Program Book ECM Microenvironments in Disease, Aging, and Regeneration

Program Book ECM Microenvironments in Disease, Aging, and Regeneration

American Society for Matrix Biology BIENNIAL 2018 MEETING OCTOBER 14-17, 2018 Red Rock CASINO RESORT SPA LAS VEGAS, NV Thank you to our 2018 sponsors! Welcome Letter ASMB is your society, so please attend and participate in Dear Matrix Biology Community, discussions about our current and future activities. Finally, we On behalf of the American Society for Matrix Biology (ASMB), let hope to see you at the Banquet on Tuesday evening, where you GOLD LEVEL SPONSOR me extend a warm welcome to our attendees at this 8th Biennial can express the “Las Vegas” part of your personalities. Also be Conference of ASMB, “ECM Microenvironments in Disease, sure to enjoy the natural beauty in the surrounding Red Rock Aging, and Regeneration.” Our Incoming President, Lynn Sakai, Canyon national conservation area. and the Program Committee have assembled an innovative and This conference is the culmination of the dedicated and fresh program that highlights emerging concepts and state of the professional efforts of many people. Kendra LaDuca, ASMB art technologies in matrix biology. Dr. David Lyden from Memorial Executive Director, is the glue that holds us all together, oversees SILVER LEVEL SPONSOR Sloan Kettering Cancer Center, our keynote lecturer, will speak essential details, and keeps us cost efficient. ASMB is extremely on “Exosomes and Integrins in Cancer.” The increasing reach of fortunate to have Kendra at the helm, now running her 4th ASMB matrix biology across scientific disciplines is evidenced by the conference. Lynn Sakai and her vision, the Program Committee, participation of Tissue Engineering and Regenerative Medicine Executive Council, and ASMB Council members have all made International Society North America (TERMIS), the Histochemical important contributions to the content and organization of this Society, and the Alport Syndrome Foundation. The global reach of conference. Thank you so very much! this conference is reflected by the participation of Matrix Biology Ireland (MBI) and the continued contributions of the International Finally, our sponsors are essential. We are grateful for the Society for Matrix Biology (ISMB), a long-time, important ASMB continuing support of the NIH and the National Institute of partner. We greatly appreciate the roles of these societies in the Arthritis and Musculoskeletal Diseases (NIAMS), The Company meeting and look forward to years of productive interactions. of Biologists, Matrix Biology/Elsevier, the Vanderbilt Center for BRONZE LEVEL SPONSOR Matrix Biology, and the Marfan Foundation, as well as the many One of the highlights of this meeting is recognition of ASMB industry sponsors noted on the inside cover, who make this event scientists who are making especially important contributions possible. We additionally thank our organizational partners, ISMB, to the field of matrix biology. In 2018, we are very pleased to the Alport Syndrome Foundation and the Histochemical Society recognize Jean Schwarzbauer (ASMB Senior Investigator), Rachel for their support of the meeting and provision of travel awards. Lennon (Iozzo Award Winner), and Alexandra Naba (ASMB Junior Investigator). We are also very pleased to present the first This is your meeting and its success and the continued Founders Award prize to Vincent Fiore. The Founders Award robustness of matrix biology is due to your participation and honors the memory of the leaders responsible for the founding of sharing of your findings. Please consider becoming more ASMB in 2001 and is given to young investigators in the process involved in promoting matrix biology locally at your institutions of establishing their independent careers. It is also a great and at the ASMB level through volunteering on committees, by CONTRIBUTOR LEVEL SPONSOR pleasure that this ASMB Conference is the venue for presentation running for ASMB Council (no need to form PACs!), or by making of the ISMB Distinguished Investigator Award to Billy Hudson. In tax-deductible contributions. Membership is important as this Plenary Session II, Pepper Schedin will present a tribute to the allows ASMB to support trainee travel awards and develop new late Patricia Keely. initiatives and partnerships. We also hope to see you at the two 2019 ASMB workshops that are planned: Fibroblasts: The Continuing the tradition established at the 2014 meeting, ASMB Arbiters of Extracellular Matrix Remodeling, June 24-25, 2019 2018 will feature 3 sessions organized and led by trainees at the University of Virginia, Charlottesville, VA and the Workshop on Sunday, Tuesday, and Wednesday. I encourage you all to on Basement Membranes, July 10-12, 2019 at Vanderbilt support these young investigators by attending and participating University Medical Center, Nashville, TN. A Very Special Thank You vigorously. In addition, ASMB will host two mentoring breakfasts to facilitate informal discussions between younger investigators Contrary to the popular slogan advocating Las Vegas tourism, Funding for this conference was made possible (in part) by(1 R13AR074236-01) from the National Institute Of Arthritis and trainees and more established scientists. The Career we really do hope that what happens in Vegas gets widely And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and disseminated from Vegas. Leave this ASMB Conference by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; Mentoring Breakfast is Monday morning and the Women nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. Mentoring Women Breakfast is Tuesday morning. energized, inspired, and ready to spread the word about the importance of matrix biology! We are pleased to see a large number of poster submissions. Please take advantage of these sessions to meet your colleagues Best wishes and safe travels, one on one and remember that important science occurs at the Joanne Murphy-Ullrich posters! The ASMB Business meeting is mid-day on Monday: ASMB President

