Kayexalate® (Sodium Polystyrene Sulfonate)

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Kayexalate® (sodium polystyrene sulfonate) – Drug Safety Communication • On October 22, 2015, the FDA announced that it is requiring the manufacturer of Kayexalate (sodium polystyrene sulfonate) to conduct studies to investigate Kayexalate’s potential to bind to other oral medications. • Kayexalate is indicated for the treatment of hyperkalemia. — Sodium polystyrene sulfonate is also generically available. Kionex® and SPS® are branded generics. • This safety communication was prompted by the FDA’s review of another potassium-lowering drug, Veltassa (patiromer). The FDA discovered that Veltassa bound to about half of the medications tested, some of which are commonly used in patients who require potassium-lowering drugs. — Similar to Veltassa, Kayexalate may also bind to other oral medications, which could decrease the effects of these medications. — Currently, the approved label for Kayexalate describes its potential to decrease absorption of lithium and thyroxine; however, extensive drug-drug interaction studies with Kayexalate have not been performed. • Patients should not stop taking their potassium-lowering drugs without talking to their healthcare provider. However, to reduce the risk of binding, prescribers and patients should consider separating the dose of Kayexalate from other oral medications by at least 6 hours. This includes both prescription and over-the-counter medications. • Healthcare providers should monitor blood levels or clinical response to other medications when appropriate. • If the studies conducted by the Kayexalate manufacturer, Concordia Pharmaceuticals, confirm significant interactions with other medications, the FDA will require all manufacturers of sodium polystyrene sulfonate products to update the drug labels to include information about these drug interactions. optumrx.com OptumRx specializes in the delivery, clinical management and affordability of prescription medications and consumer health products. We are an Optum™ company — a leading provider of integrated health services. Learn more at optum.com. All Optum™ trademarks and logos are owned by Optum, Inc. All other brand or product names are trademarks or registered marks of their respective owners. ©2014 Optum, Inc. All rights reserved. .

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Evaluation of Single Dose Sodium Polystyrene
Open Access Original Article Sodium Polystyrene Sulfonate For Management of Hyperkalemia Pak Armed Forces Med J 2019; 69 (1): 37-42 EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES Shoaib Alam, Azfar Athar Ishaqui, Masood Ahmed Khan, Adnan Iqbal, Syed Hameez Jawed, Farah Khalid, Mir Muhammad Uzairullah, Muhammad Talha*, Usman Ashfaq*, Najam Zehra* University of Karachi, Karachi Pakistan, *Hamdard University Karachi Pakistan ABSTRACT Objective: To assess the effectiveness of sodium polystyrene sulphonate in treating hyperkalemia and its effect on different serum electrolytes level. Study Design: Quasi-experimental study. Place and Duration of Study: Lyari general hospital, 500 bedded tertiary care public sector hospital at Karachi, from Jan 2017 to Mar 2017. Material and Methods: Hyperkalemic patients were included in study who fulfilled inclusion criteria and were administered with single STAT 30 grams dose of Sodium Polystyrene Sulfonate. Serum electrolytes such as sodium, chloride, magnesium, phosphate and calcium were measured before and after 2 hours of administration of Sodium Polystyrene Sulfonate. Paired t-test was used as tool for statistical analysis. Results: Significant (p<0.05) decrease in serum potassium level with mean decrease of 0.61 mmol/L was observed in hyperkalemic patients (n=83) after single dose of Sodium Polystyrene Sulfonate. Among 83 studied patient, 67 (81%) recovered from hyperkalemia. Besides, there was significant (p<0.05) increase in sodium level with a mean increase of 2.26 mmol/L. Serum magnesium and calcium levels were significantly decreased (p<0.05) with mean difference of 0.02mmol/L and 0.13mmol/L respectively.
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Reference ID: 4131527
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