DOCSLIB.ORG

Preparation of the Materials for an Injection ĂŢ

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Preparation of the Materials for an Injection �����������������������Ă���Ţ PREPARATION OF THE MATERIALS FOR AN INJECTION Ovidiu Fabian, Emilia ăţ Learning objectives What you should know What is an injection What are the parenteral routes of administration of drugs; what types of injections are there What are the advantages of parenteral drug administration What is a syringe; which are the parts of the syringe and needle What information should be looked for in the prescription / medical indication What important information should be looked for on the syringe package What information should be sought on the package of the medicine to be administered What materials are necessary for the injection procedure The technique of dissolving medication and aspirating it into the syringe What is a container for sharp objects What you should do Choose the right materials for an injection Check the identity of the patient that is about to have the injection Check the ’medication Open the packaging for the syringe / needle Attach the needle to the syringe; loosen and remove the needle sheath Open a vial and aspire the contents into the syringe Dissolve a medicinal powder in the vial and absorb the contents into the syringe Place the filled syringe into a position that is convenient to use Disinfect the place of the future injection Keep material sterility throughout the entire procedure Discharge the needle into the container for sharp objects Definition Injection is a procedure by which a drug substance is introduced into tissues using a special needle and a syringe. Drug administration through injections is called parenteral administration (bypass digestive tract). The ways of parenteral drug administration are: Intradermal route (intradermal injection) Hypodermic route (subcutaneous),(subcutaneous injection) Intramuscular route (intramuscular injection) Intravenous route (intravenous injection and infusion) Intra-arterial route (intra-arterial injection) Intraosseous route (intraosseous injection and infusion) Indication An injection can be made for therapeutic or diagnostic purposes o For example administration of an intramuscular or intravenous antibiotic is for therapeutic purposes o Testing of antituberculous immunity (so-called intradermally in tuberculin) is done by an intradermal injection (diagnostic purpose). Some drugs may be administered both orally and parenterally. Sometimes, however, the oral route is not available: o Patients with digestive stasis (as is the case with most patients in the first hours / days after surgery) o Patients who throw up o Patients in coma / uncooperative / oro-tracheal catheterization o Patients with facial trauma Some substances can not be given orally (enterally) because they are digested in the digestive tract, inactivated in the liver or have hepatotoxic effects. Even if it involves minor trauma, parenteral drug administration has several advantages: o Precise dosing of the administered substance o Absorption and bioavailability of the substance are virtually complete (100%) o Quick action o Allows administration of medication even when the oral route is not usable o Allows the administration of substances that would be digested in the digestive tract, would be inactivated in the liver or would have liver side effects. Contraindications . There are no contraindications to injections as a procedure itself. The choice of medication should take into account possible allergies, side effects. Anatomical regions with infections, scars, hematoma, etc. Will be avoided as places for administration. Description of the syringe and needle The syringe is a single use disposable plastic instrument (not re-sterilized) used for Figure 1. Syringe parental drug administration. It consists of a plastic tube (barrel) and a plunger. The needle attaches to the syringe through which the medication is inserted into the tissue. The syringe body has, at one end, a truncated cone extension - the adapter for the needle. The adapter can be located centrally or eccentrically. At the other end, the syringe body has two lateral extensions useful for securing the Figure 2. Parts of the syringe syringe while pushing the plunger. There are syringes with different volumes (1, 2, 5, 10, 20, 50 ml). A scale (milliliters or tenths of milliliter) is marked on the barrel to allow a precise amount of substance to be introduced into the syringe. The plunger is perfectly sealed on the inner diameter of the barrel. Both filling and emptying the syringe is done with the help of the plunger. The syringe needle is a skewed steel tube at one end and has at Figure 3. Needle for injection its other end a funnel-shaped plastic that allows attachment to the syringe. The oblique cut tip of the needle is called bevel. The needle is delivered in the same package as the syringe or is packaged separately. It is covered with a plastic sheath. Figure 4. The needle cover(sheath) of the needle Needles are of different thicknesses