Health and Safety Code Chapter 481. Texas Controlled Substances
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Monoamine Oxidase Inhibitory Properties of Some Methoxylated and Alkylthio Amphetamine Derivatives Strucrure-Acfivity RELA TIONSHIPS Ma
Biochemieal PhannaeoloR)'. Vol. 54. pp. 1361-1369, 1997. ISSN 0006-2952/97/$17.00 + 0.00 © 1997 Elsevier Scienee Ine. Al! rights reserved. PIl SOOO6-2952(97)00405·X ELSEVIER Monoamine Oxidase Inhibitory Properties of Some Methoxylated and Alkylthio Amphetamine Derivatives STRUcruRE-ACfIVITY RELA TIONSHIPS Ma. Cecilia Scorza,* Cecilia Carrau,* Rodolfo Silveira,* GemId Zapata,Torres,t Bruce K. Casselst and Miguel Reyes,Parada*t *DIVISIÓNBIOLOGíACELULAR,INSTITUTODEINVESTIGACIONESBIOLÓGICASCLEMENTeEsTABlE, CP 11600, MONTEVIOEO,URUGUAY;ANDtDEPARTAMENTODEQUíMICA, FACULTADDECIENCIAS,UNIVERSIDADDECHILE, SANTIAGO,CHILE ABSTRACT. The monoamine oxidase (MAO) inhibitory propenies of a series of amphetamine derivatives with difTerent substituents at or around rhe para position of the aromaric ring were evaluateJ. i¡, in viero stuJies in which a crude rar brain mirochllndrial suspension was used as rhe source of MAO, several compounds showed a srrong (ICS0 in rhe submicromolar range), selecrive, reversible, time-independenr, and concenrrarion-related inhibition of MAO-A. After i.p. injection, the compounds induced an inerease of serotonin and a decrease of j-hydroxyindoleacetic acid in the raphe nuclei and hippocampus, confinning rhe in virro results. The analysis of structure-activity relationships indicates rhat: molecules with amphetamine-Iike structure and different substitutions nn the aromaric ring are potentially MAO-A inhibitors; substituents at different positions of the aromatic ring moditY the porency but have litde inf1uence "n the selectiviry; substituents at rhe para position sllch as ,lmino, alkoxyl. halogens. or alkylthio produce a significant increase in rhe acrivity; the para-substituent musr be an e1ectron Jonor; hulky ~roups next to rhe para subsriruent Icad ro a Jecrease in the actÍ\'ityi ,ubstiruents loearcd ar posirions more Jistant ,m rhe aromaric ring havc less intluence anJ, even when the subsriruent is '1 halogen (CI, Br), an increase in rhe acrivity "f rhe cllmpound is llbtained. -
Hallucinogens: an Update
National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES Hallucinogens: An Update 146 U.S. Department of Health and Human Services • Public Health Service • National Institutes of Health Hallucinogens: An Update Editors: Geraline C. Lin, Ph.D. National Institute on Drug Abuse Richard A. Glennon, Ph.D. Virginia Commonwealth University NIDA Research Monograph 146 1994 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGEMENT This monograph is based on the papers from a technical review on “Hallucinogens: An Update” held on July 13-14, 1992. The review meeting was sponsored by the National Institute on Drug Abuse. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the U.S. Department of Health and Human Services. The U.S. Government does not endorse or favor any specific commercial product or company. -
Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected]
Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 4-25-2018 Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected] DOI: 10.25148/etd.FIDC006565 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Chemistry Commons Recommended Citation Seither, Joshua Zolton, "Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances" (2018). FIU Electronic Theses and Dissertations. 3823. https://digitalcommons.fiu.edu/etd/3823 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida APPLICATION OF HIGH RESOLUTION MASS SPECTROMETRY FOR THE SCREENING AND CONFIRMATION OF NOVEL PSYCHOACTIVE SUBSTANCES A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in CHEMISTRY by Joshua Zolton Seither 2018 To: Dean Michael R. Heithaus College of Arts, Sciences and Education This dissertation, written by Joshua Zolton Seither, and entitled Application of High- Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved. _______________________________________ Piero Gardinali _______________________________________ Bruce McCord _______________________________________ DeEtta Mills _______________________________________ Stanislaw Wnuk _______________________________________ Anthony DeCaprio, Major Professor Date of Defense: April 25, 2018 The dissertation of Joshua Zolton Seither is approved. -
Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines
ORIGINAL RESEARCH published: 28 November 2019 doi: 10.3389/fphar.2019.01423 Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines Karolina E. Kolaczynska 1, Dino Luethi 1,2, Daniel Trachsel 3, Marius C. Hoener 4 and Matthias E. Liechti 1* 1 Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland, 2 Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Vienna, Austria, 3 ReseaChem GmbH, Burgdorf, Switzerland, 4 Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland Background: 2,4,5-Trimethoxyamphetamine (TMA-2) is a potent psychedelic compound. Structurally related 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamine congeners (2C-O derivatives) have been described but their pharmacology Edited by: is mostly undefined. Therefore, we examined receptor binding and activation profiles of M. Foster Olive, these derivatives at monoamine receptors and transporters. Arizona State University, United States Methods: Receptor binding affinities were determined at the serotonergic 5-HT1A, 5-HT2A, Reviewed by: Luc Maroteaux, and 5-HT2C receptors, trace amine-associated receptor 1 (TAAR1), adrenergic α1 and INSERM U839 Institut du Fer à α2 receptors, dopaminergic D2 receptor, and at monoamine transporters, using target- Moulin, France Simon D. Brandt, transfected cells. Additionally, activation of 5-HT2A and 5-HT2B receptors and TAAR1 was Liverpool John Moores University, determined. Furthermore, we assessed monoamine transporter inhibition. United Kingdom Results: Both the phenethylamine and amphetamine derivatives (Ki = 8–1700 nM and *Correspondence: Matthias E. Liechti 61–4400 nM, respectively) bound with moderate to high affinities to the 5-HT2A receptor [email protected] with preference over the 5-HT1A and 5-HT2C receptors (5-HT2A/5-HT1A = 1.4–333 and Specialty section: 5-HT2A/5-HT2C = 2.1–14, respectively). -
Novel Hallucinogens and Plant-Derived Highs
Novel Hallucinogens and Plant-Derived Highs Emily Dye Forensic Chemist Special Testing and Research Laboratory Drug Enforcement Administration Outline • Hallucinogens • Plant-Derived Highs – 2C Compounds – Kratom – NBOMe Compounds – Fly Agaric Mushrooms – DOX Compounds – Kava Kava – Kanna • Empathogens – Aminoindanes – APDB – APB DEA Special Testing and Research Laboratory Emerging Trends Program 2C Compounds • Psychedelic phenethylamines • Synthesized by Alexander Shulgin – Published in PiHKAL • 27 known compounds – Most common: 2C-C, 2C-B, and 2C-I DEA Special Testing and Research Laboratory Emerging Trends Program 2C Compounds DEA Special Testing and Research Laboratory Emerging Trends Program 2C-B-FLY • Psychedelic phenethylamine • Synthesized by Aaron Monte www.erowid.org DEA Special Testing and Research Laboratory Emerging Trends Program Bromo-DragonFLY • Psychedelic phenethylamine • Synthesized in the lab of David Nichols • Deaths associated with misrepresentation as 2C-B-FLY www.erowid.org DEA Special Testing and Research Laboratory Emerging Trends Program NBOMe Compounds • Hallucinogenic phenethylamines • Synthesized by Heim, et al. • Isomers can be distinguished via RT and MS DEA Special Testing and Research Laboratory Emerging Trends Program Name R1 R2 R3 R4 Name R1 R2 R3 R4 25B-NB2OMe Br OCH3 H H 25N-NB2OMe NO2 OCH3 H H 25B-NB3OMe Br H OCH3 H 25N-NB3OMe NO2 H OCH3 H 25B-NB4OMe Br H H OCH3 25N-NB4OMe NO2 H H OCH3 25C-NB2OMe Cl OCH3 H H 25P-NB2OMe CH2CH2CH3 OCH3 H H 25C-NB3OMe Cl H OCH3 H 25P-NB3OMe CH2CH2CH3 H OCH3 H 25C-NB4OMe -