1 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 2 Planning Team Acknowledgement Table Of Contents

ASMB and the Meeting Chair extend a heartfelt thank you to those who helped to make this meeting possible.

ECM Microenvironments in ASMB Scientific Program Planning Committee Disease, Aging, and Regeneration

Suneel Apte Wei Kong Pyong Park American Society for Matrix Biology Ashley Brown Beth Kozel Bill Parks Adam Engler Shireen Lamande Ambra Pozzi BIENNIAL MEETING Yutaka Inagaki Karen Lyons Liliana Schaefer 2018 Luisa Iruela-Arispe Joanne Murphy-Ullrich Pepper Schedin OCTOBER 14-17, 2018 Zenzo Isogai Enid Neptune Michelle Tallquist

Welcome Letter...... 2 Special Interest Session leaders Planning Team Acknowledgement...... 3 Shyam Kumar Bandari Reut Shainer Officers and Council Listing...... 5 Davy Vanhoutte Invited Speakers and Chairs...... 6 2018 Award Winners...... 7 Guest Symposia Organizers Exhibitors...... 8 Lilliana Schaefer and Charles Frevert, The Histochemical Society General Information...... 9 Adam Engler and Thomas Barker, TERMIS Jeffrey Miner, Alport Syndrome Foundation Meeting Floor Plan...... 10 Dimitrios I. Zeugolis, Matrix Biology Ireland Scientific Program...... 11 Poster Program ...... 19

A special thank you as well to those unnamed In Memoriam...... 37 who participated in reviewing abstracts and planning the mentoring breakfasts. Your contributions are invaluable!

3 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 4 Officers and Council Listing Invited Speakers and Chairs