and lengths, which are noted on the packaging. The thickness of the needle is expressed in the Gauge scale; The higher the number G, the smaller the needle. Needles are used between 14 G and 30 G. The syringes and needles are delivered in a sealed package that keeps them sterile. The packaging consists of a wrinkled sheet of paper and a transparent plastic sheet bonded together; Sometimes they are only sealed in transparent plastic. Only syringes with intact packaging may be used; those whose packaging is damaged can no longer be considered as sterile, so they are unusable. On the packaging is indicated by an arrow (triangle) the place where to open. For some syringes, specific names are used: tuberculin syringe, insulin syringe, Guyon syringe, pre-filled syringe (syringe-vial). Tuberculin syringe Is a small volume syringe Figure 5. Tuberculin syringe (1 ml) and a small diameter, graded in milliliters, with a needle of 25-30G, suitable for administration of small but precise quantities of the substance – for example: medication administered to the newborn or for tuberculin intradermosis for which it was conceived. Insulin syringe ’s also a small Figure 6. Insulin syringe volume (1 ml) thin needle syringe, graded in insulin units; it is used for subcutaneous administration of insulin. Guyon Syringe It is a large volume sy- ringe (50-60 ml); The ori- Figure 7. Guyon Syringe ginal Guyon syringe has a handle made up of 2 rings; With the generalization of single use syringes, its shape has been simplified and the appearance of a typical syringe, but it has a larger volume. Pre-filled syringe Some medi- cines are de- livered in Figure 8. Pre-filled syringe (syringe-vial) sterile syringes, with accurate dose (marked on the package) ready for use. Some syringes are provided with needle cover systems after use, which prevent injury and transmission of potential pathology through the syringe. Some important information is noted on the packaging: Volume of the syringe (in milliliters) - important for choosing the right syringe depending on the type injection: o For intradermal injections: syringes of up to 1 ml o For subcutaneous injections: 1 ml syringes o For intramuscular injections: syringes of 2 - 5 ml o For intravenous injections: syringes of 10 - 20 ml Needle size - important for choosing the right needle depending on the type of injection: o 18-19 G: for geting the medication into the syringe o 20-21 G: for intramuscular and intravenous injections o 25-30 G: for intradermal and hypodermic injections (subcutaneous) Shelf life - only syringes / needles are used that are within viability Stages of an injection Preparation of the syringe; Preparation of the injecting area: choice of the injection area – depending on the type of injection and disinfection of the skin; The injection itself (puncture, medication introduction, needle removal): the technique differs according to the type of injection. Drugs to be administered Parenteral medicines are delivered either as a solution (usually in ampoules / vials) or in powder form (usually packed in bottles). The vials have a circle or a point Figure 9. Vial and ampoule in the neck. These markers are useful for breaking the neck of the vial. The vials that have a circle are held in any position. The vials having a point are held in such a way that the point is in front of the person that is opening the vial, and the neck of the ampoule is inverted in the Figure 10. Markers opposite direction. for vial opening: The bottles are provided with a plastic point or line or metal cap and a rubber sealing plug that is pierced with the syringe needle to dissolve and aspire the substance. The plug is usually provided with 2 slots allowing the needle to be seen in the vial. Figure 11. The bottles are provided In the case of solutions only aspiring into with a rubber stopper the syringe is necessary; In the case of powders, the substance must first be dissolved in physiological serum or (less commonly) sterile distilled water; Some drugs come with specific solvent. The labeling on vials or bottles must be checked for: o Substance name - this verification should be done systematically to avoid any confusion; we never have to rely solely on the appearance of the packaging (there are medicines with similar packaging); o The amount of substance contained - usually there is the quantity for a single administration in the vial / bottle, but there are cases where there are doses for multiple administrations; o The expiration date. Necessary materials Syringe and needle - of the right size A thick needle (18 G) for suction can be used The administered drug: vial (dissolved drug) or bottle (powder to be dissolved) + a solvent vial (physiological serum) 2 alcohol pads or a cotton pads with alcohol. Syringe preparation techniquening Washing of hands Place the necessary materials on a table at hand Check the identity of the patient receiving the medication Verify the medication: o The substance (confirmation that the prepared substance is the one indicated in the prescription), o Dose, o Expiration date.
