List of "Designated Substances" in Japan (As of August 25, 2021)
List of "Designated Substances" in Japan (as of October 8, 2021) Drug category, "Designated Substances (*)" was newly established in 2007 to control new psychoactive substances (NPS). Their manufacture, import, sale, display, possession, use etc. are generally prohibited except for scietific purposes. A total 2392 substances including 2 plants (Salvia Divinorum and Mitragina Speciosa (Kratom)) are currently controlled as "Designated Substances". (Substances basis 299, Generic scheduling 2098) 69 substances, such as JWH-018, mephedrone, MDPV etc. have been already reclassified to be "Narcotics". (*)They are controlled by "The Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices".
No. Name Other Name Chemical Structure Date of Enforcement
1 Isobutyl nitrite April 1, 2007 ONO
2 Isopropyl nitrite April 1, 2007 ONO
3 Isopentyl nitrite Isoamyl nitrite April 1, 2007 ONO
4 tert-Butyl nitrite April 1, 2007 ONO
ONO 5 Cyclohexyl nitrite April 1, 2007
6 Butyl nitrite April 1, 2007 ONO
N O
4-Acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9- 7 ALD-52 N February 28, 2020 hexahydroindolo[4,3-fg]quinoline-9-carboxamide
N
O
O O
8 4-Acetoxy-N -isopropyl-N- metyltryptamine 4-AcO-MIPT N April 4, 2015
N H
O O
9 4-Acetoxy-N -ethyl-N -methyltryptamine 4-AcO-MET N August 8, 2015
N H
O O
10 4-Acetoxy-N ,N -diallyltryptamine 4-AcO-DALT N August 8, 2015
N H
O O
11 4-Acetoxy-N ,N -diisopropyltryptamine 4-AcO-DIPT N April 1, 2007
N H
O O
12 4-Acetoxy-N,N -diethyltryptamine 4-AcO-DET N August 8, 2015
N H
O O
13 4-Acetoxy-N,N -dimethyltryptamine 4-AcO-DMT N August 8, 2015
N H
O
N H N N -(1-Adamantyl)-1-(5-chloropentyl)-1H -indazole-3- APINACA N -(5- N 14 April 18, 2016 carboxamide chloropentyl) analog
Cl
1 No. Name Other Name Chemical Structure Date of Enforcement
N -(1-Adamantyl)-1-[(tetrahydro-2H -pyran-4-yl)methyl]-1H - Adamantyl-THPINACA 15 March 6, 2017 indazole-3-carboxamide ATHPINACA
O
Adamantyl-THPINACA 2- N N -(2-Adamantyl)-1-[(tetrahydro-2H -pyran-4-yl)methyl]-1H - adamantyl isomer H N 16 indazole-3-carboxamide ATHPINACA 2-adamantyl N March 6, 2017 isomer
O
O
N H
N -(1-Adamantyl)-1-(4-fluorobenzyl)-1H -indazole-3- N 17 carboxamide FUB-APINACA N January 5, 2015
F
O
N H APICA N-(5-fluoropentyl) N -(1-Adamantyl)-1-(5-fluoropentyl)-1H -indole-3- N 18 derivative May 30, 2013 carboxamide STS-135
F
O
N H N APINACA N 19 N -(1-Adamantyl)-1-pentyl-1H -indazole-3-carboxamide July 1, 2012 AKB48
O
O
N 20 1-Adamantyl 1-pentyl-1H -indazole-3-carboxylate ACBL(N)-018 N December 29, 2017
O
N 21 1-Adamantyl(1-pentyl-1H -indol-3-yl)methanone AB-001 May 30, 2013
O
N H
APICA N 22 N -(1-Adamantyl)-1-pentyl-1H -indole-3-carboxamide July 1, 2012 2NE1
O
1-Adamantyl{1-[(1-methylpiperidin-2-yl)methyl]-1H -indol-3- 23 AM1248 N May 30, 2013 yl｝methanone
N
O
H2N N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1- APP-CHMINACA N 24 H September 3, 2016 (cyclohexylmethyl)-1H -indazole-3-carboxamide PX-3 O N N
2 No. Name Other Name Chemical Structure Date of Enforcement
O
H2N N N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(4-fluorobenzyl)- H 25 FU-PX-2 August 29, 2015 1H -indazole-3-carboxamide O N N
F
O
H2N N H
N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)- O N 26 PX-2 November 28, 2014 1H -indazole-3-carboxamide N
F
O
H2N N N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)- H O 27 1H -indole-3-carboxamide PX-1 N November 28, 2014
F
O
H2N N N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1- ADB-CHMICA、 H 28 O February 19, 2019 (cyclohexylmethyl)-1H -indole-3-carboxamide MAB-CHMICA N
N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H- 29 ADB-BUTINACA March 15,2021 indazole-3-carboxamide
O
H2N N H N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5- O N 30 fluoropentyl)-1H -indazole-3-carboxamide 5F-ADB-PINACA N November 28, 2014
F
O
H2N N H
N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5- O 31 fluoropentyl)-1H -indole-3-carboxamide 5-fluoro-ADBICA N February 9, 2015
F
O
H2N N N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H - H O N 32 indazole-3-carboxamide ADB-PINACA N July 11, 2014
O
H2N N H O N N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H - N 33 ADBICA May 30, 2013 indole-3-carboxamide
3 No. Name Other Name Chemical Structure Date of Enforcement
O O
NH 2 34 2-Amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone bk-2C-B April 4, 2015
Br
O
O
H2N N H
O N N -(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-chloropentyl)- N 35 5Cl-AB-PINACA November 8, 2014 1H -indazole-3-carboxamide
Cl
O
H2N N N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(2-fluorobenzyl)- H AB-FUBINACA 2- O N 36 1H -indazole-3-carboxamide N December 5, 2015 fluorobenzyl isomer
F
O
H2N N H N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)- O N N 37 1H -indazole-3-carboxamide 5‐Fluoro‐AB‐PINACA July 11, 2014
F
O
H2N N H
O N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)- N 38 5-Fluoro-ABICA August 25, 2014 1H -indole-3-carboxamide
F
O NH 2 39 2-(4-Allyloxy-3,5-dimethoxyphenyl)ethanamine Allylescaline April 4, 2015
O
O
N O 7-Allyl-N,N-diethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg] 40 quinoline-9-carboxamide AL-LAD February 28, 2020 N
HN
O NH2 41 1-(4-Isopropylsulfanyl- 2,5-dimethoxyphenyl)propan-2-amine ALEPH-4 May 14, 2011
S O
N 42 N -Isopropyl-N -methyltryptamine MIPT April 1, 2007
N H
