List of "Designated Substances" in Japan (as of October 8, 2021) Drug category, "Designated Substances (*)" was newly established in 2007 to control new psychoactive substances (NPS). Their manufacture, import, sale, display, possession, use etc. are generally prohibited except for scietific purposes. A total 2392 substances including 2 plants (Salvia Divinorum and Mitragina Speciosa (Kratom)) are currently controlled as "Designated Substances". (Substances basis 299, Generic scheduling 2098) 69 substances, such as JWH-018, mephedrone, MDPV etc. have been already reclassified to be "Narcotics". (*)They are controlled by "The Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices". No. Name Other Name Chemical Structure Date of Enforcement 1 Isobutyl nitrite April 1, 2007 ONO 2 Isopropyl nitrite April 1, 2007 ONO 3 Isopentyl nitrite Isoamyl nitrite April 1, 2007 ONO 4 tert-Butyl nitrite April 1, 2007 ONO ONO 5 Cyclohexyl nitrite April 1, 2007 6 Butyl nitrite April 1, 2007 ONO N O 4-Acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9- 7 ALD-52 N February 28, 2020 hexahydroindolo[4,3-fg]quinoline-9-carboxamide N O O O 8 4-Acetoxy-N -isopropyl-N- metyltryptamine 4-AcO-MIPT N April 4, 2015 N H O O 9 4-Acetoxy-N -ethyl-N -methyltryptamine 4-AcO-MET N August 8, 2015 N H O O 10 4-Acetoxy-N ,N -diallyltryptamine 4-AcO-DALT N August 8, 2015 N H O O 11 4-Acetoxy-N ,N -diisopropyltryptamine 4-AcO-DIPT N April 1, 2007 N H O O 12 4-Acetoxy-N,N -diethyltryptamine 4-AcO-DET N August 8, 2015 N H O O 13 4-Acetoxy-N,N -dimethyltryptamine 4-AcO-DMT N August 8, 2015 N H O N H N N -(1-Adamantyl)-1-(5-chloropentyl)-1H -indazole-3- APINACA N -(5- N 14 April 18, 2016 carboxamide chloropentyl) analog Cl 1 No. Name Other Name Chemical Structure Date of Enforcement N -(1-Adamantyl)-1-[(tetrahydro-2H -pyran-4-yl)methyl]-1H - Adamantyl-THPINACA 15 March 6, 2017 indazole-3-carboxamide ATHPINACA O Adamantyl-THPINACA 2- N N -(2-Adamantyl)-1-[(tetrahydro-2H -pyran-4-yl)methyl]-1H - adamantyl isomer H N 16 indazole-3-carboxamide ATHPINACA 2-adamantyl N March 6, 2017 isomer O O N H N -(1-Adamantyl)-1-(4-fluorobenzyl)-1H -indazole-3- N 17 carboxamide FUB-APINACA N January 5, 2015 F O N H APICA N-(5-fluoropentyl) N -(1-Adamantyl)-1-(5-fluoropentyl)-1H -indole-3- N 18 derivative May 30, 2013 carboxamide STS-135 F O N H N APINACA N 19 N -(1-Adamantyl)-1-pentyl-1H -indazole-3-carboxamide July 1, 2012 AKB48 O O N 20 1-Adamantyl 1-pentyl-1H -indazole-3-carboxylate ACBL(N)-018 N December 29, 2017 O N 21 1-Adamantyl(1-pentyl-1H -indol-3-yl)methanone AB-001 May 30, 2013 O N H APICA N 22 N -(1-Adamantyl)-1-pentyl-1H -indole-3-carboxamide July 1, 2012 2NE1 O 1-Adamantyl{1-[(1-methylpiperidin-2-yl)methyl]-1H -indol-3- 23 AM1248 N May 30, 2013 yl｝methanone N O H2N N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1- APP-CHMINACA N 24 H September 3, 2016 (cyclohexylmethyl)-1H -indazole-3-carboxamide PX-3 O N N 2 No. Name Other Name Chemical Structure Date of Enforcement O H2N N N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(4-fluorobenzyl)- H 25 FU-PX-2 August 29, 2015 1H -indazole-3-carboxamide O N N F O H2N N H N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)- O N 26 PX-2 November 28, 2014 1H -indazole-3-carboxamide N F O H2N N N -(1-Amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)- H O 27 1H -indole-3-carboxamide PX-1 N November 28, 2014 F O H2N N N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1- ADB-CHMICA、 H 28 O February 19, 2019 (cyclohexylmethyl)-1H -indole-3-carboxamide MAB-CHMICA N N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H- 29 ADB-BUTINACA March 15,2021 indazole-3-carboxamide O H2N N H N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5- O N 30 fluoropentyl)-1H -indazole-3-carboxamide 5F-ADB-PINACA N November 28, 2014 F O H2N N H N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5- O 31 fluoropentyl)-1H -indole-3-carboxamide 5-fluoro-ADBICA N February 9, 2015 F O H2N N N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H - H O N 32 