PRESIDENT PAST PRESIDENT Suneel Apte, Cleveland Clinic David C. Lyden, Weill Cornell Joanne Murphy-Ullrich Suneel Apte Foundation Medicine, Meyer Cancer Center University of Alabama at Birmingham Lerner Research Institute, Ashley Brown, North Carolina State Karen Lyons, University of California The Cleveland Clinic Foundation University and University of North Los Angeles PRESIDENT ELECT Carolina at Chapel Hill Lynn Sakai SECRETARY/TREASURER Peter Marinkovich, Stanford University Portland Shriners Hospital for Children Ambra Pozzi Sergei Budko, Vanderbilt Medical School of Medicine Oregon Health & Science University Vanderbilt University Medical Center Center James Martin, Baylor College of Atul Chopra, Baylor College of Medicine Medicine Alexandra Naba, University of Illinois Aris Economides, Regeneron Chicago COUNCILORS Janine Erler, University of Copenhagen Enid Neptune, Johns Hopkins Medical Institute Thomas Barker Alexandra Naba Jeffrey D. Esko, University of University of Virginia University of Illinois at Chicago California, San Diego William Parks, Cedars-Sinai Medical Center Cyrus Ghajar, Fred Hutchinson Cancer Adam Engler Karen Posey Research Center Ambra Pozzi, Vanderbilt University University of California San Diego University of Texas Medical School Medical Center Joe Gray, Oregon Health & Science Marion Gordon Christopher Overall University Francesco Ramirez, Icahn School of Rutgers University University of British Columbia Medicine at Mount Sinai Farshid Guilak, Washington University St. Louis Kota Saito, Akita University Dirk Hubmacher Michelle Tallquist Icahn School of Medicine at Mount Sinai University of Hawaii Kirk Hansen, University of Colorado Liliana Schaefer, Goethe University, School of Medicine Frankfurt, Germany Andrew Leask Western University in London, Ontario Editor, The Matrix Letter Jeffrey Holmes, University of Virginia Pepper Schedin, Oregon Health & Science University Dwayne Stupack Dirk Hubmacher, Icahn School of Merry Lindsey University of California, San Diego Medicine at Mt. Sinai Jean Schwartzbauer, Princeton University of Mississippi Medical Center University Billy Hudson, Vanderbilt University Kiyotoshi Sekiguchi, Osaka University Luisa Iruela-Arispe, University of California Los Angeles David R. Soto-Pantoja, Wake Forest School of Medicine Comprehensive Sarah Knox, University of California Cancer Center Thank You to ASMB Outgoing Council Members San Francisco Tim Springer, Harvard University Beth Kozel, National Institutes of Health Olga Stenina-Adognravi, Cleveland 2017 Clinic David Birk, Beth Kozel, and Liliana Schaefer Deborah Krakow, University of California Los Angeles Hiromi Yanagisawa, University of Tsukuba Shireen Lamande, Murdoch Children’s 2018 Research Institute Weilan Ye, Genentech Inc Suneel Apte, Adam Engler, and Michelle Tallquist

5 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 6 2018 Award Winners Exhibitors

3Helix Elsevier 675 Arapeen Drive, Suite 302 Radarweg 29, 1043 NX Salt Lake City, UT 84108 Amsterdam, The Netherlands https://www.3helix.com/ +31 20 485 2648 On-site Representative: Yang Li www.elsevier.com Email: [email protected] On-site Representative: Valerie Teng-Broug Email: [email protected]

Advanced BioMatrix, Inc Senior Investigator Junior Iozzo Award Founders Award ISMB 5930 Sea Lion Place, Suite 100 International Society for Matrix Investigator Distinguished Carlsbad, CA 92010 Biology Jean Schwartzbauer, Rachel Lennon, Vincent Fiore, Investigator 800-883-8220 www.ismb.org Princeton University Alexandra Naba, University of The Rockefeller University of Manchester University Billy Hudson, www.advancedbiomatrix.com President: Liliana Schaefer Illinois at Chicago Vanderbilt University On-site Representative: Email: [email protected] Medical Center David Bagley and Bowman Bagley Email: [email protected] Nippi/Matrixome 520-11 Kuwabara ASMB Travel AMSBIO Toride, Ibaraki 302-0017, Japan Dwight Chambers, Georgia Institute of Technology 1035 Cambridge Street, Suite 21D http://www.nippi-inc.co.jp Danielle Kamato, University of Queensland Cambridge, MA 02141 On-site Representative: Kazunori Mizuno Shyam Kumar Bandari, The University of Alabama at Birmingham 617-945-5033 Email: [email protected] Anna Kornmuller, The University of Western Ontario http://www.amsbio.com/ Jared Saunders, Princeton University On-site Rep: Andrew Hydrusko Email: [email protected] The Histochemical Society ASMB Underrepresented Minority Travel 9650 Rockville Pike Melisa DeGroot, Cornell University Bethesda, MD 20814 Maria Eugenia Vega, Princeton University CedarLane President: Margarida Barroso Selene Colon, Vanderbilt University Medical Center 1210 Turrentine Street http://histochemicalsociety.org/ Burlington, NC, 27215 Email: [email protected] ISMB International Travel Awards +1 (800) 721-1644 Rocco Bernasconi, Uniklinik Freiburg www.cedarlanelabs.com Joan Chang, University of Manchester On-site Representative: Cynthia Greer Tissue Source, LLC Wing Ying Chow, Leibniz Forschungsinstitut for Molecular Pharmacology Email: [email protected] Lafayette, IN 47909 888-984-7783 Histochemical Society Travel Awards http://www.tissue-source.com/ Sumeda Nandadasa, Cleveland Clinic Lerner Research Institute On-site Rep: Bill MacFie Blain Jones, Ohio State University Email: [email protected] Elee Shimshoni, Weizmann Institute of Science Pascal Morrissette Martin, University of Western Ontario Yue Leng, Purdue University