Load more

Recommended publications
  • Unit 4: Medication Administration Fundamental of Nursing
    Unit 4: Medication Administration Fundamental of Nursing Unit 4: Medication Administration: Medication: Is a substance administered for the diagnosis, cure, treatment, relief, or prevention of disease. Six Rights of Medication Administration After paramedics have received the medication or fluid order, they should then administer the drug in question. In performing drug administration, pre-hospital care providers adhere to the six rights of medication administration: 1. Right patient 2. Right medication 3. Right dose 4. Right route 5. Right time 6. Right documentation Basic principle of nurse on drugs administration 1. The nurse must know the drug's prescribed dose, method of administration, actions, expected therapeutic effect, possible interactions with other drugs, and adverse effects. 2. The nurse must know the institution's administration procedures for the client's welfare and the nurse's legal protection. 3. The nurse must Review physician's order for completeness the client's name, date of the order, name of the drug, dose, rout, time of administration, and the physician's signature. 1 Unit 4: Medication Administration Fundamental of Nursing 4. The nurse discusses the medication and its actions with the client; recheck the medication order if the client disagrees with the dose or the physician's order. 5. The nurse must check the physician's order against the client's medication administration record for accuracy. 6. The nurse gives the patient the right to know about the medication he is receiving and the right to refuse it. Routes of Administration A: Enteral Tract Routes The common enteral routes of administration used in general medical practice are as follows: 1.
    [Show full text]
  • Smallpox Vaccination by Intradermal Jet Injection* 1
    Bull. Org. mond. San)e 1969, 41, 749-760 Bull. Wld Hlth Org. Smallpox Vaccination by Intradermal Jet Injection* 1. Introduction, Background and Results of Pilot Studies J. DONALD MILLAR,1 RONALD R. ROBERTO,2 HERTA WULFF,3 HERBERT A. WENNER4 & D. A. HENDERSON 5 Jet injection has met with great success in the rapid and effective mass administration of several immunizing agents. The recent development of a jet injector nozzle specifically designedfor intradermal inoculation suggested thepossible extension ofjet injector methodo- logy to mass smallpox vaccination. A total of 156 volunteer subjects, 16 unvaccinated and 140 vaccinated more than 5 years previously, received either undiluted smallpox vaccine by the multiple-pressure technique, or 0.1 ml of various dilutions of smallpox vaccine by jet injector using the new nozzle. Cutaneous and serological responses in revaccinees revealed that jet injection of diluted vaccine with a titre of 107 TCID50/ml was as effective as multiple-pressure inoculation of undiluted vaccine. Among the small number ofprimary vaccinees, jet injection ofdiluted vaccine with a titre of 106 TCID5o/ml appearedas effective as multiple-pressure inoculation of undiluted vaccine. No complications of vaccination occurred. The findings confirm the utility of the intradermal nozzle for jet injection of smallpox vaccine. In view of the speed ofadministration and the economy of vaccine, it is suggested that there is a distinct role for jet injection in global smallpox eradication efforts. Further studies on larger numbers of unvaccinated subjects and on persons with significant residual vaccinial immunity are needed to define the optimal concentration of vaccine for mass vaccination by iet injection.
    [Show full text]
  • Injections in Dogs and Cats
    SOP: Injections in Dogs and Cats These SOPs were developed by the Office of the University Veterinarian and reviewed by Virginia Tech IACUC to provide a reference and guidance to investigators during protocol preparation and IACUC reviewers during protocol review. They can be used as referenced descriptions for procedures on IACUC protocols. However, it is the sole responsibility of the Principal Investigator to ensure that the referenced SOPs adequately cover and accurately represent procedures to be undertaken in any research project. Any modification to procedure as described in the SOP must be outlined in each IACUC protocol application (e.g. if the Principal Investigator plans to use a needle size that is not referenced in the SOP, simply state that alteration in the IACUC protocol itself). Table of Contents I. Procedure Summary & Goal ......................................................................................... 1 II. Personal Protective Equipment & Hygiene ................................................................... 1 III. Supply List .................................................................................................................... 1 IV. Detailed Procedure ........................................................................................................ 1 V. Potential Adverse Effects, Mitigation, or Treatment .................................................... 2 VI. Variations .....................................................................................................................
