University of Miami

UNIVERSITY OF MIAMI CURRICULUM VITAE

1. DATE: October, 2014

I. PERSONAL 2. Name: Yeon S. Ahn 3. Home Phone: 4. Office Phone: (305) 243-6606 Fax: 243-4975 Wallace H Coulter (WHC) Platelet Laboratory: (305) 243-6703; Fax: 243-5957 5. Home Address: 6. Current Academic Rank: Professor 6a. Current Track of Appointment: Division of Hematology/Oncology 7. Primary Department: Medicine 8. Secondary or Joint Appointment: Dept. of Medicine 9. Citizenship: U.S. 10. Visa Type (if non-citizen): N/A

II. HIGHER EDUCATION 11. Institutional (institution; degree; date conferred): College of Liberal Arts and Science, Seoul National University, Seoul, Korea, 1958. Seoul National University School of Medicine, Seoul, Korea, M.D., 1964. 12. Non-institutional (description; dates): None 13. Certification, licensure (description; board or agency; dates): • Diplomat, American Board of Internal Medicine, 1970. • Diplomat, American Board of Internal Medicine, Hematology Subspecialty, 1972. • Diplomat, American Board of Internal Medicine, Medical Oncology Subspecialty, 1975. • Licensed to practice medicine in Florida, 1972.

III. EXPERIENCE 14. Academic (institutions; rank/status; dates): • Assistant Professor of Medicine, University of Miami School of Medicine, 1972-78. • Associate Professor of Medicine, University of Miami School of Medicine, 1978-1985.

1 • Chief, Hematology Service, Jackson Memorial Hospital (Main Teaching Hosp,UM), 1980 - 1990. • Director, Special Hematology Laboratory, Division of Hematology. 1990 - 1997 • Director, Wallace H. Coulter Platelet Laboratory, Dept. Medicine. 1997 - Present • Professor of Medicine and Oncology, Univ. of Miami School of Medicine, 1985 - present. 15. Hospital Appointments (institutions, dates): • Attending physician in Medicine and Hematology, Jackson Memorial Hospital, University of Miami Medical Center, 1972-present. • Attending physician in Medicine and Hematology, VA Medical Center, Miami, Florida, 1972- 1994. • Attending physician, University of Miami Hospital & Clinics, Miami, Florida, 1972-present. Teaching: • Mechanisms of Disease Course for sophomore medical students. Mechanisms of Disease Course for Ph.D. - M.D. students. • Physical Diagnosis Course for PhD/MD students. • Teaching Coordinator, Hematology Service, University of Miami Hospital and Clinics (1980 - 1985). 16. Non-Academic (employers; title; responsibilities; dates): None 17. Military (branch; rank; responsibilities; dates): Captain, Naval Officer, Korean Navy, 1964 - 1967.

IV. PUBLICATIONS

18. Books and Monographs Published (Book Chapters):

Ahn YS, Horstman LL, Ahn ER, Jy W and Jimenez JJ, Endothelial Microparticles: Biology, Function, Assay and Clinical Application [Chapter 175:1621-1636]. In: Endothelial Biomedicine (Ed. Aird WC). Univ. of Cambridge Press, Cambridge, MA, 2008. Jimenez JJ, Jy W, Mauro LM, Horstman LL, Bidot CJ and Ahn YS, Endothelial microparticles as vascular disease markers. In: Advances in Clinical Chemistry, Vol. 39, pp. 131-157. Elsevier Publications, Inc., San Diego, CA, 2005. Jy W, Horstman LL, Jimenez JJ, Minagar A and Ahn YS, Circulating cell-derived microparticles in thrombotic and inflammatory disorders [Ch. 5]. In: Inflammatory Disorders of the Nervous System (Eds. Minagar A and Alexander JS), pp. 91-102. Humana Press, Totowa, N.J., 2005. Jy W, Jimenez JJ, Horstman LL and Ahn YS, Platelets, coagulation and thrombosis [Ch. 8]. In: Interventional Cardiology Secrets (Eds. Marchena Ed and Ferrara A), pp. 42-50. Elsevier Press / Hanley and Belfus, NY, London, 2003. Ahn YS and Horstman LL, Idiopathic thrombocytopenic purpura: pathophysiology and management (Education Book). Int J Hematol 76(Suppl II): 123-131, 2002.(Presented, 29th World Congress of Int Soc Hematol, Seoul, Korea; Aug.)

2 Jy W and Ahn YS, The effects of calcium channel blockers on platelets and their application in the management of vascular diseases. In: Calcium Channels: Their properties, Functions, Regulation, and Clinical Relevance (Eds. Hurwitz L, Partridge LD and Leach JK), pp. 363-375. CRC Press, Boca Raton, FL, 1991. Ahn YS, Calcium channel blockers in thrombotic diseases. Adv Int Med 32: 137-154, 1987. Ahn YS, Promyelocytic Leukemia. In: Fundamental and Clinical Aspects of Internal Medicine (2nd edition), pp. 154-. Univ. of Miami, Miami, FL, 1981. Awad WW, Ahn YS and Byrnes JJ, Multiple myelomas and other disorders of immunoglobin secretory cells. In: Fundamental and Clinical Aspects of Internal Medicine (2nd edition), pp. 180-, Miami, FL, 1981. Harrington WJ and Ahn YS, Malignant lymphomas. In: Fundamental and Clinical Aspects of Internal Medicine (2nd edition), pp. 157-, Miami, FL, 1981. Harrington WJ and Ahn YS, Hemorrhagic diseases – General principles and disorders of platelets. In: Fundamental and Clinical Aspects of Internal Medicine (2nd edition), pp. 220-, Miami, FL, 1981. Ahn YS and Yunis AA, Antithyroid drugs and leukocytes. In: Drugs and Hematologic Reactions (Eds. Dimitrove NV and Nodine JH). Grune & Stratton, New York, NY, 1974.

19. Juried or Refereed Journal Articles:

Jy W, Gómez-Marín O, Salerno TA, Panos AL, Williams D, Horstman LL and Ahn YS, Pre-surgical levels of circulating cell-derived microparticles discriminate between patients with and without transfusion in coronary artery bypass graft surgery J. Thorac. Cadiov. Surg. 2014 (In press). Jy W, Johansen M, Bidot, C Jr, Horstman LL, Ahn YS. Red cell-derived microparticles (RMP) as hemostatic agent. Thromb Haemost 110(4):751-60. 2013. Jy W, Ricci M, Shariatmadar S, Gomez-Marin O, Horstman LH, and Ahn YS. Microparticles in stored red blood cells as potential mediators of transfusion complications. Transfusion;51(4):886- 9.2011. Horstman LL, Jy W, Ahn YS, Maghzi AH, Etemadifar M, Alexander JS, McGee JC, Minagar. Complement in neurobiology. Front Biosci; 17: 2921-60. 2011. Jy W, Horstman LL, Ahn YS: Microparticle size and its relation to composition, functional activity, and clinical significance. Semin Thromb Hemost; 36(8): 876-80. 2011. Fontana V, Dudkiewicz P, Ahn ER and Ahn YS, Danazol therapy combined with intermittent application of chemotherapy induces lasting remission in myeloproliferative disorders (MPD): an alternative for the elderly with advanced MPD. Hematology. 16 (2): 90-94, 2011. Corrales-Medina VF, Simkins J, Chirinos JA, Serpa JA, Horstman LL, Jy W, Ahn YS. Increased levels of platelet microparticles in HIV-infected patients with good response to highly active antiretroviral therapy. J Acquir Immune Defic Syndr.;54(2):217-8. 2010 Ahn YS: Triple play of H Pylori in ITP [Editorial]. Blood.115 (9):4155-4116, 2010 . Horstman LL, Jy W, Ahn YS, Zivadinov R, Maghzi AH, Etemadifar M, Alexander JS, Minagar A. Role of platelets in neuroinflammation: A wide-angle perspective. J Neurioinflamm;7:10, 2010. Horstman LL, Jy W, Bidot CJ, Ahn YS, Kelley RE, et al: Antiphospholipid antibodies: Paradigm in transition. J Neuroinflammation 6(3): 1-21, 2009. Horstman LL, Jy W, Bidot C, Nordberg ML, Minagar A, Alexander JS, Kelley RE, Ahn YS. Potential roles of cell-derived microparticls in ischemic brain disease. Neurol Res, 31:8:799-806, 2009. Ahn YS, Jy W, Horstman LL: Cell-derived microparticles: A mediator of inflammation in aortic valve stenosis? [Editorial]. Thromb Haemost; 99(4): 657-658, 2008.

3 Sheremata WA, Jy W, Horstman LL, Ahn YS, Alexander JS, Minagar A: Evidence of platelet activation in multiple sclerosis. J Neuroinflammation; 5:27-47, 2008 Fontana V, W Jy, Dudkiewicz P, Horstman L, E Ahn, C Bidot and Ahn YS, Increased procoagulant cell derived microparticles (C-MP) in patients with ITP after splenectomy. Thrombosis Research 22(5): 599-603, 2008. Fontana V, Dudkiewicz P, Jy W, Horstman L and Ahn YS, Interleukin-11 for treatment of hepatitis C- associated ITP. Acta Haematologica, 119(2); 126-32, 2008. Fontana V, W Jy, Dudkiewicz P, Horstman L, E Ahn, C Bidot and Ahn YS, Increased procoagulant cell derived microparticles (C-MP) in patients with ITP after splenectomy. Thrombosis Research 122(5): 599-603, 2008. Fontana V, Dudkiewicz P, Jy W, Horstman L and Ahn YS, Interleukin-11 for treatment of hepatitis C- associated ITP. Acta Haematologica, 119(2); 126-32, 2008. Jimenez J, Jy W, Mauro LM, Horstman LL, Fontana V and Ahn YS, Transendothelial migration of leukocytes is promoted by plasma from a subgroup of immune thrombocytopenic patients with small-vessel ischemic brain disease. Am J Hematol. 83:206-211, 2008. Fontana V, Dudkiewicz P, Horstman L, Tzakis AG and Ahn YS, Atypical chronic myeloid leukemia following treatement with tacrolimus in patients with organ transplants. Clinical Transplantation 22(2): 258-261, 2007. Bidot CJ, Horstman LL, Jy W, Jimenez JJ, BidotJr C, Ahn YS, Alexander JS, Gonzalez-Toledo E, Kelley RE and Minagar A, Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis. BMC Neurol 7:36, 2007. Horstman LL, Minagar A, Jy W, Bidot CJ, Jimenez JJ and Ahn YS, Cell-derived microparticles and exosomes in neuroinflammatory conditions [Review]. Int Rev Neurobiol 79: 227-268, 2007. Jy W, Tiede M, Bidot CJ, Horstman LL, Jimenez JJ, Chirinos J and Ahn YS, Platelet activation rather than endothelial injury identifies risk of thrombosis in subjects positive for antiphospholipid antibodies. Thromb Res 121:319-325, 2007. Fontana V, Dudkiewicz P, Horstman LL, Tzakis AG and Ahn YS. Atypical chronic myeloid leukemia following organ transplants. Clinical Transplant:22: 258-261, 2007. Ahn ER, Tiede MP, jy W, Bidot C, Fontana V and Ahn YS, Eradication of Helicobacter pylori improves platelet counts in chronic ITP patients. Acta Haematologica 116: 19-24, 2006. Arteaga R, Chirinos JA, Soriano AO, Jy W, Horstman LL, Jimenez J, Mendez A, Ferreira A, DeMarchena E and Ahn YS, Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Am J Cardiol 98: 70-74, 2006. Bidot CJ, Jy W, Horstman LL, Ahn ER, Yaniz M and Ahn YS, Antiphospholipid antibodies (APLA) in immune thrombocytopenic purpura (ITP) and antiphospholipid syndrome (APS). Am J Hematol 81: 391-396, 2006. Fontana V, Ahn YS, Horstman LL, Tzakis AG and O'Brian CB, Primary sclerosing cholangitis complicating plasma cell dyscrasia (PCD): Remission of PCD following liver transplant. Eur J Haematol 76: 167-170, 2006. Fontana V, Donna E, Dudkiewcz P, Ahn ER, Horstman L, Bidot CJ and Ahn YS, Interstitial lung disease (ILD) and severe ITP. Hematology 12(1): 75-80, 2006. Ahn ER, Lander G, Bidot CJ, Jy W and Ahn YS, Long-term remission from life-threatening hypercoagulable state associated with lupus anticoagulant (LA) following rituximab therapy. Am J Hematol 78(2): 127-129, 2005. Ahn YS, Cell-derived microparticles: "Miniature envoys with many faces" [Editorial]. J Thromb Haemost 3: 884-887, 2005. Bidot CJ, Jy W, Horstman LL, Ahn ER, Bidot L, Fontana V and Ahn YS, Antiphospholipid antibodies and platelet activation as risk factors for thrombosis in thrombocythaemia. Hematology 10(6): 451-456, 2005.

