Appendix 2: Data Extraction Form for Eligible Studies: Protocolization of Severe TBI Care

Reviewer: ______Date of Extraction: ______(dd/mm/yyyy)

Article Identification:

RefWorks ID#: ______

Title: ______

______

First Author: ______

Second Author: ______

Journal Name/ Reference Source: ______

Journal Article Published Abstract Conference Proceeding Other: ______

Year: ______Volume: ______Starting Page: ______

Full Publication: Yes No Comment: ______

Language of Publication: English and / or ______

Source of sponsorship (Study): ______

Study – Country of Origin: ______

Number of Centres Participating: ______

Comments: ______

______

______Verification of Eligibility: Inclusion Criteria: (verified by “tick” mark)

Controlled Trial

Patients were ≥ 18 years of age

Suffering from severe traumatic brain injury; Def’n: ______

Protocol-based care compared with control group

ICU/Neuro unit based care

Medical management protocol (with or without decompressive craniotomy)

Study Design: Type of Study:

Prospective experimental Other: data ______Retrospective experimental Prospective control data data Retrospective control data Consecutive control patients Consecutive control patients Case-control study Cross-sectional study

Inclusion Criteria:

a..1. ______

Exclusion Criteria:

1. ______2. ______

3. ______

4. ______

5. ______

6. ______

Type of ICU: ______

Lead ICU MD: ______Team members: Intensivist Neurologist Neurointensivist Neurosurgeon Anesthesia Trauma Housestaff Nurse Educator/Specialist Not specified

Protocol Characteristics: Multidisc. Nursing care driven o ER derived MD care driven Rescussicitation ICP-driven Descriptive (ie: no OR CPP-driven diagram) Other: ______Guideline Admission orders Based, specify: Flow diagram ______Step/Phase approach ______Pre-ICU care protocols:

Co-Interventions: ______

Control Group Mgmt: ______

______

Protocol Specifics: Variable/Intervention if not Co met: T T mm ent: ICP target: ICP monitor IVD Imaging

CSF drainage ______

Sedation/anagelsia hypertonic saline _____% mannitol ______

Vasoactive meds: cooling ______C

PaCO2 other: ______other: ______CPP target: ICP monitor IVD

Imaging

CSF drainage ______sedation hypertonic saline _____% mannitol ______

Vasoactive meds: cooling ______C

PaCO2 other: ______other: ______

SjO2 target:

Imaging

CSF drainage ______sedation hypertonic saline _____% mannitol ______Vasoactive meds: cooling ______C

PaCO2 other: ______other: ______

Hypothermia

Nutrition

Tracheostomy

Barbiturate coma

Oxygen Saturation/FiO2

CVP/PCWP

Decompressive craniectomy Other:

Comments/Clarification: ______

______

Stated Outcomes: Outcome: P S P

Screening and Enrollment: Total patients enrolled: ______Control pts: ______Intervention pts: ______

Timing of enrolment (mm/yy): Control pts: ______Intervention pts: ______

Consecutive patients: Yes No Description of why not: ______

______Participant identification: ICU database Hospital database Prospective enrolment Medical records coding Other: ______Baseline Characteristics: C I O n Int N t T e R r #2: O v L e n t i o n # 1 :

______Demographics:

Age (SD)

Male Sex (SD)

APACHE (SD) (circle) 2 or 3 SOFA/MODS/SAPS

Admission GCS (SD)

ISS (SD)

Post-op admission Transferred from another institution Diagnostic Category:

SAH SDH Intracerebral hemorrhage

No Mass

Marshall Score % Multiple Injuries (in add’n to head) Baseline Hemodynamics:

Temperature

CVP/PWP

SvO2 Outcomes and Results: C I O n Int N t T e R r #2: O v L e n t i o n # 1 :

______Mortality:

Death (SD)

Withdrawal of Care (SD)

Non TBI-related (SD)

Post-admission day

Morbidity:

ICU LOS

Hospital LOS

Ventilator days Day of tracheostomy insertion Initiation of feeds

Day of PEG insertion GOS: ______

Discharge status Pt questionnaire: ______Physiologic/Adverse Events: OR (ie: craniectomy) Seizure

ICP control

CPP control Barbiturate coma Pneumonia

CNS infection

Resources:

Health Care Costs