Anesthesia and Cardiovascular Disease Bhavna Gupta*, Lalit Gupta Maulana Azad Medical College and Loknayak Hospital, New Delhi-110002
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Archives of Anesthesiology Volume 1, Issue 1, 2018, PP: 8-16 Anesthesia and Cardiovascular Disease Bhavna Gupta*, Lalit Gupta Maulana Azad Medical College and Loknayak Hospital, New Delhi-110002. [email protected] *Corressponding Author: Bhavna Gupta, Maulana Azad Medical College and Loknayak Hospital, New Delhi. Abstract In this Review article, we have discussed the anesthesia considerations in a case of pre-existing cardiac disease. Successful anesthesia in these patients revolves around careful planning, team work, communication and perioperative formulation of plan, execution and management. Keywords: Anesthesia, Cardiovascular Disease. Introduction An adrenergic surge leading to an imbalance in myocardial O supply-demand ratio. This in turn Administering anesthesia to patients with preexisting 2 causes ischemic myocardium. It is primarily cardiac disease is an anesthetic challenge. Most common cause of peri-operative morbidity and mortality in cardiac patients is ischemic heart disease affecteda) Tachycardia by: (IHD). IHD is number one cause of morbidity and b) increased wall tension mortality all over the world.Successful perioperative c) increased preload management of ischemic heart disease patients undergoing non cardiac surgery requires careful team d) increased after load work and communication between patient, primary e) increased myocardial contractility care physician, anesthesiologist and surgeon. • Myocardial Oxygen Supply: Increase in oxygen requirement of myocardium can be met by intervention strategy, risks associated with non- In assessing the risks and benefits of a perioperative cardiac surgery must be individualized. Therefore the anesthesiologist must exercise judgment to correctly increasing coronary blood flow. It can be affected • Decreased Coronary Blood Flow: which in turn assess perioperative surgical risks and the need for by: further evaluation.Care of these patients require isa. affectedTachycardia by following: which cause decrease in diastolic & optimization, medical therapy, monitoring and the perfusion time identification of risk factors, pre-operative evaluation choice of appropriate anesthetic technique and drugs b. Hypotension especially because of fall in Coronary Artery Disease (Cad) diastolic BP c. Incrreased Pre load by causing decreased Prevention of myocardial ischemia during surgery perfusion pressure decreases the incidence of perioperative myocardial infarction (MI). Optimizing oxygen delivery to the d. Hypocapnia by causing coronary myocardium is equally important for hemodynamic vasoconstriction management. e. Coronary Vasopasm • Myocardial Oxygen Demand: The principal • Decreased Oxygen Content And Availability: determinants of myocardial oxygen demand a. Anemia are wall tension and contractility. The increase which in turn is affected by in stress during perioperative period causes. b. Hypoxia. Archives of Anesthesiology V1 . I1 . 2018 8 Anesthesia and Cardiovascular Disease Hemodynamic Goals 3. patients with cardiovascular disease include 1. Although the precise relationship between statinsPharmacologic and angiotensin-converting agents which may enzymebenefit intraoperative myocardial ischemia and (ACE) inhibitors (stabilize atherosclerotic postoperative MI remains controversial, plaques) and volatile anesthetics (anesthetic there is consensus that a primary goal of a preconditioning). successful anesthetic is the prevention of myocardial ischemia. Monitoring for Ischemia 2. A well balanced approach of combination of A. The preferable monitoring technique (as per availability) for detecting myocardial ischemia anesthetics, sedative agents, muscle relaxants and vasoactive agents are chosen to decrease myocardial oxygen requirements and decrease • involves:Electrocardiogram (Table-1) (ST segment analysis of leads the likelihood of myocardial ischemia. V5 and II) Table 1. Relation between areas of myocardial ischemia and ECG leads1 ECG leads Coronary artery Area of ischemia I, AVL Lateral aspect of left ventricle II, III, AVF CircumflexRight coronary artery artery Right atrium, Right ventricle V3 - V5 Anterior descending artery Anterolateral aspect of left ventricle • Heart rate and blood pressure (not a sensitive myocardial depression; amnesia; and reliable predictor of myocardial ischemia) suppression of sympathetic nervous system responses to surgical stress. Disadvantages include • myocardial depression, systemic hypotension, ischemia-induced papillary muscle dysfunction Pulmonary artery catheter (V waves reflect and lack of postoperative analgesia. • Transesophageal echocardiography (regional Combinations of opioids and volatile anesthetics wall motion abnormalities