4 Bidot CJ, Jy W, Horstman LL, Ahn ER, Jimenez JJ, Yaniz M, Lander G and Ahn YS, Antiphospholipid antibodies in immune thrombocytopenic purpura tend to emerge in exacerbation and decline in remission. Br J Haematol 128: 366-372, 2005. Chirinos JA, Castrellon A, Zambrano JP, Jimenez JJ, Jy W, Horstman LL, Willens H, Castellanos A, Myerberg RJ and Ahn YS, Digoxin use is associated with increased platelet and endothelial cell activation in patients with non-valvular atrial fibrillation. Heart Rhythm 2(5): 525-529, 2005. Chirinos JA, Heresi GA, Velasquez H, Jy W, Jimenez JJ, Ahn ER, Horstman LL, Soriano AO, Zambrano JP, Peter A, Zambrano JP and Ahn YS, Elevation of endothelial microparticles, platelet and leukocyte activation in patients with venous thromboembolism. J Am Coll Cardiol 45(9): 467- 471, 2005. Chirinos JA, Zambrano JP, Virani SS, Jimenez JJ, Jy W, Ahn ER, Horstman LL, Castellanos A, Willens H, Myerberg RJ and Ahn YS, Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men. Am J Cardiol 95(10): 1258-1260, 2005. Jimenez JJ, Jy W, Mauro L, Horstman LL, Ahn ER, Ahn YS and Minagar A, Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes. Multiple Sclerosis 11(3): 310-315, 2005. Jy W, Jimenez JJ, Mauro LM, Horstman LL, Cheng P, Ahn ER, Bidot CJ and Ahn YS, Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor / ristocetin dependent pathway, rendering them resistant to dissociation. J Thromb Haemost 3(6): 1301-1308, 2005. Soriano AO, Jy W, Chirinos JA, Valdivia MA, Velasquez HS, Jimenez JJ, Horstman LL, Kett DH, Schein RMH and Ahn YS, Levels of endothelial and platelet microparticles and their interactions with leukcytes negatively correlate with organ dysfunction and predict mortality in severe sepsis. Crit Care Med 33(11): 2540-2546, 2005. Tiede M, Ahn ER, Jy W, Scagnelli T, Bidot CJ, Horstman LL, Jimenez JJ and Ahn YS, Life- threatening hypercoagulable state following splenectomy in ITP: Successful management with aggressive antithrombotic therapy and danazol. Clin Appl Thromb Hemost 11(3): 347-352, 2005. Ahn ER, Lander G, Jy W, Bidot C, Jimenez JJ, Horstman LL and Ahn YS, Differences of soluble CD40L in sera and plasma: Implications on CD40L assay as a marker of thrombotic risk. Thromb Res 114(2): 143-148, 2004. Ahn YS, Jy W, Jimenez JJ and Horstman LL, More on: Cellular microparticles: what are they bad or good for? [Letter. invited]. J Thromb Haemost 2: 1215-1216, 2004. (On review by J.M. Freyssinet JTH 2003, 1:1655.) Bernal-Mizrachi L, Jy W, Fiero C, McDonough E, Purow J, Velasquez HS, Jimenez JJ, Horstman LL, Ahn YS and DeMarchena E, Endothelial microparticles correlate with high-risk angiographic lesions in acute coronary syndromes. Int J Cardiol 97: 439-446, 2004. Ferreira AC, Peter A, Mendez AJ, Jimenez JJ, Mauro LM, Chirinos JA, Ghany R, Virani S, Garcia S, Horstman LL, Purow J, Jy W, Ahn YS and Marchena Ed, Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. Circulation 110(23): 3599-3603, 2004. Gonzalez-Quintero VH, Smarkusky L, Jimenez JJ, Mauro L, Jy W, Horstman LL, O'Sullivan M and Ahn YS, Elevated plasma microparticles: preeclampsia vs. gestational hypertension. Am J Obstet Gynecol 191(4): 1418-1424, 2004. Horstman LL, Jy W, Jimenez JJ and Ahn YS, Endothelial microparticles as markers of endothelial dysfunction (Review). Frontiers in Bioscience 9: 1118-1135, 2004.

5 Horstman LL, Jy W, Jimenez JJ, Bidot C and Ahn YS, New horizons in the analysis of circulating cell- derived microparticles (Review). Keio J Med [Tokyo] 53(4): 210-230, 2004.(Lectures delivered to Japan Society of Hematology (Nov. 28) and Keio School of Medicine (Dec 1); invited for publication by Editor) Jimenez JJ, Jy W, Horstman LL and Ahn YS, Measuring circulating cell-derived microparticles: six viewpoints [invited; Forum article]. J Thromb Haemost 2: 1850-1851, 2004. Jimenez JJ, Jy W, Mauro LM, Horstman LL, Soderland C and Ahn YS, Response to letter by Laurence [Invited]. Br J Haematol 125(3): 416, 2004. (Response to letter by J. Laurence, Br J Haematol 125(3):415.) Jy W, Horstman LL, Jimenez JJ and Ahn YS, Measuring circulating cell-derived microparticles [Forum Article]. J Thromb Haemost 2: 1842-1851, 2004. Jy W, Minagar A, Jimenez JJ, Sheremata WA, Mauro L, Horstman LL, Bidot CJ and Ahn YS, Endothelial microparticles (EMP) bind to monocytes to activate and enhance transmigration: Elevated circulating EMP-monocyte conjugates in multiple sclerosis. Frontiers Biosci 9: 3137- 3144, 2004. Bernal-Mizrachi L, Jy W, Jimenez JJ, Pastor J, Mauro L, Horstman LL, deMarchena E and Ahn YS, High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Amer Heart J 145(6): 962-970, 2003. Bidot CJ, Jy W, Horstman LL, Huang H, Jimenez JJ, Yaniz M and Ahn YS, Factor VII/VIIa: A new antigen in the antiphospholipid antibody syndrome. Br J Haematol 120: 618-626, 2003. Gonzalez-Quintero V, Jimenez J, Jy W, Mauro LM, Horstman L, O'Sullivan M and Ahn YS, Elevated plasma endothelial microparticles in preeclampsia. Am J Obstet Gynecol 189(2): 589-593, 2003. (with Introduction by the Editor) Jimenez JJ, Jy W, Mauro L, Soderland C, Horstman LL and Ahn YS, Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res 109: 175-180, 2003. Jimenez JJ, Jy W, Mauro LM, Horstman LL, Soderland C and Ahn YS, Endothelial microparticles released in thrombotic thrombocytopenic purpura express von Willebrand factor and markers of endothelial activation. Br J Haematol 123(5): 896-902, 2003. Jy W, Gaglione-DeCesare T, Kett DH, Huang H, Horstman LL, Jimenez JJ, Bidot CJ and Ahn YS, Life-threatening bleeding from refractory acquired FVIII inhibitor successfully treated with Rituximab. Acta Haematologica 109: 206-208, 2003. Preston RA, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Valle M, Aime G and Ahn YS, Effect of severe hypertension on endothelial and platelet microparticles. Hypertension 41: 211-217, 2003. Rosado MF, Donna E and Ahn YS, Challenging problems in advanced malignancy: Case 3. Imatiman mesylate-induced interstitial lung disease. J Medical Oncology 21(16): 3171-3173, 2003. Willens HJ, Ahn YS and Gallagher AJ, Evaluation and management of left atrial lymphoma guided by transesophageal echocardiology. Echocardiography 20(6): 561-562, 2003. Ahn YS, Horstman LL, Jy W, Jimenez JJ and Bowen B, Vascular dementia in patients with immune thrombocytopenic purpura (ITP). Thromb Res 107: 337-344, 2002. Ahn YS, Horstman LL, Jy W, Jimenez JJ and Bowen B, Vascular DUPE USE 176. Thromb Res 107: 337-344, 2002. Jy W, Jimenez JJ, Mauro LM, Ahn YS, Newton KR, Mendez AJ, Arnold PI and Schultz DR, Agonist- induced capping of adhesion proteins and microparticle shedding in cultures of human renal microvascular endothelial cells. Endothelium 9: 179-189, 2002. Jimenez J, Jy W, Mauro L, Horstman L and Ahn Y, Elevated endothelial microparticles in thrombotic thrombocytopenic purpura (TTP): Findings from brain and renal microvascular cell culture and patients with active disease. Br J Haematol 112: 81-90, 2001.

6 Minagar A, Jy W, Jimenez J, Mauro L, Horstman L, Ahn Y and Sheremata W, Elevated plasma endothelial microparticles in multiple sclerosis. Neurology 56(10): 1319-1324, 2001. Horstman LL and Ahn YS, Platelet microparticles: A wide-angle perspective. Crit Rev Oncol/Hematol 30: 111-142, 1999. Jy W, Mao WW, Horstman LL, Valant PA and Ahn YS, A flow cytometric assay of platelet activation marker P-selectin (CD62p) distinguishes heparin-induced thrombocytopenia (HIT) from HIT- with-thrombosis (HITT). Thromb Haemost 82: 1255-1259, 1999. Jy W, Horstman LL, Park H, Mao WW, Valant PA and Ahn YS, Platelet aggregates as markers of platelet activation: Characterization of flow cytometric method suitable for clinical applications. Am J Hematol 57(1): 33-42, 1998. Schultz DR, Arnold PI, Jy W, Valant PA, Gruber J, Ahn YS, Mao FW and Horstman LL, Anti-CD36 autoantibodies in thrombotic thrombocytopenic purpura and other thrombotic disorders: identification of an 85kd form of CD36 as a target antigen. Br J Haematol 103: 849-857, 1998. Sevush S, Jy W, Horstman LL, Mao WW, Kolodny L and Ahn YS, Platelet activation in Alzheimer's disease. Arch Neurol 55(4): 530-536, 1998. Valant PA, Jy W, Horstman LL, Mao WW and Ahn YS, Thrombotic thrombocytopenic purpura (TTP) plasma enhances platelet-leukocyte interaction in vitro. Br J Haematol 100: 24-32, 1998. Elgart GW, Sheremata W and Ahn YS, Cutaneous reaction to recombinant interferon beta-1b: The clinical and histologic spectrum [See also letter v39(5 prt 1):807-8]. J Am Acad Dermatol 37(4): 553-558, 1997. Harrington WJ, Kolodny L, Horstman LL, Jy W and Ahn YS, Danazol for paroxysmal nocturnal hemoglobinuria. Am J Hematol 54: 149-154, 1997. Katopodis JN, Kolodny L, Jy W, Horstman LL, DeMarchena EJ, Tao JG, Haynes DH and Ahn YS, Platelet microparticles and calcium homeostasis in acute coronary ischemias. Am J Hematol 54: 95-101, 1997. Ozner MD, Ahn YS, Horstman LL, Jy W, Kolodny L and Myerburg RJ, Chronic platelet activation and acute coronary syndromes in 13 middle-aged patients. Clin Appl Thromb Hemost 3(1): 46-53, 1997. Ahn YS, Jy W, Kolodny L, Horstman LL, Mao WW, Valant PA and Duncan RC, Activated platelet aggregates in thrombotic thrombocytopenic purpura: decrease with plasma infusions and normalization in remission. Br J Haematol 95: 408-415, 1996. Kolodny L, Horstman LL, Sevin BU, Brown H and Ahn YS, Danazol relieves refractory pruritus associated with myeloproliferative disorders and other diseases. Am J Hematol 51: 112-116, 1996. Moffat FL, Han T, ZhiMing L, Peck MD, Falk RE, Spalding PB, Jy W, Ahn YS, Chu AJ and Bourguignon LYW, Involvement of CD44 and the cytoskeletal linker protein, ankyrin, in human neutrophil bacterial phagocytosis. J Cellul Physiol 168: 638-647, 1996. Moffat FL, Han T, ZhiMing L, Peck MD, Jy W, Ahn YS, Spalding PB, Jy W, Chu AJ and Bourguignon LYW, Supplemental L-arginine HCl augments bacterial phagocytosis in human polymorphonuclear leukocytes. J Cellul Physiol 168: 26-33, 1996. Peck MD, Zhiming L, Han T, Wang W, Jy W, Ahn YS, Ziboh VA, Chu AJ and Bourguignon LYW, Fatty acid unsaturation increases expression and capping of murine lymphocyte CD44 and CD45. Nutrition 12(9): 616-622, 1996. Horstman LL, Jy W, Arce M and Ahn YS, Danazol distribution in plasma and cell membranes as related to altered cell properties: Implications for mechanism. Am J Hematol 50: 179-187, 1995. Horstman LL, Valle-Riestra BJ, Jy W, Wang F, Mao WW and Ahn YS, Desmopressin [DDAVP] acts on platelets to generate platelet microparticles and enhanced procoagulant activity. Thromb Res 79(2): 163-174, 1995.

