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Full Throttle Hip Replacement Restores a Marine’S Lifestyle NOTESNOTES DISCOVERIES

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Full Throttle Hip Replacement Restores a Marine’S Lifestyle NOTESNOTES DISCOVERIES EQUAL ACCESS A COMPREHENSIVE APPROACH TO CLINICAL TRIALS FOR PROSTATE CANCER live well SUMMER 2021 SMARTER HEALTHCARE FOR SOUTHERN CALIFORNIA Full Throttle Hip replacement restores a Marine’s lifestyle NOTESNOTES DISCOVERIES ON THE FRONT LINE A BETTER WAY TO TARGET VICE CHANCELLOR, UCI HEALTH AFFAIRS OF HEALTHCARE Steve A.N. Goldstein CHIEF EXECUTIVE OFFICER, UCI HEALTH METASTATIC SPINE TUMORS Chad T. Lefteris am often asked how COVID-19 has WRITTEN BY MELANIE ANDERSON affected UCI Health. My response is DEAN, UCI SCHOOL OF MEDICINE Michael J. Stamos always, “We were built for this.” As an I EXECUTIVE MARKETING DIRECTOR academic health system, our mission is Brian M. O’Dea broad: Discover. Teach. Heal. PUBLIC INFORMATION OFFICER From the earliest days of the pandemic, John Murray our researchers began working to find MANAGING EDITOR treatments and sharing what they Kristina Lindgren ach year, hundreds of thousands learned to benefit patients at UCI Health of Americans are diagnosed with BRACHYTHERAPY and beyond. This is what we do. Every Ea cancer that has spread to the BONE CEMENT day we push the boundaries of what is DESIGN, EDITORIAL & CONTRIBUTORS spine — a condition that can be painful Moon Tide Media possible to better serve our patients and and debilitating. UC Irvine radiology n A radioisotope is mixed ensure that UCI Health continues to be ART DIRECTOR researchers have developed a new therapy Michelle Villas into bone cement. the best place to give and get care. with the potential to more precisely In this issue of Live Well, I invite you to GRAPHIC DESIGNER target a patient’s tumors and improve Nikki Smith n The cement is read about the myriad ways we are creating their quality of life by sparing them the EDITOR injected directly into new therapies, advancing patient care and promoting well-being in our community. Shari Roan risks and side effects of conventional the vertebrae. On page 8, learn how advances in hip replacement technology and techniques radiation therapy. BRAND PUBLISHER ensure quicker recovery and make the surgery possible for younger patients with Hannah Lee To relieve pain, patients today receive n The result is a more damaged joints. On page 12, we highlight our efforts to provide state-of-the-art injections of bone-strengthening cement precise treatment. prostate cancer care to our region. For comments or questions, contact before conventional radiation therapy UCI Health Marketing & Communications at Research and clinical trials are also central to improving patient care. On 333 City Blvd. West, Suite 1250, Orange, CA 92868 to shrink spinal tumors. “These patients page 3, read about a radiology scientist’s breakthrough method to precisely 714-456-5496 are often bedridden from the pain. After target bone tumors, reducing the risks and side effects of conventional radiation Information in this magazine is not meant to a bone cement injection, many can therapy. On page 14, learn how patients like Alberta Bustamante, from under- replace the advice of your physician. actually walk,” says Joyce Keyak, PhD, a contains beta-emitting radioisotopes — mainly that it doesn’t hurt their spinal represented populations, are gaining access to promising cancer clinical trials. professor of radiological sciences and with a range of only 3 to 6 millimeters, cord, and they can still walk around.” Caring for thousands of COVID-19 patients over the past year enabled us biomedical engineering at the UCI School which means the radiation doesn’t affect In fact, the sheep with the radioactive to learn more about this new virus. On page 6, read about “long COVID-19 of Medicine. “That’s an improvement anything else. cement were on their feet and eating syndrome” and our efforts to treat this perplexing condition, which leaves in quality of life, but then they get “It won’t hit the gastrointestinal tract, within a few hours. “We ran tests and many patients with baffling and debilitating symptoms long after the infection radiation, and that takes its toll.” so people won’t get nausea, vomiting and found no radioactivity in the blood, urine subsides. On page 18, a compassionate medical student describes the daunting Keyak and her collaborators have devised diarrhea,” Keyak explains. “The dosage or feces,” she says. “That shows the experiences our caregivers faced tending to the sickest COVID-19 patients during a way to reduce that two-step process to reaching the spinal cord is much lower, radioactivity stays localized in the cement the winter surge. We take pride in training the next generation of healthcare SUPPORT UCI HEALTH a single outpatient procedure by mixing a and the radiation is focused where it and the vertebral body.” providers. This group of future caregivers will graduate with unique skills forged Few things in life matter more than your health. radioactive