Center for Clinical and Translational Science and Training s1

Center for Clinical and Translational Science and Training University of Cincinnati Academic Health Center 3333 Burnet Avenue Loc. S, 10th Floor, Suite 300, ML 11028 Cincinnati, OH 45229 Voice: 513.803.1044 Fax: 513.803.1039 Web: cctst.uc.edu

Center for Clinical and Translational Science and Training Just-In-Time Core Funds Grant Application Instructions 7/1/2012-6/30/13

DEADLINES Continuous (first-come, first-serve) Note: Prospective applicants should check the CCTST website to be certain the funds have not yet been exhausted for the fiscal year.

For questions regarding these instructions, please visit http://cctst.uc.edu/programs/pilot-studies or contact Katie Scharf at (513) 803-2778 or [email protected] .

1. Background: The Center for Clinical and Translational Science and Training (CCTST) is supported by the NIH Clinical and Translational Science Award. Integral to the mission of the CCTST is to stimulate the development of pre-clinical and human clinical trials that seek to improve medical care.

2. Purpose of grants: This small grants program is designed to support clinical and translational science investigators who are seeking preliminary data needed for K23, R01 or similar grant submissions and need the services of one or more of the institutional cores. Investigators may apply for up to $7,500 annually in support for services that would help them obtain preliminary data needed for a new or revised application for extramural funding. The Just- In-Time funding will be awarded to projects which demonstrate an imme- diate need to complete preliminary data with the expectation to expend the funds within 3 to 6 months of award and within the fiscal year awarded.

3. Participating cores: a. Center for Imaging Research University of Cincinnati http://www.cir.uc.edu Director: Stephen Strakowski, MD, [email protected], 558-4871/558-2958 b. Drug Discovery Center University of Cincinnati http://www.drugdiscovery.uc.edu/ Director: Ruben Papoian, PhD, [email protected], 558-0516 c. Genomic Microarray Core University of Cincinnati http://microarray.uc.edu/ Director: Shuk-mei Ho, PhD, [email protected], 558-5701 d. Proteomics Core University of Cincinnati http://cancerbiology.uc.edu/about-cancer--cell-biology/core-facilities/proteomics.aspx Director: Kenneth Greis, PhD, [email protected], 558-7102 e. Affymetrix Core Cincinnati Children’s Hospital Medical Center http://www.cincinnatichildrens.org/research/cores/affymetrix/default.htm Director: Steven Potter, PhD, [email protected], 636-4850 f. Human Genetics Core Cincinnati Children’s Hospital & Medical Center http://www.cincinnatichildrens.org/research/div/genetics/default.htm