Alport Syndrome Foundation Travel Awards Pinyuan Tian, University of Manchester Michael Yu, University of Utah

7 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 8 General Information Meeting Floor Plan

Registration Hours Audio Visual Information Poster Set-up/Poster Business Meeting Liability for Speakers Sessions The meeting registration desk is located All ASMB members are encouraged and Neither the host venue nor the organizers ASMB Policy on Photography and Audio in the Summerlin Foyer of the Red Rock Presenters are asked to load their talks as Poster boards will be set-up in the invited to attend the Member Business can be held responsible for any personal / Video Recording at ASMB Conferences Resort. Name badges and conference early as possible into the assigned on-line Summerlin A-B-C Ballroom. All posters Meeting on Monday, October 15th injury, loss, damage to private property materials can be picked up at the ASMB folder. Presenters are asked to meet with will be on display throughout the entire from 12:00–12:30pm. The advice and or additional expense incurred as a result During ASMB meetings, attendees and Registration Desk. The desk will be an AV tech in the back of their presenta- conference but will be presented in two guidance of the membership on current of delays or changes in air, rail, sea, road guests are prohibited from visual or audio staffed during the following hours. tion room at least 2 hours prior to their separate sessions. Odd number board society issues is welcome in these “open or other services. All participants are recording of scientific presentations. Sunday, October 14th sessions. If you require any assistance, numbers will formally present on Mon- forum” meetings. If you are not currently encouraged to make their own arrange- Poster materials may only be photo- 9:00am–6:00pm please contact one of the AV Technicians day, October 15th from 12:30–2:30PM, a member, applications are available at ments for health and travel insurance. graphed the Registration Desk. Monday, October 15th in advance of your presentation. Please while even numbers boards will formally 7:30am–5:30pm arrive in the session room at least 15 min- present on Tuesday, October 16th from utes prior to the start of your session. 12:00–2:00PM. Set-up and breakdown Tuesday, October 16th for ALL poster boards is as follows: 7:30am–5:30pm Wednesday, October 17th Set-up posters starting 8:00am–12:00pm Airport and Monday, October 15th, 7:30am Remove posters by Transportation Wednesday, October 17th, 2:00PM

The Las Vegas McCarran International Air- Poster Session I Registration port is just 25 minutes from the Red Rock Monday, October 15th Canyon Resort. A complimentary resort 12:30–2:30pm Registration fees include the main con- shuttle is available to and from the airport. ference scientific sessions, one program Pick-up at the airport is at ground zero. Poster Session II book and the meals included below. Tuesday, October 16th Registration fees exclude hotel costs. 12:00–2:00pm On-site registration will be accepted with payment via checks and credit cards. The organizers are not responsible for Banquet tickets must be purchased Parking any materials posted. Push pins will be separately and in advance and are not provided. included in the registration fee. For meeting attendees, the hotel offers complimentary valet and self-parking.

Accompanying Persons Catering Exhibits Included in registration fees are the Guests are welcome to enjoy the city following catered events: Please take time to visit the exhibit dis- during the conference hours. There are Sunday Night Opening Reception plays in the Summerlin Foyer area during many sites and attractions within walking Monday, Tuesday, and Wednesday the breaks and poster sessions. See the distance. For the most complete infor- Continental Breakfast exhibitor listing for detailed information mation about the local area and things to Monday and Tuesday Poster Session regarding our sponsoring companies. do while in Las Vegas, check out the Visit Boxed Lunch Las Vegas website or contact the hotel AM and PM coffee breaks concierge at (702) 797-7877. Exhibits Schedule Internet Access Sunday, October 14th 12:00pm–6:00pm Special Needs Internet access is provided in the guest Monday, October 15th rooms for those staying onsite at the Red 7:30am–5:30pm Registrants with special needs are invited to contact the Registration Desk or hotel Rock Resort within the meeting block Tuesday, October 16th concierge for assistance. as part of the resort fee. Complimentary 7:30am–5:30pm access is also provided by ASMB in the Wednesday, October 17th meeting spaces (Username: ASMB2018 8:00am–1:00pm Password: ASMB2018!).

