Krka, D. D., Novo Mesto

Krka, d. d., Novo mesto Krka, d. d., Novo mesto Krka, d.d., Novo mesto 2 Living a healthy life. 3 Committed The results which we are achieving today will be important for the realisation to the future of new plans. We would like to achieve even better results and help create a more pleasant and safer life in the environment in which we live. We set Krka is one of the leading international high standards in all areas of our work generic pharmaceutical companies. and business operations. This is also We have been consolidating our global one of the reasons Krka is a successful position with investments enabling Slovenian company offering products progress, many research projects of European quality with which we can and stable sales growth, as well as by successfully compete in the global achieving good results in our existing pharmaceutical market. markets and entering new ones. The respect of our partners and trust Our developmental strength is the of our end-users commit us to result of clear strategies, development continuing success in development, strategies and dedication to our production and sales. So that people common values: speed and flexibility, can live a healthy life. partnership and trust, creativity and efficiency. Numerous new products, investments and the knowledge of our employees around the world are the Jože Colarič foundation on which we will continue President of the Management Board and to create added value in the future. Chief Executive 4 Living a healthy life. 5 WE ARE ONE OF THE LEADING GENERIC PHARMACEUTICAL COMPANIES WORLDWIDE Living a healthy life. 60 years of experience Our beginnings reach back to 1954, when Boris Andrijanič established the Krka pharmaceutical laboratory in Novo mesto. At first, only nine people worked in two small laboratories, production and packaging facilities equipped with a tablet press and a machine for mixing Today, Krka is internationally medicines. renowned and ranks among the 10 largest generic pharmaceutical Stable sales growth, investments, many research projects and the good results achieved under the leadership of the President of the companies worldwide. Management Board and Chief Executive Miloš Kovačič contributed to the company becoming the largest public limited company in Slovenia. In addition to the parent company, Krka, d. d., Novo mesto, the Krka Group comprises other subsidiaries in Slovenia and abroad with over 40 companies and representative offices. Krka’s main activities are the development, production, marketing and sale of prescription products, non-prescription products and animal health products, as well as Terme Krka health resort and tourist services. 8 Living a healthy life. 9 A pharmaceutical laboratory named 1962 1990 2001 Today after the River Krka was established. The first medicines acquired A new production plant with laboratories was built in Ločna. We expanded our marketing and The first production plant abroad Krka is one of the world’s marketing authorisations. We began selling our products in foreign markets. sales network abroad and built was opened in Poland. leading generic pharmaceutical new production plants. companies. From a small laboratory to the world 1954 1964 1974 1984 1994 2004 2008 2012 Over 60 years, Krka has developed into an international company employing more than 10,000 people. The US Food and Drug Administration (FDA) With the acquisition of the German company The first patent application was filed granted marketing authorisations for the Krka shares were quoted on the TAD Pharma, our marketing and sales network for diuretic hydrochlorothiazide. production of antibiotics. Ljubljana Stock Exchange. was expanded to Western European markets. 1959 1980s 1997 2007 10 Living a healthy life. 11 We develop What are generic medicines? generic medicines • They contain the same active with added value substances as the original medicines. Our generic medicines are based on: • They equal the originators’ medicines in quality, safety and our own, innovative synthesis procedures, efficacy. our own, innovative pharmaceutical forms and technologies, extensive studies, which ensure quality, safety and efficacy. 