1 Director: Greg Grabowski, MD, [email protected], 636-7290 g. Cytokine Core Cincinnati Children’s Hospital & Medical Center http://www.cincinnatichildrens.org/research/divisions/d/dhc/cores/expression-sequence/ Director: Steve Potter, PhD, [email protected], 636-4850 h. Pathology Core Cincinnati Children’s Hospital & Medical Center http://www.cincinnatichildrens.org/svc/alpha/p/pathology/ Director: David Witte, MD, [email protected], 636-4261/303-1785 i. Imaging Research Center Cincinnati Children’s Hospital & Medical Center http://www.irc.cchmc.org Director: Chuck Dumoulin, PhD, [email protected] , 636-7721 j. Echocardiography Core Cincinnati Children’s Hospital & Medical Center http://www.cincinnatichildrens.org/research/cores/echocardiography/default.htm Director: Thomas R. Kimball, MD, [email protected], 636-8270 k. Flow Cytometry University of Cincinnati and Cincinnati Children’s Hospital & Medical Center http://www.cincinnatichildrens.org/research/cores/flow-cytometry/default/ Director: Robert Franco, PhD, [email protected], 558-3241 l. Small Animal Heart Core University of Cincinnati http://www.med.research.uc.edu/core_fac/core.cfm?Corefac_ID=23 Director: Arnold Schwartz, MD, PhD, [email protected], 558-2400 m. Clinical Mass Spectrometry Cincinnati Children’s Hospital & Medical Center http://www.cincinnatichildrens.org/research/divisions/p/pathology/spectrometry-lab/ Director: Kenneth D. Setchell, PhD, [email protected], 636-4548 n. Pharmacometrics University of Cincinnati and Cincinnati Children’s Hospital & Medical Center http://math.uc.edu/~siva/NONMEM/page2/index.htm Director: Sander Vinks, PharmD, PhD, [email protected], 636-0159 o. Cell Processing and Manipulations Laboratory Cincinnati Children's Hospital Medical Center https://research.cchmc.org/translationalcores/cellular-processing/gmp-cell-manipulation Scientific Director: Carolyn Lutzko PhD, [email protected], 803-2420 p. Vector Production Facility Cincinnati Children's Hospital Medical Center https://research.cchmc.org/translationalcores/vector-production/gmp-vector-production Director: Punam Malik, MD, [email protected], 513-636-8588 q. Viral Vector Core Cincinnati Children's Hospital Medical Center https://research.cchmc.org/translationalcores/vector-production/pre-clinical-and-research-vector-products Director: Punam Malik, MD, [email protected], 513-636-8588 r. Translational Trials Development and Support Laboratory Cincinnati Children’s Hospital Medical Center https://research.cchmc.org/translationalcores/ttdsl Director: Elke Grassman, [email protected], 513-636-0958 s. Diagnostic Immunology Lab Cincinnati Children's Hospital Medical Center http://www.cincinnatichildrens.org/svc/alpha/c/cancer-blood/immune-deficiency/diagnostic-lab.htm Director: Alexandra (Lisa) Filipovich, M.D., [email protected], 513-636-7206 t. Genetic Variation and Gene Discovery Core Facility- Computational Medicine Center Cincinnati Children’s Hospital Medical Center http://dna.chmcc.org/www/main.php Contact: Mehdi Keddache, [email protected], 513-636-0122 2 u. Center for Autoimmune Genomics and Etiology (CAGE) Cincinnati Children’s Hospital Medical Center http://www.cincinnatichildrens.org/research/divisions/a/genomics-etiology/default/ Contact: John Harley, [email protected] , 513-803-3665 v. Protein Informatics Core Cincinnati Children’s Hospital Medical Center https://research.cchmc.org/proteincore/ Contact: Jarek Meller, [email protected], 513-636-0270 w. Live Microscopy Core University of Cincinnati http://www.med.uc.edu/physiology/RESOURCES_microscopy.htm Director: Marshall H. Montrose, PhD, [email protected], 558-5636 Manager: Chet Closson, [email protected], 558-3791 x. Genetically Modified Mouse Models Core University of Cincinnati http://www.molgen.uc.edu/node/51 Director: Jon Neumann, [email protected], 558-5294 y. Pluripotent Stem Cell Facility Cincinnati Children’s Hospital Medical Center https://research.cchmc.org/stemcell/ Director: James Wells, PhD, [email protected], 513-636-9254 z. Laboratory Animal Medical Services (LAMS) – per diem cost not allowed University of Cincinnati http://medcenter.uc.edu/lams Interim Directors: George Babcock ([email protected], 872-6231) or Jane Strasser ([email protected], 558-5034) aa. Vontz Core Imaging Laboratory (VCIL) University of Cincinnati www.med.uc.edu/radiology/researchfacilities/index.html Director: Jing Huei Lee, PhD, [email protected], 558-5676 bb. Confocal Imaging Core Cincinnati Children's Hospital Medical Center https://research.cchmc.org/cic/ Director: Matthew Kofron, PhD, [email protected], 803-9055 cc. Structural Biology and Protein Expression/Purification Facility University of Cincinnati Department of Molecular Genetics Contact: Tom Thompson, PhD, [email protected], 558-5525 dd. Pyrosequencing Lab for Genomic and Epigenomic Research Cincinnati Children’s Hospital Medical Center https://research.cchmc.org/plge/ Director: Hong Ji, PhD, [email protected], 803-5055

NOTE: If the core you wish to use is not on this list, or if you are a core director and would like your core to be considered, please send a formal request to have it added to the approved list to [email protected] . Include rationale regarding how your core is utilized for clinical or translational studies. The CCTST leadership will consider the request.

4. Eligibility: Applications will be accepted from all 80% or greater FTE faculty members in the AHC, including basic scientists, physicians, nurses, and other health care faculty with advanced degrees (M.D., Ph.D., M.D.-Ph.D., or equivalent). Clusters of investigators spanning disciplines and programs made up of basic and clinical faculty are strongly encouraged.