    [Show full text]
  • Intradermal Therapy (Mesotherapy) in Derma- Tology
    Canzona F, Mammucari M, Tuzi A, Maggiori E, Grosso MG, Antonaci L, Santini S, Catizzone AR, Troili F, Gallo A, Paolucci T, Rocchi P, Guglielmo C, Russo D, Giorgio C, Dorato D, Marzo RD, Viglione G, Fiorentini AG, Giardini M, Natoli S. Intradermal Therapy (mesotherapy) in Derma- tology. J Dermatol & Skin Sci. 2020;2(1):22-25 Mini-Review Article Open Access Intradermal Therapy (mesotherapy) in Dermatology Flora Canzona1, Mammucari Massimo2*, Arianna Tuzi3, Enrica Maggiori2, Maria Gabriella Grosso4, Luciano Antonaci2, Stefania Santini3, Anna Rosa Catizzone3, Fiammetta Troili3, Alessandra Gallo3, Teresa Paolucci3, Piergiovanni Rocchi3, Costanza Guglielmo3, Domenico Russo5, Chiara Giorgio6, Dario Dorato3, Raffaele Di Marzo3, Giovanna Viglione3, Anna G Fiorentini3, Manuela Giardini3, Silvia Natoli7. 1Istituto Dermopatico dell’Immacolata, IRCCS Foundation, Rome, Italy 2Primary Care Unit ASL RM 1, Rome, Italy 3Member of the Italian Society of Mesotherapy, Rome, Italy 4Ospedale Israelitico, Rome Italy 5San Marco Hospice and Palliative Care, Latina, Italy 6Rehabilitation Unit, F Pirinei Hospital, Altamura (BA), Italy 7Department of Clinical Science and Translational Medicine, Tor Vergata University, Rome, Italy Article Info Abstract Article Notes Mesotherapy consists of a series of micro injections in the superficial layer Received: January 28, 2020 of the skin of active ingredients that slowly diffuse into the underlying tissues. Accepted: March 17, 2020 This technique is applied in different clinical conditions and also in dermatology *Correspondence: it could play a useful role in the treatment path of many patients. However, *Dr.Mammucari Massimo, Primary Care Unit ASL RM 1, Rome, further clinical studies are needed to standardize its application in various Italy; Email: [email protected].
    [Show full text]
  • Intradermal Injection Simulator LF01008U Instruction Manual
    Other Available Simulators LF00698U Adult Injectable Arm (Light) LF01162U Venatech IV Trainer LF00958U Pediatric Injectable Arm LF01184U Venatech IM & Sub Q LF00961U Intramuscular Injection LF00995U Arterial Puncture Arm LF01184U LF00999U Pediatric Injectable Head LF01005U First Aid Arm Intradermal Injection LF01037U Hemodialysis Practice Arm LF01121U Advanced IV Arm Simulator LF01131U Venipuncture and Injection Arm LF01139U Advanced IV Hand LF01008U Instruction Manual LF00961U LF01121U Fort Atkinson 901 Janesville Avenue, P.O. Box 901 Fort Atkinson, Wisconsin 53538-0901 1.800.558.9595 Products by Nasco eNasco.com • E-mail: [email protected] COPYRIGHT © NASCO 1982 PRINTED IN U.S.A. NP 53-82/RV 6-15 Other Available Simulators LF00698U Adult Injectable Arm (Light) LF01162U Venatech IV Trainer LF00958U Pediatric Injectable Arm LF01184U Venatech IM & Sub Q LF00961U Intramuscular Injection LF00995U Arterial Puncture Arm LF01184U LF00999U Pediatric Injectable Head LF01005U First Aid Arm Intradermal Injection LF01037U Hemodialysis Practice Arm LF01121U Advanced IV Arm Simulator LF01131U Venipuncture and Injection Arm LF01139U Advanced IV Hand LF01008U Instruction Manual LF00961U LF01121U Fort Atkinson 901 Janesville Avenue, P.O. Box 901 Fort Atkinson, Wisconsin 53538-0901 1.800.558.9595 Products by Nasco eNasco.com • E-mail: [email protected] COPYRIGHT © NASCO 1982 PRINTED IN U.S.A. NP 53-82/RV 6-15 NP053_82.indd 1 6/1/15 3:18 PM A. Care of the Intradermal Sites Puncturing the skin with needles forms small slits or cuts which will eventually lead to deterioration. Should leakage occur, perform the following steps: 1. Using the supplied intradermal sealant and supplied 22-gauge syringe, remove the needle end of the syringe by twisting at the luer lock.