O N 43 N -Isopropyl-5-methoxy-N -methyltryptamine 5-MeO-MIPT April 1, 2007
N H
44 Nitrous oxide SIVAGUS N2O February 28, 2016
45 Indan-2-amine 2-AI January 11, 2008
NH2
O
α-PBP indane analog N 46 1-(Indan-5-yl)-2-(pyrrolidin-1-yl)butan-1-one February 9, 2015 5-PPDI
4 No. Name Other Name Chemical Structure Date of Enforcement
O
N α-PHP indane analog 47 1-(Indan-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one February 27, 2015 5-BPDI
(1H -Indol-3-yl)(2,2,3,3-tetramethylcycropropan-1- 48 DP-UR-144 September 29, 2014 yl)methanone
NH2 5-API 49 1-(1H -Indol-5-yl)propan-2-amine January 16, 2013 5-IT N H
O
H N 50 2-(Ethylamino)-1-(indan-5-yl)butan-1-one bk-IBP February 9, 2015
O
H N 51 2-(Ethylamino)-1-(indan-5-yl)pentan-1-one bk-IVP February 9, 2015
52 3-[1-(Ethylamino)cyclohexyl]phenol 3-HO-PCE HO December 17, 2019 HN
53 2-(Ethylamino)-2-(thiophen-2-yl)cyclohexanone Tiletamine March 6, 2017
Deschloro-N-ethyl- ketamine 54 2-(Ethylamino)-2-phenylcyclohexanone Eticyclidone September 1, 2018 O-PCE 2-Oxo-PCE
O N 55 N -Ethyl-N -isopropyl-5-methoxytryptamine 5-MeO-EIPT January 16, 2009
N H
H N Ephenidine 56 N -Ethyl-1,2-diphenylethylamine EPE November 11, 2016 NEDPA
O NH2 57 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine 2C-E April 1, 2007
O
O
H 2-(4-Ethyl-2,5-dimethoxyphenyl)-N -(2-methoxybenzyl) N 58 ethanamine 25E-NBOMe June 1, 2015 O
O
59 ２－［（４－Ethyl－２，５－dimethoxyphenethylamino）methyl］phenol 25E-NBOH December 19, 2018
O NH2 60 1-(4-Ethylsulfanyl-2,5-dimethoxyphenyl)propan-2-amine ALEPH-2 January 16, 2009
S O
5 No. Name Other Name Chemical Structure Date of Enforcement
HO
N 61 N -Ethyl-4-hydroxy-N -methyltryptamine 4-OH-MET April 4, 2015
N H
H 62 1-（4-Ethylphenyl）-N -(2-methoxybenzyl)propan-2-amine 4-EA-NBOMe N December 29, 2017
O
63 Ethyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate 4-Fluoroethylphenidate March 15,2021
H N 2-FEA 64 N -Ethyl-1-（2-fluorophenyl）propan-2-amine February 19, 2019 2-fluoroethamphetamine
F
3-FEA 65 N- Ethyl-1-（3-fluorophenyl）propan-2-amine November 24, 2018 3-fluoroethamphetamine
4-FEA 66 N -Ethyl-1-（4-fluorophenyl）propan-2-amine November 24, 2018 4-fluoroethamphetamine
3F-Phenetrazine 67 3-Ethyl-2-(3-fluorophenyl)morpholine September 8, 2017 3-FPE
O
O N H Ethyl 2-[1-(4-fluorobenzyl)-1H -indazole-3-carboxamido]-3- EMB-FUBINACA O N 68 September 3, 2016 methylbutanoate FUB-AEB N
F
O
O N H O N Ethyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3- N 69 5F-EDMB-PINACA January 22, 2021 dimethylbutanoate
F
O
O N H Ethyl 2-[1-(5-fluoropentyl)-1H -indazole-3-carboxamido]- O N 70 3-methylbutanoate 5F-AEB N July 2, 2016
F
O O N H O Ethyl 2-[1-(5-fluoropentyl)-1H-indole-3-carboxamido]-3- N 71 5F-EMB-PICA, EMB-2201 August 25, 2021 methylbutanoate
F
6 No. Name Other Name Chemical Structure Date of Enforcement
72 3-{2-[Ethyl(propyl)amino]ethyl}-1H-indol-4-yl acetate 4-AcO-EPT March 15,2021
N -Ethyl-N -[2-(5-methoxy-1H -indol-3-yl)ethyl]propan-1- O N 73 5-MeO-EPT May 14, 2011 amine
N H
74 N -Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine 3-MeO-PCE July 13, 2019
75 N -Ethyl-1-(4-methoxyphenyl)propan-2-amine PMEA September 29, 2014
O NH 2 76 2-(4-Ethoxy-3,5-dimethoxyphenyl)ethanamine Escaline December 31, 2016
O
O
O NH 2 77 1-(4-Ethoxy-3,5-dimethoxyphenyl)propan-2-amine 3C-E April 4, 2015
O
O
78 2-(1-Oxo-1-phenylpropan-2-yl)isoindoline-1,3-dione Phthalimidopropiophenone September 29, 2014
O
O QUCHIC 79 Quinolin-8-yl 1-(cyclohexylmethyl)-1H -indole-3-carboxylate N November 20, 2013 BB-22 N
O
O
N N 80 Quinolin-8-yl 1-（4-fluorobenzyl)-1H -indazole-3-carboxylate FUB-NPB-22 N February 27, 2015
F
O
O
N 81 Quinolin-8-yl 1-（4-fluorobenzyl)-1H -indole-3-carboxylate FUB-PB-22 N July 11, 2014
F
O
O
N N
F
O
O
N N 82 Quinoline-8-yl 1-(5-fluoropentyl)-1H -indazole-3-carboxylate 5-Fluoro-NPB-22 N August 25, 2014
F
O
O
N N 83 Quinolin－８－yl １－pentyl－１H－indazole－３－carboxylate NPB-22 N December 19, 2018
7 No. Name Other Name Chemical Structure Date of Enforcement
O
O
QUPIC N 84 Quinolin-8-yl 1-pentyl(1H -indole)-3-carboxylate N May 30, 2013 PB-22
H N O 5-Chloro-3-ethyl-N -[4-(piperidin-1-yl)phenethyl]-1H -indole- 85 Org27569 HN April 4, 2015 2-carboxamide Cl N
O NH2 86 2-(4-Chloro-2,5-dimethoxylphenyl)ethanamine 2C-C April 1, 2007
Cl O
O
O O
H 2-(4-Chloro-2,5-dimethoxyphenyl)-N -(3,4,5- 30C-NBOMe N 87 O June 1, 2015 trimethoxybenzyl)ethanamine C30-NBOMe
Cl
O
2-(4-Chloro-2,5-dimethoxyphenyl)-N -(2- 88 25C-NBF September 29, 2014 fluorobenzyl)ethanamine
HO
H 89 2-[(4-Chloro-2,5-dimethoxyphenethylamino)methyl]phenol 25C-NBOH O N July 4, 2015
Cl O
NH 2 90 1-(4-Chlorophenyl)propan-2-amine 4Cl-AMP August 25, 2014
Cl
O
Cl 91 2-(2-Chlorophenyl)-1-(1-penty-1H -indol-3-yl)ethanone JWH-203 N October 20, 2011
N -(4-Chlorophenyl)-2-methyl-N -(1-phenethylpiperidin-4- 4Cl-iBF 92 March 10, 2018 yl)propanamide p-CIBF
4-CMA 93 1-(4-Chlorophenyl)-N -methylpropan-2-amine July 1, 2017 p-CMA
O
O O Salvinorine A H H 94 O April 1, 2007 (including Salvia Divinorum ) O
O
O O
1-(4-Cyanobutyl)-N -(2-phenylpropan-2-yl)-1H -pyrrolo[2,3- 95 CUMYL-4CN-B7AICA July 13, 2019 b]pyridine-3-carboxamide
N 96 N ,N -Diisopropyltryptamine DIPT April 1, 2007
N H
8 No. Name Other Name Chemical Structure Date of Enforcement
O
97 3-Diethylamino-2,2-dimethylpropyl 4-aminobenzoate Dimethocaine O N June 1, 2015
H2N
N O N,N-Diethyl-7-ethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg] 98 quinoline-9-carboxamide ETH-LAD February 28, 2020 N
HN
OH
N 99 N ,N -Diethyl-4-hydroxytryptamine 4-OH DET May 30, 2013
N H
N O
N,N -Diethyl-7-methyl-4-propionyl-4,6,6a,7,8,9- 100 1P-LSD N April 18, 2016 hexahydroindolo[4,3-fg ]quinoline-9-carboxamide
N
O
O N 101 N,N -Diethyl-5-methoxytryptamine 5-MeO-DET April 1, 2007
N H
4-(Cyclopropylcarbonyl)-N,N-diethyl-7-methyl-4,6,6a,7,8,9- 102 1cP-LSD January 22, 2021 hexahydroindolo[4,3-fg]quinoline-9-carboxamide
O N 103 2-Cyclohexyl-1-phenyl-2-(pyrrolidin-1-yl)ethan-1-one α-PCYP August 25, 2021
2-[1-(Cyclohexylmethyl)-1H -indazole-3-carboxamido]-3- 104 CHMINACA-BA September 29, 2014 methylbutanoic acid
O
NE-CHMIMO、 ［１－（Ｃyclohexylmethyl）－１Ｈ－indol－３－yl］（naphthalen－ 105 JWH-018 cyclohexylmethyl November 14, 2019 １－yl）methanone N derivative
[1-(Cyclohexylmethyl)-1H-indol-3-yl](4-methoxynaphthalen- CHM－081(JWH-081 106 August 26, 2020 1-yl)methanone cyclohexylmethyl derivative)
Cl NH 107 methanone 2,3-DCPP Cl N May 30, 2013
O O
H 108 2-(3,4-Dichlorophenyl)-2-(piperidin-2-yl)acetate 3,4-Dichloromethylphenidate Cl N April 5, 2014
Cl
9 No. Name Other Name Chemical Structure Date of Enforcement
N 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4- 109 Diclofensine August 25, 2014 tetrahydroisoquinoline Cl
O Cl
O
N 1-(2,3-Dihydrobenzofuran-5-yl)-2-(pyrrolidin-1-yl)pentan-1- 110 5-DBFPV November 28, 2014 one O
NH 2 111 1-(2,3-Dihydrobenzofuran-5-yl)propan-2-amine 5-APDB April 5, 2014
O
112 1-(2,3-Dihydrobenzofuran-6-yl)propan-2-amine 6-APDB September 26, 2015
H N 113 1-(2,3-Dihydrobenzofuran-5-yl)-N -methylpropan-2-amine 5-MAPDB December 5, 2015
O
Diphenylprolinol 114 Diphenyl(pyrrolidin-2-yl)methanol November 20, 2009 H D2PM N HO
2-DPMP 115 2-(Diphenylmethyl)piperidine H April 18, 2016 Desoxypipradrol N
116 2-(Diphenylmethyl)pyrrolidine Desoxy-D2PM May 30, 2013 H N
O F N 117 1-[(2,2-Difluorobenzo[d ][1,3]dioxol-5-yl)methyl]piperazine DF-MDBP December 25, 2015 F NH O
118 N,N -Dipropyltryptamine DPT N April 1, 2007
N H
N
O-Desmethyltramadol 119 2-[(Dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol November 11, 2016 O-DSMT OH
OH
O
H 3,4-Dimethyl-NEB N 120 1-(3,4-Dimethylphenyl)-2-(ethylamino)butan-1-one 3,4-Dimethyl-α- February 9, 2015 ethylaminobutiophenone
O
H N 3,4-Dimethyl-α- 121 1-(3,4-Dimethylphenyl)-2-(ethylamino)pentan-1-one February 9, 2015 ethylaminopentiophenone
10 No. Name Other Name Chemical Structure Date of Enforcement
O
N 122 1-(3,4-Dimethylphenyl)-2-(pyrrolidin-1-yl)pentan-1-one 3,4-Dimethyl-α-PVP April 4, 2015
O NH 2 123 2-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]ethanamine 2C-TFM November 10, 2017 F O F F
O NH 2 124 2-(2,5-Dimethoxy-4-nitrophenyl)ethanamine 2C-N July 11, 2014
O2N O
O NH2 125 1-(2,5-Dimethoxy-4-nitrophenyl)propan-2-amine DON September 24, 2010
O2N O
126 2-(2,5-Dimethoxyphenyl)ethanamine 2C-H September 29, 2014
O
H N
127 1-(3,4-Dimethoxyphenyl)-2-(ethylamino)pentan-1-one DL-4662 August 25, 2014 O
O
O
O N 128 1-(3,4-Dimethoxyphenyl)-2-(pyrrolidin-1-yl)hexan-1-one 3,4-Dimethoxy-α-PHP November 28, 2014
O
O
O N 129 1-(3,4-Dimethoxyphenyl)-2-(pyrrolidin-1-yl)pentan-1-one 3,4-Dimethoxy-α-PVP April 5, 2014
O
O H 3,4- O N 130 1-(3,4-Dimethoxyphenyl)-2-(methylamino)propan-1-one July 2, 2016 Dimethoxymethcathinone
O
O H N 131 2-(2,5-Dimethoxyphenyl)-N -(2-methoxybenzyl)ethanamine 25H-NBOMe April 5, 2014 O
O
O NH 2 132 2-(2,5-Dimethoxy-4-propylphenyl)ethanamine 2C-P April 4, 2015
O
133 1-(3,5-Dimethoxy-4-propoxyphenyl)propan-2-amine 3C-P March 10, 2018
O NH 2
134 2-(2,5-Dimethoxy-4-methylphenyl)ethanamine 2C-D January 31, 2016
O
11 No. Name Other Name Chemical Structure Date of Enforcement
135 2-(2,5-Dimethoxy-4-methylphenyl)-2-methoxyethanamine BOD(β-METHOXY-2C-D) August 26, 2020
O
{1-[(Tetrahydropyran-4-yl)methyl]-1H -indol-3-yl}(2,2,3,3- 136 tetramethylcyclopropan-1-yl)methanone A-834735 N July 28, 2013
O
O
（2,2,3,3-Tetramethylcyclopropan-1-yl)[1-(4,4,4-trifluorobutyl)- 137 1H -indol-3-yl]methanone XLR-12 N July 11, 2014
CF 3
Cl
O NH2 138 2-(2,4,5-Trichloro-3,6-dimethoxyphenyl)ethanamine 2C-C-3 September 24, 2010
Cl O
Cl
O
NH2 139 1-(2,4,6-Trimethoxyphenyl)propan-2-amine TMA-6 April 1, 2007
O O
O O
H 140 Ethyl 2-(naphthalen-2-yl)-2-(piperidin-2-yl)acetate Ethylnaphthidate, HDEP-28 N July 2, 2016
O O Methylnaphthidate 141 Methyl 2-(naphthalen-2-yl)-2-(piperidin-2-yl)acetate H December 5, 2015 HDMP-28 N
O
N 142 1-(Naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one Naphyrone October 20, 2011
O
O
143 Naphthalen-1-yl 1-(4-fluorobenzyl)-1H -indole-3-carboxylate FDU-PB-22 N August 25, 2014
F
O
O
N Naphthalen-1-yl 1-(5-fluoropentyl)-1H -indazole-3- N 144 5-Fluoro-SDB-005 August 25, 2014 carboxylate
F
O
N H
N -(Naphthalen-1-yl)-1-(5-fluoropentyl)-1H -indole-3- N 145 5F-NNE1 November 20, 2013 carboxamide
F
12 No. Name Other Name Chemical Structure Date of Enforcement
O
O
N 146 Naphthalen-1-yl 1-(5-fluoropentyl)-1H -indole-3-carboxylate NM2201 November 8, 2014
F
O
N THJ-018 N 147 Naphthalen-1-yl(1-pentyl-1H -indazol-3-yl)methanone August 25, 2014 JWH-018 indazole analog
O
N H NNE1 indazole analog N 148 N -(Naphthalen-1-yl)-1-pentyl-1H -indazole-3-carboxamide N April 5, 2014 MN-18
O
O
N 149 Naphthalen-1-yl 1-pentyl-1H -indazole-3-carboxylate SDB-005 N November 8, 2014
O
N H
NNE1 N 150 N -(Naphthalen-1-yl)-1-pentyl-1H -indole-3-carboxamide November 20, 2013 MN-24
O
CB-13 O 151 Naphthalen-1-yl[4-(pentyloxy)naphthalen-1-yl]methanone July 1, 2012 CRA13
O
152 Naphthalen-1-yl(9-pentyl-9H -carbazol-3-yl)methanone EG-018 N November 8, 2014