indazole-3-carboxamide ADB-PINACA N July 11, 2014 O H2N N H O N N -(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H - N 33 ADBICA May 30, 2013 indole-3-carboxamide 3 No. Name Other Name Chemical Structure Date of Enforcement O O NH 2 34 2-Amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanone bk-2C-B April 4, 2015 Br O O H2N N H O N N -(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-chloropentyl)- N 35 5Cl-AB-PINACA November 8, 2014 1H -indazole-3-carboxamide Cl O H2N N N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(2-fluorobenzyl)- H AB-FUBINACA 2- O N 36 1H -indazole-3-carboxamide N December 5, 2015 fluorobenzyl isomer F O H2N N H N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)- O N N 37 1H -indazole-3-carboxamide 5‐Fluoro‐AB‐PINACA July 11, 2014 F O H2N N H O N -(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)- N 38 5-Fluoro-ABICA August 25, 2014 1H -indole-3-carboxamide F O NH 2 39 2-(4-Allyloxy-3,5-dimethoxyphenyl)ethanamine Allylescaline April 4, 2015 O O N O 7-Allyl-N,N-diethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg] 40 quinoline-9-carboxamide AL-LAD February 28, 2020 N HN O NH2 41 1-(4-Isopropylsulfanyl- 2,5-dimethoxyphenyl)propan-2-amine ALEPH-4 May 14, 2011 S O N 42 N -Isopropyl-N -methyltryptamine MIPT April 1, 2007 N H O N 43 N -Isopropyl-5-methoxy-N -methyltryptamine 5-MeO-MIPT April 1, 2007 N H 44 Nitrous oxide SIVAGUS N2O February 28, 2016 45 Indan-2-amine 2-AI January 11, 2008 NH2 O α-PBP indane analog N 46 1-(Indan-5-yl)-2-(pyrrolidin-1-yl)butan-1-one February 9, 2015 5-PPDI 4 No. Name Other Name Chemical Structure Date of Enforcement O N α-PHP indane analog 47 1-(Indan-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one February 27, 2015 5-BPDI (1H -Indol-3-yl)(2,2,3,3-tetramethylcycropropan-1- 48 DP-UR-144 September 29, 2014 yl)methanone NH2 5-API 49 1-(1H -Indol-5-yl)propan-2-amine January 16, 2013 5-IT N H O H N 50 2-(Ethylamino)-1-(indan-5-yl)butan-1-one bk-IBP February 9, 2015 O H N 51 2-(Ethylamino)-1-(indan-5-yl)pentan-1-one bk-IVP February 9, 2015 52 3-[1-(Ethylamino)cyclohexyl]phenol 3-HO-PCE HO December 17, 2019 HN 53 2-(Ethylamino)-2-(thiophen-2-yl)cyclohexanone Tiletamine March 6, 2017 Deschloro-N-ethyl- ketamine 54 2-(Ethylamino)-2-phenylcyclohexanone Eticyclidone September 1, 2018 O-PCE 2-Oxo-PCE O N 55 N -Ethyl-N -isopropyl-5-methoxytryptamine 5-MeO-EIPT January 16, 2009 N H H N Ephenidine 56 N -Ethyl-1,2-diphenylethylamine EPE November 11, 2016 NEDPA O NH2 57 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine 2C-E April 1, 2007 O O H 2-(4-Ethyl-2,5-dimethoxyphenyl)-N -(2-methoxybenzyl) N 58 ethanamine 25E-NBOMe June 1, 2015 O O 59 ２－［（４－Ethyl－２，５－dimethoxyphenethylamino）methyl］phenol 25E-NBOH December 19, 2018 O NH2 60 1-(4-Ethylsulfanyl-2,5-dimethoxyphenyl)propan-2-amine ALEPH-2 January 16, 2009 S O 5 No. Name Other Name Chemical Structure Date of Enforcement HO N 61 N -Ethyl-4-hydroxy-N -methyltryptamine 4-OH-MET April 4, 2015 N H H 62 1-（4-Ethylphenyl）-N -(2-methoxybenzyl)propan-2-amine 4-EA-NBOMe N December 29, 2017 O 63 Ethyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate 4-Fluoroethylphenidate March 15,2021 H N 2-FEA 64 N -Ethyl-1-（2-fluorophenyl）propan-2-amine February 19, 2019 2-fluoroethamphetamine F 3-FEA 65 N- Ethyl-1-（3-fluorophenyl）propan-2-amine November 24, 2018 3-fluoroethamphetamine 4-FEA 66 N -Ethyl-1-（4-fluorophenyl）propan-2-amine November 24, 2018 4-fluoroethamphetamine 3F-Phenetrazine 67 3-Ethyl-2-(3-fluorophenyl)morpholine September 8, 2017 3-FPE O O N H Ethyl 2-[1-(4-fluorobenzyl)-1H -indazole-3-carboxamido]-3- EMB-FUBINACA O N 68 September 3, 2016 methylbutanoate FUB-AEB N F O O N H O N Ethyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3- N 69 5F-EDMB-PINACA January 22, 2021 dimethylbutanoate F O O N H Ethyl 2-[1-(5-fluoropentyl)-1H -indazole-3-carboxamido]- O N 70 3-methylbutanoate 5F-AEB N July 2, 2016 F O O N H O Ethyl 2-[1-(5-fluoropentyl)-1H-indole-3-carboxamido]-3- N 71 5F-EMB-PICA, EMB-2201 August 25, 2021 methylbutanoate F 6 No.