7 Jy W, Horstman LL, Homolak D and Ahn YS, Electrophoretic properties of platelets from normal, thrombotic and ITP patients by doppler electrophoretic light scattering analysis. Platelets 6: 354- 358, 1995. Jy W, Horstman LL, Wang F, Duncan RC and Ahn YS, Platelet factor 3 in plasma fractions: Its relation to microparticle size and thromboses. Thromb Res 80(6): 471-482, 1995. Jy W, Mao WW, Horstman LL, Tao J and Ahn YS, Platelet microparticles bind, activate and aggregate neutrophils in vitro. BCMD (Blood Cells, Molecules and Diseases) 21(3): 217-231, 1995. Horstman LL, Jy W, Schultz DR, Mao WW and Ahn YS, Complement mediated fragmentation and lysis of opsonized platelets: Gender differences in sensitivity. J Lab Clin Med 123: 515-525, 1994. Dewanjee MK, Kapadvanjwala M, Mao WW, Jy W, Ahn YS, Ruzius K, Gafouripour AK, Serafine AN and Skakiannakis GN, A higher blood flow window of reduced thrombogenicity and acceptable fragmentation in a hollow fiber hemodialyzer. ASAIO J 39(3): M363-367, 1993. Dewanjee MK, Palatianos GM, Kapadvanjwala M, Novak W, Hsu LC, Jy W, Yaniz M, Ahn YS, Skakianakis GN and Kaiser GA, Increase in intraplatelet free calcium ion during extracorporeal circulation with a hollow fiber oxygenator: arterial filter and dynamics of platelet thrombosis on oxygenator and filter in a pig model. ASAIO J Lookup, 1993. Lee YJ, Horstman LL and Ahn YS, Danazol for Henoch-Schonlein Purpura. Ann Int Med 118: 827, 1993. Lee YJ, Horstman LL, Janania J, Reyes Y, Kelley R and Ahn YS, Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias. Thromb Res 72: 295-304, 1993. Jy W, Horstman LL, Arce M and Ahn YS, Clinical significance of platelet microparticles in autoimmune thrombocytopenias. J Lab Clin Med 119: 334-345, 1992. Rocha R, Horstman LL, Ahn YS, Mylvaganam R and Harrington WJ, Danazol therapy for cyclic thrombocytopenia. Am J Hematol 36: 140-143, 1991. Ahn YS, Efficacy of danazol in hematologic disorders. Acta Hematologica 84: 122-129, 1990. Ahn YS, Fernandez LF, Kim CI, Mylvaganum R, Temple JD, Cayer ML and Harrington(Sr) WJ, Danazol therapy renders red cells resistant to osmotic lysis. FASEB J 3: 157-162, 1989. Ahn YS, Rocha R, Mylvaganam R, Garcvia R, Duncan RC and Harrington WJ, Long-term danazol therapy in autoimmune thrombocytopenia: unmaintained remission and age-dependent response in women. Annals Int Med 111: 723-728, 1989. deMayolo JA and Ahn YS, Spontaneous remission of acute leukemia following termination of pregnancy. Cancer 63(8): 1621-1623, 1989. Mylvaganam R, Ahn YS, Garcia RO, Kim CI and Harrington WJ, Very low dose danazol in idiopathic thrombocytopenic purpura and its role as an immune modulator. Am J Med Sci 298(4): 215-220, 1989. Mylvaganam R, Ahn YS, Sprinz PG, Garcia RO and Harrington WJ, Sex differences in the CD4+ CD45R+ T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura. Clin Immunol Immunopath 54: 473-485, 1989. Mylvaganam R, Garcia RO, Ahn YS, Sprinz PG, Kim CI and Harrington WJ, Depressed functional and phenotypic properties of T but not B lymphocytes in idiopathic thrombocytopenic purpura. Blood 71: 1455-1460, 1988. Ahn YS, Harrington WJ and Mylvaganam R, Use of platelets as drug carriers for the treatment of hematologic diseases. Meth Enzymol 149: 312-326, 1987. Ahn YS, Jy W, Harrington WJ, Fernandez L and EtAl, Increased platelet calcium in thrombosis and related disorders and its correction by nifedipine. Thromb Res 45: 135-143, 1987. Ahn YS, Mylvaganam R and EtAl, Low dose danazol for ITP. Ann Int Med 107: 177-181, 1987. Jy W, Ahn YS, Harrington WJ and Haynes D, Abnormal calcium handling by platelets in thrombotic disorders. Circ Res 60(March): 346-355, 1987.

8 Mylvaganam R, Ahn YS, Harrington WJ and Kim CI, Immune modulation by danazol in autimmune thrombocytopenia. Clin Immunol Immunopath 42: 281-287, 1987. Shanbaky N, Ahn YS, Jy W and EtAl X, Abnormal aggregation and calcium handling of platelets in thrombosis. Hemost Thromb [Thromb Haemost?] 57: 1-10, 1987. Temple JD, Harrington WJ, Ahn YS and Rosenfeld E, Treatment of sickle cell disease with danazol. J Fla Med Assoc 73: 487-489, 1987. Mylvaganam R, Ahn YS and Kim CI, Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. Blood 66: 967-972, 1986. Ahn YS, Harrington WJ, Mylvaganam R, Ayub J and Pall LM, Danazol therapy for autoimmune hemolytic anemia. Ann Int Med 102(3): 298-301, 1985. Ahn YS, Harrington WJ, Mylvaganam R and EtAl, Danazol therapy in autoimmune hemolytic anemia (Reply to letter). Ann Int Med 298: 301, 1985. Ahn YS, Harrington WJ and EtAl, Vinca alkaloids and platelets. Ann Int Med 101: 570-, 1984. Ahn YS, Harrington WJ and EtAl, Vinca alkaloid loaded platelets (Reply to letter). N Engl J Med 311: 599, 1984. Ahn YS, Harrington WJ and Mylvaganam R, Immunosuppressive therapy of idiopathic thrombocytopenic purpura. Springer Semin Immunopathol 7: 35-42, 1984. Ahn YS, Harrington WJ, Mylvaganam R, Allen LM and Pall LM, Slow infusion of vinca alkaloid in the treatment of idiopathic thrombocytopenic purpura. Ann Int Med 100(2): 192-196, 1984. (Letters with replies in subsequent issues.) Junghans RP and Ahn YS, High dose IV gamma globulin to suppress alloimmune destruction of donor platelets. Amer J Med 76(3A): 204, 1984. Mylvaganam R, Sprinz PG, YS YSA and Harrington WJ, An animal model of alloimmune thrombocytopenia, I: The role of the mononuclear phagocytic system (MPS). Clin Imnunol Immunopathol 31: 163-170, 1984. Wang G, Ahn YS, Harrington WJ and Whitcomb C, Polycythemia vera and chronic lymphocytic leukemia during the course of idiopathic thrombocytopenic purpura. Cancer 58: 1770-1776, 1984. Ahn YS, Harrington WJ, Byrnes J and EtAl, Treatment of autoimmune hemolytic anemia with vinca alkaloids loaded platelets. JAMA 249: 2189-2194, 1983. Ahn YS, Harrington WJ, Simon SR, Mylvaganam R, Pall LM and So AG, Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med 308: 1396-1399, 1983. Harrington WJ, Ahn YS, Byrnes JJ, So AG, Mylvaganam R and Pall LM, Treatment of idiopathic thrombocytopenic purpura. Hospital Practice 18(9/83): 205-220, 1983. Penneys NS, Ahn YS and EtAl, Sinus histiocytosis with massive lymphadenopathy. A case with unusual skin involvemlent and a therapeutic response to vinblastine loaded platelets. Cancer 49: 1984-1988, 1982. Ahn YS, Clinical uses of macrophage inhibitors. Adv Int Med 25: 253-473, 1980. Ahn YS, Byrnes JJ, Harrington WJ, Cayer ML, Smith DS, Brunskill DE and Pall LM, The treatment of idiopathic thrombocytopenia with vincristine-loaded platelets. N Engl J Med 298: 1101-1107, 1978. Ahn YS and Harrington WJ, Treatment of idiopathic thrombocytopenia. Ann Rev Med 28: 299-309, 1977. Ahn YS and Harrington WJ, Platelet transfusions in clinical medicine. Adv Int Med 20: 379-398, 1975. Ahn YS and Harrington WJ, Vincristine therapy of thrombocytopenias (Reply to letter). N Engl J Med 292: 109, 1975. Ahn YS, Harrington WJ, Seelman RC and Eytel CS, Vincristine therapy of idiopathic and secondary thrombocytopenias. N Engl J Med 291: 376-380, 1974.

9 20a. Presentations at National / International Conferences:

Jy W, Johansen ME, Bidot C Jr., Pamukcu R, Gomez-Marin O, Ahn E, Horstman LL, and Ahn YS. Efficacy trial in an acute liver trauma animal model of novel infusible hemostatic product: red blood cell-derived microparticles (RMP). Blood 2013; 122(21):2342 (Abstract). (Presented at the 55th ASH meeting in Dec 2013. New Orleans, La). Jy W, Gomez-Marin O, Morgan JR, Johansen ME, Bidot C Jr., Shariatmadar S, and Ahn YS. Pre-surgical levels of circulating cell-derived microparticles are most significant predictors of transfusion requirement in coronary artery bypass graft surgery. Blood 2013; 122(21):2954 (Abstract). (Presented at the 55th ASH meeting in Dec 2013. New Orleans, La). Jy W, Gomez-Marin O, Morgan JR, Johansen ME, Bidot C Jr., Shariatmadar S, and Ahn YS. Pre-surgical levels of circulating cell-derived microparticles are most significant predictors of transfusion requirement in coronary artery bypass graft surgery. Blood 2013; 122(21):2954 (Abstract). (Presented at the 55th ASH meeting in Dec 2013. New Orleans, La). Ahn YS, Jy W, Horstman LL, Gomez-Marin O, Bidot C Jr., Johansen ME, Morgan J, Shariatmadar S. Residual platelets potentiate release of procoagulant and proinflammatory red cell microparticles (RMP) during blood storage. Presented orally at the 24th Regional Congress of the International Society of Blood Transfusion (ISBT) in December 2, 2013 at Kuala Lampur, Malaysia. Wenche Jy, Carlos J Bidot, Jr.,Max E Johansen, Lawrence L Horstman and Yeon S Ahn. Red Cell- Derived Microparticles (RMP) As Hemostatic Agent: Evaluation in a Rabbit Ear Bleeding Model. Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 2238. Presented in the 54th ASH meeting in Dec 2012, Atlanta, Ga. Wenche Jy, Carlos J Bidot, Jr., Tatsuro Yoshida, Ralph Vassallo, Jr., Max E Johansen, Lawrence L Horstman, John Morgan, Orlando Gomez-Marin, Sherry Shariatmadar, and Yeon S Ahn Release of Microparticles During Blood Storage Is Influenced by Residual Platelets, Leukocytes and Oxygen Levels. Blood Nov 2012; 120: 3435. Presented at ASH Meeting, Dec 2012, Atlanta, Ga.

Max E Johansen, Wenche Jy, Pamela B Dudkiewicz, and Yeon S Ahn. Red Cell Microparticles (RMP) and Other Cell-Derived Microparticles (C-MP) in Hemolytic Anemias. Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 5158. Jy W, Johansen ME, et al Hemostatic properties of red cell derived microparticles (RMP): Promise of universal hemostatic agent: To be presented at ISTH meeting in June 29, 2012, Liverpool, England. Jy W, Johansen ME, C Bidot J, Chen P, Horstman L, Ahn YS: Interaction of red cell microparticles (RMP) with platelets: Potential role of RMP in hemostasis and thrombosis. Blood 2011; (Ab#43127). (Presented 53rd meeting of ASH, San Diego, CA, Dec. 4-7. 2011) Jy W, Horstman L, Johansen ME, Ahn YS: Red cell-derived microparticles as hemostatic agent Haemophilia 2011; 17(Abst #41): 44. (Presented, 4th annual meeting of the European Association for Haemophilia and Allied Disorders. Feb. 2-4, 2011, Geneva, Switzerland.) Jy W, BidotJr C, Johansen ME, Horstman L, Shariatmadar S, Ricci M, Gomez-Marin O, Ahn YS: Red-Cell microparticles released from stored packed cells: possible contributing factor to adverse responses to transfusion. Blood 2010; 116(21): 154, Ab#342. [Presented, 52nd American Society of Hematology Annual Meeting, December 4-7; 2010. Orlando, FL]. Jy W, Horstman LL, Lin A, Bidot C Jr, Ahn YS: Elevated complement (C) and IgG bound microparticles (MP) in immune thrombocytopenic purpura (ITP) and hemolytic anemia (HA). Blood 114: 2991, 2009. (Presented, 50th mtng. Amer Soc Hematol.. New Orleans, LA, Dec. 5-8 ).

10 Horstman LL, Ahn YS, Esquenazi J, Jy W, Bidot CJ, Ortega C: Elevated cholinesterase activity in patients with TIA and other thrombotic disorders. Blood 114:2991, 2009 (Presented, 50th mtng. Amer Soc Hematol. New Orleans, LA. Dec 5-8) Bidot CJ, Ahn YS, Esquenosi J, Bidot CJr. Ortega C, Horstman LL, Dudkiewicz P, Jy W. Plasma cholinesterase activity in ITP patients with/without thrombosis. Blood 114:3997, 2009. (Presented. 50th mtng. Amer Soc Hematol, New Orleans, LA. Dec 5-8). Horstman LL, Esquenazi J, Jy W, Ahn YS: Increased acetylcholinesterase activity of microparticles derived from red cells (RMP) compared to platelets (PMP). Blood; 112(11) 2008: Ab3849. (Presented, ASH Meeting, Dec 11, 2008. San Francisco, CA.) Ahn ER, Byrnes JJ, Fontana V, Dudkiewicz P, Bidot CJ and Ahn YS, Recurrence of severe ITP following administration of G-CSF: remission following platelet and vinca-alkaloid infusion. Blood 110(11): 946a, Ab 3222, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Bidot CJ, Jy W, Ortega C, Horstman LL, Bidot C, Bidot L, Petit C, Fontana V, Yaniz M and Ahn YS, Increased prevalence of anti-CD36 and elevated endothelial microparticles in patients with recurrent thrombosis. Blood 110(11): 487a, Ab 1632, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Bidot L, Jy W, Horstman LL, BidotJr C, Fontana V, Jimenez JJ, Bidot CJ and Ahn YS, Surface adhesion and growth of microaggregates under flow condition (II): clinical findings in patients with thrombosis and thrombocytopenia. Blood 110(11): 1061a, Ab 3628, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Fontana V, Jy W, Ahn E, Bidot L, Dudkiewicz P, Horstman LL and Ahn YS, Effects of intravenous immunoglobulins (IVIG) on cell-derived microparticles in patients with ITP. Blood 110(11): 922a, Ab 3134, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Fontana V, Jy W, Dudkiewicz P, Ahn E, Horstmann L and Ahn YS, Cell-derived microparticles in ITP patients with vs. without bleeding tendency. Blood 110(11): 623a, Ab 2092, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Fontana V, Jy W, Horstman L, Dudkiewicz P, Ferndandez C, BidotJr C and Ahn YS, Elevated red cell microparticles (RMP) as risk factor for thrombosis in patients with renal failure. Blood 110(11): 488a, Ab 1638, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Jy W, Bang J, Jimenez JJ, Horstman LL, Bidot L, White JG and Ahn YS, Red cells release microparticles heterogeneous in phenotype, procoagulant activities, and size under different conditions. Blood 110(11): 514a, Ab 1726, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Jy W, Jimenez JJ, Bidot L, Bang J, Horstman LL, Bidot CJ, Fontana V and Ahn YS, Surface adhesion and growth of microaggregates under flow conditions (I): role of cell-derived microparticles and leukocytes. Blood 110(11): 1087a, Ab 3725, 2007. (Presented, 49th mtn'g, Amer. Soc. Hematol., Atlanta, GA, Dec. 8-11.) Ahn ER, Jy W, LBidot, Byrnes J, Jimenez JJ, Andrews D, Shariatmadar S and Ahn Y-S, Danazol increases ADAMTS13 activity and reduces requirement for therapeautic exchange plasmapheresis (TEP) and plasma infusion in patients with TTP. Blood 108(11): 314a (Ab1057), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Ahn YS, Horstman LL, Fontana V, Jimenez JJ and Ahn ER, Microparticles from RBC (RMP) exhibit hemostatic activities in vitro and in vivo, and appear to protect ITP patients from thrombocytopenic bleeding. Atherosclerosis [Supl.] 7(3): 292, Abst Tu-P10:486, 2006.(Presented at: XIV International Symposium on Atherosclerosis, Rome, Italy, June 18-22.) Bidot L, Jy W, BidotJr C, Fontana V, Horstman LL, Ahn E, Bidot CJ and Ahn Y-S, Recurrent thrombosis is frequently associated with increased microparticle-mediated thrombin generation.