5. CCTST Membership: All applicants for Just-In-Time grant consideration must be CCTST members. CCTST membership is free and open to all. For more information about CCTST

3 membership and our online membership registration form go to http://cctst.uc.edu/about/cctst- membership.

6. Process: Applicants are requested to submit a 1-page proposal in the format listed below. There is no deadline; the requests are processed in the order they are received, and the funding will be giv- en on a first-come, first serve basis during the fiscal year to be utilized within the awarded fiscal year.

7. Signatures: The signatures of all investigators and their respective division director or departmen- tal chairperson(s) are required.

8. Required format: Applications must be submitted electronically. Send a PDF file of assembled proposal to [email protected]. Application forms (modified from PHS 398 located at http://Grants.Nih.Gov/Grants/Funding/Phs398/Phs398.html) are attached. This RFA is also avail- able on the CCTST website under Funding Opportunities, http://cctst.uc.edu/research-central/funding-opportunities or under Pilot and Collaborative Translational and Clinical Stud- ies, http://cctst.uc.edu/programs/pilot-studies. Proposals must be submitted in single spaced text, one-half inch margins, and no smaller than an 11-point font. Arial or Helvetica typeface is preferred. Proposal text must be limited to one page (including figures but excluding animals and human subjects’ protection and references).

9. Composition of research proposal: Proposals should include a face page and a 1-page brief de- scription of the project including aims and hypotheses, a brief background, the services needed including costs (up to $7,500) and (most importantly) rationale about how the studies will be used to support their extramural grant submission. Because the applications must be approved by the rele- vant core director, applicants are strongly encouraged to consult with the director prior to submission.

NOTE: For the form on the next page, select Tools from the MS Word menu, then Unprotect Document to in- sert additional documents. You will be able to add text and pages as needed. To continue using the pages be- fore this page, you must protect the document; to protect this document, select Tools from the MS Word menu, then Protect Document, then Forms. You will then be able to enter information into the fields.

4 CCTST Pilot Grant Program Just-In-Time Core Funds Grant Application

1. TITLE OF PROJECT (Do not exceed 56 characters, including spaces and punctuation.)

1a. Type of application: Research proposal TR Faculty Development Award Retreat proposal Core proposal

2. PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR New CCTST Investigator No Yes 2a. NAME (Last, first, middle) 2b. DEGREE(S)

2c. POSITION TITLE 2d. MAILING ADDRESS (Street, city, state, zip code)

2e. DIVISION

2f. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT

2g. TELEPHONE AND FAX (Area code, number and extension) E-MAIL ADDRESS: TEL: FAX: 3. CO-INVESTIGATOR New CCTST Investigator No Yes

3a. NAME (Last, first, middle) 3b. DEGREE(S)

3c. POSITION TITLE 3d. MAILING ADDRESS (Street, city, state, zip code)

3e. DIVISION

3f. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT

3g. TELEPHONE AND FAX (Area code, number and extension) E-MAIL ADDRESS: TEL: FAX: 4. Human Subjects Research 4a. Research Exempt 4b. Human Subjects Assurance No. 5. Human Subjects Protec- No Yes No Yes tion Certification: No If “Yes,” Exemption No. 4c. NIH-Defined Phase I Clinical Trial Yes No Yes 5a. Certification Date:

6. Vertebrate Animals 7. IBC Protocol 8. Radiation No Yes No Yes No Yes 6a. If “Yes,” IACUC Approval 7a. If “Yes,” Approval Date: Date 8a. If “Yes,” Approval 7b. Approval Number: Date 6b. Animal Welfare Assurance No.

10.COSTS REQUESTED 9. DATES OF PROPOSED PERIOD OF Direct Costs ($) SUPPORT (month, day, year—MM/DD/YY)

From Through 07/01/2012 06/30/13 12. The undersigned reviewed this application for a CCHMC CCTST research award and are familiar with the policies, terms, and conditions of CCHMC con- cerning research support and accept the obligation to comply with all such policies, terms, and conditions. Primary Applicant: Division Chair of Primary Applicant:

Signature of Primary Applicant Date: Signature of Division Chair of Primary Applicant Date: Affiliate applicant: Division Chair of Affiliate Applicant:

5 Signature of Affiliate Applicant Date: Division Chair of Affiliate Applicant: Date:

Received By: