Heparin H 1001

Uzara plus (Uzara)-comb.; GB: Quixalin (Squibb); wfm wfm USA: Quinolor (Squibb); wfm

Heparin ATC: BOIABOI; C05BA03 Use: anticoagulant, antithrombotic

RN: 9005-49-6 MF: [C,,H,,N,O,sS,]x MW: unspecified EINECS: 232-681-7 LD,,,: 500 mglkg (M, i.v.); 1950 mglkg (R, p.0.) CN: mucopolysaccharide polysulfuric acid ester sodium salt RN: 9041-08- 1 MF: unspecified MW: unspecified LD,: 2800 mgikg (M, i.v.); >5 gkg (M, p.0.); 391821 idkg (R, i.v.); >779000 idkg (R, p.0.); I glkg (dog, i.v.) calcium salt RN: 37270-89-6 MF: unspecified MW. unspecified LD,,: A0gkg (M, i.v.); >40 gikg (R, i. v.) magnesium salt RN: 54479-70-8 MF: unspecified MW: unspecified

I Heparin

(molar mass 6000-20000, according to origin) From animal tissue, especially bovine lung and liver (e. g. autolysis of comminuted tissue parts, heating with ammonium sulfate in alkaline solution, filtration and acidification yield heparin as complex with protein, removal of fat with alcohol and treatment with trypsine for the purpose of decomposition of proteins, precipitation with alcohol and various purification methods).

Reference(s): review: Hind, H.G.: Manuf. Chem. (MACSAS) 34,510 (1963). purification: US 2 884 358 (Southerm California Gland Co; 28.4.1959; appl. 22.4.1957), US 2 989 438 (Uclaf; 20.6.1961; appl. 29.12.1958). DE 1 195 010 (Ormonoterapia Richter; appl. 12.5.1962). US 3 016 331 (Ormonoterapia Richter; 9.1.1962; I-prior. 28.1.1960). US 4 119 774 (AB Kabi; 10.10.1978; appl. 2.3.1977). GB 1 539 332 (AB Kabi; appl. 4.3.1977; S-prior. 5.3.1976).

Formulation(s): amp. 12500 iu, 20000 iu, 50000 iu, 60000 iu; cream, eye drops and eye ointment 30000 iu, 60000 iu, 150000 iu (as sodium salt or calcium salt); syringe 5000 iu, 7500 iu. Trade Name(s): D: Calciparin (Sanofi GB: Canusal (CP Pharm.) Liquemin (Roche; as

Winthrop) Clexane (RhGne-Poulenc sodium salt) Heparin-lnjekt (Immuno) Rorer) Luxazone Eparina Heparin-Na (Braun Fragmin (Pharmacia & (Allergan)-comb. Melsungen; medac; Upjohn) Normoparin (Opocrin) Nattermann; ratiopharm) Hepsal (CP Pharm.) Venotrauma (Also)-comb. Heparin Novo (Novo) Monoparin (CP Pharm.) Viteparin (Teofarma)- Heparin POS (Ursapharm) generic and combination comb. Heparin Riker (Riker) preparations numerous generic Liquemin (Roche) I: Ateroclar (Mediolanum) preparations Thrombareduct Chemyparin (SIT) J: Caprocin (Mitsui; as (Azuchemie) Clarisco (Schwarz) calcium salt)

Thrombophob (Knoll) Disebrin (Allergan) Depo-Heparin (Upjohn- , Traumalitan (3M Med~ca; Eparina (Tariff. Integrativo; Kodama; as sodium salt) as sodium salt) Bristol-Myers Squibb; Hepacarin (Eisai) Vetren (Klinge) Manetti Roberts; Parke Heparigen (Mukasa-Torii) numerous generic and Davis) Heparin Sodium (Tokyo combination preparations Eparinovis (Intes) Tanabe) F: Calciparin (Sanofi Essaven Gel (RhGne- Novo Heparin (Novo- Winthrop; as calcium salt) Poulenc Rarer)-comb. Kodama) Dioparine (ThCa; as sodium Flebs Crema (Pierre Fabre Panheprin (Nippon Abbott) salt) Phar.)-comb. numerous generic NCoparyl Framycttine Heparin Collirio preparations (CIBA Vision (Farmigea) USA: Heparin-Sodium (Wyeth- 0phthalmics)-comb. Idracemi Eparina Ayerst) numerous generic and (Farmigea)-comb. Hep-Lock (Elkins-Sinn) combination preparations Lioton (Menarini)

Hepronicate ATC: C04 Use: vasodilator

RN: 7237-81-2 MF: C2,H3,N,06 MW: 505.57 LD,,,: 5 glkg (M, p.0.) CN: 3-pyr~d~necarboxylicacid 2-hexyl-2-[[(3-pyr1d1nylcarbonyl)oxy]methyl]-1,3-propaned1ylester