11 Blood 108(11): 427a (Ab1479), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Corrales-Medina VF, Simkins J, Chirinos JA, Lopez-Sanabria B, Symes S, Jayaweera DT, Jy W, Jimenez JJ, Horstman LL and Ahn Y-S, Platelet microparticles, platelet activation and platelet- leukocyte conjugates in HIV infected patients with optimal response to highly active antiretroviral therapy (HAART). Blood 108(11): 426a (Ab1473), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Fontana V, Dudkiewicz P, Ahn E, Jy W, Horstman LL, Yaniz M and Ahn Y-S, Profile of cell-derived microparticles (C-MP) in ITP: red cell microparticles (RMP) correlate with severity of ITP. Blood 108(11): 324a (Ab1087), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Fontana V, Jy W, Dudkiewicz P, Bidot L, Gonzalez M, Yaniz M and Ahn Y-S, Elevated cell-derived microparticles (C-MP) in myeloproliferative disorders (MPD): high red cell microparticles (RMP) as risk factor for thrombosis. Blood 108(11): 428a (Ab1483), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Fontana V, Jy W, Dudkiewicz P, Horstman LL, Bidot CJ and Ahn Y-S, Cell-derived microparticles (C-MP) are elevated in splenectomized patients and depressed in those with hypersplenism, suggesting spleen as scavenger of C-MP. Blood 108(11): 428 (Ab1482), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Jimenez JJ, Ferreira A, Dodson HJ, Lens KM, Mauro LM, Jy W, Peter A, Marchena ED, Horstman LL and Ahn Y-S, Association of endothelial microparticles (EMP) and endothelial progenitors with serum cholesterol levels. Blood 108(11): 516a (Ab1819), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Jimenez JJ, Jy W, Mauro LM, Lens KM, Byrnes JJ, Shariatmadar S, Dodson HJ, Andrews D, Horstman L and Ahn Y-S, Microparticles are active components of therapeutic plasma exchange: correlation with ADAMTS13 activity in patients with thrombotic thrombocytopenic purpura. Blood 108(11): 289a (Ab959), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Jimenez JJ, Jy W, Mauro LM, Lens KM, Daghistani N, Dodson HJ, Horstman LL and Ahn Y-S, Activation of endothelial cells (EC) leads to release of inhibitory endothelial microparticles (EMP) and decreased intracellular ADAMTS13 activity. Blood 108(11): 513a (Ab1810), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Jy W, Ahn YS, Horstman LL, Jimenez JJ, Ahn ER and Fontana V, Microparticles from RBC (RMP) exhibit hemostatic activities in vitro and in vivo, and appear to protect ITP patients from thrombocytopenic bleeding. Atherosclerosis [Supl.] 7(3): 291, Abst Tu-P10:485, 2006.(Presented at: XIV International Symposium on Atherosclerosis, Rome, Italy, June 18-22.) Jy W, Bang J, Bidot L, Lin A, Jimenez JJ, Fontana V, Ahn E and Ahn Y-S, Evidence of different subspecies of microparticles (MP) derived from red blood cells (RMP) and comparison of their phenotypes and procoagulant activity. Blood 108(11): 500a (Ab1763), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Jy W, Bidot L, Jimenez JJ, Horstman LL, Bang J, Lin A, ZambranoJr W, Ahn E and Ahn Y-S, Thrombin generation profiles are qualitatively and quantitatively distinct in microparticles derived from red cells (RMP), platelets (PMP), and endothelia (EMP). Blood 108(11): 499a (Ab1759), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Jy W, Jimenez JJ, Mauro LM, BidotJr C, Horstman LL, Yaniz M, Gonzalez M and Ahn Y-S, Multiple species of endothelial microparticles (EMP) released from different membrane protein clustering domains exhibit distinctive phenotypes and activities. Blood 108(11): 511a (Ab1802), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.)

12 Jy W, Lin A, Bidot L, Bang J, Ahn E, Horstman LL, Jimenez JJ, Bidot CJ and Ahn Y-S, A significant fraction of ADAMTS13 activity is associated with activated platelets and their microparticles (PMP): implication for regulating ADAMTS13 activity. Blood 108(11): 317a (Ab1057), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Simkins J, Corrales-Medina VF, Chirinos JA, Symes S, Jayaweera DT, Espinoza L, Jimenez JJ, Jy W, Horstman LL and Ahn Y-S, Endothelial microparticles (EMP) and their interactions with leukocytes in HIV infected patients with optimal response to highly active antiretroviral therapy (HAART). Blood 108(11): 369a (Ab1255), 2006. (Presented at 48th annual mtng, Amer. Soc. Hematol., Orlando, FL, Dec. 9-12.) Ahn E, Jy W, Bidot C, Horstman L, Fontana V and Ahn YS, ITP developing in spouses of patients with chronic ITP: "Spousal ITP". J Thromb Haemost 3(supl 1): Ab #P0919, 2005. (Presented, XXth Congress of ISTH, Aug. 6-12, Sydney, Australia.) Ahn ER, Podack E, Jy W, Bidot CJ, Horstman LL and Ahn YS, Soluble CD30 (sCD30), a marker of Th2 polarization, is elevated in patients with autoimmune hemolytic anemia (AIHA) but not idiopathic thrombocytopenia (ITP). Blood 106(11): 363a #1248, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Bidot C, Jy W, Fontana V, Ahn E, Horstman L and Ahn Y, Antiphospholipid antibodies and platelet activation as thrombotic risk factors in thrombocythemia associated with myeloproliferative disorder. J Thromb Haemost 3(supl 1): Ab #P0999, 2005. (Presented, XXth Congress of ISTH, Aug. 6-12, Sydney, Australia.) Bidot CJ, Jy W, Horstman LL, Ahn E, Fontana V, Valdes Y, Llano R, Bidor L and Ahn YS, Profiles of antibodies specific to platelet glycoproteins in ITP differ in remission, relapse and stable phases; and anti-GpIIb/IIIa, -GpIb/IX were associated with bleeding manifestations. Blood 106(11): 364a #1250, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Chirinos JA, Castrellon A, Jy W, Horstman LL, Jimenez JJ, Willens HJ, Castellanos A, Myerburg RJ and Ahn YS, Endothelial microparticles, platelet and leukocyte activation and cellular interactions in patients with non-valvular atrial fibrillation. Blood 106(11): 739a #2633, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Chirinos JA, Castrellon A, Soriano AO, Arteaga R, Heresi GA, Velasquez H, Jy W, Jimenez JJ, Horstman L, Ahn E and Ahn YS, Endothelial microparticle binding to neutrophils is an important determinant of neutrophil activation in vivo in different clinical conditions. J Thromb Haemost 3(supl 1): Ab #P1763, 2005. (Presented, XXth Congress of ISTH, Aug. 6-12, Sydney, Australia.) Fontana V, Ahn YS, Donna E, Dudkiewicz P, Ahn E, Horstman L and Bidot C, Interstitial pulmonary lesions in patients with recurring severe ITP. J Thromb Haemost 3(supl 1): Ab #P0917, 2005. (Presented, XXth Congress of ISTH, Aug. 6-12, Sydney, Australia.) Fontana V, Bidot CJ, Jy W, Ahn ER, Horstman LL and Ahn YS, Hepatitis C associated ITP: High incidence of autoantibodies specific to platelet glycoproteins and favorable response to IL-11. Blood 106(11): 363a #1247, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Fontana V, Jy W, Dudkiewicz P, Bidot CJ, Jimenez JJ and Ahn YS, Increased procoagulant cell- derived microparticles (MP) in splenectomized patients with ITP: new predisposing factors for thrombosis. Blood 106(11): 740a #2637, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Horstman LL, Bidot CJ, Jy W, Fontana V, Duckiewicz P, Ahn ER, Jimenez JJ and Ahn YS, New role of antiphospholipid antibodies (APLA)? Correlations with disease activity in non-thrombotic and thrombotic autoimmune and hematologic disorders. Blood 106(11): 744a #2649, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.]

13 Jimenez JJ, Jy W, Mauro LM, Mauro AC, Horstman LL and Ahn YS, Endothelial microparticles (EMP) inhibit ADAMTS13 activity: Implications in thrombotic thrombocytopenic purpura. Blood 106(11): 1024a #3676, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Jy W, Jimenez JJ, Bidot CJ, Horstman LL, Ahn YS and Minagar A, Antiphospholipid antibodies in multiple sclerosis are exclusively IgM class, and occur prediminately in exacerbations. Neurology 64(6, supl 1): A194 (Ab #PQ3.123), 2005.(Presented, 57th annual meeting of the American Acadamy of Neurology, Apr 9-16, Miami Beach, FL) Jy W, Jimenez JJ, Horstman LL, Mauro LM, Bidot CJ, Yaniz M, Gonzalez M, Ahn ER, Bidot CJ and Ahn YS, Microparticles derived from platelets (PMP), endothelia (EMP), and leukocytes (LMP) exhibit distinctive hemostatic and inflammatory activities. Blood 106(11): 1029a #3699, 2005. [Presented, meeting of the American Society of Hematology (ASH), Dec. 10-13, Atlanta, GA.] Ahn ER, Fein S, Lander G, Jy W, Garcia M, Bidot CJ and Ahn YS, Rituximab induces long lasting serological and clinical remission in refractory antiphospholipidsyndrome (APS) and related disorders. Blood 104(11): 826a (Ab3024), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Arteaga R, Soriano AO, Chirinos JA, Jy W, Gonzalez M, Yaniz M, Horstman LL, JimÈnez JJ and Ahn YS, Elevated endothelial microparticles (EMP) and platelet activation in patients with the metabolic syndrome (MTS) at low to intermediate risk for cardiovascular diseases. Diabetes Vasc Res 1(Supl S34-6), 2004.(Presented at First World Congress on Insulin Resistence, WHERE? WHEN?) Bidot CJ, Jy W, Jimenez JJ, Horstman L, Ahn E, Lander G, Yaniz M, Fontana V and Ahn YS, Antiphospholipid antibodies, platelet and endothelial activation in acute thrombocytopenic purpura (TTP). Blood 104(11): 242a (Ab847), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Castrellon A, Chirinos JA, Zambrano JP, Jy W, Horstman LL, Ahn ER, Jimenez JJ, Willens H, Castellanos A, Myerburg RJ and Ahn YS, Platelet activation promotes formation of platelet- leukocyte conjugates (PLC) in non-valvular atrial fibrillation. Blood 104(11): 957a (Ab3513), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Chirinos JA, Castrellon A, Zambrano JP, Jy W, Horstman LL, Ahn ER, Jimenez JJ, Willens H, Castellanos A, Myerberg RJ and Ahn YS, Platelet activation promotes formation of platelet leukocyte conjugates (PLC) in non-valvular atrial fibrillation (AF). J Am Coll Cardiol 45(3; supl 1), 2004.(Presented, annual meeting of the American College of Cardiology, Orlando, FL, DATE? PUBLISH 2004 OR as my notes say 2005?)) Chirinos JA, Castrellon A, Zambrano JP, Willens H, Castellanos A, Myerberg RJ and Ahn YS, Digoxin use is associated with increased platelet and endothelial cell activation in patients with non-valvular atrial fibrillation. Heart Rhythm 27: S5, 2004.(Presented, annual meeting of the Heart Rhythm Society, San Francisco, CA, in May) Chirinos JA, Garcia S, Jimenez J, DelCarpio F, Lascano J, Jy W, Jimenez JJ, Ahn ER, Horstman LL, Pham SM, Bauerlein J, Mallon S and Ahn YS, Endothelial cells switch from activation to apoptosis post heart transplantation. J Cardiac Failure 10(4): S59, 2004.(Presented, 8th annual meeting of the Heart Failure Society of America, Toronto, Ontario, Canada, Sept. __, 2004.) Chirinos JA, Heresi GA, Velasquez H, Soriano AO, Jy W, Ahn ER, Jimenez JJ, Horstman LL, Peter A, Zambrano JP and Ahn YS, Leukocyte activation, platelet activation and formation of platelet leukocyte conjugates in venous thromboembolism. J Am Coll Cardiol 45(3; supl 1), 2004. (Presented, annual meeting of the American College of Cardiology, Orlando, FL, DATE???) Chirinos JA, Tiede M, Jy W, Bidot CJ, Horstman LL, Jimenez JJ, Ahn ER and Ahn YS, Endothelial injury is common in antiphospholipid-positive patients but risk of thrombosis depends on platelet activation. Blood 104(11): 143a (Ab490), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.)