are the most sensitive may produce the advantages of each with minimal indicator of myocardial ischemia) Selection of Anesthesia anesthetic could be used as a balanced technique. undesirable side effects. It is likely that any volatile There is no ideal anesthetic agent of choice in patients with Ischemic Heart Disease. Choice of anesthetic Isoflurane is a coronary vasodilator (more so depends on the extent of pe existing myocardial than other volatile anesthetics), but this effect is alveolar concentration (MAC). There is no evidence dysfunction and pharmacological properties of clinically insignificant in doses below 1 minimum of an increased incidence of myocardial ischemia or specificI. Opioids drugs. such as fentanyl in higher dosage in the worsened outcome.Desfluraneand sevoflurane possess range 50-100 µg/kg intravenously are preferred the advantage of faster recovery. A sudden increase in in severe myocardial dysfunction as they lack hemodynamic profiles similar to isoflurane but have increased plasma epinephrine concentration. good left ventricular function, opioids may be the inspired concentration of desflurane may result in myocardial depressant effect. In patients with inadequate to depress sympathetic nervous Treatment of Ischemia system activity, requiring the addition of a Anesthetics or vasoactive drugs that enable the heart volatile anesthetic or vasoactive drug. to return to a slower rate, and well-perfused state are frequently essential during anesthesia. II. Inhalation anesthetics have the advantages of dose dependency; easily reversible, titratable a) Nitrates. Nitroglycerin is the drug of choice 9 Archives of Anesthesiology V1 . I1 . 2018 Anesthesia and Cardiovascular Disease for the treatment of coronary vasospasm. As a anxiety, assessment of vital signs, JVP pulsation, venodilator, this drug decreases venous return carotid bruit, and oedema. Investigations thus wall tension. and decreases ventricular filling pressures and 1. Haemogram b) Vasoconstrictors. Phenylephrine increases 2. myocardial oxygen requirements, but this increase 3. CardiacBlood glucose specific levels tests – ECG, ECHO produced by the increased coronary perfusion 4. Blood urea , Serum Creatinine is offset by improvements in oxygen delivery pressure. 5. LFT c) Supplemental Evaluation oxygen balance by preventing or treating β-blockers: β-blockade improves myocardial tachycardia and by decreasing contractility. Atenolol improves long-term survival in patients Done1. Resting in specific LV function situations. It includes: with heart disease undergoing noncardiac 2. Exercise/ Pharmacological Stress Testing surgery. 3. d) Calcium channel blockers are useful in slowing 4. AmbulatoryCoronary Angiography ECG monitoring 5. the ventricular response in atrial fibrillation treatment of perioperative hypertension. and flutter, as coronary vasodilators, and in the Ina. patientsExercise with Echo abnormal resting ECG LBBB,LVF) Preoperative Clinical Evaluation b. Exercise Myocardial perfusion imaging This includes history, physical examination, 6. investigation, clinical risk predictors, risk assessment, a. Dobutamine stress Echo and functional capacity. In patients who cannot exercise: b. Thallium Scintigraphy History Functional capacity 1. Exercise tolerance is assessed by history and is i. Angina at unaccustomed work. No limitation History of Angina: NYHA Grading expressed as metabolic equivalents (MET). (MET; 1 of physical activity ii. Angina on moderate exertion. Mild limitation Duke Activity Status Index in order to estimate the MET = 3.5 ml O2/kg/min) on a scale defined by the of physical activity patient’s maximal oxygen consumption capacity (Table 2). iii. Angina on mild exertion. Marked limitation of physical activity Patients with moderate or excellent functional capacity and low clinical predictors of risk do not need iv. Angina at rest. further cardiac investigation. The functional capacity 2. History of Dyspnea of some patients might be limited by other conditions 3. Oedema (e.g. Respiratory, peripheral vascular or joint disease). These patients and those with poor functional 4. History of Myocardial infarction capacity should undergo detailed cardiac assessment 5. Family History of CAD Preoperative coronary angiography 6. Current medications Indicated in certain conditions like patients with Physical Examination proven CAD, unstable angina, angina resistant to Look for cyanosis, pallor, dyspnea during conversation, medical therapy, urgent surgery in a patient resolving nutritional status, skeletal deformities, tremors & from acute MI. Archives of Anesthesiology V1 . I1 . 2018 10 Anesthesia and Cardiovascular Disease Table 2: Metabolic Equivalents2 MET (metabolic Estimated energy requirements for various activities equivalents) Poor functional Light housework capacity (1-4 MET) Shower or dress without stopping