12 13 Half of all Our products are 10 million the Krka Group’s available in over patients are employees work 70 countries. treated with outside Slovenia. Krka’s medicines Over 90% for the treatment of products are of cardiovascular sold outside diseases every Slovenia. day. 14 Living a healthy life. 15 Key Mission Living a healthy life. strategic objectives Our main aim is to enable people to live a healthy and high-quality up to 2016 life. Vision We are continually Average annual sales growth of at least 6%. consolidating our position In addition to organic growth, expand through mergers and as one of the leading acquisitions and long-term partnerships. generic pharmaceutical Have new products account for at least one third of total sales. companies worldwide. Strengthen the competitive advantage of the product portfolio by maintaining vertical product integration and launching selected This is accomplished independently products as the first generic pharmaceuticals in selected key markets. by strengthening long-term business connections and partnerships in the Increase the cost efficiency of products. field of development, product supply Improve asset efficiency. and marketing. Strengthen innovation in all business functions. Values Maintain independence. speed and flexibility partnership and trust creativity and efficiency 16 Living a healthy life. 17 WE MARKET OUR OWN BRANDS Living a healthy life. The Krka Group sells over Prescription pharmaceuticals 1 billion euros worth of products and services Our core products are prescription pharmaceuticals, which account for over every year 80% of Krka’s sales. We manufacture prescription pharmaceuticals, non-prescription products and animal health products, which are marketed under our own brand Non-prescription products names. Our range of operations is further complemented by the health resort and tourist services of Terme Krka. Animal health products Health resort and tourist services 20 Living a healthy life. 21 Products for the Other Vitamins and minerals cardiovascular system The most significant therapeutic groups of Other prescription pharmaceuticals are medicines for Hair products Products for the genito-urinary system treating cardiovascular diseases, gastrointestinal and metabolic diseases and medicines for the The most significant therapeutic groups of Analgesics Products for the blood treatment of diseases of the central nervous and blood-forming organs non-prescription products are vitamins and system. Products for the minerals, products for improving cerebral and alimentary tract Products for General anti-infectives and metabolism improving cerebral peripheral circulation, products for cold and and peripheral Medicines and products are produced in various pharmaceutical circulation forms: tablets, capsules, powders, syrups, ampoules, ointments cough relief, and products for the oral cavity, etc. We develop and acquire marketing authorisations for new throat, alimentary tract and metabolism. Products for the pharmaceutical forms of medicines, which are more suitable for use central nervous system Oral cavity and and offer new ways of administration. throat products Krka medicines and products can treat and prevent the majority of Cough and the most prevalent illnesses. cold products Products for the alimentary tract and metabolism The leading prescription pharmaceuticals are: Atoris (atorvastatin), Enap (enalapril), Lorista/Lavestra (losartan), Prenessa/Perineva (perindorpil), Nolpaza (pantoprazole), Zylit/Kardogrel (clopidogrel), Emanera/Emozul (esomeprazole), Zalasta/Zolrix (olanzapine), Lanzul/Lansoptol (lansoprazole), Valsacor (valsartan), Vasilip (simvastatin) and Fromilid (clarithromycin). Our leading non-prescription products are Bilobil, Septolete, Herbion and Pikovit. 22 Living a healthy life. 23 Antimicrobial products for food-producing animals Other products Slovenia for companion animals West Europe and Overseas Markets Antimicrobial products for companion animals South-East Europe Antiparasitics for 90% of the Krka Group’s total sales are companion animals The most important therapeutic groups of generated in markets outside Slovenia. Other products for animal health products are general systemic food-producing Krka is the leader in the local market and is also widely present in the animals anti-infectives and antiparasitics for food- generic pharmaceutical markets of South-East, Central and Eastern producing and companion animals. Europe. During the last few years, we have been increasing our sales in Western European markets. Central Europe East Europe Antiparasitics for food-producing animals Our leading animal health products are Enroxil, Floron* and Fypryst. * Krka does not manufacture, offer for sale, or sell florfenicol manufactured following the process protected under the patent EP 922 040 in countries in which this patent is valid. 24 Living a healthy life. 25 VERTICAL INTEGRATION ENABLES CONTROL OF THE ENTIRE PROCESS FROM DEVELOPING RAW MATERIALS TO PRODUCING FINISHED PRODUCTS Living a healthy life. 28 Living a healthy life. 29 Our generic medicines are based on our own innovative The quality of our products is further synthesis procedures. underlined by modern and attractive packaging. Our competitive advantage is a vertically integrated business model, which enables planning and control of the entire process from customer demands,

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