14 Chirinos JA, Velasquez H, Canoniero M, Soriano AO, Bernal-Mizrachi L, Jy W, Horstman LL, Jimenez JJ, DeMarchena E, Ferreira A and Ahn YS, Levels of GP-IIb/IIIa positive platelet microparticles (PMP) but not CD31+/CD42+ PMP predict adverse outcomes in troponin-negative patients with chest pain. Blood 104(11): 707a (Ab2583), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) DelCarpio F, Chirinos JA, Jimenez J, Lascano J, Castrellon A, Garcia S, Jy W, Jimenez JJ, Horstman LL, Ahn ER, Bauerlein J, Mallon S and Ahn YS, Endothelial, platelet, and leukocyte activation in patients with congestive heart failure. J Cardiac Failure 10(4): S55, 2004.(Presented, 8th annual meeting of the Heart Failure Society of America, Toronto, Ontario, Canada, Sept. __, 2004.) DelCarpio F, Chirinos JA, Jimenez J, Lascano J, Mallon S, Castrellon A, Jy W, Garcia S, Jimenez JJ, Horstman LL, Ahn ER and Ahn YS, Poor Minnesota Living With Heart Failure scores are associated with decreased endothelial cell apoptosis, increased leukocyte activation, and increased endothelial cell-leukocyte interaction in patients with congestive heart failure. J Cardiac Failure 10(4): S60, 2004.(Presented, 8th annual meeting of the Heart Failure Society of America, Toronto, Ontario, Canada, Sept. __, 2004.) Garcia S, Chirinos JA, Jimenez J, DelCarpio F, Lascano J, Jy W, Jimenez JJ, Ahn ER, Horstman LL, Pham SM, Bauerlein J, Mallon S and Ahn YS, Endothelial cells switch from activation to apoptosis post heart transplantation. J Am Coll Cardiol 45(3; supl 1), 2004.(Presented, annual meeting of the American College of Cardiology, Orlando, FL, in March.) Horstman LL, Jy W, Bidot CJ, Jimenez JJ and Ahn YS, Tissue factor (TF) activity in trauma patients is supressed on cell-derived microparticles (MP). Blood 104(11): 297a Ab#1040, 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Jimenez JJ, Jy W, Mauro LM, Markou NM, BurkeIII GW, Horstman LL and Ahn YS, Circulating CD62E occurs in soluble form as well as bound to endothelial microparticles (EMP): Functional differences in platelet aggregation in thrombotic thrombocyopenic purpua (TTP). Blood 104(11): 718a (Ab2624), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Jy W, High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Cytometry [Part B, Clinical]:, 2004. (Presented, oral lecture, 19th annual mtng of The Clinical Cytometry Society, Oct. 17-19, Long Beach, CA.) Jy W, Jimenez JJ, Cheng P, Mauro LM, Horstman LL, Ahn ER, Bidot CJ and Ahn YS, Endothelial microparticles (EMP) bind and complex with unusually-large multimers of von Willebrand factor (ULvWF) and act as potent inducers of platelet adhesion and aggregation. Blood 104(11): 997a (Ab3667), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Soriano AO, Chirinos J, Valdivia MA, Velasquez HS, Jy W and Ahn YS, Reduced levels of activation markers of inflammatory cells are associated with and predict higher mortality in sepsis. Am J Resp Crit Care Med 169(Supl to vol 9), 2004. (Presented at American Thoracic Society Annual Scientific Meeting, Orlando, FL, May 2004.) Soriano AO, Chirinos JA, Jy W, Horstman LL, Valdivia MA, Velasquez HS, Jimenez JJ and Ahn YS, Endothelial microparticles (EMP) expresing CD31 but not CD62E correlate with improved survival in sepsis patients. Blood 104(11): 718a (Ab2625), 2004. (Presented, 46th ASH, Dec. 4-7, San Diego, CA.) Virani S, Chirinos JA, Zambrano JP, Jimenez JJ, Jy W, Ahn ER, Horstman LL, Castellanos A, Myerberg RJ and Ahn YS, Correlation between apoptotic endothelial microparticles and subclinical inflammation in healthy individuals. J Am Coll Cardiol 45(3; supl 1), 2004.(Presented, annual meeting of the American College of Cardiology, Orlando, FL, in March) Ahn ER, Tiede MP, Bidot C, Jy W, Yaniz M, Gonzalez M, Marcelo B and Ahn YS, Eradication of Helicobacter pylori improves platelet counts in chronic ITP patients. Blood 102(11): 297a (Ab 1063), 2003. (Presented, 45th ASH meeting, Dec 6-9, San Diego, CA.)

15 Bidot CJ, Jy W, Ahn ER, Tiede MP, Horstman LL, Yaniz M, Jimenez JJ and Ahn YS, IgM antibodies to platelet glycoproteins are more prevalent in chronic stable ITP than in acute exacerbations of remissions. Blood 102(11): 295a (Ab 1054), 2003.(Presented, 45th ASH meeting, Dec 6-9, San Diego, CA.) Bidot CJ, Tiede MP, Jy W, Horstman LL, Ahn ER, Yaniz M, Jimenez JJ and Ahn YS, Antiphospholipid antibodies (APA) are prevalent in patients with thrombocytosis (TS) and are associated with thrombotic complications. Blood 102(11): 787a (ab 2910), 2003. (Presented, 45th ASH meeting, Dec 6-9, San Diego, CA.) Heresi GA, Chirinos JA, Velasquez H, Zambrano JP, Soriano AO, Horstman LL, Jy W and Ahn YS, Elevated endothelial microparticles (EMP) and activation markers of platelets and leukocytes in venous thromboembolism (VTE). Blood 102(11): 804a (Ab 2977), 2003. (Presented, 45th mtng of ASH, Dec 6-9, San Diego, CA) Horstman LL, Cast L, Jy W, Jimenez JJ, Proctor K and Ahn YS, Tissue factor activity is controlled by its inhibitor and redox state: Findings in endothelial microparticles, monocytes, and a porcine trauma model. J Thromb Haemost TBA, 2003. (Presented, 49th Annual ISTH Congress, Birmingham, U.K., July 12-18.) Jimenez JJ, Jy W, Mauro LM, Ahn ER, Horstman LL and Ahn YS, Plasma from patients with ITP- associated dementia (ITPAD) activates endothelial cells (EC) and enhances transendothelial migration of leukocytes (TEML). Blood 102(11): 294a (Ab 1052), 2003.(Presented, 45th mtng of ASH, Dec 6-9, San Diego, CA) Jy W, Jimenez JJ, Mauro LM, Horstman LL, Bidot CJ, Tiede MP, Ahn ER and Ahn YS, Endothelial microparticles (EMP) interact with platelets via a vWF dependent pathway to form platelet aggregates, more resistant to dissociation than those induced by soluble vWF. Blood 102(11): 783a (Ab 2896), 2003. (Presented, 45th ASH meeting, Dec 6-9, San Diego, CA.) Horstman LL, Cast L, Jy W, Jimenez JJ, Proctor K and Ahn YS, Tissue factor activity is controlled by its inhibitor and redox state: Findings in endothelial microparticles, monocytes, and a porcine trauma model. J Thromb Haemost TBA, 2003. (Presented, 49th Annual ISTH Congress, Birmingham, U.K., July 12-18.) Bernal-Mizrachi L, Fiero C, Macdonough E, Purow J, Jy W, Velazques SA, Jimenez JJ, Horstman LL, Ahn YS and DeMarchena E, Endothelial microparticles correlate with high-risk angiographic lesions in acute coronary syndromes. J Am Coll Cardiol 39(5 Supl A): 273A (Abst #881-6), 2002. (Presented orally, 51st mt'g, American College of Cardiology, Atlanta, GA, Mar 20.) Bidot CJ, Jy W, Horstman LL, Jimenez JJ, Yaniz M and Ahn YS, Target antigens of antiphospholipid antibodies in idiopathic thrombocytopenic purpura (ITP) and its clinical significance. Blood 100(11): 4801 (Abst #1865), 2002.(Presented, 44th ASH mt'ng, Philadelphia, PA, Dec. 8.) Jimenez JJ, Jy W, Mauro LM, Valle MS, Horstman LL and Ahn YS, Activation-derived endothelial microparticles (EMP) are elevated in thrombotic thrombocytopenic purpura (TTP): Detection of von Willebrand factor (vWf)-positive EMP during the acute phase of TTP. Blood 100(11): 16a (Abst #47), 2002. (Presented orally 44th ASH mt'g, Philadelphia, PA, Dec 6-10.) Jy W, Jy W, Jimenez JJ, Minagar A, Mauro L, Horstman LL, Bidot CJ, Sheremata WA and Ahn YS, Endothelial microparticles (EMP) enhance adhesion and transmigration of monocytes: EMP- monocyte conjugates as a marker of disease activity in multiple sclerosis (MS). Blood 100(11 Prt 2): 460a (Abst #1783), 2002. (Presented, 54th ASH mt'g, Philadelphia, PA, Dec 6-10.) Ahn YS, Horstman LL, Jy W, Jimenez JJ and Scagnelli T, Thrombotic complications in patients with ITP. Thromb Haemost (July Suppl, CD/ROM): Abst #P1943, 2001.(Presented, XVIII Congress of ISTH, Paris, France, July 6-12.) Gonzalez-Quintero V, Horstman L, Jy W, Tolaymat L, Jimenez J, Bidot C, OSollivan M and Ahn YS, Elevated endothelial microparticles in preeclampsia. Amer J Obstet Gynecol 185(6 part 2): No.14, 2001.(Presented orally, Jan 17.)

16 Jimenez JJ, Jy W, Mauro L, Valle M, Horstman LL and Ahn YS, Endothelial cells (EC) release phenotypically distinct endothelial microparticles (EMP) in activation vs. apoptosis: Findings in TTP patients. Blood 98(11): 249a (Ab#1045), 2001. (Presented, 43rd ASH mt'g, Orlando, FL, Dec 7-11.) Jimenez JJ, Jy W, Mauro LM, Horstman LL, Bernal-Mizrachi L and Ahn YS, Phenotypic chararacterization of microvascular endothelial cells (MVEC) and endothelial microparticles: Activation vs. apoptosis. Thromb Haemost (July Sup'l CD/ROM): Abst #OC980, 2001.(Presented, XVIII Congress of ISTH, Paris, France, July 6-12.) Jy W, Jimenez JJ, Mauro L, Horstman LL, Bernal-Mizrachi L, Minagar A, Soderland C and Ahn YS, Interaction of endothelial microparticles (EMP) with leukocytes: potential roles of EMP in thrombosis and inflammation. Blood 98(11): 226a (Ab#944), 2001.(Presented, 43rd ASH mt'g, Orlando, FL, Dec 7-11.) Jy W, Schultz DR, Jimenez JJ, Mauro L, Newton KR and Ahn YS, Relationship between release of endothelial microparticles (EMP) and capping of adhesins during endothelial activation: No correlation with apoptosis. Blood 98(11): 250a (Ab#1049), 2001. (Presented, 43rd ASH mtn'g, Orlando, FL, Dec 7-11.) Preston RA, Jy W, Mauro LM, Horstman LL, Ledford M and Ahn YS, Effect of severe uncontrolled hypertension on novel markers of endothelial and platelet activation: endothelial and platelet microparticles. J Hypertension 19(Suppl 2): S122-123 (Abst # P2.61), 2001. (Presented, 11th Europ. Mt'g on Hypertension, Milan, Italy, June 15-19.) Ahn YS, Jy W, Jimenez JJ, Cui Y, Escobar MA and Bowen B, Vascular dementia among patients with ITP (immune thrombocytopenic purpura) and risk factors. Blood 96(11,Prt1): 250a(#1074), 2000. (Presented, 42nd ASH mtn'g, San Francisco, CA, 12/1-5) Bernal-Mizrachi L, Jy W, Horstman LL, Pastor J, Mao WW, Jimenez JJ, Mauro LM and Ahn YS, Disturbance of endothelium in acute coronary syndromes monitored with flowcytometric assay of endothelial microparticles (EMP). Blood 96(11,Prt1): 270a (Abst #1161), 2000.(Presented, 42nd ASH mtn'g, San Francisco, CA, 12/1-5.) Jimenez J, Jy W, Horstman LL, Mauro LM and Ahn YS, Microvascular endothelial cell microparticles (EMP): Markers of endothelial cell activation / damage. J Invest Med 48(2): 191A(#60), 2000. (Presented, Soc. Exp. Biol., San Diego, CA, Apr 15-18. Also in FASEB J 14(4):A459, #329.18.) Jimenez JJ, Jy W, Horstman LL, Mauro LM, Bernal-Mizrachi L and Ahn YS, TTP plasma induces release of procoagulant EMP (endothelial microparticles) from endothelial cells in culture; and EMP is markedly elevated in patients. Blood 96(11,Prt1): 531a(#2283), 2000.(Presented, 42nd ASH mtn'g, San Francisco, CA, 12/1-5.) Jy W, Jimenez JJ, Mauro LM, Newton KR, Arnold PI, Ahn YS and Schultz DR, Capping and microparticle shedding in human renal microvascular endothelial cells (MVEC) activated by TNF- alpha or IFN-gamma. Blood 96(11,Prt1): 42a(#172), 2000.(Presented, 42nd ASH mt'g, San Francisco, CA, 12/1-5.) Minagar A, Jimenez J, Jy W, Mauro LM and Sheremata WA, Plasma from MS patients in exacerbation induces shedding of PECAM-1 from cultured microvascular endothelial cells (CMVEC). Soc Neurosci Abstr 26(Prt1of2): 341 (Abst#127.1), 2000.(Presented, 30th mt'g of Soc. for Neurosci., New Orleans, LA., Nov 4-9.) Minagar A, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Mao WW, Sheremata WA and Ahn YS, Increased endothelial microparticles (EMP) and platelet activation in multiple sclerosis (MS) in exacerbation and presence in plasma of a factor inducing EMP generation in vitro. Blood 96(11,Prt1): 43a(#175), 2000.(Presented, 42nd ASH mtn'g, San Francisco, CA, 12/1-5.) Minagar A, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Sheremata WA and Ahn YS, Endothelial microparticles in multiple sclerosis, as defined by expression of PECAM-1, are elevated in

