DOCSLIB.ORG

Heparin H 1001

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Heparin H 1001 Heparin H 1001 Uzara plus (Uzara)-comb.; GB: Quixalin (Squibb); wfm wfm USA: Quinolor (Squibb); wfm Heparin ATC: BOIABOI; C05BA03 Use: anticoagulant, antithrombotic RN: 9005-49-6 MF: [C,,H,,N,O,sS,]x MW: unspecified EINECS: 232-681-7 LD,,,: 500 mglkg (M, i.v.); 1950 mglkg (R, p.0.) CN: mucopolysaccharide polysulfuric acid ester sodium salt RN: 9041-08- 1 MF: unspecified MW: unspecified LD,: 2800 mgikg (M, i.v.); >5 gkg (M, p.0.); 391821 idkg (R, i.v.); >779000 idkg (R, p.0.); I glkg (dog, i.v.) calcium salt RN: 37270-89-6 MF: unspecified MW. unspecified LD,,: A0gkg (M, i.v.); >40 gikg (R, i. v.) magnesium salt RN: 54479-70-8 MF: unspecified MW: unspecified I Heparin (molar mass 6000-20000, according to origin) From animal tissue, especially bovine lung and liver (e. g. autolysis of comminuted tissue parts, heating with ammonium sulfate in alkaline solution, filtration and acidification yield heparin as complex with protein, removal of fat with alcohol and treatment with trypsine for the purpose of decomposition of proteins, precipitation with alcohol and various purification methods). Reference(s): review: Hind, H.G.: Manuf. Chem. (MACSAS) 34,510 (1963). purification: US 2 884 358 (Southerm California Gland Co; 28.4.1959; appl. 22.4.1957), US 2 989 438 (Uclaf; 20.6.1961; appl. 29.12.1958). DE 1 195 010 (Ormonoterapia Richter; appl. 12.5.1962). US 3 016 331 (Ormonoterapia Richter; 9.1.1962; I-prior. 28.1.1960). US 4 119 774 (AB Kabi; 10.10.1978; appl. 2.3.1977). GB 1 539 332 (AB Kabi; appl. 4.3.1977; S-prior. 5.3.1976). Formulation(s): amp. 12500 iu, 20000 iu, 50000 iu, 60000 iu; cream, eye drops and eye ointment 30000 iu, 60000 iu, 150000 iu (as sodium salt or calcium salt); syringe 5000 iu, 7500 iu. Trade Name(s): D: Calciparin (Sanofi GB: Canusal (CP Pharm.) Liquemin (Roche; as Winthrop) Clexane (RhGne-Poulenc sodium salt) Heparin-lnjekt (Immuno) Rorer) Luxazone Eparina Heparin-Na (Braun Fragmin (Pharmacia & (Allergan)-comb. Melsungen; medac; Upjohn) Normoparin (Opocrin) Nattermann; ratiopharm) Hepsal (CP Pharm.) Venotrauma (Also)-comb. Heparin Novo (Novo) Monoparin (CP Pharm.) Viteparin (Teofarma)- Heparin POS (Ursapharm) generic and combination comb. Heparin Riker (Riker) preparations numerous generic Liquemin (Roche) I: Ateroclar (Mediolanum) preparations Thrombareduct Chemyparin (SIT) J: Caprocin (Mitsui; as (Azuchemie) Clarisco (Schwarz) calcium salt) Thrombophob (Knoll) Disebrin (Allergan) Depo-Heparin (Upjohn- , Traumalitan (3M Med~ca; Eparina (Tariff. Integrativo; Kodama; as sodium salt) as sodium salt) Bristol-Myers Squibb; Hepacarin (Eisai) Vetren (Klinge) Manetti Roberts; Parke Heparigen (Mukasa-Torii) numerous generic and Davis) Heparin Sodium (Tokyo combination preparations Eparinovis (Intes) Tanabe) F: Calciparin (Sanofi Essaven Gel (RhGne- Novo Heparin (Novo- Winthrop; as calcium salt) Poulenc Rarer)-comb. Kodama) Dioparine (ThCa; as sodium Flebs Crema (Pierre Fabre Panheprin (Nippon Abbott) salt) Phar.)