Table 3. HLA Haplotypes in Alabama Subjects.1

HLA-A HLA-B Hemochromatosis Probands Controls (1,210 Significant values

(236 chromosomes) chromosomes) of p 01 07 0.0042 0.0124

08 0.0720 0.0669

14 0.0042 0.0017

37 0.0042 0.0050

44 0.0042 0.0091

57 0.0085 0.0066

60 0.0085 0 0.0265

62 0.0085 0.0050

70 0.0042 0

02 07 0.0127 0.0331

08 0.0127 0.0083

14 0.0085 0

15 0.0042 0

18 0.0042 0.0050

27 0.0042 0.0083

35 0.0042 0.0083

37 0.0042 0

39 0.0169 0.0033 0.0282

44 0.0508 0.0603

48 0.0042 0

51 0.0085 0.0132

56 0.0085 0.0017

60 0.0127 0.0083

62 0.0085 0 0.0265

03 07 0.2966 0.0331 < 0.0001

13 0.0169 0 0.0007

14 0.0847 0.0083 < 0.0001

15 0.0085 0 0.0265 17 0.0042 0

27 0.0085 0 0.0265

35 0.0127 0 0.0043

37 0.0042 0

44 0.0339 0 < 0.0001

47 0.0127 0 0.0043

51 0.0085 0.0017

57 0.0169 0 0.0007

62 0.0212 0.0099

72 0.0042 0

11 07 0.0085 0.0066

14 0.0042 0

18 0.0042 0.0017

27 0.0042 0

35 0.0085 0.0066

37 0.0042 0

40 0.0042 0.0017

51 0.0042 0.0033

60 0.0042 0.0017

23 44 0.0085 0.0033

24 07 0.0085 0.0050

44 0.0085 0.0083

51 0.0042 0.0017

55 0.0042 0

56 0.0042 0

25 18 0.0042 0.0033

35 0.0042 0

39 0.0042 0

44 0.0042 0

56 0.0042 0

60 0.0042 0

28 08 0.0042 0 14 0.0042 0.0033

55 0.0042 0

44 0.0127 0.0066

29 44 0.0127 0.0099

30 60 0.0042 0

31 08 0.0042 0

40 0.0042 0.0033

60 0.0042 0.0017

32 35 0.0042 0

38 0.0042 0

44 0.0042 0

33 14 0.0042 0.0050

1These data represent 118 unrelated white C282Y homozygous hemochromatosis probands (= 236 chromosomes) and 605 white persons (= 1,210 chromosomes) who underwent haplotype analysis for paternity testing. All subjects were residents of

Alabama. All haplotypes could be detected with DNA-based and serologic methods with the exception of haplotypes containing B*70 and B*72 that were not detected by serologic methods.