17 exacerbation: A new aspect of disease pathogenesis. Annals Neurology 48: 429 (Abst#225), 2000. (Presented, Amer. Neurol. Assoc., Boston, MA, Oct.) Ahn YS, Horstman LL, Jy W, Cui Y and Bowen B, Chronic platelet activation and progressive vascular dementia in patients with immune thrombocytopenic purpura (ITP). Proceedings:, 1999. (Presented, 1st Int'l Cngr's on Vascular Dementia, Geneva, Switzerland, Oct 3, 1999; proceedings edited by Amos D. Korczyn; publisher: Monduzzi Editore.) Ahn YS, Jy W, Horstman LL, Mao WW and Yaniz M, Spectrum of disorders associated with excessive platelet microparticle (PMP) generation. Thromb Haemost Aug Sup'l: 381 (Abst #1211), 1999.(Presented, XVII Cngr's of ISTH, Washington, D.C., Aug 14-21.) Jy W, Mao W, Park H, Horstman LL and Ahn YS, Leukocyte CD11b expression induced by ADP- stimulated platelets is contact dependent. Thromb Haemost Aug Suppl: 462 (Abst#1461), 1999. (Presented, XVII Cng's of ISTH, Washington, DC, Aug 14-21.) Horstman LL, Sequeira R, Galvez A, Hitz F, Jy W and Ahn YS, Rapid method for monitoring of GP IIb/IIIa blockade by ReoPro™ employing commercially available FITC-anti-CD41. Blood 92(Supl)(10): 189a(#765), 1998.(Presented, 40th ASH mt'g, Miami, FL, Dec 4-8.) Jy W, Horstman LL, Yick L, Mao WW, Sequeira R and Ahn YS, Effect of Abciximab (ReoPro™) on formation of platelet-platelet and platelet-leukocyte aggregates. Blood 92(Supl)(10): 189a(#764), 1998.(Presented, 40th ASH mt'g, Miami, FL, Dec 4-8.) Mao WW, Jy W, Horstman LL, Valant PA and Ahn YS, Flow cytometric assay of P-selectin (CD62P) appears useful in distinguishing heparin induced thrombocytopenia with thrombosis (HITT) from heparin induced thrombocytopenia (HIT). Platelets 9: 417, 1998.(Presented, 7th Erfurt Conference on Platelets, Augustiner-Kloster, Erfurt, Germany; June28-July1.) Schultz DR, Arnold PI, Ahn YS, Jy W, Valant PA, Horstman LL, Wang F and Mao WW, Antibodies to platelet membrane glycoprotein CD36 (GP IV) in patients with or without thrombotic complications. J Invest Med 46(1): 37A, 1998.(Presented, AFCR Southern Regional mt'g, New Orleans, LA, Feb.) Schultz DR, Arnold PI, Jy W, Valant PA, Gruber J, Ahn YS, Wang F, Mao WW and Horstman LL, Anti-CD36 autoantibodies in thrombotic thrombocytopenic disorders: studies of a previously unrecognized 85 kD form of CD36. Blood 92(Supl)(10): 175a(#707), 1998.(Presented, 40th ASH mt'g, Miami, FL, Dec 4-8.) Mao WW, Jy W, Kolodny L, Horstman LL, Valant PA and Ahn YS, Discrimination of heparin- induced thrombocytopenia (HIT) from HIT with thrombosis (HITT) by flow cytometric analysis of activation marker CD62p. Thromb Haemost Supplement: 448 (Abst PS-1831), 1997. (Presented, XVI Congress ISTH, Florence, Italy, Jun 6-12.) Kolodny L, Ahn YS, Horstman LL and Sheremata WA, Evidence of platelet activation in multiple sclerosis. Ann Neurol 40(3): 520 abst M117, 1996.(Presented, 121st Mtn'g Amer Neurol Assoc, Miami, FL, Oct 13-16.) Valant PA, Jy W, Horstman LL, Mao WW, Kolodney L and Ahn YS, Leukocyte binding of platelet aggregates in thrmobotic thrombocytopenic purpura and heparin induced thrombocytopenia with thrombosis. Conference Proceedings:, 1996.(Presented, 4th European Symposium on Platelet and Granulocyte Immunology; Hameenlinna, Finland, May 20-21.) Valant PA, Jy W, Horstman LL, Mao WW, Kolodny L and Ahn YS, Leukocyte binding of platelet aggregates in thrombocytopenic purpura (TTP) and heparin induced thrombocytopenia with thrombosis (HITT). Proceedings of Meeting:, 1996.(Presented, 4th European Symposium on Platelet and Granulocyte Immunology; Hameenlinna, Finland, May 20-21.) Ahn YS, Jy W, Kolodny L, Horstman LL, Mao WW, Byrnes JJ and T TN, Activated platelet aggregates in thromobotic thrombocytopenic purpura (TTP). Blood 86(10): 89a (Abst #342), 1995.(Presented, ASH mtn'g, Seattle, WA, Dec 1-5.)

18 Horstman LL, Jy W, Morgan BP and Ahn YS, CD59 expression on platelets in ITP and PNH. La Revista de Investigacion Clinica (Suppl): 212 (Abst 110), 1994.(Presented, XXV Cong's of ISH, Cancun, Mexico, April 17-22.) Horstman LL, Valle-Riestra BJ, Jy W, Wang F, Meneses MC and Ahn YS, Desmopressin (DDAVP) acts directly on platelets in vitro and in vivo to generate platelet microparticles and enhanced procoagulant activity. Clin Res 42: 183A, 1994.(Presented, AFCR mt'g, Baltimore, MD, Apr 30.) Jy W, Horstman LL, Mao WW and Ahn YS, Increased sensitivity of platelets to complement in immune thrombocytopenia (ITP) and protection by danazol. La Revista de Investigacion Clinica (suppl): 214 (a120), 1994.(Presented, XXV Congress of ISH, Cancun, Mexico, Apr 17-22.) Jy W, Mao WW, Horstman LL, Tao J, Haynes DH and Ahn YS, Platelet microparticles (PMP) bind, activate and aggregate neutrophils. Clin Res 42: 184A, 1994.(Presented, AFCR mt'g, Baltimore, MD, April 30.) Horstman LL, Jy W, Schultz DR, Mao W and Ahn YS, Complement mediated fragmentation and lysis of platelets: gender different in sensitivity. Blood 82: 2403A, 1993.(Presented, ASH mt'g, St Louis, MO, Dec 6.) Jy W, Horstman LL, Mao WW and Ahn YS, Platelet microparticles adhere to polymorphonuclear leukocytes: possible mode of clearance. Blood 82: 1110A, 1993.(Presented, ASH mt'g, St. Louis MO, Dec 6.) Jy W, Horstman LL, Wang F and Ahn YS, Procoagulant activity of platelet microparticles (PAPM) correlates with thrombotic risks. Blood 82: 1111A, 1993.(Presented, ASH mt'g, St Louis, MO, Dec 6.) Sheremata WA, Fineberg M and Ahn YS, Association of immune thrombocytopenia and abnormal platelet functions with multiple sclerosis [Abst]. Brain Pathol 3: 293, 1993. Ahn YS, Ozner MD, Janania J, Jy W and Horstman LL, Platelet activation and coronary ischemic syndromes. Br J Haematol: Abst 327, 1992.(Presented, 24th ISH mt'g, London, UK, Aug 24.) Jy W, Homolak D, Horstman LL, Sugrue S and Ahn YS, Abnormal electrophoretic mobilities of platelets in immune thrombocytopenias and thromboses and their correction by taurine. Clin Res 40: 149A, 1992.(Presented, AFCR mt'g, Baltimore, MD, May.) Lee YJ, Jy W, Horstman LL, Janania J, Kelley R and Ahn YS, Elevated platelet microparticles in multiinfarct dementias and transient ischemic attacks. Clin Res 40(2): L359A, 1992.(Presented, AFCR mt'g, Baltimore, MD, May.) Horstman LL, Jy W and Ahn YS, Danazol inhibits autoantibody binding to erythrocytes in vitro at physiologic concentrations. Clin Res 39(2): 364A, 1991.(Presented, Am Soc Clin Invest, Seattle, WA, May 5.) Jy W, Horstman LL, Arce M, Janania J, Lee YJ and Ahn YS, Clinical significance of elevated platelet microparticles in autoimmune thrombocytopenias. Clin Res 39(2): 364A, 1991.(Presented, AFCR mt'g, Seattle, WA, May 5.) Horstman LL, Jy W, Miller K and Ahn YS, Danazol concentrations in sera and RBC: selective accumulation in RBC membrane. Blood 79: 131A, 1990.(Presented, Soc Exper Hematol, Seattle, WA, Oct.) Jy W, Horstman LL and Ahn YS, Stimulation and inhibition of platelet membrane fragmentation.:, 1990.(Presented, ASH mt'g, Boston, MA., Dec 4.) O'Neill GJ, Horstman LL, Yaniz M, Jy W and Ahn YS, Target antegens in men and women with idiopathic thrombocytopenic purpura. WHAT????, 1989.(Presented, Am Soc Exper Hematol, Oct 1989, Seattle, WA) Sprinz PG, Mylvaganam R and Ahn YS, Flow cytometric determination of leukemic cell drug sensitivities in vitro by bromodeoxyuridine labelling.:, 1988.(Presented, XIII Int’l. Soc. for Analytical Cytology, Breckenridge, CO, Sept. 4.)

19 Garcia R, Mylvaganam R, Kim CI, Ahn YS and EtAl, Short-lived suppressor cells in idiopathic thrombocytopenic purpura (ITP).:, 1986.(Presented, symposium, 6th Int’l. Cong. Imnunol, Toronto, Canada, June.) Mylvaganam R, Ahn YS, Garcia R and EtAl, Effect of danazol on lymphocyte blastogenesis.:, 1986. (Presented, 6th Int’l. Cong. Immunol, Toronto, Canada, July.) Mylvaganam R, Garcia R, Kim CI, Ahn YS and EtAl, Depressed lymphocyte blastogenesis in idiopathic thrombocytopenic purpura (ITP).:, 1986.(Presented, 6th Int’l. Cong. Imnunol., Toronto, Canada, July.) Ahn YS, Jy W, Sosenko JM and EtAl, Abnormal calcium handling of platelets in diabetics. Thromb Haemost 54: 768(A), 1985.(Presented, Int’l. Soc. Hematol, San Diego, CA, July.) Ahn YS, Jy W, Chua L, Haynes DH, Harrington WJ and Brown HE, Calcium channel blockade for thrombosis and other disorders. Clin Res 32: 494(A), 1984.(Presented, Amer Soc Clin Invest, Washington DC, May.) Harrington WJ, Ahn YS, Cohen L, Chua L, Ayub L and Pall LM, Treatment of paroxysmal nocturnal hemoglobinuria with danazol.:, 1984.(Presented, 20th Cong. of Int’l. Soc. of Hematol, Buenos Aires, Argentina. Sept.) Moreno JM, Harrington WJ, Ahn YS, Collin AS, Pall LM and Wortzell EM, Splenomegaly as a cause of fecal incontinence.:, 1984.(Presented, 20th Congr. of Int’l. Soc. of Hematol., Buenos Aires, Argentina, Sept.) Ahn YS, Harrington WJ, Mylvaganam R, Chua L, Otoya J and Pall LM, Danazol therapy restores helper/suppressor (T4/T8) ratios in patients with idiopathic thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA). Blood 62(5): 241(A), 1983.(Presented, 25th ASH mt'g, San Francisco, CA, Dec.) Sfakianakis GN, Mylvaganam R, Sprinz PG, Junghans RP, Ahn YS, Harrington WJ and Serafini A, In III: Platelet clearance, scintigraphy and distribution studies in experimental and clinical immune thrombocytopenia. J Nucl Med 24: 74-?, 1983.(Presented, 30th Ann Mtg. of Soc. Nucl. Med., St. Louis, MO, June 7-10.) Ahn YS, Mylvaganam R, J McCrannie J B and Harrington WJ, Detection of platelet-bound antibodies by immunoperoxidase in idiopathic thrombocytopenic purpura (ITP). Clin Res 29(5): 862(A), 1982.(Presented, So. Soc. for Clin. Invest., New Orleans, LA.) Quillen M, Castello C, Ahn YS and EtAl, The significance of cell-surface tubulin on human leukemic cells.:, 1982.(Presented, Mtg. on Cell Biology. Baltimore, MD, Dec.) Ahn YS, Byrnes JJ, Harrington WJ, Collin AS and Pall LM, Treatment of malignancies of the mononuclear phagocyte system with vinca-laden platelets. Clin Res 29(5): 864A, 1981 (?). (Presented, Am. Soc. of Clin. Invest, Washington DC, May 1.) Ahn YS, Harrington WJ and So AG, Vinca alkaloids in the treatment of thrombotic thrombocytopenic purpura (TTP). Blood 58(5): 187(A), 1981.(Presented, Amer. Soc. Hematol, San Antonio, TX, Dec. 6.) Mylvaganam R, Bailey EM, Chun TH, Ahn YS and Harrington WJ, In vitro binding of vinblastine and vincristine: Two modes of administration in rabbits. Clin Res 29(5): 864(A), 1981.(Presented, So. Soc. Clin. Invest., New Orleans, LA.) Ahn YS, Harrington WJ, Byrnes JJ and EtAl, Selective chemotherapy in the disorders of MPS.:, 1979. (Presented, 4th Int’l. Soc. Hematol, Asian-Pacific Division, Seoul, Korea, June.) Ahn YS, Byrnes JJ, Brunskill DE and EtAl, Selective injury to macrophages, a new treatment of idiopathic autoimmune hemolytic anemia. Blood 50: 234A, 1978.(Presented, Amer. Soc. of Clin. Invest, San Francisco, CA, April 30.) Ahn YS and Byrnes JJ, Selective injury to macrophages: A new approach for the treatment of ITP. Clin Res 25: 472(A), 1977.(Presented, ASH, Washington, DC, May 1.)