HO~OH H 0

octanol 2-hexyl-2-hydroxy- methyl- 1,3- proponediol (I)

pyridine 1 + 0

nicotinoyl Hepronicote chloride Heptabarb H 1003

Reference(s): US 3 384 642 (Yoshitomi; 21.5.1968; J-prior. 18.11.1964, 12.10.1965)

Formulation(s): tabl. 100 mg

Trade Name(s): I: Megrin (Yoshitomi)

Heptabarb ATC: NOSCA~I (Heptabarbital; Heptabarbitone; Heptamalum) Use: hypnotic. sedative

RN: 509-86-4 MF: Cl3HI8N2O3MW: 250.30 EINECS: 208-107-6 LD,,: 180 mglkg (M, i.v.); >800 mglkg (M, p.0.); >S glkg (R, p.0.); 105 mglkg (dog, i.v.) CN: 5-(l-cyclohepten-l-yl)-5-ethyl-2,4,6(1H,3H,SH)-pyrimidinetrione

H$"B~ , NOOCH~ ------+I CN ethyl bromide

cyclo- methyl methyl heptanone cyanoocetate 1 -cycloheptenyl- cyanaacetate

urea ( Heptobarb I

Reference(s): FR 870 714 (Geigy; appi. 1941 ; Palestine-prior. 1940). DE 756 489 (Geigy; appl. 1941; Palestine-prior. 1940).

Forrnulation(s): tabl. 200 mg

Trade Name(s): D: Medomin (Geigy); wfm F: Medomine (Geigy); wfm GB: Medomin (Gcigy); wfm

Heptaminol ATC: COlDX08 Use: cardiotonic, sympathomimetic

RN: 372-66-7 MF: C8Hl9NO MW: 145.25 EINECS: 206-758-0 LD,,,: 1250 mgikg (M, i.p.) CN: 6-amino-2-methyl-2-heptanol hydmchloride RN: 543-15-7 MF: C,H,,NO. HCI MW: 181.71 EINECS: 208-837-5 LD,,: 900 mglkg (M, i.p.) 1004 H Hetacillin

180 OC H3C,p,yCH3 conc. HCI H3C~CH3OHC-NH2-b 0 CH3 OHC/NH CH3

6-methyl- forrnarnide 5-hepten-2-one

~ejizrence(s): Dceuvre, I.; Pozat, I.: C. R. Hebd. Seances Acad. Sci. (COREAF) 224,286 (1947).

Formulation(s): amp. 250 mg, 500 mg; drg. 50 mg; drops 50 mg/ml;tabl. 150 mg (as hydrochloride)

Trade Name(s): D: Normotin (0TW)-comb. DCbmmyl (Pierre Fabre numerous combination Perivar (Intersan)-comb. Sant6)-comb. preparations F: Amptcyclal (Sargel) Sureptil (SynthClab0)- I: Coreptil (Delalande comb. Isnardi)

Hetacillin ATC: JOlCA18 Use: antibiotic

RN: 3511-16-8 MF: C,,HZ3N3O4S MW: 389.48 EINECS: 222-512-5 CN: [2S-[2a,5a,6~(S*)]]-6-(2,2-dimethyl-5-oxo-4-pheny-l-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-l- azabicyclo[3.2.0]heptane-2-carboxylicacid monopotassium salt RN: 5321 -32-4 MF: C,,H,KN,04S MW: 427.57 EINECS: 226-182-3 LD,,,: 650 mglkg (M, i.v.); >15 gkg (M, p.0.); >1400 mgkg (R, i.v.); >I0 gikg (R, p.0.); 2200 mgkg (dog, 1.v.); >4 gkg (dog, p.0.)

ONa

, CH,

ornp~c~ll~nsod~urn salt acetone Hetac~ll~n

(q v)

Reference(s): US 3 198 804 (Bristol-Myers; 3.8.1965; appl. 6.1.1965; prior. 25.1.1963).

