Syllabus for BIO 205, Summer 2014

Syllabus for BIO 205, Summer 2014 Introduction to Cell and Developmental Biology Course Website: Professor

Dr. Cris Ledón-Rettig

Room Number: Wilson G11 email: [email protected] Teaching Assistants

Chris Cowden (email: [email protected]) Class Schedule

Monday-Thursday, 3:00pm-5:00pm Recitation Schedule

Section 602; Tuesday-Thursday, 2:00pm-2:50pm Required Text

1. Essential Cell Biology, 4th edition, by Alberts et al.

2. Developmental Biology, 4th edition, by Wolpert and Tickle

Both are available in the Student Stores. The required readings from these texts are indicated on the schedule. Goals/Objectives

The first part of Biology 205 (Cell Biology) provides a comprehensive introduction to the biology of cells of eukaryotic organisms. This part of the course introduces the four major macromolecules of cells and how they function in metabolism, gene regulation, cell communication, cell structure and cell division.

The second part of Biology 205 (Developmental Biology) provides a comprehensive introduction to the development of eukaryotic organisms. This part of the course introduces mechanisms and processes that are common to the development of organisms (e.g., induction and tube formation) and also explores the diversity of developmental patterns among different taxa, including several model organisms that are used in the laboratory to understand human health and disease. This section will conclude with and introduction to the exciting and emerging fields of evo- and eco-devo, that will put your new understanding of development into the context of the environment and natural selection.

With respect to both halves of the course, we will cover the scientific methods used to study cellular activities and developmental mechanisms. This course as a whole will also introduce to primary scientific literature. Exams/Assignments/Grading Exams: Typical exams will be a mix of multiple choice, short answer and longer answers that mainly cover material from class. You will be expected to integrate information from class to answer questions about material that you haven’t seen before. Makeup exams are only offered under very few circumstances. You are strongly advised to pre-clear your reason for missing an exam with me before exam time. Make up exams will be oral and likely more difficult than the scheduled exam.

Quizzes: Will be daily. They should be straightforward if you have reviewed and understood your notes from the day before.

Grading:

Exam 1: 37%

Exam 2: 37%

Recitation: 16%

Quizzes: 10%

Tips for success: This class moves fast, especially during the summer, so it is essential that you come to class prepared. The best way to prepare is to (1) read the assigned readings before each lecture (2) download and read the presentation slides from Sakai before each lecture and (3) attend class, pay attention, and participate. After class each day, read through your notes from the lecture and make sure they make sense, and that you have crystallized the concepts. In other words, keep up! The quizzes are designed to help encourage you to keep up and come to class. If you do well on quizzes, then you will likely do well on tests. If you do not do well on quizzes, you need to put in more effort and/or change your approach.

I highly encourage you to contact me with questions and to attend office hours if you need help. However, do not come to office hours and expect that I will repeat what was covered during class. Sitting in my office, blankly, without questions or direction, will not improve your comprehension or grade. Delimit what you do not understand or what needs clarification, attempt to answer your own question through the use of resources made available to you (e.g., textbook, assigned readings, recitation and lecture notes), and only then come to office hours prepared with specific questions.

My goal is to maximize your learning experience and comprehension of cellular and developmental biology. Learning a lot and doing well is more fun than the alternative and, more importantly, will give you a solid foundation for other biology classes you will take later on. Once you understand basic principles of cellular and developmental biology, it will be straightforward to apply these concepts to other topics (neurobiology, immunology, evolution, etc…). Honor Code and Course Policies

All work done in this class must be carried out within the letter and spirit of the UNC Honor Code.

Do not attempt to ask me questions immediately preceding lecture: feel free to bring them to your TA during recitation or me during office hours.

Turn your cell phones to silent during lecture and recitation

Social media, gaming, and texting are prohibited during lectures – no exceptions

Food is prohibited during class – water or drink bottles are acceptable and encouraged

*Phone rings, social media distraction and food smells are potentially detrimental to the students around you; i.e., these policies are in place for the greater good of the class. Topic Schedule

Cell Biology

May 13th Tues 1.1. Introduction and How to Study Cells 2. Proteins (Ch. 4, pg. 121-127, 130-132, 136-145, 148, 150-156)

May 14th Wed 2.1. Lipids and Membranes (Ch. 11, pg. 359-372, 374-381) 2. Membrane Transport (Ch. 12, pg. 383-394, 396-399, 402-405, 407-414)

May 15th Thurs 3.1. Intracellular Compartments and Transport (Ch. 15, pg. 487-520)

May 19th Mon 4.1. Mitochondria (Ch. 14, pg. 448-482) 2. Cell Communication (Ch. 16, pg. 525-561)

May 20th Tues 5.1. Microtubules/Intermediate Filaments 2. Actin, Muscle Contractility (both: Ch. 17, pg. 565-598)

May 21st Wed 6.1. Cell Cycle and Cell Death 2. Mitosis (both: Ch. 18, pg. 603-641)

May 22nd Thurs 7.1. Meiosis (Ch. 19, pg. 645-657) 2. Cell Communities (Ch. 20, pg. 702-720)

May 26th Holiday

May 27th Tues Exam

Developmental Biology

May 28th Wed 8.1. Introduction 2. Oogenesis and Fertilization

May 29th Thurs 9.1. Cleavage & Gastrulation

June 2nd Mon 10.1. Neurulation 2. Tube formation

June 3rd Tues 11.1. Induction, Signaling

June 4th Wed 12.1. Determination & Differentiation

June 5th Thurs 13.1. Drosophila & C. elegans

June 9th Mon 14.1. Mouse & Xenopus & Chick

June 10th Tues 15.1. Cancer: an aberration of development

June 11th Wed 16.1. EvoDevo 2. EcoDevo

June 12th Thurs 1. Review

June 16th Mon Exam Day

June 17th Tues Exam Day

*Note that I do not expect any of the items on this syllabus to change, but I reserve the right to make changes. Exam states will not change under any circumstances. Recitation Topic Schedule

May 13th Tues 1.1. Introduction and How to Study Cells 2. Proteins

Reading: Dobson CM. 1999. Protein misfolding, evolution and disease.

May 14th Wed 2.1. Lipids and Membranes 2. Membrane Transport

May 15th Thurs 3.1. Intracellular Compartments and Transport

May 20th Tues 5.1. Actin, Muscle Contractility 2. Microtubules/Intermediate Filaments

May 21st Wed 6.1. Cell Cycle and Cell Death 2. Mitosis

May 22nd Thurs 7.1. Meiosis 2. Cell Motility