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Supplementary Table 2 Table 2 : List of the 336 genes regulated in human adipose tissue during 3 hours hyperglycemic clamp UGCluster Name Symbol Fold Change Cytoband Response to stress Hs.322430 NDRG family member 4 NDRG4 1.41 16q21-q22.1 Hs.9613 Angiopoietin-like 4 ANGPTL4 -1.46 19p13.3 Hs.274363 Neuroglobin NGB -1.47 14q24 Hs.433213 Hypoxia-inducible protein 2 HIG2 -1.48 7q32.1 Hs.150837 Thioredoxin domain containing 5 TXNDC5 -1.52 6p24.3 Hs.523836 Glutathione S-transferase pi GSTP1 -1.54 11q13 Hs.523012 DNA-damage-inducible transcript 4 DDIT4 -1.96 10pter-q26.12 Immune response, cytokines & related Hs.478275 Tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 1.41 3q26 Hs.2164 Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) PPBP 1.41 4q12-q13 Hs.375108 CD24 molecule CD24 1.41 6q21 Hs.534322 Major histocompatibility complex, class II, DR beta 1 HLA-DRB1 1.41 6p21.3 Hs.278391 Toll-like receptor adaptor molecule 2 TICAM2 1.40 5q23.1 Hs.579550 Deleted in colorectal carcinoma DCC -1.47 18q21.3 Hs.232543 Programmed cell death 4 (neoplastic transformation inhibitor) PDCD4 -1.49 10q24 Hs.499674 Mannose-binding lectin (protein C) 2, soluble MBL2 -1.81 10q11.2-q21 Hs.80395 Mal, T-cell differentiation protein MAL -1.89 2cen-q13 Hs.583348 Inhibin, beta A (activin A, activin AB alpha polypeptide) INHBA -2.07 7p15-p13 Hs.522572 B-lymphocyte antigen precursor RP13-297E16.1 -2.52 Xp22.32 Hs.276925 GTP binding protein 1 GTPBP1 -2.24 22q13.1 Circulating active peptides Hs.432400 Agouti signaling protein, nonagouti homolog (mouse) ASIP -1.42 20q11.2-q12 Hs.160562 Insulin-like growth factor 1 (somatomedin C) IGF1 -1.45 12q22-q23 Hs.441047 Adrenomedullin ADM -1.45 11p15.4 Hs.1103 Transforming growth factor, beta 1 TGFB1 -1.49 19q13.2 Hs.156979 Interleukin 17B IL17B -2.05 5q32-34 Hs.2561 Nerve growth factor, beta polypeptide NGFB -2.46 1p13.1 Receptors Hs.369592 Thyroid adenoma associated THADA 1.46 2p21 Hs.525666 Olfactory receptor, family 4, subfamily N, member 4 OR4N4 1.42 15q11.2 Hs.52931 Adrenergic, alpha-1A-, receptor ADRA1A 1.40 8p21-p11.2 Hs.101480 AP1 gamma subunit binding protein 1 AP1GBP1 -1.42 17q12 Hs.155048 Basal cell adhesion molecule (Lutheran blood group) BCAM -1.43 19q13.2 Hs.438311 Angiotensin II receptor-like 1 AGTRL1 -1.53 11q12 Hs.72550 Hyaluronan-mediated motility receptor (RHAMM) HMMR -1.55 5q33.2-qter Hs.171844 Poliovirus receptor PVR -1.60 19q13.2 Hs.525105 SLIT and NTRK-like family, member 6 SLITRK6 -1.68 13q31.1 Endothelial differentiation, lysophosphatidic acid G-protein- Hs.515061 EDG6 -1.76 19p13.3 coupled receptor, 6 Hs.109514 Ryanodine receptor 2 (cardiac) RYR2 -1.77 1q42.1-q43 Hs.178066 Membrane-spanning 4-domains, subfamily A, member 5 MS4A5 -1.78 11q12 Signaling pathways Protein phosphatases Hs.19281 Protein tyrosine phosphatase, non-receptor type 14 PTPN14 -1.44 1q32.2 Hs.291000 Protein phosphatase 1K (PP2C domain containing) PPM1K -1.46 4q22.1 Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR Hs.584790 PPP2R1B -1.60 11q23.2 65), beta isoform Hs.106019 Protein phosphatase 1, regulatory subunit 10 PPP1R10 -1.62 6p21.3 Hs.148340 Protein tyrosine phosphatase, receptor type, G PTPRG -1.87 3p21-p14 Protein kinases Hs.164267 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 DYRK3 1.46 1q32.1 Hs.7200 NIMA (never in mitosis gene a)- related kinase 9 NEK9 -1.45 14q24.3 Hs.36566 LIM domain kinase 1 LIMK1 -1.47 7q11.23 Hs.431550 Mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 -1.49 2q11.2-q12 Hs.291623 TAO kinase 2 TAOK2 -1.63 16p11.2 Hs.468878 AP2 associated kinase 1 AAK1 -1.63 2p24.3-p14 Hs.531704 Protein kinase C, alpha PRKCA -1.67 17q22-q23.2 Hs.234521 Mitogen-activated protein kinase-activated protein kinase 3 MAPKAPK3 -1.73 3p21.3 Hs.133534 Kinase suppressor of ras 1 KSR1 -1.85 17q11.1 Calcium/calmodulin-dependent serine protein kinase (MAGUK Hs.495984 CASK -2.16 Xp11.4 family) Hs.478199 Protein kinase C, iota PRKCI -2.28 3q26.3 Hs.541273 V-akt murine thymoma viral oncogene homolog 2 AKT2 -2.46 19q13.1-q13.2 Hs.495731 BMX non-receptor tyrosine kinase BMX -2.53 Xp22.2 Hs.466743 Mitogen-activated protein kinase kinase kinase 10 MAP3K10 -3.06 19q13.2 cAMP Pathway Hs.194350 Protein kinase, cAMP-dependent, catalytic, alpha PRKACA -1.34 19p13.1 Hs.129493 Adenylate cyclase 5 ADCY5 -1.43 3q13.2-q21 Hs.572993 2'-phosphodiesterase 2'-PDE -1.46 3p14.3 Hs.132902 CAP, adenylate cyclase-associated protein, 2 (yeast) CAP2 -1.47 6p22.3 Hs.486483 A kinase (PRKA) anchor protein 7 AKAP7 -1.48 6q23 Hs.170839 Phospholamban PLN -1.61 6q22.1 Others signaling pathways Hs.6136 Rho GTPase activating protein 20 ARHGAP20 1.47 11q22.3-q23.1 Hs.233495 Pleckstrin homology domain containing, family A member 8 PLEKHA8 1.45 7p21-p11.2 Hs.125293 RasGEF domain family, member 1A RASGEF1A 1.41 10q11.21 Hs.535257 Centaurin, beta 5 CENTB5 -1.41 Hs.778 Guanylate cyclase activator 2A (guanylin) GUCA2A -1.41 1p35-p34 Hs.469593 LIM and senescent cell antigen-like domains 1 LIMS1 -1.42 2q12.3-q13 Hs.477142 Phosphatidic acid phosphatase type 2B PPAP2B -1.43 1pter-p22.1 Hs.121593 Centaurin, alpha 1 CENTA1 -1.43 7p22.3 Hs.465506 Phosphatidic acid phosphatase type 2C PPAP2C -1.43 19p13 Hs.531752 RAN binding protein 3 RANBP3 -1.43 19p13.3 Hs.303208 SH2 domain containing 4A SH2D4A -1.46 8p21.2 Hs.442344 Insulin receptor substrate 2 IRS2 -1.48 13q34 Hs.225356 CDC42 effector protein (Rho GTPase binding) 1 CDC42EP1 -1.49 22q13.1 Hs.32966 Guanylate cyclase activator 2B (uroguanylin) GUCA2B -1.52 1p34-p33 Hs.302435 Centaurin, gamma 1 CENTG1 -1.54 12q14.1 Hs.522378 DAB2 interacting protein DAB2IP -1.57 9q33.1-q33.3 Hs.50640 Suppressor of cytokine signaling 1 SOCS1 -1.60 16p13.13 Pleckstrin homology domain containing, family G (with RhoGef Hs.1116 PLEKHG6 -1.78 12p13.31 domain) member 6 Pleckstrin homology domain containing, family G (with RhoGef Hs.189781 PLEKHG1 -1.82 6q25.1 domain) member 1 Hs.515469 Vasodilator-stimulated phosphoprotein VASP -1.91 19q13.2-q13.3 Hs.368808 EH-domain containing 3 EHD3 -1.92 2p21 Hs.133044 Raptor raptor -2.10 17q25.3 Hs.435019 Neurexophilin 2 NXPH2 -2.21 2q22.1 Hs.521482 Src homology 2 domain containing adaptor protein B SHB -2.25 9p12-p11 Enzymes Carbohydrate metabolism Hs.591588 Hexokinase 2 HK2 1.65 2p13 Hs.26010 Phosphofructokinase, platelet PFKP 1.40 10p15.3-p15.2 Phosphorylase, glycogen; muscle (McArdle syndrome, glycogen Hs.154084 PYGM -1.40 11q12-q13.2 