Psychedelics and Religious Insight: a Precedent in American Psycho-Spirituality from 1 William James to Timothy Leary
Psychedelics and Religious Insight: A Precedent in American Psycho-Spirituality from 1 William James to Timothy Leary Psychedelics and Religious Insight: A Precedent in American Psycho-Spirituality from 2 William James to Timothy Leary Psychedelics and Religious Insight: A Precedent in American Psycho-Spirituality from 3 William James to Timothy Leary ABSTRACT Psychedelics and Religious Insight: A Precedent in American Psycho- Spirituality from William James to Timothy Leary by Connor James Storck The primary purpose of this thesis is to stress that there is a relationship between the texts one reads and psychedelic experiences. Reading texts has an effect on set and setting with respect to psychedelic experiences. Further, texts read—by figures like Timothy Leary—in the afterglow of a psychedelic experience can influence later integration of said experiences into one’s worldview. This thesis tracks this through the influence of mind-altering substances in the works of both William James (1842-1910) and Timothy Leary (1920-1996) in order to display James’ influence on Leary. James’ impact of Leary intellectually is critical because recent scholarship and changes in cultural and societal perspectives have led to a Psychedelic Renaissance in many disciplines from the clinical-therapeutic to the religious-spiritual. The paper covers select and relevant historical information relating to periods of the Anesthetic Revolution and the Long Sixties. I show how James came to experiment with various mind-altering substances and the results of those experiments. For this reason, the thesis also interacts with Benjamin Paul Blood, a figure whose work guided James’ thought towards the use of mind-altering substances. -
Controlled Substances List (Adopted by Alabama State Board of Health on January 20, 2021, Effective January 20, 2021)
1 Controlled Substances List (Adopted by Alabama State Board of Health on January 20, 2021, effective January 20, 2021) Schedule I (a) Schedule I shall consist of the drugs and other substances, by whatever official name, common or usual name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it. (b) Opiates. Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters and ethers, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation (for purposes of 3-methylthiofentanyl only, the term isomer includes the optical and geometric isomers): (1) Acetyl-alpha-methylfentanyl (N-[1-[1-methyl-2-phenethyl]-4-piperidinyl]- N-phenylacetamide -------------------------------------------------------------------- 9815 (Federal Control Nov. 29, 1985; State Dec. 29, 1985) (2) Acetylmethadol ------------------------------------------------------------------------- 9601 (3) AH-7921 (3,4-dichloro-N-[(1-dimethylamino)cyclohexylmethyl] benzamide -------------------------------------------------------------------------------- 9551 Federal Control May 16, 2016; State June 15, 2016 (4) Allylprodine ----------------------------------------------------------------------------- 9602 (5) Alphacetylmethadol --------------------------------------------------------------------- 9603 (6) Alphameprodine -
Synthetic Designer Drugs Presentation