9 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 10 Scientific Program Scientific Program

ASMB Biennial Meeting • October 14-17, 2018 1:45pm Dysregulation of Matricellular Protein 2:00pm A Fibronectin Matrix-Based Mechanism for Thrombospondin-2 in Diabetes; TSP2 Deficient Proteolytic Processing of Procollagen I, Jared Red Rock Canyon • Las Vegas, NV Hydrogel Derived from Extracellular Matrix Saunders, Princeton University Accelerates Diabetic Wound Healing, Poster B013 ECM Microenvironments in Disease, Aging and Regeneration Britta Kunkemoeller, Yale University 2:15pm Structural Insights Into Collagen Lysyl Meeting Chair: Lynn Sakai, Shriners Hospital for Children and Oregon Health & Science University Poster B004 Hydroxylases, Hou-Fu Guo, The University of Texas 2:00pm Connective Tissue Growth Factor Is Secreted MD Anderson Cancer Center as A Preproprotein that Requires Proteolytic PosterB014 Activation, Ole J. Kaasboell, Oslo University Hospital, Sunday, October 14th Institute for Surgical Research 10:00am–12:00pm Poster B005 2:30-2:45pm Guest Symposium III–Alport Syndrome Foundation 2:15pm SPARC Produced by Bone-Marrow Derived Cells Break Location: Summerlin F Contributes to Myocardial Fibrosis, Hannah Riley, 9:00am–6:00pm Chair: Jeffrey Miner, Washington University School of MUSC 2:45-4:15pm Registration Medicine Poster B006 Concurrent Sessions Location: Summerlin Foyer 10:00am Biochemical Mechanisms of Collagen IV Assembly, Gautam Jay Bhave, Vanderbilt University Concurrent 2: Proteoglycans SIS 1: Trainee Led Session: Extracellular Vesicles — Medical Center 10:00am–12:00pm Location: Summerlin E The Next SMALL Thing Guest Symposium I–TERMIS 10:30am Proteomics of the Glomerular Basement Chair: Liliana Schaefer, Goethe University *Session Sponsored by Bio-Techne,System Biosciences, LLC., Rachel Lennon, Location: Summerlin D Membrane in Alport Syndrome, 1:00pm Proteoglycan Signaling at the Crossroads, Liliana and iZon Science. University of Manchester Chairs: Adam Engler, University of California San Diego and Schaefer, Goethe University 11:00am Thomas Barker, University of Virginia Targeting the Activin Receptor to Slow 1:30pm Versican Is Required for Primary Hematopoiesis Keith Hruska, Progression of Alport Syndrome, and Yolk Sac Vasculogenesis in the Mouse 10:00am Opening Remarks Washington University School of Medicine Location: Summerlin D Embryo, Sumeda Nandadasa, Cleveland Clinic Lerner Organizer: Shyam Kumar Bandari, University of Alabama at 10:15am 11:30am Modelling Alport Syndrome Using Patient-Derived 3D Collagen Fibril Architecture Regulates Cancer Research Institute Birmingham Migration and Morphogenesis, Stephanie Fraley, Kidney Organoids, Pinyuan Tian, University of Poster B007 University of California San Diego Manchester 2:45pm Tumor Exosomes: From Mediators of Systemic 1:45pm Endorepellin Evokes A Pro-mitophagic Disease to Biomarkers of Metastatic Spread, Irina 10:50am Poster B001 The Extracellular Matrix Dictates Cellular Force Transcriptomic Signature and Regulates Matei, Drukier Institute for Childrens Health and Meyer Generation Through Tropomyosin-Dependent 11:45am Collagen Hybridizing Peptide: New Molecular Mitochondrial Homeostasis in Endothelial Cells, Cancer Center Mechanisms, Ryan J. Petrie, Drexel University Probe for In Vitro and In Vivo Detection of