O
153 Naphthalen-1-yl(1-pentyl-1H -pyrrol-3-yl)methanone JWH-030 N May 30, 2013
O
Naphthalen-1-yl(1-pentyl-5-phenyl-1H -pyrrol-3- N 154 JWH-145 April 4, 2015 yl)methanone
N N -（Naphthalen-1-yl)-1-pentyl-N -(1-pentyl-1H -indole-3- O 155 carbonyl)-1H -indole-3-carboxamide BｉPＩCANA N August 25, 2014 N
O
13 No. Name Other Name Chemical Structure Date of Enforcement
156 2-｛[Bis (4-fluorophenyl)methyl]sulfinyl｝acetamide Bisfluoromodafinil March 19, 2016
F
Modafiendz 157 2-{[Bis (4-fluorophenyl)methyl]sulfinyl}-N -methylacetamide N -Methyl-4,4-difluoro- January 31, 2016
H modafinil N S
O O F
HO
158 4-Hydroxy-N -isopropyl-N -metyltryptamine 4-OH-MIPT N April 4, 2015
N H
OH
N 159 4-Hydroxy-N,N -diisopropyltryptamine 4-OH-DIPT April 1, 2007
N H
N -{1-[2-Hydroxy-2-(thiophen-2-yl)ethyl]piperidin-4-yl}-N - 160 β-hydroxythiofentanyl June 17, 2021 phenylpropanamide
OH
OH (1RS ,3SR )-3-[2-Hydroxy-4-(2-methyloctan-2- 161 CP-47,497 November 20, 2009 yl)phenyl]cyclohexan-1-ol
3-HO-PCP,３-OH-PCP,３- 162 ３－[１－(Piperidin－１－yl)cyclohexyl]phenol December 19, 2018 hydroxy-PCP,PCP-３-OH
163 2-(Pｙrrolidin-1-yl)-1-(thiophen-2-yl)butan-1-one α-PBT September 29, 2014
O
N S 164 2-(Pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one α-PVT May 30, 2013
O
N 2-(Pyrrolidine-1-yl)-1-(5,6,7,8-tetrahydronaphtalen-2-yl) 165 TH-PVP December 25, 2015 pentan-1-one
O O
166 Isopropyl 2-phenyl-2-(piperidin-2-yl)acetate Isopropylphenidate H December 5, 2015 N
O
167 1-Phenyl-2-(piperidin-1-yl)butan-1-one α-PBP piperidine analog N April 5, 2014
OO O
N N N N
N -(2-Phenylpropan-2-yl)-1-[(tetrahydro-2H -pyran-4- 168 CUMYL-THPINACA March 19, 2016 yl)methyl]-1H -indazole-3-carboxamide
14 No. Name Other Name Chemical Structure Date of Enforcement
N 169 1-(1-Phenylpentan-2-yl)pyrrolidine Prolintane February 27, 2015
170 N-(1-Phenethylpiperidin-4-yl)-N-phenylisobutyramide Isobutyrylfentanyl August 26, 2020
O N Ｎ -(1-Phenethylpiperidin-4-yl)-Ｎ -phenylcyclopentane 171 Cyclopentylfentanyl N August 29, 2019 carboxamide
N O
4-Butanoyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9- 172 1B-LSD N August 26, 2020 hexahydroindolo[4,3-fg]quinoline-9-carboxamide
N
O
O H 173 2-(Butylamino)-1-(4-chlorophenyl)propan-1-one 4-Chloro-N-butylcathinone N December 17, 2019
Cl
O
H N O 174 2-(Butylamino)-1-(3,4-methylenedioxyphenyl)pentan-1-one N-Butylpentylone February 28, 2020 O
O
N H
175 1-Butyl-N -(2-phenylpropan-2-yl)-1H -indole-3-carboxamide CUMYL-BICA N February 20, 2016
N-{1-[2-(Furan-2-yl)ethyl]piperidin-4-yl}-N- 176 Furanylethylfentanyl (FUEF) August 26, 2020 phenylpropanamide
O
H N 4F-IPV 177 1-(4-Fluorophenyl)-2-(isopropylamino)pentan-1-one January 5, 2015 4-Fluoro-NPP
F
178 1-[1-(3-Fluorophenyl)cyclohexyl]piperidine ３F-PCP（3-Fluoro-PCP） March 15,2021
NH
N 179 1-(4-Fluorophenyl)piperazine 4FPP November 20, 2009
F
O O
4-Fluoromethylphenidate H 180 Methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate 4-FMPH N November 10, 2017 4F-MPH
F
O
N 4-Fluoro-α-PVP piperidine 181 1-(4-Fluorophenyl)-2-(piperidin-1-yl)pentan-1-one February 9, 2015 analog
F
O
N
F
15 No. Name Other Name Chemical Structure Date of Enforcement
O
N
F
NH 2 2FMP 182 1-(2-Fluorophenyl)propan-2-amine 2-Fluoroamphetamine January 5, 2015 2F-AMP F
3FMP F NH 2 183 1-(3-Fluorophenyl)propan-2-amine 3-Fluoroamphetamine February 9, 2015 3F-AMP
O
F [5-(2-Fluorophenyl)-1-pentyl-1H -pyrrol-3-yl](naphthalen-1- 184 JWH-307 N May 30, 2013 yl)methanone
O
F [5-(3-Fluorophenyl)-1-pentyl-1H -pyrrol-3-yl](naphthalen-1- N 185 JWH-368 April 4, 2015 yl)methanone
O O
H N H N
F
F
2-Fluorodeschloroketamine 186 2-(2-Fluorophenyl)-2-(methylamino)cyclohexanone September 8, 2017 2-FDCK
H N N -Methyl-2-FMP 187 1-(2-Fluorophenyl)-N -methylpropan-2-amine September 24, 2010 2-FMA F
H N 3-Fluoromethamphetamine 188 1-(3-Fluorophenyl)-N -methylpropan-2-amine July 28, 2013 3-FMA
F
H N N -Methyl-4-FMP 189 1-(4-Fluorophenyl)-N -methylpropan-2-amine January 16, 2009 4-Fluoromethamphetamine F
2-FPM 190 2-(2-Fluorophenyl)-3-methylmorpholine March 6, 2017 2-Fluorophenmetrazine
O 3-Fluorophenmetrazine 191 2-(3-Fluorophenyl)-3-methylmorpholine F NH December 5, 2015 3-FPM
4-Fluorophenmetrazine 192 2-(4-Fluorophenyl)-3-methylmorpholine March 19, 2016 4-FPM
O
［1-(4-Fluorobenzyl)-1H -indol-3-yl］(2,2,3,3- 193 FUB-144 N August 25, 2014 tetramethylcyclopropyl)methanone
F
O
[1-(4-Fluorobenzyl)-1H -indol-3-yl](naphthalen-1- 194 FUB-JWH-018 December 5, 2015 yl)methanone N
F
16 No. Name Other Name Chemical Structure Date of Enforcement
O
N H 1-(4-Fluorobenzyl)-N -(naphthalen-1-yl)-1H -indole-3- 195 FDU-NNE1 N July 4, 2015 carboxamide
F
N -(2-Fluorobenzyl)-2-(4-iodo-2,5- 196 25I-NBF June 1, 2015 dimethoxyphenyl)ethanamine
O
N ［1-(5-Ｆluoropentyl)-1H -indazol-3-yl］(naphthalen-1- N 197 THJ-2201 August 25, 2014 yl)methanone
F
O
N
5-Fluoropentyl-3- N 198 [1-(5-Fluoropentyl)-1H -indol-3-yl](pyridin-3-yl)methanone May 30, 2013 pyridinoylindole
F
I O
N 199 [1-(5-Fluoropentyl)-1H -indol-3-yl](2-iodophenyl)methanone AM694 October 20, 2011
F
O
N H 5-Fluoro-MN-18 N 1-(5-Fluoropentyl)-N -（naphthalen-1-yl）-1H -indazole-3- N 200 5-Fluoro-NNE1indazole July 11, 2014 carboxamide analog
F
201 1-(5-Fluoropentyl)-N -phenyl-1H -indole-3-carboxamide LTI-701 September 8, 2017
O NH
1-(5-Fluoropentyl)-N -(2-phenylpropan-2-yl)-1H -indazole-3- 202 CUMYL-5F-PINACA N August 29, 2015 carboxamide N
F
O NH
1-(5-Fluoropentyl)-N -(2-phenylpropan-2-yl)-1H -indole-3- 203 CUMYL-5F-PICA August 29, 2015 carboxamide N