-comb. numerous generic NCoparyl Framycttine Heparin Collirio preparations (CIBA Vision (Farmigea) USA: Heparin-Sodium (Wyeth- 0phthalmics)-comb. Idracemi Eparina Ayerst) numerous generic and (Farmigea)-comb. Hep-Lock (Elkins-Sinn) combination preparations Lioton (Menarini) Hepronicate ATC: C04 Use: vasodilator RN: 7237-81-2 MF: C2,H3,N,06 MW: 505.57 LD,,,: 5 glkg (M, p.0.) CN: 3-pyr~d~necarboxylicacid 2-hexyl-2-[[(3-pyr1d1nylcarbonyl)oxy]methyl]-1,3-propaned1ylester HO~OH H 0 octanol 2-hexyl-2-hydroxy- methyl- 1,3- proponediol (I) pyridine 1 + 0 nicotinoyl Hepronicote chloride Heptabarb H 1003 Reference(s): US 3 384 642 (Yoshitomi; 21.5.1968; J-prior. 18.11.1964, 12.10.1965) Formulation(s): tabl. 100 mg Trade Name(s): I: Megrin (Yoshitomi) Heptabarb ATC: NOSCA~I (Heptabarbital; Heptabarbitone; Heptamalum) Use: hypnotic. sedative RN: 509-86-4 MF: Cl3HI8N2O3MW: 250.30 EINECS: 208-107-6 LD,,: 180 mglkg (M, i.v.); >800 mglkg (M, p.0.); >S glkg (R, p.0.); 105 mglkg (dog, i.v.) CN: 5-(l-cyclohepten-l-yl)-5-ethyl-2,4,6(1H,3H,SH)-pyrimidinetrione H$"B~ , NOOCH~ ----------+I CN ethyl bromide cyclo- methyl methyl heptanone cyanoocetate 1 -cycloheptenyl- cyanaacetate urea ( Heptobarb I Reference(s): FR 870 714 (Geigy; appi. 1941 ; Palestine-prior. 1940). DE 756 489 (Geigy; appl. 1941; Palestine-prior. 1940). Forrnulation(s): tabl. 200 mg Trade Name(s): D: Medomin (Geigy); wfm F: Medomine (Geigy); wfm GB: Medomin (Gcigy); wfm Heptaminol ATC: COlDX08 Use: cardiotonic, sympathomimetic RN: 372-66-7 MF: C8Hl9NO MW: 145.25 EINECS: 206-758-0 LD,,,: 1250 mgikg (M, i.p.) CN: 6-amino-2-methyl-2-heptanol hydmchloride RN: 543-15-7 MF: C,H,,NO. HCI MW: 181.71 EINECS: 208-837-5 LD,,: 900 mglkg (M, i.p.) 1004 H Hetacillin H3C~CH3OHC-NH2-b 180 OC H3C,p,yCH3 conc. HCI 0 CH3 OHC/NH CH3 6-methyl- forrnarnide 5-hepten-2-one ~ejizrence(s): Dceuvre, I.; Pozat, I.: C. R. Hebd. Seances Acad. Sci. (COREAF) 224,286 (1947). Formulation(s): amp. 250 mg, 500 mg; drg. 50 mg; drops 50 mg/ml;tabl. 150 mg (as hydrochloride) Trade Name(s): D: Normotin (0TW)-comb. DCbmmyl (Pierre Fabre numerous combination Perivar (Intersan)-comb. Sant6)-comb. preparations F: Amptcyclal (Sargel) Sureptil (SynthClab0)- I: Coreptil (Delalande comb. Isnardi) Hetacillin ATC: JOlCA18 Use: antibiotic RN: 3511-16-8 MF: C,,HZ3N3O4S MW: 389.48 EINECS: 222-512-5 CN: [2S-[2a,5a,6~(S*)]]-6-(2,2-dimethyl-5-oxo-4-pheny-l-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-l- azabicyclo[3.2.0]heptane-2-carboxylicacid monopotassium salt RN: 5321 -32-4 MF: C,,H,KN,04S MW: 427.57 EINECS: 226-182-3 LD,,,: 650 mglkg (M, i.v.); >15 gkg (M, p.0.); >1400 mgkg (R, i.v.); >I0 gikg (R, p.0.); 2200 mgkg (dog, 1.v.); >4 gkg (dog, p.0.) ONa , CH, ornp~c~ll~nsod~urn salt acetone Hetac~ll~n (q v) Reference(s): US 3 198 804 (Bristol-Myers; 3.8.1965; appl. 6.1.1965; prior. 