    [Show full text]
  • NEEDLE-FREE JET INJECTION BIBLIOGRAPHY, DEVICE & MANUFACTURER ROSTER, and PATENT LIST
    JET INJECTION Bibliography p. 1 of 79 Bruce G. Weniger file: Jetinject-Bib.doc & .pdf last update: 2004-Apr-06 NEEDLE-FREE JET INJECTION BIBLIOGRAPHY, DEVICE & MANUFACTURER ROSTER, and PATENT LIST last update: 2004-April-06 (Available at: http://www.cdc.gov/nip/dev/jetinject.htm#bibliography) New or updated entries added since website-posting of 2003-Dec-24: References: Carter2003, Haupt2003 Devices: GunA, EMS/RPM, EMS/MPM Patents: US 6063053, 6080130, 6156008, 6223786, 6302160 B2, 6447475 B1, 6474369 B2, 6500239 B2, 6610042 B2, 6613010 B2, 6613011 B2 Acknowledgements: Bibliography initiation, 1994-1995 – Lisa Lindsay, Emory Univ. Russian translations/summaries, 1999-2002 – Dr. Vitali Pool, CDC German translation, 2003 – Dr. Katrin Kohl, CDC Bibliographic retrievals and collection, 1998-2000 – Robyn Kaiser, Emory Univ. Update, April-May, 2002 – Christine Korhonen, Emory Univ. Barclay1962 – Joanne Penkalski, Academy of Medicine Cleveland/Northern Ohio Medical Association Béclard/Galante1866, Galante1866/1885 – Bernadette Molitor & Marie Peyraube, Bibliothèque Interuniversitaire de Médecine, Paris, France Linder1979 – Darin Zehrung, PATH, Seattle, Washington Schön1965 – Urda Guse, Zentrale Hochschulbibliothek, Lübeck, Germany Spiegel1994a – Philippe Stoeckel, Association pour l’Aide à la Médecine Préventive, Paris; Betty Dodet, Fondation Mérieux, Lyon, France Legend: ~R.200#MonDay: Reprint copy requested on date indicated. Double-indented items: Paper copy not yet received or not yet filed. *ID: Article on intradermal vaccination but NOT via needle-free injection device. Kindly please address any additions, updates, corrections, and suggestions to: Bruce G. Weniger, MD bgw2(-at-)cdc.gov Fax: [+1] 404-639-8834 JET INJECTION Bibliography p. 2 of 79 Bruce G. Weniger file: Jetinject-Bib.doc & .pdf last update: 2004-Apr-06 REFERENCES {Abb1981} Abb J, Deinhardt F, Eisenberg J.
    [Show full text]
  • Routes of Administration R UE of OUTES
    C HAPTER32 Routes of Administration R OUTES OF Shinya Shimizu A DMINISTRATION National Institute of Animal Health,Tsukuba, Japan increases successful treatment. Personnel using experi- General mental animals should be well trained in handling and restraint, should obtain authentication for responsible Mice are the most widely used animals for a range of use of experimental animals and attain a scientifically experiments including medical, chemical, pharmaco- high standard (ETS 123, 1986; Nebendahl, 2000). 527 logical, toxicological, biological, and genetic. The Further experience will lead to repeatable and reliable administration of test substances, such as chemical ele- results (see Chapter 31 on Handling and Restraint). P ments, compounds, drugs, antibodies, cells or other During administration mice should be protected ROCEDURES agents, to mice is one of the major methods for evalu- from pain, suffering, distress or lasting harm or at least ating their biological activity. pain and distress shall be kept to a minimum (ETS The route of administration is largely dependent on 123, 1986). Some injections (such as footpad injec- the property of the test substance and the objective of tion) are strongly discouraged and if required must be the experiment. All administration should be performed justified on a case by case basis (CCAC, 2002). with knowledge of the chemical and physical characteris- tics of the substance. All routes have both demerit and merit, such as the absorption, bioavailability and metab- olism of the substance. Consideration should be paid to Principles of the pH, viscosity, concentration, sterility, pyrogenicity, toxicity as well as the existence of hazardous substances. administration A knowledge of available methods and techniques of administration as well as knowledge of the deposition Handling and restraint and fate of the administered substance will help the scien- tist/investigator to select the most appropriate route for Good handling and restraint is the most important her/his purpose.
