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Molecular Pathology Tests Cleveland Clinic Laboratories Molecular Pathology Tests Molecular Cytogenetics IGK PCR (BIOMED-2 Primers) Chromosome Studies TCRB PCR (BIOMED-2 Primers) Postnatal: TCRG PCR (BIOMED-2 Primers) Peripheral blood IGH (Southern blot) Fibroblasts TCRß (Southern blot) Products of Conception: BCL2 mbr (PCR) CVS (chorionic villi) p210 BCR/ABL1( RT-PCR, quantitative) Placenta p190 BCR/ABL1( RT-PCR, quantitative) Skin BCR/ABL Kinase Domain Mutation Analysis Bone PML/RARA RT-PCR, qualitative Cancer: Nucleophosmin gene (NPM1) mutation analysis ** Bone Marrow FLT3 Gene Mutations Leukemic blood JAK2 V617F mutation (PCR) Lymph node Fluorescence in-situ hybridization Fatty tumors 5q Renal tissue ALK Chromosomal Microarray BCL2 Whole Genome microarray (Oligo array) BCL6 BCR/ABL1 Molecular Genetic Pathology BIRC3(API2)/MALT1 Alpha-1-Antitrypsin genotyping (S and Z alleles) CBFB/MYH11 (inv 16) CYP2C9 and VKORC1 Warfarin PGX CLL (13q,11q, 17p,+12) CYP2C19 Clopidogrel PGX ETV6/RUNX1 (TEL/AML1) CYP2D6 FGFR1 CYP2D6 Tamoxifen PGX IGH Cystic fibrosis [ACOG panel] (PCR) IGH/BCL2 DNA fingerprinting for identity (STR;PCR) IGH/CCND1 Factor V Leiden (PCR) IGH/MALT1 Fragile X syndrome (FMR1) DNA analysis (PCR) IGH/MYC HFE [Hereditary Hemochromatosis] (PCR) MALT1(18q21) MTHFR (PCR) MLL PLA1, PLA2 (PCR) MYC Progenitor cell engraftment monitoring (STR;PCR) Myelodysplasia (-5/5q, -7/7q,+8,-20q) Prothrombin G20210A (PCR) Plasma cell myeloma [13q, IGH, TP53, t(11,14), t(4;14), Transthyretin (TTR) exon sequencing t(14;16)] VWF exon 28 sequencing PDGFRA PDGFRB Molecular Hematopathology PML/RARA Alpha thalassemia (HBA1/2) gene deletions RARA B-cell clonality (IGH + IGK BIOMED-2 PCR) RUNX1/RUNX1T1 (AML1/ETO) T-cell clonality (TCRB + TCRG BIOMED-2 PCR) Trisomy 4, 10 and 17 IGH PCR (BIOMED-2 Primers) Continued on back **Performed at LabPMM 9500 Euclid Avenue | Cleveland, Ohio 44195 | 216.444.2200 | 800.628.6816 | clevelandcliniclabs.com ClevelandCleveland Clinic Clinic Laboratories Laboratories Molecular Microbiology FOXO1A (FKHR) Affirm (for vaginitis) FUS BK virus (FISH) HER2 (ERBB2) Chlamydia trachomatis (NAAT) MDM2 Clostridium difficile PCR SS18 (SYT) CMV detection (quantitative CMV PCR) LOH for 1p (PCR) Dimorphic fungi (probe analysis) LOH for 19q (PCR) EBV detection (quantitative EBV PCR) MGMT promoter methylation Enterovirus detection (RT-PCR) Microsatellite Instability (MSI) HBV detection (quantitative HBV PCR) PCA3 HCV genotyping (RT-PCR with reverse hybridization) Tests in Development HCV viral load (quantitative HCV RT-PCR) Acanthamoeba PCR HIV DNA PCR ACTA2 exon sequencing HIV viral load (quantitative HIV RT-PCR) Alpha-1 antitrypsin exon sequencing HPV DNA (high-risk types; hybrid capture) BK virus PCR, quantitative HSV PCR (for CSF) BRAF for Hairy Cell Leukemia Influenza A/Influenza B/RSV (multiplexed RT-PCR) CEBPA mutation analysis Legionella pneumophilia (PCR) COL3A1 exon sequencing Mycobacterium sp. identification (pyrosequencing and Constitutional Microarray: probe analysis) Whole Genome microarray (SNP array) Mycobacterium tuberculosis vs. NTM PCR FISH for aneusomy of chromosomes 7 & 17 Neisseria gonorrhoeae (NAAT) KIT AML mutation analysis Nocardia and other aerobic actinomycetes identification KIT D816V PCR (pyrosequencing) MLH1 methylation S. aureus and Candida albicans/C. glabrata from positive MPL mutation analysis blood cultures identification (FISH) Pneumocystis jiroveci (PCR) S. aureus (MRSA/MSSA) PCR (screens from nasal swabs ) PRKAG2 and LAMP2 Streptococcus Group A, probe analysis RT PCR for EWSR1 (gene rearrangement) Streptococcus Group B PCR RT PCR for SYT (gene rearrangement) Molecular Oncology Solid Tumor SNP chromosomal array BRAF mutational analysis Spectral Karyotyping EGFR mutational analysis Bone Marrow KIT mutational analysis GIST & Melanoma Blood KRAS mutational analysis Cell lines FISH for bladder CA recurrence Constitutional FISH: Fluorescence in-situ hybridization X cen on PB 1p Y cen on PB 19q SRY on PB ALK NSCLC FFPET XIST on PB ALK NSCLC ThinPrep SMAD3 exon sequencing DDIT3 (CHOP) TGFBR1 exon sequencing TGFBR2 exon sequencing EGFR EWSR1 Vascular Panel (ACTA2, COL3A1, SMAD3,TGFBR1, TGFBR2) 201301.017.1.
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