Thomas Neill, Thomas Jefferson University Poster B015 11:25am Regulation of Endothelial Cell Function and Fate Degraded and Denatured Collagen, Michael Yu, Poster B008 3:05pm Chemoexosomes Secreted By Myeloma Cells Using the Extracellular Matrix, Ngan F. Huang, University of Utah 2:00pm ADAMTS5 Is Coupled with Mechanical Load Enhance Osteoclast Formation and Promote Stanford University Poster B002 During Mandibular Condylar Development, Aggressive Myeloma Bone Disease, Shyam Kumar Alexandra Rogers, Medical University of South Carolina Bandari, University of Alabama at Birmingham Poster B009 10:00am–12:00pm 12:00-6:00pm Poster B016 2:15pm Biofabrication of An Ideal ECM Mimetic to Guest Symposium II – The Histochemical Society Imagining Exhibits 3:25pm Inflaming the Masses: Glioma Exosomes Promote Location: Summerlin Foyer Function As A Small Diameter Artery, William D. Inflammatory Response in Normal Brain, Michael the Matrix – Just Do it Right Wagner and Harleigh J. Warner, Wake Forest University Location: Summerlin E W Graner, University of Colorado Denver School of Medicine Poster B017 Chairs: Liliana Schaefer, Goethe University and Charles 12:00-1:00pm Poster B010 Frevert, University of Washington 3:45pm PMN-derived Exosomes Are New Pathogenic Break – Lunch on Your Own 10:00am Introduction: The Relevance of Histochemistry Entities in COPD Lung Disease, Amit Gaggar, Concurrent 3: Collagens University of Alabama at Birmingham and Immunohistochemistry in the Era of “Omics” Location: Summerlin F 1:00-2:30pm 10:15am Rediscovering the Interstitium: The Effect Chair: Sergei Budko, Vanderbilt University Medical Center 4:00pm Exosomes in Fibronectin Matrix Organization, of Tissue Fixation and Processing on the Concurrent Sessions Merlyn Emmanuel, Vanderbilt University School of 1:00pm Collagen IV Assembly Mechanisms, Sergei Budko, Medicine Extracellular Matrix, Stephen Hewitt, National Concurrent 1: Matricellular Proteins Vanderbilt University Medical Center Cancer Institute, NIH Location: Summerlin D 1:30pm VPS33b Is Essential for Collagen Homeostasis, 10:40am Advances in Digital Imaging and Microscopy Chair: Olga Stenina-Adognravi, Cleveland Clinic Concurrent 4: Elastic Fiber Proteins Joan Chang, Wellcome Centre for Cell-Matrix Location: Summerlin E That Allow for Better Imaging of the Extracellular 1:00pm Thrombospondins in Tissue Remodeling, Olga Research, University of Manchester Chair: Hiromi Yanagisawa, University of Tsukuba Matrix (ECM), Paul Goodwin, AppliedPrecision/GE Stenina-Adognra, Cleveland Clinic Poster B011 2:45pm Short Fibulins in Maintenance of Vessel Walls, 11:05am Quantitative Analysis of the ECM Using Special 1:30pm Activation of Cancer-associated Fibroblasts Is 1:45pm Zebrafish Round Mutations Reveal A Novel Post- Hiromi Yanagisawa, University of Tsukuba Stains, Immunohistochemistry, and Quantitative Required for Metastasis in A Murine Model of Golgi Collagen Secretory Pathway Linked to a Digital Pathology, Charles Frevert, University of Melanoma, Andrew Leask, University of Western Developmental TICCA Syndrome, Gokhan Unlu, 3:15pm Fibulin-4 Deficiency Differentially Affects TGF Washington Ontario Vanderbilt University Signaling As Well As Cytoskeleton Structure and 11:40am Panel Discussion Poster B003 Poster B012 Dynamics, Joyce Burger, Erasmus Medical Center Poster B018