25.1.1963). Formulation(s): amp. 250 mg, 500 mg, 1 g; tabl. 50 mg (as potassium salt) Trade Name(s): D: Penplenum (Bristol); wfm Etadipen (Ghimas)-comb. J: Natacillin (Banyu) F: Versapen (Allard); wfm with dicloxacillin; wfm USA: Versapen (Bristol); wfm I: Dicloeta (Lusopharma)- Versaclox (Bristo1)-comb. comb. with dicloxacillin; with dicloxacillin; wfm wfm Versapen (Bristol); wfm Heteronium bromide H 1005 Heteronium bromide AX: A03 Use: anticholinergic RN: 7247-57-6 MF: C,*H,,BrN03S MW: 41 2.35 LDs,,: 3576 mgkg (R, p.0.) CN: 3-[(hydroxyphenyl-2-thienylacety1)oxyl-1,l-dimethylpyrrolidinium bromide NaOCH,, n-C7HI6 sodium 0 H OH methylate I-methyl- phenyl- 3-pyrrolidinol (2-thieny1)- glycolic acid H,C-Br 1 b methyl bromide I Heteroniurn bromide us3 138 614 (Eli Lilly; 23.1.1964; prior. 18.12.1961, 3.8.1960). slarting material: US 2 830 997 (A. H. Robins; 1958; prior. 1956). Formulation(s): tabl. 1 mg Trade Name(s): I: Quentar (Ravizza)-comb. USA: Hetrum Bromide (Lilly); with oxazepam; wfm - wfm Hexachlorophene ATC: D08AE01 Use: topical antiinfective, disinfectant, parasiticide RN: 70-30-4 MF: C,,H6c160, MW: 406.9 1 EINECS: 200-733-8 LD,,: 67 mgkg (M, p.0.); 7500 @kg (R, i.v.); 56 mglkg (R, p.0.) CN: 2,2'-methylenebis[3,4,6-trichlorophenol] 1006 H Hexafluronium bromide I. oleurn I I 2. NaOH 3. t12s04 , clmcl + (CH,O), 1 1 CI CI CI 2,4.5-trichloro- poroform- Hexachlorophene phenol oldehyde Refirence(s): . US 2 250 480 (B. T. Bush; 1941; appl. 1939). US 2 435 593 (B. 1: Bush; 1948; appl. 1945). US 2 8 12 365 (Givaudan Corp.; 1957; prior. 1951, 1954). Forniulation(s): cream 0.5 g1100 g; emulsion 0.5 gt100 g; lotion 0.5 gt100 g Trade Narne(s): D: Aknefug (Wolff) GB: Dermalex (Sanofi Phisohex disinf (Magg~om- Aknefug (Wo1ff)-comb. Winthrop)-comb. W1nthrop)-comb., wfm I with estrad~ol Ster-Zac D.C. (Seton) Vestene (Eurospital); wfm F: Acnestrol (Po1rier)-comb. 1: Etaproctene (Ange1ini)- USA: pHisoHex (Sanofi) comb.; wfm f Hexafluronium bromide ATC: ~03~~05' Use: muscle relaxant (Hexafluorenium bromide) RN: 3 17-52-2 MF: C,,H,,Br2N2 MW: 662.55 EINECS: 206-265-0 I LD,,. 1760 pglkg (M, I.v.); 280 mglkg (M, p.0.) CN: N,N-di-9H-fluoren-9-yl-N,N,N,W-tetramethyl-1.6-hexanediam~nrum dihromide 9-bromo- 1,6-bis(dimethy1- Hexafluronium bromide fluorene amin0)hexane Reference(s): 1 US 2 783 237 (Irwin, Neisler & Co.; 1957; prior. 