20 Ahn YS, Byrnes JJ, Cayer ML and EtAl, The platelet as a vehicle for selective delivery of drugs. Blood 50(Supl 1): 234, 1977.(Presented, ASH., San Diego, CA, Dec. 4.) Harrington WJ, Ahn YS and Giliberti JJ, Vincristine therapy of idiopathic thrombocytopenia. Clin Res 20: 787(A), 1972.(Presented, Central Soc. Clin. Res.)

20b. Other Works and Publications (Abstracts):

Alvarez O, Jimenez J, Donovan M, Ahn YS, Lopez-Mitnik G, Bidot C, Jy W, Bidot L, Horstman L and Ahn YS, Plasma endothelin-1 and leukocyte microparticles increase during pain episode in patients with sickle cell disease. Blood 110(11): 19b, Ab 3087, 2007. Fontana V and Ahn YS, Cell-derived microparticle (C-MP) profiles in lymphoproliferative disorders: red cell microparticles (RMP) as a risk factor for thrombosis. Blood 110(11): 65b, Ab 3988, 2007. Jimenez JJ, Jy W, Mauro LM, Bidot L, Salgueiro LM, Andrews D, Shariatmadar S, Horstman LL, Fontana V and Ahn YS, Increased endothelial colony-forming cells (ECFC) and endothelial microparticles (EMP) and their interaction in thrombotic thrombocytopenic purpura (TTP). Blood 110(11): 45b, Ab 3908, 2007. Bidot CJ, Jy W, Bidot L, Horstman LL, Fontana V, Gonzalez M, Dudkyewicz P and Ahn YS, Anti- platelet glycoprotein antibodies in thrombocytosis are frequently detected and are associated with platelet activation and thrombosis. Blood 108(11): 70b (Ab3974), 2006. Bidot CJ, Jy W, BidotJr C, Horstman LL, Fontana V, Yaniz M, Gonzalez M and Ahn YS, Antibodies against platelet glycoprotein target antigens in antiphospholipid syndrome (APS). Blood 108(11): 70b (Ab3973), 2006. Fontana V, Ahn E, Dudkiewicz P, Horstman LL, Fernandez C and Ahn Y-S, Danazol with intermittent chemotherapy induces lasting remissions in advanced and refractory MPD in elderly patients. Blood 108(11): 308b (Ab4887), 2006. Zuckerman D, Hofmeyer M, Chirinos JA, Jy W, Jimenez JJ, Horstman LL, Corrales-Medina VF, Pennel P and Ahn Y-S, Endothelial microparticles and their binding to leukocytes in patients with end-stage renal disease. Blood 108(11): 62b (Ab3939), 2006. Ahn ER, Bidot CJ, Fontana V, Dudkiewicz P, Jy W, Horstman LL and Ahn YS, Rituximab therapy induces long lasting clinical remission and reduction of anti-platelet glycoprotein antibodies in patients with chronic immune thrombocytopenic purpura. Blood 106(11): 81b #4006, 2005. Chirinos JA, Jy W, DelCarpio F, Arteaga R, Gustavo HA, Valvidia M, Horstman LL, Jimenez JJ and Ahn YS, Correlation between endothelial microparticle binding to monocytes and monocyte nitric oxide production in prothrombotic and inflammatory disorders. Blood 106(11): 45b #3860, 2005. Chirinos JA, Jy W, Soriano AO, Castrellon A, DelCarpio F, Arteaga R, Heresi GA, Jimenez JJ, Horstman LL and Ahn YS, CD62E-positive endothelial microparticle-neutrophil conjugates, a novel marker of prothrombotic and inflammatory disorders. Blood 106(11): 69b #3958, 2005. Chirinos JA, Jy W, Tiede M, Castrellon A, Soriano AO, DelCarpio F, Arteaga R, Jimenez JJ, Horstman LL, Bidot CJ and Ahn YS, Platelet binding to leukocytes as a determinant of leukocyte activation in vivo. Blood 106(11): 46b #3862, 2005. Fontana V, Jy W, Ahn ER, Dudkiewicz P, Horstman LL, Bidot CJ and Ahn YS, Activation of clotting factors in thrombocytopenia due to platelets destruction: a possible compensated mechanism for hemostasis. Blood 106(11): 79b #3999, 2005. Ahn ER, Podack ER, Lander G, Bidot CJ, Jy W and Ahn YS, Soluble CD30 levels are highest in autoimmune hemolytic anemia (AIHA) and lymphoma among hematologic disorders, but are not elevated in ITP. Blood 104(11): 55b Ab3872, 2004. (46th ASH, Dec. 4-7, San Diego, CA.)

21 Fontana V, Ahn ER, Jimenez JJ, Dudkiewicz P, Jy W and Ahn YS, Danazol in combination with busulfan induces long-term remission in myeloproliferative disorders (MPD). Blood 104(11): 270b Ab4748, 2004. (46th ASH, Dec. 4-7, San Diego, CA.) Fontana V, Donna E, Dudkiewicz P, Lander G and Ahn YS, Interstitial pneumonia in patients with idiopathic thrombocytopenic purpura. Blood 104(11): 74b Ab3953, 2004. (46th (ASH, Dec. 4-7, San Diego, CA.) Ahn ER, Tiede MP, Bidot CJ, Horstman LL, Jy W, Jimenez JJ, Blaya M and Ahn YS, ITP (immune thrombocytopeniic purpura) and atypical lymphoproliferative disroder (LPD) among spouses of patients with ITP: four case reports. Blood 102(11): 85b (Ab 4048), 2003. Ahn YS, Lander G, Ahn ER, Horstman LL, Bidot CJ, Tiede MP, Jy W and Gonzalez M, Severe hypercoagulanble state and concommitant life-threatening bleeding successfully treated with rituximab. Blood 102(11): 108b (Ab 4139), 2003. Arteaga RB, Soriano AO, Chirinos JA, Jy W, Gonzalez M, Yaniz M, Horstman LL, Jimenez JJ and Ahn YS, Elevated endothelial microparticles (EMP) and platelet activation in patients with the metabolic syndrome (MTS) at low to intermediate risk for cardiovascular diseases. Blood 102(11): 74b (Ab 4001), 2003.(Forty-fifth annual meeting of ASH, Dec 6-9, San Diego, CA) Jimenez JJ, Ferreira A, Peter A, Jy W, Mauro LM, Mendez AJ, DeMarchena E, Soderland C, Horstman LL and Ahn YS, Elevated endothelial microparticles (EMP) and decreased endothelial progenitors are associated with increased serum cholesterol levels. Blood 102(11): 73b (Ab 3997), 2003.(Forty-fifth annual meeting of ASH, Dec 6-9, San Diego, CA) Jimenez JJ, Jy W, Mauro LM, Minagar A, Soderland C, Horstman LL and Ahn YS, Transendothelial migration (TEM) in multiple sclerosis: Induction by patient plasma and its augmentation by leukocyte-endothelial microparticle (L-EMP) complexes. Blood 102(11): 72b (Ab 3994), 2003. (Forty-fifth mtng of ASH, Dec 6-9, San Diego, CA) Soriano AO, Jy W, Valdivia MA, Velasquez HS, Chirinos J, Tiede MP, Ahn ER, Kett D, Horstman LL, Jimenez JJ and Ahn YS, Reduced endothelial and platelet microparticles and their interaction with leukocytes correlate with organ dysfunction and predict mortality in severe sepsis. Blood 102(11): 58b (Ab 3934), 2003. (45th ASH Mtn'g, San Diego, CA; Dec. 6-9.) Bernal-Mizrachi L, Soriano A, Valle M, Jy W, Jimenez JJ, Horstman LL and Ahn YS, Repeated ischemia reduces the capacity of endothelium to release endothelial microparticles (EMP): in vivo experiment and clinical observations. Blood 100(11 Prt 2): 71b (Abst #3756), 2002.(44th ASH meeting, Philadelphia, PA, Dec 6-10.) Bernal-Mizrachi L, Velasquez HS, Valle M, Soriano AO, Zimbrano JP, Mcdonough R, Jy W, Ahn YS and Mallon SM, Normal levels of endothelial microparticles (EMP) predict negative cardiac stress test in patients with chest pain. Blood 100(11 Prt 2): 76b (Abst #3776), 2002.(44th ASH meeting, Philadelphia, PA, Dec 6-10.) Bidot CJ, Jy W, Horstman LL, Jimenez JJ, Yaniz M and Ahn YS, Antiphospholipid antibodies (APA) is a risk factor for thrombosis and factor FVIIa and phosphatidylethanolamine (PE) are most frequent antigens in patients with clonal thrombocytosis (TS) and thrombosis. Blood 100(11 Prt 2): 83b (Abst #3804), 2002.(44th ASH meeting, Philadelphia, PA, Dec 6-10.) Decesare T, Kett DH, Huang H, Horstman LL, Jimenez JJ, Bidot CJ, Jy W and Ahn YS, Successful outcome of Rituxan therapy for spontaneously acquired high-titer refractory factor VIII inhibitor. Blood 100(11 Prt 2): 105b (Abst #3897), 2002.(44th ASH meeting, Philadelphia, PA, Dec 6-10.) Donna E, Ahn YS, Huang HS, Horstman LL, Jimenez JJ and Jy W, Interstitial lung disease associated with Imatinib (Gleevec) therapy for chronic myelogenous leukemia (CML). Blood 100(11 Prt 2): 327b (Abst #4857), 2002.(44th ASH meeting, Philadelphia, PA, Dec 6-10.) Jimenez JJ, Jy W, Mauro LM, Horstman LL, Bernal-Mizrachi L, Preston RA, Minagar A, Gonzalez- Quintero VH and Ahn YS, Distinct species of endothelial microparticles (EMP) reflect distinct