    [Show full text]
  • Comparison of the Effectiveness of Intradermal Injection of Lidocaine, Iontophoretic Delivery of Lidocaine, and Topical Emla
    Grand Valley State University ScholarWorks@GVSU Masters Theses Graduate Research and Creative Practice 1997 Comparison of the Effectiveness of Intradermal Injection of Lidocaine, Iontophoretic Delivery of Lidocaine, and Topical Emla Cream as Local Anesthetics for Venipuncture Carol Straight Grand Valley State University Follow this and additional works at: http://scholarworks.gvsu.edu/theses Part of the Nursing Commons Recommended Citation Straight, Carol, "Comparison of the Effectiveness of Intradermal Injection of Lidocaine, Iontophoretic Delivery of Lidocaine, and Topical Emla Cream as Local Anesthetics for Venipuncture" (1997). Masters Theses. 421. http://scholarworks.gvsu.edu/theses/421 This Thesis is brought to you for free and open access by the Graduate Research and Creative Practice at ScholarWorks@GVSU. It has been accepted for inclusion in Masters Theses by an authorized administrator of ScholarWorks@GVSU. For more information, please contact [email protected]. COMPARISON OF THE EFFECTIVENESS OF INTRADERMAL INJECTION OF LIDOCAINE, lONTOPHORETIC DELIVERY OF LIDOCAINE, AND TOPICAL EMLA CREAM AS LOCAL ANESTHETICS FOR VENIPUNCTURE By Carol Straight A THESIS Submitted to Grand Valley State University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN NURSING Kirkhof School of Nursing 1997 Committee Members: Jean NageUcerk, R.N., Ph.D. Timothy Esser, M.D. Michelle Arthur, R.N., M S N. Terry Bauman, Pharm.D. ABSTRACT COMPARISON OF THE EFFECTIVENESS OF INTRADERMAL INJECTION OF LIDOCAINE, lONTOPHORETIC DELIVERY OF LIDOCAINE, AND TOPICAL EMLA CREAM AS LOCAL ANESTHETICS FOR VENIPUNCTURE By Carol Straight ' This study was undertaken to establish whether the administration of a local anesthetic, lidocaine, significantly reduces the pain of venipuncture in adults, to i g establish the degree of tolerability and effectiveness of each of three delivery methods for Lidocaine, and to identify recipient's preferences among the three pain-relieving measures.
    [Show full text]
  • Subcutaneous Injection Considerations for Needle Length and Gauge Selection*
    Subcutaneous injection considerations For needle length and gauge selection* Subcutaneous (SubQ) Location of injection Needle length Needle gauge Needle angle 12 months (infants) Anterolateral thigh, 1/2” – 5/8” 26 – 31 G upper outer tricep area, Pediatric 12 months to upper buttocks, 45º – 90º to adult 18 years abdomen (avoid 2” 5/32” – 1/2” 29 – 32 G radius around umilicus) (Diabetes Care) (Diabetes Care) > 18 years * Adapted from Fundamentals of Nursing: Human Health and Function. R. Craven, C. Hirnle, 4th ed. Lippincott Williams & Wilkins 2003. 30G 29G 28G 27G 26G 25G 24G 23G 22G 21G 20G 19G 18G ISO hub color standards for safety-engineered needles 50 45 40 35 30 25 Subcutaneous20 (SubQ) injection considerations: 15 10 4545° 9090° Injection procedure Outer aspect of the Outer aspect of the • Raise a fold of skin between upper thigh upper arm the thumb and forefinger, (not prefered site) and insert the needle at a 45º – 90º angle. • Pull back plunger slightly. If blood appears in syringe, remove needle, dispose properly and prepare a new injection.* * It is not necessary to aspirate for blood return when administering insulin or heparin. Abdomen—avoid Upper buttocks injecting within 2” around the umbilicus This information is being provided for convenience only and is not intended to replace clinical decision making. Each clinician is soley responsible for determinng the correct needle for each patient. bd.com BD and the BD Logo are trademarks of Becton, Dickinson and Company or its affiliates. All other trademarks are the property of their respective owners. © 2019 BD. All rights reserved.
    [Show full text]
  • Nursing Procedure for Initiating Subcutaneous Fluid Administration with Hylenex Recombinant
    Nursing Procedure for Initiating Subcutaneous Fluid Administration with hylenex recombinant PREP INSERT INFUSE Please see back cover for Indication and Important Safety Information and accompanying full Prescribing Information. These draft policies and procedures have been adapted from the Infusion Nurses Society (INS), the Oncology Nursing Society (ONS), and the hylenex recombinant (hyaluronidase human injection) prescribing information. It is the responsibility of the healthcare organization considering the use of this procedure to conduct an independent review and assessment to determine applicability and appropriateness of this document to their institution and to any particular clinical setting. Infusion therapies present risks; it is the responsibility of the healthcare organization to manage these risks, including the skills and competency validation of personnel. The healthcare organization that uses these guidelines should be aware that an annual review of organizational policies and procedures should continue to occur in accordance and compliance with regulatory and nonregulatory agencies. The Purpose of this Guide To outline nursing responsibilities in providing symptom control and/or fluid and electrolyte replacement by administering fluids subcutaneously. Policy Subcutaneous access is utilized to administer fluids via single injection or continuous infusion into the subcutaneous tissue. The fluid is absorbed through both adipose and connective tissue.1 hylenex recombinant is used for subcutaneous fluid administration, enabling enzymatically augmented subcutaneous infusion. In subcutaneous fluid administration, a catheter is placed in the subcutaneous tissue.1 Skilled and competent nurses knowledgeable in subcutaneous administration and the operation of electronic infusion devices may initiate and manage subcutaneous infusions.1 Some state and facility regulations allow this procedure to be performed by LVNs/LPNs.