1953). Frtio(): amp. 20 mgln~l. 1 Trade Name(s): J: Mylaxen (Nippon Shoji); USA: Mylaxen (Mallinckrodt); Mylaxen (Wallace); wfm wfm wfm b Hexamethonium chloride H 1007 Hexamethonium chloride ATC: C02 Use: ganglionic blocker, antihypertensive RN: 60-25-3 MF: CI2H3,Cl2N2 MW: 273.29 EINECS: 200-465-1 LD,,,: 26.7 mglkg (M, i.v.); 35 mgkg (dog, i.v.) CN: N, N, N,N,N,N-hexamethyl-1,6-hexanediaminium dichloride hexamethylenediamine dimethyl sulfate hexarnethanium sulfate (1) OH- OH- CI- CI- NaOH, C2H50H H3C\+/~~3 , , H3C\+ , H3C\+ CH3 hexamethonium hydroxide I Hexomethonium chloride Reference(s): DE 900 097 (May & Baker; appl. 195 1; GB-prior. 1950). Formulation(s): oral: 0.5 gld Trade Name(s): D: Raucombin forte (Voigt); Gastrometonio (Fabo; as w fm iodide); wfm 1: Gastrometonio (Fabo); J: Methobromin w fm (Yamanouchi); wfm Hexcarbacholine bromide ATC: M03 (Carbolonium bromide) Use: muscle relaxant RN: 306-41-2 MF: C,,H,,,Br,N,O, MW: 536.35 CN: N,N,N,N,N,N-hexamethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-,16-diaminiumdibromide H thionyl H H hem- ethylene methylene- carbonate diamine .
Load more

Recommended publications
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • Drug Discovery by Polypharmacology- Based Interaction Profiling
    Zoltán Simon Drug Discovery by Polypharmacology- based Interaction Profiling PhD thesis Supervisor: András Málnási-Csizmadia DSc. Structural Biochemistry Doctoral Program Doctoral School in Biology Program Leader: Prof. László Gráf DSc. Head of the School: Prof. Anna Erdei DSc. Eötvös Loránd University Budapest, Hungary 2010 A tudomány és művészet hazája nem a lét, az „esse”, hanem a lehetőség, a „posse”, s ha a létben megnyilvánul, attól a lét lesz gazdagabb; a tudomány és művészet részéről végtelen alázat, hogy a létben magát megnyilatkoztatni engedi, hiszen minden alakot-öltése fogyatékos. WEÖRES SÁNDOR Preface Since the first Venus statues carved by the prehistoric man, artists attempt to reach the divine and bring it from the heaven down to the earth, to the community. Similarly, science aspires to get acquainted with the phenomena of the world and to understand their nature. As no artist has ever been able to capture and artificially reproduce the ultimate Beauty, scientists have never found the Truth in its entirety. Art and science, as stated by Sándor Weöres in its work entitled Towards completeness, are necessarily incomplete and deficient in our world. Nevertheless, science struggles to understand the complex nexus of things for several thousand years. Recent methodical improvements, especially the rapidly increasing computational capacity and mathematical systems theory enable us to find answers or at least approximations for complex questions in a new, complex manner. Prediction of the behavior of drug molecules in the human body is one of the most complex questions. It is not surprising that pharmacology has not yet solved the problem of capturing the entire bioactivity profiles of small-molecule compounds.