22 kinds of endothelial injury: EMP as a promising new marker of vascular disorders. Blood 100(11): 73b (Abst #3763), 2002.(44th annual ASH meeting, Philadelphia, PA, Dec 6-10.) Soriano A, Ahn YS, Horstman LL, Jimenez JJ, Jy W and Bidot C, Overlapping syndromes of ITP and TTP: Case reports and delineation of the syndrome. Blood 100(11 Prt 2): 81b (Abst #3796), 2002.(44th ASH meeting, Philadelphia, PA, Dec 6-10.) Ahn YS, Bernal-Mizrachi LL, Jimmenez JJ, Saltzman M, Horstman LL and Jy W, Long-term remission in myeloproliferative disorder (MPD) by combination therapy with danazol and busulfan. Blood 98(11): 277b (Ab#4846), 2001. Bidot C, Jy W, Horstman LL, Jimenez JJ, Yaniz M and Ahn YS, Factor VIIa: A new antigen in antiphospholipid antibody syndrome (APS). Blood 98(11): 68b (Ab#3890), 2001. Horstman LL, Jy W, Bidot C, Cast L, Valle M, Huang H, Dacas SB, Jimenez JJ and Ahn YS, Factor VIIa clot time (FVIIa CT) is more sensitive to lupus anticoagulant (LAC) than a widely used commercial method. Blood 98(11): 73b (Ab#3914), 2001. Preston RA, Jy W, Jimenez JJ, Mauro LM, Horstman LL and Ahn YS, Elevated endothelial microparticles (EMP) and platelet activation in severe hypertension. Blood 98(11): 56b (Ab#3839), 2001. Jy W, Mao WW, Park H, Horstman LL and Ahn YS, Platelet-leukocyte interaction and CD11b expression: Relative role of contact vs. soluble factors. Blood 92(Supl Prt 2)(10): 70b(#3280), 1998.(40th ASH mt'g, Dec 4-8, 1998, Miami, FL.) Valant PA, Jy W, Horstman LL, Mao WW, Schultz DR and Ahn YS, Intravenous immune globulin (IV-IgG) inhibits platelet activation induced by plasma from a thrombotic thrombocytopenic purpura patient. Blood 92(Supl)(10): 90b(#3370), 1998.(40th ASH mt'g, Dec 4-8, 1998, Miami, FL) Sheremata S, Jy W, Sheremata WA, Horstman LL, Valant PA and Ahn YS, Elevation of platelet- leukocyte aggregates (PLAg) and of leukocyte activation marker CD11b in multiple sclerosis. Blood 90 (Suppl 1, prt 2): 48-49b (A 2915), 1997.(39th mt'g of ASH, Dec 5-9, 1997, San Diego, CA) Valant PA, Jy W, Mao WW, Horstman LL and Ahn YS, TTP plasma promotes platelet-leukocyte interaction in vitro. Blood 90 (Suppl 1, prt 2): 90b (A 3114), 1997.(39th mt'g of ASH, Dec 5-9, 1997, San Diego, CA) Valant PA, Jy W, Horstman LL, Mao WW and Ahn YS, Increased leukocyte binding and P selectin expression in platelet aggregates induced by TTP plasma. Clin Res 44: 327(A), 1996. Jy W, Horstman LL, Park H, Mao WW, Kolodny L and Ahn YS, Flowcytometric assay of platelet aggregates in whole blood: detection of effects of TTP plasma and DDAVP. Blood 86(10): 899a (Abst #3584), 1995. Horstman LL, Jy W, Morgan BP and Ahn YS, CD59 expression on platelets in ITP and PNH. La Revista de Investigacion Clinica Supplement: 212 (Ab#109), 1994.(XXV Congress of ISH, Apr 17-22, 1994, Cancun, Mexico) Jy W, Horstman LL, Wang F, Duncan RC and Ahn YS, Platelet microparticle number and specific procoagulant activity are both elevated in thrombotic disorders. Blood 84: 2736(A), 1994. Horstman LL, Jy W, Mao WW and Ahn YS, Women's platelets are more sensitive than men's to complement mediated lysis; and danazol protects both. Clin Res 41(2): 364A, 1993. Jy W, Horstman LL, Mao WW, Schultz DR and Ahn YS, Mechanisms of platelet fragmentation in immune thrombocytopenias: role of complement. Clin Res 41(2): 364A, 1993. Horstman LL, Jy W, Horton A and Ahn YS, Improved quantitation and characterization of platelet microparticles. Clin Res 40(2): 422A, 1992. Ozner MD, Jy W, Horstman LL, Janania J and Ahn YS, Acute coronary syndrome and elevated platelet microparticles in immune thrombocytopenia. Blood 80: 316a, Ab#1256A, 1992.(34th ASH Mtng, Dec 4-8 1992, Anaheim, CA)

23 Horstman LL, Ahn YS, Pressman BC, Jy W and Le AD, Protection against osmotic hemolysis by ionophores and danazol, and possible application to sickle cell disease. Clin Res 39: 431(A), 1991. Horstman LL, Jy W, Miller K and Ahn YS, Danazol assay in sera and RBC: accumulation of danazol in RBC membrame and its correlation with osmotic protection {PRESENTED?}. Blood 76: 131(A), 1990.(Presented, ASH Mtg., Boston, MA, Dec 4.) Temple JD, Gold P, Mylvaganam R, Ahn YS and Harrington WJ, Danazol therapy decreases mechanical fragility of normal and sickle erythrocytes. Blood 72: 207(A), 1988. Ahn YS, Chin KB, Garcia-Moore M, Mylvaganam R and Harrington WJ, Danazol for chronic urticaria and related disorders. Clin Res 35: 569(A), 1987. Ahn YS, Garcia-Moore M, Karl NS, Restrepo JG, Temple JD and Harrington WJ, Vinblastine and low-dose ARA-C infusion in elderly patients with acute myelogenous leukemia. Blood 70: 739(A), 1987. Ahn YS, Otero J, Yunis AA, Mylvaganam R and Harrington WJ, Refractory reversible anemia associated with long-term conventional-dose danazol therapy. Blood 70: 56(A), 1987. Ahn YS, Harrington WJ, Fernandez LF et al, Danazol therapy in idiopathic thrombocytopenic purpura: A follow up study. Blood 66 Supl 1: 308a, 1985. Barreras LR, Ahn YS, Temple JD and Harrington WJ, Successful use of cyclosporin-A in severe aplastic anemia. Blood 66: 361A, 1985. Junghans RP and Ahn YS, High-dose intravenous gammaglobulin to suppress alloimmune destruction of donor platelets. Clin Res 31: 482a, 1983. Ahn Y, Harrington WJ, Byrnes JJ, Collin AS, Cayer ML, McCranie J and Pall LM, Vinblastine loaded platelets in the treatment of acute monocytic leukemia. Blood 58 supl(5): 200a, 1981.

21. Other works for publications (Manuscripts submitted and ready to submit):

Johansen M, Jy W, Horstman LL, Ahn YS. Hemostatic property of red cell microparticles: Effect on factor deficient plasma and hemodilution. Submitted to Thromb & Haemost in 9.2014.

Jy W, Gómez O, Salerno T, Williams D, Morgan J, Johansen M, Bidot C Jr, Horstman LL, Shariatmadar S and Ahn YS. Pre-surgical levels of circulating cell-derived microparticles are robust predictors of transfusion requirement in coronary artery bypass graft surgery. Submitted to J TCS (Thoracic Cardiovasc Surgery). 7. 2014. Jy W, Bidot C Jr., Johansen ME, Gomez O, Shariatmadar S and Ahn YS. Effects of storage time, leukoreduction, and residual platelets on release of procoagulant and proinflammatory cell- derived microparticles (MP). Vox Sanguinis (Ready to submit) 2014. Jy W, Gomez O, Morgan J, Salerno T, Williams D, Shariatmadar S and Ahn Y. Outcomes of washed vs non washed packed red cell (PC) transfusions in patients undergoing CABG Surgery. Reduced mortality and complications with washed PC transfusion. Lancet. (Ready to submit) 2014.

V. PROFESSIONAL 22. Funded Research:

24 Funding in the past NIH Grant (lROl AM 25485-01): P.I., $40,000 per year for three years, 1979 - 1982. VA Merit Review: P.I., $25,000 per year for three years, 1979 - 1982. VA Merit Review Award: P.I., $30,000 per year, 1984 - 1987. VA Merit Review Award: P.I., $30,000 per year, 1987 - 1990. NIH Grant (1 ROl AMHL 33813-01): P.I., $100,000 per year for four years, 1986-1990. AHA (91GIA/737): P.I., $39,838 per year for two years, 1991 - 1993. AHA: P.I., 35,900 per year for two years, 1993 - 1995.

Active Funding.

1). NIH R01 Grant (NIH 1R01HL 098031-01) Title: “Microparticles (MP) shed in stored RBC as potential mediators of transfusion complications”. Direct cost $ 400.000 + Indirect cost $ 212.000 per year for 4 years. (Oct, 2009 - Sept, 2013). Funding is extended to Sept, 2014. PI: Wenche Jy PhD. Co-PI: Yeon S Ahn MD. 2). Award from WHC Foundation, 1996-Present. $ 420.000 / year.in 2009. “Clinical and laboratory research in platelet and hematologic disorders” 3). Translational Research Award: The Center for Translational Research at UM. “Red cell derived microparticles as hemostatic agent to treat bleeding disorders” $60.000 in 2008-2009.

RO1 grant submitted in October 4, 2013 Title: Cell derived microparticles in surgery hemostasis. PI: Wenche Jy PhD. Co-PI: Barth Green MD. Department of Neurosurgery, Michael Wang MD. Department of Neurosurgery Yeon Ahn MD. Hematology/Oncology. Orlando Gomez-Marin PhD. Department of Biostatistics Budget: $ 3,009,582 in 4 years. SBIR grant to be submitted in 2014. Small business grant submitted to NIH to begin clinical application and commercialization of our invented product, “ Red cell derived microparticles (RMP)”, as hemostatic agent to treat excessive bleeding in various bleeding situations. RxMP Therapeutics, LLC (the name of the company) was established for this purpose. President/CEO of RxMP Therapeutics, Dr. Rifat Pamukcu, had submitted Phase 1 small business grant (SBIR) for $ 203K with our lab, the WHC Platelet Laboratory. If approved, it will lead us for a $1.5M Phase 2 phase application for clinical trial.

23. Editorial Responsibilities: 25 Advisory Board Member, Journal of Thrombosis and Haemostasis. Reviewer of Thrombosis and Haemostasis. Reviewer of Atherosclerosis, Thrombosis and Vascular Biology. Reviewer of Blood. Reviewer of American Journal of Hematology Reviewer of Circulation. Reviewer of New England Journal of Medicine Reviewer of Annals of Internal Medicine Reviewer of Journal of American Medical Association

24. Professional and Honorary Organizations Member, Scientific Review Committee, NIH grants, April, 2204 and February, 2005. Member, International Society of Thrombosis and Haemostasis. Member of American Society of Hematology. Member, Fellow, American College of Physicians Member, Thrombosis Journal, American Heart Association.

25. Honors and Awards: Hamchoon Medical Award in December 116, 2006: Annual award in recognition of distinguished medical research, endowed by the association of alumni, Seoul National University College of Medicine.:

26. Post-Doctoral Fellowships: Internship rotation St. Francis General Hospital, Pittsburg, PA 1967 - 1968. Residency in Internal Medicine, St. Francis General Hospital, Pittsburg, PA, 1968 - 1970. Hematology Fellowship, University of Miami School of Medicine, Miami, FL., 1970 - 1972.

27. Other Professional Activities: Invited Speaker at National and International Conferences. The platelet as a vehicle for drug delivery. Invited speaker in Symposium on Immune Thrombocytopenia at the International Society Hematology and Transfusion, Paris, France, July 1978. Idiopathic thrombocytopenic purpura, Medical Grand Rounds: Univ. of Cincinnati, School of Medicine, May, 1979. High dose IV gammaglobulin to suppress alloimnune destruction of donor platelets: Invited speaker at Symposium on IV gammaglobulin and compromised host in medicine. Dallas, Texas, September 1983.

26 Advances in the management of idiopathic thrombocytopenic purpura and autoimnune hemolytic anemia. Visiting professorship. Mayo Clinic, Rochester, Minnesota, August 1986. Assessment of the potential clinical value of danazol in the treatment of selected hematologic disorders. Invited speaker at the symposium on danazol. New York, NY, April 12, 1986. Sponsored by Sterling-Winthrope Inc. Invited speaker at the symposium on danazol: use of danazol in non-gynecologic disorders. Sponsored by Sterling Winthrope, Inc. Atlanta, GA. August 1986. Approaches to patients with thrombocytopenia and ITP. Grand Rounds, Wright Medical School. June 6, 1988, Dayton, Ohio. ITP in adult; Invited lecturer at the symposium on platelets by Korean Society of Hematology: Taegu, Korea, November 3, 1996. ITP: Pathophysiology and management. 29th World Congress of International Society of Hematology; Seoul, Korea, August 17, 2002.

VI. TEACHING 28. Teaching Awards Received 29. Teaching Specialization (courses taught): Attending physician in Medicine and Hematology, Jackson Memorial Hospital, University of Miami Medical Center, 1972-present. Attending physician in Medicine and Hematology, VA Medical Center, Miami, FL, 1972-1994. Attending physician, University of Miami Hospital & Clinics, Miami, FL, 1972-present. Mechanisms of Disease Course for sophomore medical students. Mechanisms of Disease Course for Ph.D. - M.D. students. Physical Diagnosis Course for Ph.D. - M.D. students. Teaching Coordinator, Hematology Service, University of Miami Hospital and Clinics (1980-1985).

30. Thesis and Dissertation Advising: Dissertation committee members: Mr. Peter Buschbaum: Monoclonal antibodies to antigens associated with chronic myelogenous leukemia. Dissertation committee members: Mr. Wenche Jy: Studies in calcium influx in human platelets. Dissertation committee members: Mr. Jonas S. Johansson: Characterization of the Ca2+ extrusion system of human platelets. Dissertation committee member: Mr. Jianguo Tao: Effects of cyclic AMP, protein kinase C on Ca hemostasis in platelets. 1994s Dissertation committee member: Mr. Christoph C Glismann: Shear induced platelet activation in time varying shear flow. 1996

VII. SERVICE

27 30. University Committee and Administrative Responsibilities: Chairman, Executive Committee, Stanley Glaser Research Foundation, 1996- 2008. Chairman, Blood Utilization Review Committee, University of Miami Hospitals and Clinics, 1982 - 1989. Chief of Hematology Service, Jackson Memorial Hospital, University of Miami, Medical Center, 1980 - 1990. Member of Transfusion Committee, Jackson Memorial Hospital, 1983 - 1991. Investigator responsible for conducting chemotherapy protocols for hematologic malignancies in the South Eastern chemotherapy group, University of Miami, 1975 - 1984. Member, Transfusion Committee, 1988 - 1991. Member, Admissions Committee, 1992 – 1994 Member, Transfusion Committee , University of Miami Hosptital and clinics. 2008 – present. Director, Special Hematology Laboratory, 1990 - 1997 Director, Wallace H. Coulter Platelet Laboratory, 1997 - Present