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3:30pm Molecular Interaction Between Elastogenic 5:30pm Senior Investigator Awardee 9:30am A Multiscale View of Breast Tumor-ECM 3:45pm Proteomic Analysis of Extracellular Matrix Proteins Impacting Matrix Assembly and How to Build a Matrix, Jean Schwarzbauer, Interactions, Joe Gray, Oregon Health and Science Dynamics During Mouse Forelimb Development, Function, Heena Kumra, McGill University Princeton University University Kathryn R. Jacobson, Purdue University Poster B019 Poster B029 3:45pm Smooth Muscle and Endothelial Cell 6:00-7:00pm 10:00-10:30am Contributions to Arterial Elastin Deposition, M. Concurrent 7: ECM of Inflamation, Infection and Immunity Catalin Staiculescu, Washington University Opening Reception Coffee Break Location: Summerlin E Poster B020 Location: Veranda Location: Veranda Chair: David R. Soto-Pantoja, Wake Forest School of 4:00pm Aortic Smooth Muscle Cell Elastogenesis Driven Medicine Comprehensive Cancer Center by Adipose-Derived Mesenchymal Stem Cell 7:00-7:15pm 10:30-12:00pm 2:30 pm Thrombospondin-1 Regulates Microbiota and Secreted Factors, Aneesh K Ramaswamy, University Founders Award Talk Plenary II: ECM in Disease, Aging and Regeneration Metabolic Associated Inflammation to Impact of Pittsburgh Location: Summerlin E-F Location: Summerlin E-F Carcinogenesis, David R. Soto-Pantoja, Wake Forest Poster B021 Introduction by: Robert Mecham, Washington University St. Louis Chair: Suneel Apte, Cleveland Clinic Foundation School of Medicine Comprehensive Cancer Center Mechanical Force and Matrix Regulation of Tumor Initiation 10:30am Collagen as a Target for NSAID-Based Breast 3:00pm ADAMTS7 and Influenza Virus Immunity,John Concurrent 5: Matrix in Morphogenesis and Progression, Vincent Fiore, The Rockefeller University Cancer Prevention—A Tribute to Patricia Keely, Stambas, Deakin University Location: Summerlin F Pepper Schedin, Oregon Health & Science University Poster B030 Chair: Sarah Knox, UCSF 3:15pm Thrombospondin-4 Produced by Pro- 7:15-8:00pm 11:00am Imaging, Modeling, and Modifying Matrix 2:45 pm It Takes Nerve: How Neuronal Cues Control Organ Remodeling Following Myocardial Infarction, Inflammatory Macrophages Promotes Morphogenesis and Regeneration, Sarah Knox, Keynote Lecture Jeffrey Holmes, University of Virginia Inflammation,Mohammed Tanjimur Rahman, University of California San Francisco Chair: Lynn Sakai, ASMB President Elect Cleveland Clinic Location: Summerlin E-F 11:30am Hippo/Yap Signaling in Heart Regeneration, James Poster B031 3:15pm Dystroglycan Regulates Signaling Pathways Martin, Baylor University Critical to Postnatal Brain Development, Holly Tumor Exosomes and Exomeres Promote Cancer 3:30pm Extracellular Superoxide Dismutase (EC-SOD) Colognato, Stony Brook University Metastasis and Systemic Disease, David Lyden, Weill Cornell Knockout Mice Have Worse Alveolarization, Poster B022 Medical College 12:00-12:30pm Inflammation and Cytokine Elaboration After 3:30pm ECM Omics Identifies Signature ECMs for the ASMB Business Meeting Neonatal Hyperoxia Exposure, Rashmin C. Savani, Sites of Inter-tissue Interactions in Mouse Hair Chair: Joanne Murphy-Ullrich, ASMB President University of Texas Southwestern Medical Center Follicles, Ko Tsutsui, Riken Center for Biosystems Location: Summerlin E-F Poster B032 Dynamics Research Monday, October 15th 3:45pm Distinct Sorting of Subsets of Extracellular Poster B023 Vesicles Expressing CD63, MHC Class 1, and 12:30-2:30pm 3:45pm ADAMTS9 and