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • A Abacavir Abacavirum Abakaviiri Abagovomab Abagovomabum
    A abacavir abacavirum abakaviiri abagovomab abagovomabum abagovomabi abamectin abamectinum abamektiini abametapir abametapirum abametapiiri abanoquil abanoquilum abanokiili abaperidone abaperidonum abaperidoni abarelix abarelixum abareliksi abatacept abataceptum abatasepti abciximab abciximabum absiksimabi abecarnil abecarnilum abekarniili abediterol abediterolum abediteroli abetimus abetimusum abetimuusi abexinostat abexinostatum abeksinostaatti abicipar pegol abiciparum pegolum abisipaaripegoli abiraterone abirateronum abirateroni abitesartan abitesartanum abitesartaani ablukast ablukastum ablukasti abrilumab abrilumabum abrilumabi abrineurin abrineurinum abrineuriini abunidazol abunidazolum abunidatsoli acadesine acadesinum akadesiini acamprosate acamprosatum akamprosaatti acarbose acarbosum akarboosi acebrochol acebrocholum asebrokoli aceburic acid acidum aceburicum asebuurihappo acebutolol acebutololum asebutololi acecainide acecainidum asekainidi acecarbromal acecarbromalum asekarbromaali aceclidine aceclidinum aseklidiini aceclofenac aceclofenacum aseklofenaakki acedapsone acedapsonum asedapsoni acediasulfone sodium acediasulfonum natricum asediasulfoninatrium acefluranol acefluranolum asefluranoli acefurtiamine acefurtiaminum asefurtiamiini acefylline clofibrol acefyllinum clofibrolum asefylliiniklofibroli acefylline piperazine acefyllinum piperazinum asefylliinipiperatsiini aceglatone aceglatonum aseglatoni aceglutamide aceglutamidum aseglutamidi acemannan acemannanum asemannaani acemetacin acemetacinum asemetasiini aceneuramic
    [Show full text]
  • I (Acts Whose Publication Is Obligatory) COMMISSION
    13.4.2002 EN Official Journal of the European Communities L 97/1 I (Acts whose publication is obligatory) COMMISSION REGULATION (EC) No 578/2002 of 20 March 2002 amending Annex I to Council Regulation (EEC) No 2658/87 on the tariff and statistical nomenclature and on the Common Customs Tariff THE COMMISSION OF THE EUROPEAN COMMUNITIES, Nomenclature in order to take into account the new scope of that heading. Having regard to the Treaty establishing the European Commu- nity, (4) Since more than 100 substances of Annex 3 to the Com- bined Nomenclature, currently classified elsewhere than within heading 2937, are transferred to heading 2937, it is appropriate to replace the said Annex with a new Annex. Having regard to Council Regulation (EEC) No 2658/87 of 23 July 1987 on the tariff and statistical nomenclature and on the Com- mon Customs Tariff (1), as last amended by Regulation (EC) No 2433/2001 (2), and in particular Article 9 thereof, (5) Annex I to Council regulation (EEC) No 2658/87 should therefore be amended accordingly. Whereas: (6) This measure does not involve any adjustment of duty rates. Furthermore, it does not involve either the deletion of sub- stances or addition of new substances to Annex 3 to the (1) Regulation (EEC) No 2658/87 established a goods nomen- Combined Nomenclature. clature, hereinafter called the ‘Combined Nomenclature’, to meet, at one and the same time, the requirements of the Common Customs Tariff, the external trade statistics of the Community and other Community policies concerning the (7) The measures provided for in this Regulation are in accor- importation or exportation of goods.
