarb Hannah Schmieg1*, Sven Huppertsberg2, Thomas P. Knepper2, Stefanie Krais1, Katharina Reitter1, Felizitas Rezbach1, Aki S. Ruhl3,4, Heinz‑R. Köhler1 and Rita Triebskorn1,5 Abstract Background: There has been a rising interest within the scientifc community and the public about the environmen‑ tal risk related to the abundance of microplastics in aquatic environments. Up to now, however, scientifc knowledge in this context has been scarce and insufcient for a reliable risk assessment. To remedy this scarcity of data, we inves‑ tigated possible adverse efects of polystyrene particles (10 4 particles/L) and the pesticide methiocarb (1 mg/L) in juvenile brown trout (Salmo trutta f. fario) both by themselves as well as in combination after a 96 h laboratory expo‑ sure. PS beads (density 1.05 g/mL) were cryogenically milled and fractionated resulting in irregular‑shaped particles (< 50 µm). Besides body weight of the animals, biomarkers for proteotoxicity (stress protein family Hsp70), oxidative stress (superoxide dismutase, lipid peroxidation), and neurotoxicity (acetylcholinesterase, carboxylesterases) were analyzed. As an indicator of overall health, histopathological efects were studied in liver and gills of exposed fsh. Results: Polystyrene particles by themselves did not infuence any of the investigated biomarkers. In contrast, the exposure to methiocarb led to a signifcant reduction of the activity of acetylcholinesterase and the two carboxy‑ lesterases. Moreover, the tissue integrity of liver and gills was impaired by the pesticide. -
Bayesian Nonparametric Model for Clustering Individual Co-Exposure to Pesticides Found in the French Diet
Bayesian nonparametric model for clustering individual co-exposure to pesticides found in the French diet. Amélie Crépet, Jessica Tressou To cite this version: Amélie Crépet, Jessica Tressou. Bayesian nonparametric model for clustering individual co-exposure to pesticides found in the French diet.. 2009. hal-00438796v2 HAL Id: hal-00438796 https://hal.archives-ouvertes.fr/hal-00438796v2 Preprint submitted on 12 Jan 2011 (v2), last revised 4 Feb 2011 (v3) HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Bayesian nonparametric model for clustering individual co-exposure to pesticides found in the French diet. Am´elieCr´epet a & Jessica Tressoub January 12, 2011 aANSES, French Agency for Food, Environmental and Occupational Health Safety, 27-31 Av. G´en´eralLeclerc, 94701 Maisons-Alfort, France bINRA-Met@risk, Food Risk Analysis Methodologies, National Institute for Agronomic Re- search, 16 rue Claude Bernard, 75231 Paris, France Keywords Dirichlet process; Bayesian nonparametric modeling; multivariate Normal mixtures; clustering; multivariate exposure; food risk analysis. Abstract This work introduces a specific application of Bayesian nonparametric statistics to the food risk analysis framework. The goal was to determine the cocktails of pesticide residues to which the French population is simultaneously exposed through its current diet in order to study their possible combined effects on health through toxicological experiments. -
Methiocarb (132)
531 METHIOCARB (132) EXPLANATION Methiocarb, or mercaptodimethur, an insecticide, acaricide, molluscicide, and bird repellent was identified by the 1995 CCPR as a candidate for periodic review (ALINORM 95/24A, Annex 1). It was scheduled for toxicological and residue reviews by the 1998 and 1999 JMPR respectively (ALINORM 97/24A, Appendix III). The most recent extensive reviews of methiocarb residue chemistry were in 1981 and 1983. The manufacturer is Bayer AG. IDENTITY ISO common name: methiocarb mercaptodimethur Chemical names: IUPAC: 4-methylthio-3,5xylyl methylcarbamate CA: 3,5-dimethyl-4-(methylthio)phenyl methylcarbamate