    [Show full text]
  • Brief Note on Inactive Ingredients Approved by USFDA
    Brief note on Inactive Ingredients approved by USFDA FOR DIFFERENT DOSAGE FORMS WITH SPECIFIED ROUTE OF ADMINISTRATION Contents 1.0 Introduction………………..………………………………………………………………………………………………… 2.0 Inactive Ingredient Field Descriptions ….…………….....……………………………………………………… 3.0 Top Ten Inactive Ingredients……………….…………………………………………………………………………. a. List of Top 10 Inactive Ingredients (out of 3017) Approved by USFDA for specific dosage forms with specified route of administration-Pharmexcil Analysis (Table 1)….…………………….. 4.0 Top Ten Dosage Forms With Specific Route Of Administration And Number Of Inactive Ingredients……………………………………………………………………………………………………………………….. a. List indicating the number of inactive ingredients used in USFDA approved products for a specific route of administration and dosage form-Top 10-Pharmexcil Analysis (Table 2)…..….. b. Dosage form with specified route of administration vs. No. of Inactive ingredients approved by USFDA-Top 10- Pharmexcil Analysis (Figure 1)…...…………………………………………………………….. Figures: 1. Dosage form with specified route of administration vs. No. of Inactive ingredients approved by USFDA-Top 10- Pharmexcil Analysis Tables: 1. List of Top 10 Inactive Ingredients (out of 3017) Approved by USFDA for specific dosage forms with specified route of administration-Pharmexcil Analysis ………………………………..………………….. 2. List indicating the number of inactive ingredients used in USFDA approved products for a specific route of administration and dosage form-Top 10-Pharmexcil Analysis ……………..…..….. 3. List of Inactive ingredients approved by USFDA for specific dosage forms and route of administration – Pharmexcil Analysis………………………………………………………………………………………. 4. List indicating the number of inactive ingredients used in USFDA approved products for a specific route administration and dosage form – Pharmexcil Analysis ….………………………………….. 5. List of inactive ingredients for USFDA approved Drug Products………………………………………………... DISCLAIMER 1. The data should not be copied or transmitted to others in any means.
    [Show full text]
  • Administration Routes
    Administration Routes Mice & Rats -Intramuscular Injection (IM) IM injections are administered in the thigh muscles of the hind limb. Caution must be used to avoid injury to the sciatic nerve, which is located in close proximity to the femur. 1. Restrain the animal by grasping the skin along its back with your left hand (if right-handed). 2. Clean the injection site with alcohol. 3. Insert needle into thigh muscles, and directed away from the femur avoiding the sciatic nerve. 4. Pull back the syringe plunger to aspirate the syringe. Any blood indicates improper needle placement, and needle must be repositioned. 5. Administer substance in a steady, fluid motion. Take care not to administer fluid too rapidly. 2 Administration Routes Mice & Rats –Subcutaneous Injection (SQ or SC) SQ injections are administered in the space between the skin and the underlying muscles. 1. Restrain the animal by grasping the skin along its back with your left hand (if right-handed), as shown in picture. 2. Clean injection site with alcohol. 3. Insert needle at base of skin fold between thumb and finger. 4. Pull back the syringe plunger to aspirate the syringe. Any blood indicates improper needle placement, and needle must be repositioned. 5. Administer substance in a steady, fluid motion. 3 Administration Routes Mice & Rats -Intradermal Injection (ID) ID injections are administered between the layers of the skin. The animal must be under general anesthesia for this procedure. 1. Anesthetize animal as described in your approved Animal Study Proposal. 2. Clip hair on animal’s back. 3. Clean the injection site with alcohol.
    [Show full text]