    [Show full text]
  • Methylnaltrexone Bromide
    含溴药物品种资料汇编 药智数据 编纂 简要说明： 本资料汇编由正文 100 页，附件 112 页构成。正文部分汇总了全部含溴药物， 包括曾经研究过、曾经上市应用、目前尚在应用以及目前尚在研的含溴药物，计 259 种。对于其中 15 种重点药物，在附件部分给出其合成方法、研发背景、药理、 药代、安全性、临床试验等方面详细的研究结果。 著录体例： 1，【别 名】，包括药物的试验编号、商标名称及其英文异名； 2，【名称来源】，指的是 WHO DI 网站上公布的推荐 INN 表和建议 INN 表， 例如，pINN-073,1995 rINN-036,1996 表示该 INN 名称来自于 1995 年的推荐 INN 第 73 表和 1996 年的建议 INN 第 36 表。 3，【中文 CADN】，指的是经国家药典委员会确定的中国药品通用名称，名 后注(97)，表示该名称见于《中国药品通用名称》（1997 年版）；名后注(GB4)， 表示该名称见于《国家药品标准工作手册》（第四版）。 4，【建议 CADN】，指的是第 3 条中所述两书均未收录，由《药智数据》根据 INN 和 CADN 命名规律而自拟的药品中文译名。 【英文 INN】acebrochol 【别 名】acebrocol 【名称来源】pINN-001,1953 rINN-001,1955 【中文 CADN】醋溴考尔 (97) 【建议 CADN】 【化学表述】Cholestan-3-ol, 5,6-dibromo-, acetate, (3β,5α,6β)- 【CA 登记号】[514-50-1] 【分 子 式】C29H48Br2O2 【结 构 式】 【品种类别】神经系统>催眠镇静药>其它 【英文 INN】azamethonium bromide 【别 名】 【名称来源】pINN-001,1953 rINN-001,1955 【中文 CADN】阿扎溴铵(GB4) 【建议 CADN】 【化学表述】3-methyl-3-azapentane-1,5-bis(ethyl dimethyl ammonium) bromide 【CA 登记号】[306-53-6] 【分 子 式】C13H33Br2N3 【结 构 式】 【品种类别】心血管系统>抗高血压药>双季铵盐类 【英文 INN】benzpyrinium bromide 【别 名】 【名称来源】pINN-001,1953 rINN-001,1955 【中文 CADN】苄吡溴铵(GB4) 【建议 CADN】 【化学表述】Pyridinium, 1-benzyl-3-(dimethylcarbamyloxy)-, bromide 【CA 登记号】[587-46-2] 【分 子 式】C15H17BrN2O2 【结 构 式】 【品种类别】拟胆碱药 英文 INN】bibrocathol 【别 名】Noviform 【名称来源】pINN-001,1953 rINN-001,1955 【中文 CADN】铋溴酚(97) 【建议 CADN】 【化学表述】4,5,6,7-Tetrabromo-2-hydroxy-1,3,2-Benzodioxabismole 【CA 登记号】[6915-57-7] 【分 子 式】C6HBiBr4O3 【结 构 式】 【品种类别】眼科用药>消毒防腐药>其它 【英文 INN】carbromal 【别 名】 【名称来源】pINN-001,1953 rINN-001,1955 【中文 CADN】卡溴脲(97) 【建议 CADN】 【化学表述】Butanamide, N-(aminocarbonyl)-2-bromo-2-ethyl- 【CA 登记号】[77-65-6]
    [Show full text]
  • Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes
    Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABACAVIR 136470-78-5 ACEXAMIC ACID 57-08-9 ABAFUNGIN 129639-79-8 ACICLOVIR 59277-89-3 ABAMECTIN 65195-55-3 ACIFRAN 72420-38-3 ABANOQUIL 90402-40-7 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABCIXIMAB 143653-53-6 ACITEMATE 101197-99-3 ABECARNIL 111841-85-1 ACITRETIN 55079-83-9 ABIRATERONE 154229-19-3 ACIVICIN 42228-92-2 ABITESARTAN 137882-98-5 ACLANTATE 39633-62-0 ABLUKAST 96566-25-5 ACLARUBICIN 57576-44-0 ABUNIDAZOLE 91017-58-2 ACLATONIUM NAPADISILATE 55077-30-0 ACADESINE 2627-69-2 ACODAZOLE 79152-85-5 ACAMPROSATE 77337-76-9 ACONIAZIDE 13410-86-1 ACAPRAZINE 55485-20-6 ACOXATRINE 748-44-7 ACARBOSE 56180-94-0 ACREOZAST 123548-56-1 ACEBROCHOL 514-50-1 ACRIDOREX 47487-22-9 ACEBURIC ACID 26976-72-7
    [Show full text]
  • Customs Tariff - Schedule
    CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2018 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT, CEUT, UAT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
    [Show full text]
  • Drug Discovery by Polypharmacology- Based Interaction Profiling
