<p>Appendix 2: Data Extraction Form for Eligible Studies: Protocolization of Severe TBI Care</p><p>Reviewer: ______Date of Extraction: ______(dd/mm/yyyy)</p><p>Article Identification:</p><p>RefWorks ID#: ______</p><p>Title: ______</p><p>______</p><p>______</p><p>______</p><p>First Author: ______</p><p>Second Author: ______</p><p>Journal Name/ Reference Source: ______</p><p>Journal Article Published Abstract Conference Proceeding Other: ______</p><p>Year: ______Volume: ______Starting Page: ______</p><p>Full Publication: Yes No Comment: ______</p><p>Language of Publication: English and / or ______</p><p>Source of sponsorship (Study): ______</p><p>Study – Country of Origin: ______</p><p>Number of Centres Participating: ______</p><p>Comments: ______</p><p>______</p><p>______Verification of Eligibility: Inclusion Criteria: (verified by “tick” mark)</p><p>Controlled Trial</p><p>Patients were ≥ 18 years of age</p><p>Suffering from severe traumatic brain injury; Def’n: ______</p><p>Protocol-based care compared with control group</p><p>ICU/Neuro unit based care</p><p>Medical management protocol (with or without decompressive craniotomy)</p><p>Study Design: Type of Study:</p><p>Prospective experimental Other: data ______Retrospective experimental Prospective control data data Retrospective control data Consecutive control patients Consecutive control patients Case-control study Cross-sectional study</p><p>Inclusion Criteria:</p><p> a..1. ______</p><p> a..1. ______</p><p> a..1. ______</p><p> a..1. ______</p><p> a..1. ______</p><p> a..1. ______</p><p>Exclusion Criteria:</p><p>1. ______2. ______</p><p>3. ______</p><p>4. ______</p><p>5. ______</p><p>6. ______</p><p>Type of ICU: ______</p><p>Lead ICU MD: ______Team members: Intensivist Neurologist Neurointensivist Neurosurgeon Anesthesia Trauma Housestaff Nurse Educator/Specialist Not specified</p><p>Protocol Characteristics: Multidisc. Nursing care driven o ER derived MD care driven Rescussicitation ICP-driven Descriptive (ie: no OR CPP-driven diagram) Other: ______Guideline Admission orders Based, specify: Flow diagram ______Step/Phase approach ______Pre-ICU care protocols:</p><p>Co-Interventions: ______</p><p>Control Group Mgmt: ______</p><p>______</p><p>______</p><p>______</p><p>Protocol Specifics: Variable/Intervention if not Co met: T T mm ent: ICP target: ICP monitor IVD Imaging</p><p>CSF drainage ______</p><p>Sedation/anagelsia hypertonic saline _____% mannitol ______</p><p>Vasoactive meds: cooling ______C</p><p>PaCO2 other: ______other: ______CPP target: ICP monitor IVD</p><p>Imaging</p><p>CSF drainage ______sedation hypertonic saline _____% mannitol ______</p><p>Vasoactive meds: cooling ______C</p><p>PaCO2 other: ______other: ______</p><p>SjO2 target: </p><p>Imaging</p><p>CSF drainage ______sedation hypertonic saline _____% mannitol ______Vasoactive meds: cooling ______C</p><p>PaCO2 other: ______other: ______</p><p>Hypothermia</p><p>Nutrition</p><p>Tracheostomy</p><p>PEG</p><p>CEEG</p><p>Barbiturate coma</p><p>Oxygen Saturation/FiO2</p><p>CVP/PCWP</p><p>MAP</p><p>PaCO2</p><p>Decompressive craniectomy Other:</p><p>Comments/Clarification: ______</p><p>______</p><p>______</p><p>______</p><p>Stated Outcomes: Outcome: P S P</p><p>Screening and Enrollment: Total patients enrolled: ______Control pts: ______Intervention pts: ______</p><p>Timing of enrolment (mm/yy): Control pts: ______Intervention pts: ______</p><p>Consecutive patients: Yes No Description of why not: ______</p><p>______Participant identification: ICU database Hospital database Prospective enrolment Medical records coding Other: ______Baseline Characteristics: C I O n Int N t T e R r #2: O v L e n t i o n # 1 :</p><p>______Demographics:</p><p>Age (SD)</p><p>Male Sex (SD)</p><p>APACHE (SD) (circle) 2 or 3 SOFA/MODS/SAPS</p><p>Admission GCS (SD)</p><p>ISS (SD)</p><p>Post-op admission Transferred from another institution Diagnostic Category:</p><p>DAI</p><p>SAH SDH Intracerebral hemorrhage</p><p>No Mass</p><p>Marshall Score % Multiple Injuries (in add’n to head) Baseline Hemodynamics:</p><p>ICP</p><p>CPP</p><p>SjO2</p><p>BP</p><p>HR</p><p>Temperature</p><p>GCS</p><p>CVP/PWP</p><p>SvO2 Outcomes and Results: C I O n Int N t T e R r #2: O v L e n t i o n # 1 :</p><p>______Mortality:</p><p>Death (SD)</p><p>Withdrawal of Care (SD)</p><p>Non TBI-related (SD) </p><p>Post-admission day</p><p>Morbidity:</p><p>ICU LOS</p><p>Hospital LOS</p><p>Ventilator days Day of tracheostomy insertion Initiation of feeds</p><p>Day of PEG insertion GOS: ______</p><p>Discharge status Pt questionnaire: ______Physiologic/Adverse Events: OR (ie: craniectomy) Seizure</p><p>ICP control</p><p>CPP control Barbiturate coma Pneumonia</p><p>CNS infection</p><p>Resources:</p><p>Health Care Costs</p>