Additional file 4: Table S1. Proteins identified by Mascot in the samples treated with a combination of carprofen and IL-1 and their corresponding Mascot scores.

Protein Carprofen Carprofen Carprofen Carprofen Carprofen SwissProt + IL1 + IL1 + IL1 + IL1 + IL1 accession Sample 1 Sample 2 Sample 3 Sample 4 Sample 5 number Cartilage oligomeric 901 1234 1117 1163 1078 matrix protein Q9R0G6 Aggrecan core protein 611 665 680 943 677 Q28343 Fibronectin 309 215 415 339 237 Q28275 Clusterin 169 128 127 72 108 P25473 Decorin 117 124 153 143 97 Q29393 Chondroadherin 64 76 174 134 194 O15335 Trypsin 129 107 103 120 71 P00761 Keratin, type II 64 73 - - 43 cytoskeletal 1 A5A6M6 Biglycan 68 71 - 64 58 O02678 Anionic trypsin-1 70 67 60 69 51 P00762 Thrombospondin-3 50 57 54 - - P49746 Fibromodulin 43 - - 49 - P50608 Ribonuclease 4 37 49 43 - 56 P15467 Vimentin - 64 54 - 75 P48616 Metalloproteinase - 41 - - - inhibitor 1 P81546 Uncharacterized endonuclease O60168 48 - - 62 58 C19F8.04c Hyaluronan and proteoglycan link protein P55252 - 43 - 37 - 1 Cartilage intermediate - 42 40 41 56 layer protein 1 O19112 Thrombospondin-4 - 60 54 - - Q3SWW8 C-type lectin domain - - 48 - - family 3 member A Q9EPW4 Protoheme IX - 50 - 50 - farnesyltransferase C1DG34 Chemotaxis response regulator protein- Q39S45 - 50 - 50 - glutamate methylesterase 4 Cartilage intermediate - 75 60 37 48 layer protein 2 Q8IUL8 Aspartyl-tRNA 34 - - 36 - synthetase A1KAJ9 Dihydrodipicolinate 34 - - 36 - reductase A1S8K1 Uncharacterized 34 - - 36 - oxidoreductase ycsN P42972 Transmembrane 34 - - 35 - GTPase Marf Q7YU24 IAA-amino acid - - - 32 - hydrolase ILR1-like 3 Q851L5 Stromelysin-1 139 94 104 73 - Q6Y4Q5 Thrombospondin-1 64 - 85 - - P35441 Alpha-enolase 83 - - - - Q9PVK2 Phosphomethylpyrimidin - 49 53 - - e synthase C0QJ00 Serum amyloid A protein 53 48 54 - - P35541 47 - - 26 - Syndecan-4 P31431 Alpha-2-HS-glycoprotein - - - - 32 P12763 Keratin, type II 67 - - - - cytoskeletal 5 Q5XQN5 Enolase - 73 - - - O02654 Macrophage migration - 52 - - - inhibitory factor P14174 Interleukin-8 44 44 58 42 61 P41324 Keratin, type II 24 - - - - cytoskeletal 1b Q6IG01 4-hydroxy-3-methylbut- 2-enyl diphosphate A1JJE4 - - - 72 - reductase Genome polyprotein - - - - 16 Q6YMS3 Prolargin 39 - - - - Q9JK53 Lumican 43 - 44 41 - P51884 Centrosome-associated 39 - - - - protein 350 Q5VT06 Desmin - 49 - - - O62654 Electron transport - 28 26 - - complex protein rnfC Q5PIB9 Uncharacterized protein - 26 - - - V11 B4YNF1 SPBc2 prophage- derived uncharacterized O34869 - 22 - - - protein yopV Single-stranded DNA- - - 31 - - binding protein Q8G757 Vacuolar protein-sorting - - 30 - - protein BRO1 Q6BRL3 Protein EFR3 - - 27 - - Q4I1T9 Urocanate hydratase - - - 38 - A7ZAE5 OS=Erwinia carotovora Q6D401 subsp. atroseptica - - - 32 - GN=aroA PE=3 SV=1 Shikimate - - - 32 - dehydrogenase Q1AWA3 Hybrid signal transduction histidine Q86AT9 - - - 24 - kinase I Forkhead-associated domain-containing A6PWD2 - - - - 36 protein 1 Uncharacterized 17.7 kDa protein in e-segB P32271 - - - - 27 intergenic region Probable LRR receptor- like serine/threonine- C0LGJ9 - - - - 24 protein kinase At2g02780 Serine/threonine-protein - - - - 16 kinase STE20 Q03497