    Zoltán Simon Drug Discovery by Polypharmacology- based Interaction Profiling PhD thesis Supervisor: András Málnási-Csizmadia DSc. Structural Biochemistry Doctoral Program Doctoral School in Biology Program Leader: Prof. László Gráf DSc. Head of the School: Prof. Anna Erdei DSc. Eötvös Loránd University Budapest, Hungary 2010 A tudomány és művészet hazája nem a lét, az „esse”, hanem a lehetőség, a „posse”, s ha a létben megnyilvánul, attól a lét lesz gazdagabb; a tudomány és művészet részéről végtelen alázat, hogy a létben magát megnyilatkoztatni engedi, hiszen minden alakot-öltése fogyatékos. WE ÖRES SÁNDOR Preface Since the first Venus statues carved by the prehistoric man, artists attempt to reach the divine and bring it from the heaven down to the earth, to the community. Similarly, science aspires to get acquainted with the phenomena of the world and to understand their nature. As no artist has ever been able to capture and artificially reproduce the ultimate Beauty, scientists have never found the Truth in its entirety. Art and science, as stated by Sándor Weöres in its work entitled Towards completeness, are necessarily incomplete and deficient in our world. Nevertheless, science struggles to understand the complex nexus of things for several thousand years. Recent methodical improvements, especially the rapidly increasing computational capacity and mathematical systems theory enable us to find answers or at least approximations for complex questions in a new, complex manner. Prediction of the behavior of drug molecules in the human body is one of the most complex questions. It is not surprising that pharmacology has not yet solved the problem of capturing the entire bioactivity profiles of small-molecule compounds.
    [Show full text]
  • Pharmaabkommen A1 E
    Annex I - Pharmaceutical substances, which are free of duty_______________________________________________ Pharmaceutical substances which are Annex I free of duty CAS RN Name 136470-78-5 abacavir 129639-79-8 abafungin 792921-10-9 abagovomab 65195-55-3 abamectin 90402-40-7 abanoquil 183849-43-6 abaperidone 183552-38-7 abarelixe 332348-12-6 abatacept 143653-53-6 abciximab 111841-85-1 abecarnil 167362-48-3 abetimus 154229-19-3 abiraterone 137882-98-5 abitesartan 96566-25-5 ablukast 178535-93-8 abrineurin 91017-58-2 abunidazole 2627-69-2 acadesine 77337-76-9 acamprosate 55485-20-6 acaprazine 56180-94-0 acarbose 514-50-1 acebrochol 26976-72-7 aceburic acid 37517-30-9 acebutolol 32795-44-1 acecainide 77-66-7 acecarbromal 827-61-2 aceclidine 89796-99-6 aceclofenac 77-46-3 acedapsone 127-60-6 acediasulfone sodium 556-08-1 acedoben 80595-73-9 acefluranol 10072-48-7 acefurtiamine 70788-27-1 acefylline clofibrol 18428-63-2 acefylline piperazine 642-83-1 aceglatone 2490-97-3 aceglutamide 110042-95-0 acemannan 53164-05-9 acemetacin 131-48-6 aceneuramic acid 152-72-7 acenocoumarol 807-31-8 aceperone 61-00-7 acepromazine 13461-01-3 aceprometazine 42465-20-3 acequinoline 33665-90-6 acesulfame 118-57-0 acetaminosalol 97-44-9 acetarsol 59-66-5 acetazolamide 3031-48-9 acetergamine 299-89-8 acetiamine 2260-08-4 acetiromate 968-81-0 acetohexamide 546-88-3 acetohydroxamic acid 2751-68-0 acetophenazine 1 / 135 (As of: 1.4.2013) Annex I - Pharmaceutical substances, which are free of duty_______________________________________________ CAS RN Name 25333-77-1 acetorphine
    [Show full text]
  • Customs Tariff - Schedule Xxi - 1
    CUSTOMS TARIFF - SCHEDULE XXI - 1 Section XXI WORKS OF ART, COLLECTORS' PIECES AND ANTIQUES Issued January 1, 2013 CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2013 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT: Free Artificial bait; Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
    [Show full text]