CAS Number: 2032-65-7 CIPAC Number: 165 Synonyms: BAY 37344 Mesurol Structural formula: CH3 S O CH3 H3C N O CH3 Molecular formula: C11H15NO2S Molecular weight: 225.3 Physical and chemical properties Pure active ingredient Vapour pressure: 0.015 mPa at 20°C 0.036 mPa at 25°C Melting point: 119°C 532 methiocarb Octanol/water partition Coefficient: log Pow = 3.11 at 20°C and pH 4 log Pow = 3.18 at 20°C and pH 7 degradation at pH 9 log Pow = 3.08 at 20°C unbuffered (Krohn, 1995) Solubility: 0.027 g/l at 20°C in water (Krohn, 1989) 1.3 g/l at 20°C in n-hexane 33 g/l at 20°C in toluene >200 g/l at 20°C in dichloromethane 53 g/l at 20°C in 2-propanol Specific gravity: 1.236 g/cm3 at 20°C Hydrolysis: half-lives of 763 days, 28 days, and 2.2 days at pH 5, 7, and 9 respectively (Saakvitne, 1981). -
Ust Be Reregistration Registered by EPA, Based on Scientific Studies Showing That They Can Be Used Without Posing Unreasonable Risks to People Or the Environment
United States Prevention, Pesticides EPA-738-F-94-002 Environmental Protection And Toxic Substances February 1994 Agency (7508W) R.E.D. FACTS Methiocarb Pesticide All pesticides sold or distributed in the United States must be Reregistration registered by EPA, based on scientific studies showing that they can be used without posing unreasonable risks to people or the environment. Because of advances in scientific knowledge, the law requires that pesticides which were first registered years ago be reregistered to ensure that they meet today's more stringent standards. In evaluating pesticides for reregistration, EPA obtains and reviews a complete set of studies from pesticide producers, describing the human health and environmental effects of each pesticide. The Agency imposes any regulatory controls that are needed to effectively manage each pesticide's risks. EPA then reregisters pesticides that can be used without posing unreasonable risks to human health or the environment. When a pesticide is eligible for reregistration, EPA announces this and explains why in a Reregistration Eligibility Decision (RED) document. This fact sheet summarizes the information in the RED for methiocarb. Use Profile Methiocarb is an insecticide, acaricide and molluscicide. It is used to control snails, slugs, spider mites and insects on lawns, turf and ornamentals, around building foundations, and in ginseng gardens. Methiocarb has no remaining food uses; the use on ginseng has a 12-month preharvest interval and therefore is not considered a food use. Methiocarb end-use products formulated as granulars and pellets/tablets are used on residential and commercially grown lawns, turfgrass and ornamentals, in commercial greenhouses and nurseries, around building foundations, and in ginseng gardens. -
Chapter 3 Sensors and Biosensors for Endocrine Disrupting Chemicals: State-Of-The-Art and Future Trends
Chapter 3 Sensors and biosensors for endocrine disrupting chemicals: State-of-the-art and future trends Achintya N. Bezbaruah and Harjyoti Kalita 3.1 INTRODUCTION Endocrine systems control hormones and activity-related hormones in many living organisms including mammals, birds, and fish. The endocrine system consists of various glands located throughout the body, hormones produced by the glands, and receptors in various organs and tissues that recognize and respond to the hormones (USEPA, 2010a). There are some chemicals and compounds that cause interferences in the endocrine system and these substances are known as endocrine disrupting chemicals (EDCs). Wikipedia states that EDCs or ‘‘endocrine disruptors are exogenous substances that act like hormones in the endocrine system and disrupt the physiologic function of #2010 IWA Publishing. Treatment of Micropollutants in Water and Wastewater . Edited by Jurate Virkutyte, Veeriah Jegatheesan and Rajender S. Varma. ISBN: 9781843393160. Published by IWA Publishing, London, UK. 94 Treatment of Micropollutants in Water and Wastewater endogenous hormones. They are sometimes also referred to as hormonally active agents.’’ EDCs can be man-made or natural. These compounds are found in plants (phytochemicals), grains, fruits and vegetables, and fungus. Alkyl-phenols found in detergents, bisphenol A used in PVC products, dioxins, various drugs, synthetic estrogens found in birth control pills, heavy metals (Pb, Hg, Cd), pesticides, pasticizers, and phenolic products are all examples of EDCs from a long list that is rapidly getting longer. It is suspected that EDCs could be harmful to living organisms, therefore, there is a concerted effort to detect and treat EDCs before they can cause harm to the ecosystem components. -
1 of 3 GC+LC-USA
Updated: 07/18/2016 1 of 3 GC+LC-USA Limit of Quantitation (LOQ): 0.010 mg/kg (ppm) Sample Types: Low Fat Content Samples Minimum Sample Size: 100 grams (~1/4 pound). Certain products require more for better sample representation. Instrument: GC-MS/MS and LC-MS/MS Turnaround: 24-48 hours Accreditation: Part of AGQ USA's ISO/IEC 17025 Accreditation Scope 4,4'-Dichlorobenzophenone Bupirimate Cyantraniliprole Diflufenican Abamectin Buprofezin Cyazofamid Dimethoate Acephate Butachlor Cycloate Dimethoate (Sum) Acequinocyl Butocarboxim Cycloxydim Dimethomorph Acetamiprid Butralin Cyflufenamid Diniconazole Acetochlor Cadusafos Cyfluthrin Dinocap Acrinathrin Captafol Cymoxanil Dinotefuran Alachlor Captan Cyproconazole Diphenylamine Aldicarb Captan (Sum) Cyprodinil Disulfoton Aldicarb (Sum) Carbaryl Cyromazine Disulfoton (Sum) Aldicarb-sulfone Carbofuran DDD-o,p Disulfoton-sulfone Aldicarb-sulfoxide Carbofuran-3-hydroxy DDD-p,p +DDT-o,p Disulfoton-sulfoxide Aldrin Carbophenothion DDE-o,p Ditalimfos Ametryn Carbosulfan DDE-p,p Diuron Amitraz Carboxine DDT (Sum) Dodemorph Atrazine Carfentrazone-ethyl DDT-p,p Dodine Azadirachtin Chinomethionat DEET Emamectin Benzoate Azamethiphos Chlorantraniliprole Deltamethrin Endosulfan (A+B+Sulf) Azinphos-ethyl Chlordane Demeton Endosulfan Alfa Azinphos-methyl Chlordane Trans Demeton-S-methyl-sulfone Endosulfan Beta Azoxystrobin Chlorfenapyr Desmedipham Endosulfan Sulfate Benalaxyl Chlorfenson Diafenturion Endrin Ben-Carb-TPM (Sum) Chlorfenvinphos Dialifos EPN Bendiocarb Chlorfluazuron Diazinon Epoxiconazole -
A Toxic Eden: Poisons in Your Garden an Analysis of Bee-Harming Pesticides in Ornamental Plants Sold in Europe
A TOXIC EDEN: POISONS IN YOUR GARDEN AN ANALYSIS OF BEE-HARMING PESTICIDES IN ORNAMENTAL PLANTS SOLD IN EUROPE A TOXIC EDEN: POISONS IN YOUR GARDEN AN ANALYSIS OF BEE-HARMING PESTICIDES IN ORNAMENTAL PLANTS SOLD IN EUROPE April 2014 Technical Report 1 A TOXIC EDEN: POISONS IN YOUR GARDEN AN ANALYSIS OF BEE-HARMING PESTICIDES IN ORNAMENTAL PLANTS SOLD IN EUROPE A TOXIC EDEN: POISONS IN YOUR GARDEN An analysis of bee-harming pesticides in ornamental plants sold in Europe Summary and recommendations by Greenpeace 3 1. Introduction 5 2. Materials & Methods 6 2.1 Overview of Results 6 2.2 Bee-harming pesticides 8 2.3 The maximum concentrations of bee-harming pesticides detected 10 2.4 Most frequently detected pesticides 11 2.5 Authorization status of the detected pesticides 14 2.6 Pesticide residue categories 16 2.7 Manufacturer/Authorization Holder of the bee-harming pesticides 17 3. Annex 18 4. Literature 41 For more information contact: [email protected] Written by: Wolfgang Reuter, ForCare, Freiburg - Germany Dipl.-Biol., Fach-Toxikologe Layout by: Juliana Devis Cover image by: Axel Kirchhof Greenpeace International Ottho Heldringstraat 5 1066 AZ Amsterdam The Netherlands greenpeace.org © Greenpeace / Herman van Bekkem © Greenpeace 2 A TOXIC EDEN: POISONS IN YOUR GARDEN AN ANALYSIS OF BEE-HARMING PESTICIDES IN ORNAMENTAL PLANTS SOLD IN EUROPE SUMMARY AND RECOMMENDatIONS BY GREENPEACE © Greenpeace / Christine Gebeneter Current industrial agriculture relies on diverse synthetic chemical inputs, ranging from synthetic fertilisers through to toxic pesticides. These pesticides are designed to address insect and fungal pests as well as control weed plant species. -