Bertha K. Madras, PhD Professor of Psychobiology Department of Psychiatry Harvard Medical School Digitalis 1875 Atropine 1831 Aspirin 1853 Quinine 1820 CathinoneCocaine Δ-9-tetrahydrocannabinol (THC) Methamphetamine Heroin • What are Designer Drugs? • What Drives Designer Drug Markets? • Trends? • Are Designer Drugs Legal? • Who Uses “Bath Salts”, Synthetic Cannabinoids, and Why? • Effects and Harmful Effects? • Summary • Bath salts: stimulants hallucinogens, entactogens, “empathogens” • These are not bath salts!!!!!!! They are chemicals. • “Spice”, “K2” Cannabinoids: marijuana-like chemicals • “Dragonflys”: Hallucinogens • Morphine-like: Krokodil • Tryptamines: Hallucinogens DISSOCIATIVES Methoxetamine Ketamine Hallucinogens Phencyclidine CATHINONES DOB Aleph-2 DOM Cathinone 2C-D 2C-B 2CT-2 Methcathinone 2-CE 2C-C 2C-I Mephedrone 2C-T-2 2C-T-4 2C-N SYNTHETIC Flephedrone CANNABINOIDS 2C-P Pyrovalerone MDPV CP 47,497 CP 55,940 Pentylone Naphyrone Cannabicyclohexanol JWH-007, -018, -073, -081, -098, -122, -164, -210, PIPERAZINES UR-144 XLR-11 UR HALLUCINOGENIC BZP MDBP mCPP AMPHETAMINES TFMPP MeOPP (rigid dragonflies) MDMA –related 2C-Bfly Br-Fly PFA PFMA 6-APB Br-dragonfly TCB-2 MDAI 5-IAI MDAT 60 50 40 2010 30 2011 20 2012 10 0 Synthetic cannabinoids Synthetic cathinones Source: US DEA, Office of Division Control, National Forensic Laboratory Information System, 2012 NH2 Phenethylamine (PEA) H H NH2 N O N CH3 CH3 CH3 CH3 CH3 O Amphetamine Methamphetamine MDMA or ecstasy methylenedioxymethamphetamine O O O H H NH N 2 O N CH3 CH3 CH CH3 -
1 Monoamine Receptor Interaction Profiles of 4-Thio-Substituted
Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs) Dino Luethi,a Daniel Trachsel,b Marius C. Hoener,c Matthias E. Liechtia aDivision of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland bReseaChem GmbH, Burgdorf, Switzerland cNeuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland Running title: Pharmacology of 2C-T drugs *Corresponding author: Prof. Dr. med. Matthias E. Liechti, Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Hebelstrasse 2, Basel, CH-4031, Switzerland. Tel: +41 61 328 68 68; Fax: +41 61 265 45 60; E-mail: [email protected] Word count: Manuscript: 6127, Abstract: 222, References: 42, Tables: 2, Figures: 1 1 Abstract Background: 4-Thio-substituted phenethylamines (2C-T drugs) are potent psychedelics with poorly defined pharmacological properties. Because of their psychedelic effects, 2C-T drugs are sometimes sold as new psychoactive substances (NPSs). The aim of the present study was to characterize the monoamine receptor and transporter interaction profiles of a series of 2C- T drugs. Methods: We determined the binding affinities of 2C-T drugs at monoamine receptors and transporters in human cells that were transfected with the respective receptors or transporters. We also investigated the functional activation of serotonergic 5-hydroxytryptamine 2A (5- HT2A) and 5-HT2B receptors, activation of human trace amine-associated receptor 1 (TAAR1), and inhibition of monoamine uptake transporters. Results: 2C-T drugs had high affinity for 5-HT2A and 5-HT2C receptors (1-54 nM and 40-350 nM, respectively). With activation potencies of 1-53 nM and 44-370 nM, the drugs were potent 5-HT2A receptor and 5-HT2B receptor, respectively, partial agonists. -
13974/02 JV/Dp 1 DG H II COUNCIL of the EUROPEAN UNION
COUNCIL OF Brussels, 8 November 2002 THE EUROPEAN UNION 13974/02 CORDROGUE 94 NOTE from : EMCDDA and EUROPOL to : Council Secretariat Subject : Joint information from EMCDDA and Europol to the Horizontal Working Party on Drugs of the Council of the European Union in the framework of the Joint Action on new synthetic drugs 13974/02 JV/dp 1 DG H II EN Draft joint information from EMCDDA and EUROPOL to the Horizontal Working Party on Drugs of the Council of the European Union in the framework of the Joint Action on new synthetic drugs. 1. Since the adoption of the Joint Action in June 1997 and the setting-up of the Early-warning System, a certain number of synthetic substances have been detected and monitored. 