F
17 No. Name Other Name Chemical Structure Date of Enforcement
O
N 5-(5-Fluoropentyl)-2-(2-phenylpropan-2-yl)-2,5-dihydro-1 Ｈ- 5FｰCUMYL-PEGACLONE、 N 204 August 29, 2019 pyrido[4,3-b]indol-1-one 5FｰSGT-151
F
O
N H
1-(5-Fluoropentyl)-N -(2-phenylpropan-2-yl)-1H - N N 205 CUMYL-5F-P7AICA February 20, 2016 pyrrolo[2,3-b]pyridine-3-carboxamide
F
O N
N FUBIMINA ［1-(5-Ｆluoropentyl)-1H -benzo[d]imidazol-2-yl］(naphthalen- 206 AM2201 benzimidazole August 25, 2014 1-yl)methanone analog
F
2-(4-Bromo-2,5-dimethoxyphenyl)-N -(2- 207 25B-NBF September 29, 2014 fluorobenzyl)ethanamine
H 25B-NBOH O N 208 2-［(4-Bromo-2,5-dimethoxyphenethylamino)methyl］phenol 2C-B-NBOH December 29, 2017 NBOH-2C-B OH Br O
O
2-(8-Bromo-2,3,6,7-tetrahydrobenzo[1,2-b :4,5-b' ]difuran NH 2 209 -4-yl)ethanamine 2C-B-FLY February 20, 2016
Br
O
O
210 1-(8-Bromobenzo[1,2-b :4,5-b ’]difuran-4-yl)propan-2-amine Bromo-DragonFLY August 29, 2015
NH 2 Br
O
O H 211 2-Benzylamino-1-(3,4-methylenedioxyphenyl)propan-1-one BMDP O N November 16, 2012
O
212 4-Benzylpiperidine February 27, 2015 NH
O
N H
N 213 N -Benzyl-1-(5-fluoropentyl)-1H -indole-3-carboxamide 5F-SDB-006 April 4, 2015
F
214 N -Benzyl-1-pentyl-1H -indole-3-carboxamide SDB-006 September 29, 2014
N 215 1-Benzyl-4-methylpiperazine MBZP April 1, 2007 N
18 No. Name Other Name Chemical Structure Date of Enforcement
NH 216 1-(Benzofuran-2-yl)-N -ethylpropan-2-amine 2-EAPB February 9, 2015
O
217 １－(Benzofuran－４－yl)－Ｎ－ethylpropan－２－amine 4-EAPB November 14, 2019
H N 218 1-(Benzofuran-5-yl)-N -ethylpropan-2-amine 5-EAPB January 5, 2015
O
219 １－（Benzofuran－６－yl）－Ｎ－ethylpropan－２－amine 6-EAPB November 14, 2019
O 220 1-(Benzofuran-2-ly)propan-2-amine 2-APB NH 2 February 27, 2015
221 1-(Benzofuran-5-yl)propan-2-amine 5-APB September 26, 2015
O NH2 222 1-(Benzofuran-6-yl)propan-2-amine 6-APB January 16, 2013
NH 223 1-(Benzofuran-2-yl)-N -methylpropan-2-amine 2-MAPB August 25, 2014
O
H N 224 1-(Benzofuran-5-yl)-N -methylpropan-2-amine 5-MAPB August 25, 2014
O
O
N H N N 225 1-Pentyl-N -(quinolin-8-yl)-1H -indazole-3-carboxamide THJ N July 2, 2016
O NH 1-Pentyl-N -(2-phenylpropan-2-yl)-1H -indazole-3- 226 CUMYL-PINACA N August 29, 2015 carboxamide N
O NH
227 1-Pentyl-N -(2-phenylpropan-2-yl)-1H -indole-3-carboxamide CUMYL-PICA August 29, 2015
N
O
［1-(1-Methylazepan-3-yl)-1H -indol-3-yl］(naphthalen-1- 228 AM1220 azepan isomer August 25, 2014 yl)methanone N
N
19 No. Name Other Name Chemical Structure Date of Enforcement
O H N 229 2-(Methylamino)-1-(3,4-dimethylphenyl)propan-1-one 3,4-Dimethylmethcathinone July 1, 2012
O H 230 2-(Methylamino)-1-(thiophen-2-yl)propan-1-one 2-Thiothinone, βk-MPA S N August 25, 2021
Deschloroketamine 231 2-(Methylamino)-2-phenylcyclohexanone DXE July 1, 2017 DCK
232 2-[(Methylamino)methyl]-3,4-dihydronaphthalen-1(2H )-one Mephtetramine September 26, 2015
233 N -Methylindane-2-amine N -methyl-2-AI NH April 5, 2014
O OH
(E )-Methyl 2-[(2S ,3S ,7aS ,12bS )-3-ethyl-7a-hydroxy-8- H N methoxy-1,2,3,4,6,7,7a,12b-octahydroindolo[2,3-a ]quinolizin-2- 7-Hydroxymitragynine N 234 March 19, 2016 yl]-3-methoxyacrylate 7a-Hydroxy-7H -mitragynine (including Mitragyna Speciosa (Kratom)) O O
O
O
(E )-Methyl 2-[(2S ,3S ,12bS )-3-ethyl-8-methoxy- H N 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a ]quinolizin-2-yl]-3- N 235 Mitragynine H March 19, 2016 methoxyacrylate (including Mitragyna Speciosa (Kratom))
O O
O
O
O N Methyl 2-[1-(cyclohexylmethyl)-1H -indazole-3- H 236 MDMB-CHMINACA O N January 5, 2015 carboxamide]-3,3-dimethylbutanoate N
O
O N H
Methyl 2-[1-(cyclohexylmethyl)-1H -indazole-3- O N 237 MA-CHMINACA January 5, 2015 carboxamide]-3-methylbutanoate N
O
O N H
O N
O
O N Methyl 2-[1-(cyclohexylmethyl)-1H -indole-3-carboxamido]- H O 238 3-methylbutanoate AMB-CHMICA N December 31, 2016
Methyl 3-(3,4-dichlorophenyl)-8-methyl-8- RTI-111 239 azabicyclo[3.2.1]octane-2-carboxylate Dichloropane March 6, 2017 O-401
240 N -Methyl-1-(naphthalen-2-yl)propan-2-amine Methamnetamine September 26, 2015
20 No. Name Other Name Chemical Structure Date of Enforcement
O
N
N N 241 (4-Methylpiperazin-1-yl)(1-pentyl-1H -indol-3-yl)methanone MEPIRAPIM November 8, 2014
O
{1-[(1-Methylpiperidin-2-yl)methyl] -1H -indol-3-yl} 242 AM1220 July 1, 2012 (naphthalen-1-yl)methanone N
N
O
N O O
H 243 Methyl 2-(4-methylphenyl)-2-(piperidin-2-yl)acetate 4-Methylmethylphenidate N July 2, 2016
244 4-Methyl-1-phenyl-2-(pyrrolidin-1-yl)pentan-1-one α－PiHP (α－PHiP) August 26, 2020
1-[2-Methyl-4-(3-phenylprop-2-en-1-yl)piperazin-1- 245 2-methyl-AP-237 November 19, 2020 yl]butan-1-one
NH2 246 1-(4-Methylphenyl)propan-2-amine 4-Methylamphetamine November 16, 2012
t- BOC-Methamphetamine N O 247 1,1-Dimethylethyl methyl(1-phenylpropan-2-yl)carbamate tert -Butoxycarbonyl- December 29, 2017 Methamphetamine O
O
248 2-(2-Methylphenyl)-1-(1-pentyl-1H -indol-3-yl)ethan-1-one JWH-251 N May 14, 2011
1-（3- N 249 1-［（3-Methylphenyl）methyｌ］piperazine July 11, 2014 Methylbenzyl)piperazine NH
O O N Methyl 2-[1-(4-fluorobutyl)-1H -indole-3-carboxamido]-3,3- 4F-MDMB-BICA, 4F- H 250 O June 17, 2021 dimethylbutanoate MDMB-BUTICA N
F
O
O N Methyl 2-[1-(4-fluorobenzyl)-1H -indazole-3-carboxamido]- MDMB-FUBINACA H 251 O N February 27, 2015 3,3-dimethylbutanoate FUB-ADB N
F
O
O N Methyl 2-[1-(4-fluorobenzyl)-1H -indole-3-carboxamido]- H 252 MDMB-FUBICA O July 2, 2016 3,3-dimethylbutanoate N
F