Nontargeted Discovery of Xenobiotics in Human Urine by Maldi-Tof/Tof-Ms
NONTARGETED DISCOVERY OF XENOBIOTICS IN HUMAN URINE BY MALDI-TOF/TOF-MS Dissertation Presented by Yuanyuan Yao To The Bouve’ Graduate School of Health Sciences in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Pharmaceutical Sciences with specialization in Biomedical Sciences NORTHEASTERN UNIVERSITY BOSTON, MASSACHUSETTS April 2018 ABSTRACT In this dissertation research, nontargeted analysis of the urine metabolome, including xenobiotics, was studied using LC (Liquid Chromatography)-MALDI (Matrix Assisted Laser Desorption Ionization) MS (Mass Spectrometry) techniques. MALDI is a sensitive soft ionization MS technique that has been mainly used to analyze large molecules such as peptides, proteins, and nucleic acids. Here, MALDI MS methods were employed for detection of urine metabolites. To increase the recovery of nonpolar metabolites, a novel porous extraction paddle (PEP) was validated with co-workers and used for urine extraction. A method for sample preparation including UHPLC (Ultra High-Performance Liquid Chromatography) was optimized to facilitate detection of nonpolar urine sulfate metabolites by MALDI MS. Using this approach, the detection coverage of such compounds was greatly expanded as compared to prior methods. Detection of 1129 MS precursor ions corresponding to putative sulfate and glucuronide metabolites was achieved. Combining MS and MS/MS experiments, a strategy was developed for tentative identification of the detected metabolites. This led to the first nontargeted analysis of environmental contaminants in urine. It was shown that the detection sensitivity of positive-mode MALDI MS can be enhanced using enzymatic deconjugation and cationic tagging methods. Also, an evaporative derivatization method was developed to increase the sensitivity of negative-mode MALDI MS for detection of phenolic compounds. -
(12) United States Patent (10) Patent No.: US 8,486,374 B2 Tamarkin Et Al
USOO8486374B2 (12) United States Patent (10) Patent No.: US 8,486,374 B2 Tamarkin et al. (45) Date of Patent: Jul. 16, 2013 (54) HYDROPHILIC, NON-AQUEOUS (56) References Cited PHARMACEUTICAL CARRIERS AND COMPOSITIONS AND USES U.S. PATENT DOCUMENTS 1,159,250 A 11/1915 Moulton 1,666,684 A 4, 1928 Carstens (75) Inventors: Dov Tamarkin, Maccabim (IL); Meir 1924,972 A 8, 1933 Beckert Eini, Ness Ziona (IL); Doron Friedman, 2,085,733. A T. 1937 Bird Karmei Yosef (IL); Alex Besonov, 2,390,921 A 12, 1945 Clark Rehovot (IL); David Schuz. Moshav 2,524,590 A 10, 1950 Boe Gimzu (IL); Tal Berman, Rishon 2,586.287 A 2/1952 Apperson 2,617,754 A 1 1/1952 Neely LeZiyyon (IL); Jorge Danziger, Rishom 2,767,712 A 10, 1956 Waterman LeZion (IL); Rita Keynan, Rehovot (IL); 2.968,628 A 1/1961 Reed Ella Zlatkis, Rehovot (IL) 3,004,894 A 10/1961 Johnson et al. 3,062,715 A 11/1962 Reese et al. 3,067,784. A 12/1962 Gorman (73) Assignee: Foamix Ltd., Rehovot (IL) 3,092.255. A 6, 1963 Hohman 3,092,555 A 6, 1963 Horn 3,141,821 A 7, 1964 Compeau (*) Notice: Subject to any disclaimer, the term of this 3,142,420 A 7/1964 Gawthrop patent is extended or adjusted under 35 3,144,386 A 8/1964 Brightenback U.S.C. 154(b) by 1180 days. 3,149,543 A 9, 1964 Naab 3,154,075 A 10, 1964 Weckesser 3,178,352 A 4, 1965 Erickson (21) Appl.