storage disease type V) Hs.411695 Hexokinase 3 (white cell) HK3 -1.70 5q35.2 Hs.8364 Pyruvate dehydrogenase kinase, isozyme 4 PDK4 -2.17 7q21.3-q22.1 Hs.195471 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PFKFB3 -2.23 10p14-p15 Hs.590891 Phosphoglucomutase 3 PGM3 -2.69 6q14.1-q15 Lipid metabolism Hs.122038 Acyl-CoA thioesterase 6 ACOT6 1.46 14q24.3 Hs.128598 3-hydroxyisobutyryl-Coenzyme A hydrolase HIBCH 1.41 2q32.2 Hs.303980 Cytochrome P450, family 11, subfamily A, polypeptide 1 CYP11A1 -1.45 15q23-q24 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic Hs.320151 AGPAT2 -1.49 9q34.3 acid acyltransferase, beta) Hs.50727 Hydroxysteroid (17-beta) dehydrogenase 1 HSD17B1 -1.51 17q11-q21 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta- Hs.364941 HSD3B1 -1.65 1p13.1 isomerase 1 ATPase Hs.34114 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide ATP1A2 1.58 1q21-q23 Hs.370834 ATPase family, AAA domain containing 2 ATAD2 1.43 8q24.13 Hs.306212 ATPase, Class I, type 8B, member 3 ATP8B3 -1.90 19p13.3 Others enzymes Hs.67201 5', 3'-nucleotidase, cytosolic NT5C 1.48 17q25.1 Hs.524579 Lysozyme (renal amyloidosis) LYZ 1.48 12q15 Hs.104347 2-aminoadipic 6-semialdehyde dehydrogenase AASDH 1.43 4q12 Hs.284491 Pyridoxal (pyridoxine, vitamin B6) kinase PDXK 1.42 21q22.3 Hs.75372 N-acetylgalactosaminidase, alpha- NAGA -1.47 22q13-qter Hs.500750 Heparanase 2 HPSE2 -1.49 10q23-q24 Sulfotransferase family, cytosolic, 1A, phenol-preferring, member Hs.567342 SULT1A1 -1.49 16p12.1 1 Hs.512181 Spermidine/spermine N1-acetyl transferase-like 1 SATL1 -1.57 Xq21.1 Hs.458332 Pyrroline-5-carboxylate reductase 1 PYCR1 -1.81 17q25.3 Hs.369762 Enolase superfamily member 1 ENOSF1 -1.88 18p11.32 Hs.431417 Arylalkylamine N-acetyltransferase AANAT -2.30 17q25 Hs.463466 Carbonic anhydrase X CA10 -2.32 17q21 Hs.159525 Cell growth regulator with EF-hand domain 1 CGREF1 -2.62 2p23.3 Structural proteins & cytoskeleton Hs.520554 Tubulin tyrosine ligase-like family, member 2 TTLL2 1.48 6q27 Hs.60480 Keratin associated protein 19-3 KRTAP19-3 1.45 21q22.1 Hs.407580 Plakophilin 4 PKP4 -1.42 2q23-q31 Hs.2785 Keratin 17 KRT17 -1.43 17q12-q21 Hs.418012 Collagen, type IX, alpha 2 COL9A2 -1.46 1p33-p32 Hs.497350 Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) PKP1 -1.47 1q32 Hs.432390 Dynein, axonemal, heavy polypeptide 11 DNAH11 -1.51 7p21 Hs.534797 Catenin (cadherin-associated protein), alpha 1, 102kDa CTNNA1 -1.57 5q31 Hs.1076 Small proline-rich protein 1B (cornifin) SPRR1B -1.57 1q21-q22 Hs.381181 Coiled-coil domain containing 96 CCDC96 -1.60 4p16.1 Hs.125133 Hermansky-Pudlak syndrome 6 HPS6 -1.61 10q24.32 Fascin homolog 2, actin-bundling protein, retinal Hs.118555 FSCN2 -1.63 17q25 (Strongylocentrotus purpuratus) Hs.25640 Claudin 3 CLDN3 -1.67 7q11.23 Hs.487036 Myosin VC MYO5C -1.67 15q21 Microtubule associated monoxygenase, calponin and LIM domain Hs.501928 MICAL2 -1.67 11p15.3 containing 2 Hs.446867 Formin 1 FMN1 -1.69 15q13.3 Hs.34780 Doublecortex; lissencephaly, X-linked (doublecortin) DCX -1.70 Xq22.3-q23 Hs.499745 Myosin, heavy polypeptide 2, skeletal muscle, adult MYH2 -1.71 17p13.1 Hs.513915 Claudin 7 CLDN7 -1.71 17p13
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