21 No. Name Other Name Chemical Structure Date of Enforcement
O
O N H Methyl 2-[1-(4-fluorobenzyl)-1H-indole-3-carboxamido]-3- AMB-FUBICA、 O 253 N January 22, 2021 methylbutanoate MMB-FUBICA
F
Methyl 2-[1-(5-fluoropentyl)-1H-indole-3-carboxamido]-3- 254 MPHP-2201 December 17, 2019 phenylpropanoate
O
O N H
O Methyl 2-［1-(5-fluoropentyl)-1H -indole-3-carboxamido］-3- MMB2201 N 255 August 25, 2014 methylbutanoate 5-Fluoro-AMB indole analog
F
O
256 3-Methyl-2-(4-methylphenyl)morpholine Mephenmetrazine NH December 5, 2015
O
O N MMB-022、 H Methyl 3-methyl-2-[1-(pent-4-en-1-yl)-1H-indole-3- O 257 AMB-4en-PICA、 N January 22, 2021 carboxamido]-butanoate MMB-4en-PICA
O
O N H Methyl 3-methyl-2-(1-pentyl-1H -indazole-3- O N 258 AMB N November 8, 2014 carboxamido)butanoate
O 259 N -Methyl-4-(3,4-methylenedioxyphenyl)butan-2-amine HMDMA N April 1, 2007 H
O
O
260 5,6-Methylenedioxyindan-2-amine MDAI NH2 May 30, 2013 O
O
N O
O
NH O 2 261 1-(3,4-Methylenedioxyphenyl)butan-2-amine BDB April 1, 2007
O
t -BOC-3,4-MDMA 1,1-Dimethylethyl [1-(3,4-methylenedioxyphenyl)propan-2- O N O 262 tert -Butoxycarbonyl-3,4- December 29, 2017 yl]methylcarbamate MDMA O O
O N 263 1-(3,4-Methylenedioxybenzyl)piperazine MDBP January 11, 2008 NH O
O NH2 264 1-(5-Methoxy-1H -indol-3-yl)propan-2-amine 5-MeO-AMT April 1, 2007
N H
O S
(Z)-N -[3-(2-methoxyethyl)-4,5-dimethylthiazol-2(3H )- N N 265 A-836339 April 5, 2014 ylidene]-2,2,3,3-tetramethylcyclopropanecarboxamide
O
22 No. Name Other Name Chemical Structure Date of Enforcement
266 5-Methoxy-N ,N -dipropyltryptamine 5-MeO-DPT O N April 1, 2007
N H
O
O O 1-Methoxy-3,3-dimethyl-1-oxobutan-2-yl 1- 267 MO-CHMINACA O N January 31, 2016 (cyclohexylmethyl)-1H -indazole-3-carboxylate N
O N 268 5-Methoxy-N ,N -dimethyltryptamine 5-MeO-DMT April 1, 2007
N H
269 1-[1-(3-Methoxyphenyl)cyclohexyl]piperidine 3-MeO-PCP O August 25, 2014 N
270 1-[1-(4-Methoxyphenyl)cyclohexyl]piperidine 4-MeO-PCP September 29, 2014
271 4-[1-(3-Methoxyphenyl)cyclohexyl]morpholine 3-MeO-PCMo O December 25, 2015 N
O
NH
N 4MPP 272 1-(4-Methoxyphenyl)piperazine April 1, 2007 4-MeOPP O
O
N
O
N 2-MeO-diphenidine 273 1-［1-(2-Methoxｙphenyl)-2-phenylethyl］piperidine September 29, 2014 Methoxphenidine O
4-Methoxybutyrfentanyl、 N -(4-Methoxyphenyl)-N -(1-phenethylpiperidin-4- 274 p-Methoxybutylfentanyl、 February 19, 2019 yl)butanamide 4-MeO-BF、p-MeO-BF
O
O 275 2-(2-Methoxyphenyl)-1-(1-pentyl-1H -indol-3-yl)ethanone JWH-250 N September 24, 2010
O
O N 276 (2-Methoxyphenyl)(1-pentyl-1H -indol-3-yl)methanone RCS-4 ortho isomer November 16, 2012
O
277 (4-Methoxyphenyl)(1-pentyl-1H -indol-3-yl)methanone RCS-4 O N October 20, 2011
23 No. Name Other Name Chemical Structure Date of Enforcement
O Methoxmetamine 278 2-(3-Methoxyphenyl)-2-(methylamino)cyclohexanone HN February 20, 2016 MMXE
O
O
2-(2-Methoxyphenyl)-1-｛1-［(1-methylpiperidin-2-yl)methyl］- O 279 Cannabipiperidiethanone July 1, 2012 1H - indol-3-yl｝ethanone N
N
O
H 3-[2-(2-Methoxybenzylamino)ethyl]quinazoline-2,4(1H ,3H )- N 280 RH-34 N June 1, 2015 dione O N O H
O
N -(2-Methoxybenzyl)-2-(2,5-dimethoxy-4- H 281 25D-NBOMe O N April 4, 2015 metylphenyl)ethanamine
O
N -(2-Methoxybenzyl)-N -methyl-1-(4-methylphenyl)propan- 282 4-MMA-NBOMe March 10, 2018 2-amine
O H N Mexedrone 283 3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one September 3, 2016 4-MMC-OMe O
O N 284 5-Methoxy-2-methyl-N ,N -dimethyltryptamine 5-MeO-2-TMT June 1, 2015
N H
NH O 2
285 1-(2-Methoxy-4,5-methylenedioxyphenyl)propan-2-amine MMDA-2 April 1, 2007 O O
2-Methoxy-4,5- 1-(2-Methoxy-4,5-methylenedioxyphenyl)-2- 286 methylenedioxy April 4, 2015 (methylamino)propan-1-one methcathinone
O
[1-(2-Morpholinoethyl)-1H -indol-3-yl](naphthalen-1- N 287 JWH-200 May 14, 2011 yl)methanone
N
O
288 5-Iodoindan-2-amine 5-IAI NH2 January 16, 2013
I
O NH2 289 1-(4-Iodo-2,5-dimethoxyphenyl)propan-2-amine DOI January 11, 2008
I O
O
2-(4-Iodo-2,5-dimethoxyphenyl)-N -(3,4- H O N 290 methylendioxybenzyl)ethanamine 25I-NB34MD O July 4, 2015
I O
291 2-[(4-Iodo-2,5-dimethoxyphenethylamino)methyl]phenol 25I-NBOH June 30, 2018
24 No. Name Other Name Chemical Structure Date of Enforcement
I O
(2-Iodo-5-nitrophenyl){1-[(1-methylpiperidin-2-yl)methyl]- 292 1H -indol-3-yl}methanone AM1241 N May 30, 2013
NO2
N
I O
N 293 (2-Iodophenyl)(1-pentyl-1H -indol-3-yl)methanone AM679 November 16, 2012
I O
（2-Iodophenyl)［1-(1-methylazepan-3-yl)-1H -indol-3-yl］ 294 AM2233 azepan isomer N August 25, 2014 methanone
N
I O
(2-Iodophenyl){1-[(1-methylpiperidin-2-yl)methyl]-1H -indol- 295 AM2233 N July 1, 2012 3-yl}methanone
N
OO
NN JWH-019 JWH-022 JWH-072 JWH-081 JWH-120 296 Synthetic cannabinoid derivatives March 20, 2013 JWH-182 （Total 393 substances） JWH-210 JWH-398 AM2232 ※For details, please refer to the attached sheet. etc.
JWH-007 Synthetic cannabinoid derivatives JWH-015 297 (Total 377 substances) March 20, 2013 JWH-213 etc. ※For details, please refer to the attached sheet.
N -Ethylbuphedrone 4-Methylethcathinone bk-MDDMA α-PBP 3-FMC 4-FMC O α-POP α-PNP NH2 December 13, 2013 α-PHP Synthetic cathinone derivatives and 298 α-PHPP (Total 1331 substances) May 1, 2015 4-Fluolo-α-POP 4-F-PV8 4F-Octedrone ※For details, please refer to the attached sheet. MPHP MDPH 4-MeO-α-POP 4-MeO-PV8 NEB etc.
Any substance which contains any of the substances listed above. However, plants other than Salvia Divinorum and Mitragina Speciosa (Only the form 299 can be used for human body immediately.) are excluded.