2. Depending on different variables such as the gravity of the consequences (deaths), the nature of evidences (overdoses), the frequency of findings (not anecdotic), the scope of the presence in the market (notifications and seizures), the EMCDDA and EUROPOL: a) have produced joint reports for some of these substances, when the initial estimation of risks required it; b) have continued to collect information for the others, with less evident risks, in order to complete the picture with the new findings. 3. On the basis of the EMCDDA-EUROPOL joint reports, the EMCDDA’s extended Scientific Committee has been requested to carry out the risk assessment of these substances. Thus, risk- assessment reports have been produced for the substances MBDB, 4-MTA, GHB, ketamine, PMMA. 4. Following the risk-assessment exercises, and according to the procedures, decisions were taken to put under control some of these substances (4-MTA, PMMA) and to continue to monitor the others (MBDB, GHB, ketamine) for which no sufficient evidence was available to put these under control. -
1 SB333 2 158141-2 3 by Senator Orr 4 RFD: Judiciary 5 First Read: 11-FEB-14
1 SB333 2 158141-2 3 By Senator Orr 4 RFD: Judiciary 5 First Read: 11-FEB-14 Page 0 SB333 1 SB333 2 3 4 ENROLLED, An Act, 5 Relating to Schedule I controlled substances; to 6 amend Sections 13A-12-231 and 20-2-23, Code of Alabama 1975, 7 to increase the requisite weight for trafficking in controlled 8 substance analogues; to include additional synthetic 9 controlled substances and analogues to the Schedule I 10 controlled substances list; and in connection therewith would 11 have as its purpose or effect the requirement of a new or 12 increased expenditure of local funds within the meaning of 13 Amendment 621 of the Constitution of Alabama of 1901, now 14 appearing as Section 111.05 of the Official Recompilation of 15 the Constitution of Alabama of 1901, as amended. 16 BE IT ENACTED BY THE LEGISLATURE OF ALABAMA: 17 Section 1. This act shall be known and may be cited 18 as Landon's Law. 19 Section 2. Sections 13A-12-231 and 20-2-23, Code of 20 Alabama 1975, are amended to read as follows: 21 "§13A-12-231. 22 "Except as authorized in Chapter 2, Title 20: 23 "(1) Any person who knowingly sells, manufactures, 24 delivers, or brings into this state, or who is knowingly in 25 actual or constructive possession of, in excess of one kilo or Page 1 SB333 1 2.2 pounds of any part of the plant of the genus Cannabis, 2 whether growing or not, the seeds thereof, the resin extracted 3 from any part of the plant, and every compound, manufacture, 4 salt, derivative, mixture, or preparation of the plant, its 5 seeds, or resin including the completely defoliated -
Comprehensive Forensic Toxicological Analysis of Designer Drugs
The author(s) shown below used Federal funds provided by the U.S. Department of Justice and prepared the following final report: Document Title: Comprehensive Forensic Toxicological Analysis of Designer Drugs Author(s): Anthony P. DeCaprio, W. Lee Hearn, Madeleine J. Swortwood Document No.: 244233 Date Received: December 2013 Award Number: 2011-DN-BX-K559 This report has not been published by the U.S. Department of Justice. To provide better customer service, NCJRS has made this Federally- funded grant report available electronically. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. This document is a research report submitted to the U.S. Department of Justice. This report has not been published by the Department. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. Cover Page Final Report DeCaprio NIJ Grant Federal Agency and Organization Element to Which Report is Submitted: National Institute of Justice, Office of Justice Programs Federal Grant Number: 2011-DN-BX-K559 Project Title: Comprehensive Forensic Toxicological Analysis of Designer Drugs PD/PI Name, Title and Contact Information: Anthony P. DeCaprio, Ph.D. Department of Chemistry & Biochemistry International Forensic Research Institute Florida International University 11200 SW 8th St., OE116B Miami, FL 33199 305-348-2195 [email protected] Name of Submitting