Formulation(s): amp. 250 mg, 500 mg, 1 g; tabl. 50 mg (as potassium salt)

Trade Name(s): D: Penplenum (Bristol); wfm Etadipen (Ghimas)-comb. J: Natacillin (Banyu) F: Versapen (Allard); wfm with dicloxacillin; wfm USA: Versapen (Bristol); wfm I: Dicloeta (Lusopharma)- Versaclox (Bristo1)-comb. comb. with dicloxacillin; with dicloxacillin; wfm wfm Versapen (Bristol); wfm Heteronium bromide H 1005

Heteronium bromide AX: A03 Use: anticholinergic

RN: 7247-57-6 MF: C,*H,,BrN03S MW: 41 2.35 LDs,,: 3576 mgkg (R, p.0.) CN: 3-[(hydroxyphenyl-2-thienylacety1)oxyl-1,l-dimethylpyrrolidinium bromide

NaOCH,, n-C7HI6

sodium 0 H OH methylate I-methyl- phenyl- 3-pyrrolidinol (2-thieny1)- glycolic acid

H,C-Br 1 b methyl bromide

I Heteroniurn bromide

us3 138 614 (Eli Lilly; 23.1.1964; prior. 18.12.1961, 3.8.1960). slarting material: US 2 830 997 (A. H. Robins; 1958; prior. 1956).

Formulation(s): tabl. 1 mg

Trade Name(s): I: Quentar (Ravizza)-comb. USA: Hetrum Bromide (Lilly); with oxazepam; wfm - wfm

Hexachlorophene ATC: D08AE01 Use: topical antiinfective, disinfectant, parasiticide

RN: 70-30-4 MF: C,,H6c160, MW: 406.9 1 EINECS: 200-733-8 LD,,: 67 mgkg (M, p.0.); 7500 @kg (R, i.v.); 56 mglkg (R, p.0.) CN: 2,2'-methylenebis[3,4,6-trichlorophenol] 1006 H Hexafluronium bromide

I. oleurn I I 2. NaOH 3. t12s04 , clmcl + (CH,O), 1 1 CI CI CI

2,4.5-trichloro- poroform- Hexachlorophene phenol oldehyde

Refirence(s): . US 2 250 480 (B. T. Bush; 1941; appl. 1939). US 2 435 593 (B. 1: Bush; 1948; appl. 1945). US 2 8 12 365 (Givaudan Corp.; 1957; prior. 1951, 1954).

Forniulation(s): cream 0.5 g1100 g; emulsion 0.5 gt100 g; lotion 0.5 gt100 g

Trade Narne(s): D: Aknefug (Wolff) GB: Dermalex (Sanofi Phisohex disinf (Magg~om- Aknefug (Wo1ff)-comb. Winthrop)-comb. W1nthrop)-comb., wfm I with estrad~ol Ster-Zac D.C. (Seton) Vestene (Eurospital); wfm F: Acnestrol (Po1rier)-comb. 1: Etaproctene (Ange1ini)- USA: pHisoHex (Sanofi) comb.; wfm

f Hexafluronium bromide ATC: ~03~~05' Use: muscle relaxant (Hexafluorenium bromide)

RN: 3 17-52-2 MF: C,,H,,Br2N2 MW: 662.55 EINECS: 206-265-0 I LD,,. 1760 pglkg (M, I.v.); 280 mglkg (M, p.0.) CN: N,N-di-9H-fluoren-9-yl-N,N,N,W-tetramethyl-1.6-hexanediam~nrum dihromide

9-bromo- 1,6-bis(dimethy1- Hexafluronium bromide fluorene amin0)hexane

Reference(s): 1 US 2 783 237 (Irwin, Neisler & Co.; 1957; prior. 1953).

Frtio(): amp. 20 mgln~l.

1 Trade Name(s): J: Mylaxen (Nippon Shoji); USA: Mylaxen (Mallinckrodt); Mylaxen (Wallace); wfm wfm wfm b Hexamethonium chloride H 1007

ATC: C02 Hexamethonium chloride Use: ganglionic blocker, antihypertensive

RN: 60-25-3 MF: CI2H3,Cl2N2 MW: 273.29 EINECS: 200-465-1 LD,,,: 26.7 mglkg (M, i.v.); 35 mgkg (dog, i.v.) CN: N, N, N,N,N,N-hexamethyl-1,6-hexanediaminium dichloride

hexamethylenediamine dimethyl sulfate hexarnethanium sulfate (1)

OH- OH- CI- CI- NaOH, C2H50H H3C\+/~~3 , , H3C\+ , H3C\+ CH3

hexamethonium hydroxide I Hexomethonium chloride

Reference(s): DE 900 097 (May & Baker; appl. 195 1; GB-prior. 1950).

Formulation(s): oral: 0.5 gld

Trade Name(s): D: Raucombin forte (Voigt); Gastrometonio (Fabo; as w fm iodide); wfm 1: Gastrometonio (Fabo); J: Methobromin w fm (Yamanouchi); wfm

Hexcarbacholine bromide ATC: M03 (Carbolonium bromide) Use: muscle relaxant

RN: 306-41-2 MF: C,,H,,,Br,N,O, MW: 536.35 CN: N,N,N,N,N,N-hexamethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-,16-diaminiumdibromide

H

thionyl

H H

hem- ethylene methylene- carbonate diamine