25 Details of Generic Scheduling
Date of No. Basic Structure Displaceable Substituents Examples of Substances Note Enforcement Following substances are Narcotics. 1-Naphthalenyl（1-pentyl-1H-indol-3-yl)methanone
O （1-Butyl-1H-indol-3-yl)(naphthalen-1-ｙｌ)methanone
（4-Methylnaphthalen-1-yl）（1-pentyl-1H-indol-3-yl） methanone N (１)１ n -C3H7, n -C4H9, n -C5H11,n -C6H13, n -C7H15, n -C8H17 ［1-(5-Fluoropentyl）-1H-indol-3-yl］（naphthalen-1- (２) ２ -CH=CHCH CH CH , -CH CH=CHCH CH , yl)methanone (１ 2 2 3 2 2 3 -CH CH CH=CHCH , -CH CH CH CH=CH JWH-019 2 2 3 2 2 2 2 JWH-022 ［1-(5-Fluoropentyl）-1H-indol-3-yl］（4- JWH-072 methylnaphthalen-1-yl）methanone ３ -(n -C3H6)X, -(n -C4H8)X,-(n -C5H10)X JWH-081 [ X = F, Cl, Br, I, CN, OH, OCOCH3 ] JWH-120 Following substances are excluded from 295 （1H -Indol-3-yl）（naphthalen-1-yl） March 20, 2013 JWH-182 Designated Substances. methanone （4-Ethoxynaphthalen-1-yl）（1-octyl-1Ｈ -indol-3-yl） (２)１ -CH3, -C2H5, n-C3H7, n-C4H9, n-C5H11, n-C6H13 JWH-210 methanone ２ -OCH3, -OC2H5 JWH-398 ３ -F AM2232 （1-Octyl-1Ｈ -indol-3-yl）（4-pentylnaphthalen-1-yl） ４ -Cl etc. methanone 【Synthetic cannabinoid derivatives. ５ -Br ６ -I （4-Hexylnaphthalen-1-yl）（1-octyl-1Ｈ -indol-3-yl） Total 393 substances are controlled ７ -H methanone
by this definition.】 （1-Heptyl-1Ｈ -indol-3-yl）（4-hexylnaphthalen-1-yl） methanone
（4-Methoxynaphthalen-1-yl）（1-octyl-1Ｈ -indol-3- yl）methanone
(１)１ n -C3H7, n -C4H9, n -C5H11, n -C6H13, n -C7H15 O (The substituents on (１) is limited to n -C3H7 or n -C4H9 in case where the substituents on (２) is n -C6H13.）
２ n -C H N 8 17 （Limited to case the substituents on (２) is -C2H5 or n -C3H7） (２) (１) ３ -CH=CHCH2CH2CH3, -CH2CH=CHCH2CH3, -CH2CH2CH=CHCH3, -CH2CH2CH2CH=CH2 （Limited to case the substituents on (２) is hydrogen or the substuents except n -C H ） JWH-007 Following substance is excluded from 6 13. JWH-015 Designated Substances. 296 March 20, 2013 （2-Methyl-1H -indol-3-yl） JWH-213 ４ -(n -C3H6)X, -(n -C4H8)X,-(n -C5H10)X （naphthalen-1-yl）methanone [ X = F, Cl, Br, I, CN, OH, OCOCH ] etc. （2-Methyl-1-heptyl-1Ｈ -indol-3-yl）（4- 3 pentylnaphthalen-1-yl）methanone （The substituents on (１) is limited to (n -C3H6)X or (n -C4H8)X in case where the substituents on (２) is n -C6H13. ）
(２)１ -CH3, -C2H5, n-C3H7, n-C4H9, n-C5H11, n-C6H13 ２ -OCH3, -OC2H5 【Synthetic cannabinoid derivatives. ３ -F ４ -Cl Total 377 substances are controlled ５ -Br ６ -I by this definition.】 ７ -H
Following substances are Narcotics. (１) 2-Aminopropiophenone (１)１ -NHCH３ O ２ -NHC２H５ 2-Ethylamino-1-phenylpropan-1-one ３ -N（CH ） NH2 ３ ２ 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one ４ -N（CH３）（C２H５） N-Ethylbuphedrone ５ -N（C２H５）２ 4-Methylethcathinone 2-Methylamino-1-phenylpropan-1-one ６ 1-pyrrolidinyl bk-MDDMA (3) ７ -NH２ α-PBP (２) 2-(Methylamino)-1-(4-methylphenyl)propan- 3-FMC Controlled since January 12. 2014 1-one (２)１ -CH３ 4-FMC ２ -C２H５ 4-CMC 2-Methylamino-1-(3,4- ３ -H α-POP methylenedioxyphenyl)propan-1-one December 13. ４ -n-C３H７ Controlled since May 11. 2015 α-PNP 2013 ５ -n -C４H９ α-PHP 297 2-Amino-1-phenyl-propan-1-one 1-(3,4-Methylenedioxyphenyl)-2-(pyrrolidin- and ６ -n -C５H１１ α-PHPP 1-yl)pentan-1-one May 1. 2015 ７ -n -C６H１３ 4-Fluolo-α-POP ８ -n- C７H１５ 4-F-PV8 2-Ethylamino-1-(3,4- 4F-Octedrone methylenedioxyphenyl)propan-1-one 【Synthetic cathinone derivatives. MPHP (３)１ -CH３ MDPH 2-(Ethylamino)-1-（4-methylphenyl）propan-1- Total 1332 substances are ２ -C２H５ 4-MeO-α-POP one ３ -OCH３ controlled by this definition.】 4-MeO-PV8 ４ Methylenedioxy NEB 2-(Methylamino)-1-phenylpentan-1-one ５ -F etc. ６ -Cl ７ -Br Following substances are Psychotropics. ８ -I 2-(Diethylamino)propiophenone ９ -H 1-(4-Tolyl)-2-(1-pyrrolidinyl)-1-pentanone
26 I OOOOOO OO NO OOOOOOOO O O O OOOOOOOO HNH OHO O O S NH 22 H2N OOH N O OO 2 N N HNN H2N N NNON H2N NONON H H N N N OO H HHHHNH N HN NFH 2 N N NOHO NH N N N N O ON O N OH H NNNONN H NH N N NN O O N NNNNN NNNNNN N Cl OO N N N NN NN NO NNNH N N NNN O O N N NNNH Cl N H O O N N Br O O2ON O O NH O N N O O NO O O N O O CF ClO F HFF NN F 3 FFFCFlFFFFF List of "Narcotics"which were once controlled as "Designated Substances". Reclassification from "Designated Substance"to "Narcotic" was done for following 69 substances with solid evidence on its high risks. "Narcotics" are controlled more strictly under Narcotics and Psychotropics Control Act.
Date of Enforcement (Desiganted Substances) No. Name Other Name Chemical Structure Date of Enforcement (Narcotics)
April 1, 2007 1 2-(4-Ethylsulfanyl-2,5-dimethoxyphenyl)ethanamine 2C-T-2 January 18, 2008
April 1, 2007 2 2-（2,5-Dimethoxy-4-isopropylsulfanylphenyl)ethanamine 2C-T-4 January 18, 2008
April 1, 2007 3 2-（4-Iodo-2,5-dimethoxyphenyl)ethanamine 2C-I January 18, 2008
O January 16, 2009 N O 4 1-（3,4-Methylenedioxyphenyl）-2-（pyrrolidin-1-yl）pentan-1-one MDPV O August 3, 2012
O November 20, 2009
5 1-Naphthalenyl（1-pentyl-1H -indol-3-yl)methanone JWH-018 N August 3, 2012
OH November 20, 2009 Cannabicyclohexanol OH 6 (1RS ,3SR )-3-［2-Hydroxy-4-（2-methylnonan-2-yl）pentyl］cyclohexanon-1-ol CP-47,497-C8 August 3, 2012
Mephedrone O November 20, 2009 H 7 2-（Methylamino）-1-（4-methylphenyl）propan-1-one 4-Methylmethcathinone N 4-MMC August 3, 2012
April 1, 2007
8 N,N -Diallyl-5-methoxytryptamine 5-MeO-DALT O N
N H March 1, 2013
H N April 1, 2007 9 1-(4-Methoxyphenyl）-N -methylpropan-2-amine PMMA O March 1, 2013
O H January 16, 2009 10 2-Ethylamino-1-phenylpropan-1-one Ethcathinone N March 1, 2013
O September 24, 2010
11 （1-Butyl-1H -indol-3-yl)(naphthalen-1-ｙｌ)methanone JWH-073 N March 1, 2013
O May 14, 2011 12 （4-Methylnaphthalen-1-yl）（1-pentyl-1H -indol-3-yl）methanone JWH-122 N
March 1, 2013
O November 16, 2012 N 13 1-Phenyl-2-（pyrrolidin-1-yl）pentan-1-one α-PVP March 1, 2013
O October 20, 2011 14 ［1-(5-Fluoropentyl）-1H -indol-3-yl］（naphthalen-1-yl)methanone AM2201 N
May 26, 2013 F
O November 16, 2012 15 ［1-(5-Fluoropentyl）-1H -indol-3-yl］（4-methylnaphthalen-1-yl）methanone MAM-2201 N May 26, 2013
F
27 Date of Enforcement (Desiganted Substances) No. Name Other Name Chemical Structure Date of Enforcement (Narcotics)
O bk-MDEA H January 11, 2008 N 16 2-Ethylamino-1-（3,4-methylenedioxyphenyl）propan-1-one Ethylone O
MDEC O January 19, 2014
O November 16, 2012 XLR-11 N 17 ［1-(5-Fluoropentyl)-1H -indol-3-yl］（2,2,3,3-tetrametylcyclopropan-1-yl）methanone 5-Fluoro-UR-144 January 19, 2014 F
O November 20, 2013 O
N 5F-QUPIC N 18 Quinolin-8-yl 1-(5-fluoropentyl)-1H -indole-3-carboxylate 5F-PB-22 August 1, 2014
F
O H November 20, 2013 2C-C-NBOMe N 19 2-(4-Chloro-2,5-dimethoxyphenyl)-N -(2-methoxybenzyl)ethanamine O 25C-NBOMe Cl
O November 1, 2015
