International Journal of Drug Evaluation Clinical Rheumatology 9 Drug Evaluation Methotrexate in rheumatoid arthritis: benefits, limitations and the emerging value of subcutaneous administration Int. J. Clin. Rheumatol. Because of its efficacy and safety, methotrexate (MTX) is well established as the Edward Keystone*,1,2 & Bruce anchor drug for treatment of rheumatoid arthritis. Although MTX is typically Freundlich3 administered orally, parenteral MTX offers greater bioavailability and may cause 1The Rebecca MacDonald Centre for Arthritis & Autoimmune Disease, less gastrointestinal intolerability. Parenteral MTX may be considered for patients Mount Sinai Hospital, Toronto, ON, with rheumatoid arthritis who experience an inadequate response to oral MTX at Canada the highest tolerated dose; however, its use remains low in the USA. To facilitate 2Joseph & Wolf Lebovic Health Complex, the administration of subcutaneous MTX, a state of the art MTX auto-injector that 60 Murray Street, 2nd Floor (Main), enables patients to self-administer prespecified doses of MTX subcutaneously was Toronto, ON, M5T 3L9, Canada 3Medical Department, Antares recently developed. This auto-injector may improve patient adherence and the ability Pharma Inc., Ewing, NJ, USA to reach an optimally effective MTX dose, thereby allowing more patients with *Author for correspondence: rheumatoid arthritis to obtain the maximum benefit from MTX. Tel.: +1 416 586 8646 Fax: +1 416 586 8766 Keywords: auto-injector • bioavailability • disease-modifying antirheumatic drug • dose
[email protected] optimization • rheumatoid arthritis • self-administration • subcutaneous methotrexate Methotrexate (MTX) has been recognized as Clinical importance of MTX in the a valuable treatment for rheumatoid arthritis treatment of RA (RA) for more than 30 years and, despite the Owing to its efficacy and safety, MTX has emergence of many newer therapies, remains gained wide acceptance as a key treatment the cornerstone of RA treatment [1] .