isotope into bone cement. The needs to be, which is in the bone.” The study would not have been possible in a worldwide healthcare crisis. As Orange County’s only academic medical new therapy, called brachytherapy bone This also means that brachytherapy without the support and cooperation of As the pandemic begins to wane, I hope you will turn to us for any healthcare system, UCI Health is pushing the frontiers cement, irradiates the bone tumor from bone cement could be used earlier than UCI’s Division of Radiation Safety and needs you have delayed or postponed. To make it easier for you and your of life-saving research while improving health the inside without harming other tissue. conventional radiation, she says. Moreover, University Laboratory Animal Resources, loved ones to access the exceptional expertise of UCI Health, we continue to and wellness in our community and beyond. “There are many potential advantages conventional radiation still would be an Keyak says. “They went out of their way to expand our presence in the community with offices throughout Orange County, because this therapy uses a different type option later if spine tumors recur. make sure we could do this study and do including our newest center (page 4) opening in June in Laguna Hills. We couldn’t do it without you. With your of radiation,” says Keyak. “Conventional After more than a decade of research and it safely.” partnership, we will make new medical radiation passes through bone and hits persistence, Keyak tested the procedure She is now seeking funding or an industry breakthroughs, redefine patient treatment everything in its path, causing side effects in a pilot study of six sheep last year. The partner for additional animal studies — the and the teaching of personalized healthcare, such as nausea, vomiting and diarrhea. For research was funded by a seed grant from next step before applying to conduct a and empower our communities for mental Sincerely, spine tumors, we also have to limit the the radiology department and donations. clinical trial in humans. “I hope we can help and physical health. Become an active “We put the radioactive cement into patients because the current treatment for partner in charting UCI Health’s future path. radiation dose that can get to the tumor because the spinal cord is there.” three sheep and regular cement into three these tumors really takes away from their To make a gift to support the expansion of Brachytherapy bone cement can be other sheep,” says Keyak. “The goal was quality of life,” Keyak says. n UCI Health, to thank a provider or honor the injected directly into the vertebra. It to show that there are no adverse effects Chad T. Lefteris, FACHE memory of a loved one, call 714-456-7350 or Chief Executive Officer visit ucihealth.org/giving. Gifts to UCI Health Learn more at ucihealth.org/ir UCI Health support UCI’s Brilliant Future campaign. 22 liveLIVE well WELL UCIHEALTH.ORGucihealth.org 3 HEALTH FILES HEALTH FILES MAJOR GIFT BENEFITS CARDIOLOGY PROGRAM AT SAMUELI INSTITUTE COMPOUNDS IN TEA IMPACT BLOOD PRESSURE A $5 million gift to the University of California, Irvine, from NEW DEVICE EASES Linda and Mike Mussallem will support integrative cardiology UCI Health researchers have found properties in both green KIDNEY STONE REMOVAL training and research in the Susan Samueli Integrative Health and black tea that relax blood vessels by activating ion Institute and initiate an integrative health coaching program. channels in the blood vessel wall, helping to lower blood UCI Health researchers have developed a device that The Mussallems’ donation will be used to create an pressure. The findings could lead to the design of new blood enhances the safe removal of kidney stones in the ureter. innovative integrative cardiology program, including a pressure-lowering medications. The handheld device combines a catheter with a sensor fellowship and a research platform to assess how integrating The research, published in the journal Cellular Physiology to monitor and control the force applied as instruments lifestyle, complementary therapies and digital health tools can and Biochemistry, was led by Geoffrey Abbott, PhD, vice- are placed to remove the kidney stone, thus eliminating improve cardiometabolic health. It will also support the launch dean for basic science research and senior associate dean for the potential for ureteral injuries, according to Dr. Ralph of an integrative health coaching certificate program to address academic personnel in the UCI School of Medicine. Abbott V. Clayman, co-author of a recent study on the device and the shortage of professionals trained in whole-person care. and his team identified two flavonoid compounds in tea that professor of urology at the UCI School of Medicine. Linda Mussallem is an integrative health advocate and activate a specific type of ion channel protein, called KCNQ5, About 1 in 10 Americans will develop kidney stones in serves on the institute’s advisory board, and Mike Mussallem is to relax blood vessels.
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