O July 28, 2013 Cl N N 20 3,4-Dichloro-N -{[1-(dimethylamino)cyclohexyl]methyl}benzamide AH-7921 H
Cl November 1, 2015
O April 5, 2014 H N 21 2-(4-Bromo-2,5-dimethoxyphenyl)-N -(2-methoxybensyl)ethanamine 25B-NBOMe O Br
O November 1, 2015
O H November 16, 2012 N 22 2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine 25I-NBOMe O I
O November 1, 2015
July 1, 2012 Methoxetamine O 23 2-(Ethylamino)-2-(3-methoxyphenyl)cyclohexanone NH MXE O June 26, 2016
July 28, 2013
24 1-Cyclohexyl-4-(1,2-diphenylethyl)piperazine MT-45 N N June 26, 2016
O July 11, 2014
N 25 N -(1-Phenethylpiperidin-4-yl)-N -phenylacetamide Acetylfentanyl N June 26, 2016
NH 2 January 5, 2015 O 26 4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine 4,4’-DMAR N June 26, 2016
Ethylphenidate O O January 16, 2013 H 27 Ethyl 2-phenyl-2-(piperidin-2-yl)acetate EP N EPH August 25, 2017
O
N H May 30, 2013 N APINACA N 28 N -（Adamantan-1-yl）-1-(5-fluoropentyl)-1H -indazole-3-carboxamide N-(5-fluoropentyl) derivative August 25, 2017
F
H May 30, 2013 MPA N 29 N -Methyl-1-(thiophen-2-yl)propan-2-amine Methiopropamine S Methylthienylpropamine August 25, 2017
January 12, 2014 30 2-(Ethylamino)-1-（4-methylphenyl）propan-1-one 4-MEC August 25, 2017
28 Date of Enforcement (Desiganted Substances) No. Name Other Name Chemical Structure Date of Enforcement (Narcotics)
O February 9, 2015 O N MDMB-CHMICA H O 31 Methyl 2-[1-(cyclohexylmethyl)-1H -indole-3-carboxamido]-3,3-dimethylbutanoate N MMB-CHMINACA August 25, 2017
May 11, 2015 32 2-(Methylamino)-1-phenylpentan-1-one Pentedrone August 25, 2017
December 31, 2016 33 3,4-Dichloro-N -[2-(dimethylamino)cyclohexyl]-N -methylbenzamide Ｕ-47700 August 25, 2017
March 6, 2017 Butyrfentanyl O N 34 N -（1-Phenethylpiperidin-4-yl）-N -phenylbutanamide N Butyryl Fentanyl August 25, 2017
O
H2N July 25, 2014 N H
O N 35 N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H -indazole-3-carboxamide AB-CHMINACA N July 20, 2018
O
H2N May 30, 2013 N H O N 36 N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H -indazole-3-carboxamide AB-PINACA N July 20, 2018
July 1, 2017 Acryloylfentanyl 37 N -(1-Phenethylpiperidin-4-yl)-N -phenylacrylamide Acrylfentanyl July 20, 2018
THF-F March 10, 2018 38 N -(1-Phenethylpiperidin-4-yl)-N -phenyltetrahydrofuran-2-carboxamide THF-fentanyl Tetrahydrofuranyl fentanyl July 20, 2018
December 31, 2016 39 N -（1-Phenethylpiperidin-4-yl）-N -phenylfuran-2-carboxamide Furanylfentanyl July 20, 2018 4-FA
4FMP NH2 April 1, 2007 40 1-(4-Fluorophenyl)propan-2-amine 4-Fluoroamphetamine p-Fluoroamphetamine F July 20, 2018
March 10, 2018 4-FIBF 41 N -(4-Fluorophenyl)-2-methyl-N -(1-phenethylpiperidin-4-yl)propanamide p-FIBF 4-Fluoroisobutyryl fentanyl July 20, 2018
November 11, 2016 Ocfentanil O N N -(2-Fluorophenyl)-2-methoxy-N -(1-phenethylpiperidin-4-yl)acetamide O 42 Ocfentanyl N A-3217 F July 20, 2018
O November 16, 2012 43 (1-Pentyl-1H -indol-3-yl)(2,2,3,3-tetramethylcyclopropan-1-yl)methanone UR-144 N July 20, 2018
December 31, 2016 Carfentanil N 44 Methyl 1-phenethyl-4-（N -phenylpropanamido)piperidin-4-carboxylate Carfentanyl N
4-Carbomethoxyfentanyl O O O July 20, 2018
O
O November 8, 2014 N 5F-ADB H O N 45 Methyl 2-［1-(5-fluoropentyl)-1H -indazole-3-carboxamide］-3,3-dimethylbutanoate 5F-MDMB-PINACA N MDMB2201 indazole analog July 20, 2018
F
29 Date of Enforcement (Desiganted Substances) No. Name Other Name Chemical Structure Date of Enforcement (Narcotics)
November 24, 2018 46 N- （1-Phenethylpiperidin-4-yl）-N- phenylcyclopropanecarboxamide Cyclopropylfentanyl July 28. 2019
June 30, 2018 47 2-Methoxy-N -(1-phenethylpiperidin-4-yl)-N -phenylacetamide Methoxyacetylfentanyl July 28. 2019
February 19.2019 2-Fluorofentanyl、 O N
48 N -(2-Fluorophenyl)-N -(1-phenethylpiperidin-4-yl)propanamide o-Fluorofentanyl、 N 2-FF、o-FF F July 28. 2019
December 5, 2015 O N 4-FBF 49 N -(4-Fluorophenyl)-N -[1-(2-phenethyl)piperidin-4-yl]butanamide N p -Fluorobutyrylfentanyl July 28. 2019
F
O May 30, 2013 H2N N H O N 50 N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H -indazole-3-carboxamide ADB-FUBINACA N July 28. 2019
F
O
O November 8, 2014 N FUB-AMB H O N 51 Methyl 2-[1-(4-fluorobenzyl)-1H -indazole-3-carboxamido]-3-methylbutanoate AMB-FUBINACA N MMB-FUBINACA July 28. 2019
F
September 29, 2014 52 N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H -indazole-3-carboxamide ADB-CHMINACA July 28. 2019
July 1, 2017 CUMYL-4CN-BINACA 1-(4-Cyanobutyl)-N -(2-phenylpropan-2-yl)- 53 4-cyano CUMYL-BUTINACA 1H -indazole-3-carboxamide SGT-78 July 28. 2019
December 13, 2013 54 2-Ethylamino-1-(3,4-methylenedioxyphenyl)pentan-1-one N-ethylnorpentylone July 28. 2019
H3C CH 3 O
H N December 17, 2012 2 N H O N 55 N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide AB-FUBINACA N August 7, 2020
F
O H N CH 3 May 1, 2015 56 2-(Ethylamino)-1-phenylhexan-1-one N-ethylhexedrone August 7, 2020 CH 3
CH 3 December 17, 2008 O NH 2 57 1-(4-Chloro-2,5-dimethoxyphenyl)propan-2-amine DOC CH 3 Cl O August 7, 2020 CH 3
O H December 13, 2013 N 58 1-(4-Chlorophenyl)-2-(methylamino)propan-1-one 4-CMC CH 3 CH 3 Cl August 7, 2020
O
N August 15, 2014 59 1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one α-PHP August 7, 2020
CH 3
February 28, 2020 O N
60 (E)-N-(1-Phenethylpiperidin-4-yl)-N-phenylbut-2-enamide Crotonylfentanyl H3C N August 7, 2020
30 Date of Enforcement (Desiganted Substances) No. Name Other Name Chemical Structure Date of Enforcement (Narcotics)
February 28, 2020 61 N-(1-Phenethylpiperidin-4-yl)-N-phenylpentanamide Valerylfentanyl August 7, 2020
CH 3 H3C CH 3 O
O February 28, 2020 H3C N H O N 62 Methyl 2-[1-(4-fluorobutyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate 4F-MDMB-BINACA N August 7, 2020
F
H3C CH 3 O O July 15, 2014 H3C N H O N 63 Methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3-methylbutanoate 5-Fluoro-AMB N August 7, 2020
F
CH 3 H3C CH 3 O
O September 1, 2018 H3C N H O 64 Methyl 2-[1-(5-fluoropentyl)-1H-indole-3-carboxamido]-3,3-dimethylbutanoate 5F-MDMB-PICA N August 7, 2020
F
November 19, 2020 65 1-(Diethylamino)ethyl-2-(4-isopropoxybenzyl)-5-nitrobenzimidazole Isotonitazene October 8, 2021
August 25, 2014 N 66 1-(1,2-Diphenylethyl)piperidine Diphenidine October 8, 2021
O August 29, 2019 N CUMYL-PEGACLONE、 67 5-Pentyl-2-(2-phenylpropan-2-yl)-2,5-dihydro-1Ｈ-pyrido[4,3-b]indol-1-one N SGT-151 October 8, 2021
November 19, 2020 68 Methyl 3,3-dimethyl-2-[1-(pent-4-en-1-yl)-1H-indazole-3-carboxamido] butanoate MDMB-4en-PINACA October 8, 2021
August 25, 2014
O 69 1-[1-(3-Methoxyphenyl)cyclohexyl]piperidine 3-MeO-PCP N October 8, 2021
31