ADAMTS20 Have a Dual Function CD47 in Cell-Cell Communication, Sukhbir Kaur, Poster Session I Center for Cancer Research, National Cancer Institute, in ECM Remodeling and Biogenesis of the 7:15-8:30am Primary Cilium, Sumeda Nandadasa, Cleveland Clinic Location: Summerlin A-B-C National Institutes of Health Lerner Research Institute Career Mentoring Breakfast Odd Number Boards Present Poster B033 Poster B024 (Pre-registration Required) Discussion begins at 7:30am 4:00pm Mouse B3glct Knockout: A Model for Congenital 2:30-4:00pm Concurrent 8: Mechanosensing Location: Veranda C Location: Summerlin F Hydrocephaly and Craniofacial and Skeletal Concurrent Sessions Dysmorphology, Bernadette C. Holdener, Stony Chair: Ashley Brown, North Carolina State University and University of North Carolina at Chapel Hill Brook University 7:30am-5:30pm Concurrent 6: Structure &Assembly of ECM Poster B025 Location: Summerlin D 2:30pm Understanding the Role of Platelet-Mediated Registration and Exhibits Chair: Kiyotoshi Sekiguchi, Osaka University Fibrin Clot Retraction in Wound Repair, Ashley Location: Summerlin Foyer 2:30pm Mechanistic Basis for the Laminin Recognition by Brown, North Carolina State University and University 4:15-4:30pm Integrin, Kiyotoshi Sekiguchi, Osaka University of North Carolina at Chapel Hill Break 7:30-8:30am 3:00pm Collagen IV Scaffolds are Coated with Agrin/ 3:00pm Non-Coding Mechanogenomic Regulation Location: Veranda Breakfast Perlecan: A Unique Organizational Feature of a Identified in Human Cardiomyocytes,Adam J Location: Veranda Model Basement Membrane, Elena Pokidysheva, Engler, University of California San Diego 4:30-6:00pm Vanderbilt University Medical Center Poster B034 Poster B026 3:15pm Mechanical Cell Communication and Its Influence President’s Welcome & Award Talks 8:30-10:00am Location: Summerlin E-F 3:15pm Formation of Lamellae in the Corneal Stroma: on Organization of Cellular Structures, Daniel Plenary I: Novel Approaches and Technologies to Chair: Joanne Murphy-Ullrich, ASMB President New Insights in the Underlying Pathomechanism Rüdiger, Ludwig-Maximilians University, Munich Investigate the Extracellular Matrix of Keratoconus, Uwe Hansen, Institute for Poster B035 4:30pm Junior Investigator Awardee Location: Summerlin E-F Musculoskeletal Medicine, University Hospital Muenster 3:30pm Decoding the Matrix, Alexandra Naba, University of Chair: Alexandra Naba, University of Illinois at Chicago Poster B027 Mechanotransduction of the Endothelial Illinois at Chicago Glycocalyx Mediates Nitric Oxide Production 8:30am Advanced Methods to Explore Extracellular 3:30pm Hyaluronic Acid-Mediated Macromolecular Through Activation of TRP Channels, X. Frank 5:00pm Iozzo Award Winner Matrix Architecture, Kirk Hansen, University of Crowding to Stimulate Human Cell-Derived Matrix Zhang, Lehigh University The Complex and Dynamic Matrix Niche of the Colorado School of Medicine Deposition, Dalia Shendi, Worcester Polytechnic Kidney Glomerulus, Rachel Lennon, University of Poster B036 9:00am ECM Remodelling During Cancer Progression, Institute Manchester Janine Erler, University of Copenhagen Poster B028

13 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 14 Scientific Program Scientific Program

3:45pm Myosin II Governs Intracellular Pressure and 5:30pm Hyaluronan and TSG-6 in Alzheimer’s Disease 2:00pm Macromolecular Crowding Accelerates and Traction Stress by Distinct Mechanisms, Kimheak Neuropathology, May J. Reed, University of 7:30-8:30am Enhances Extracellular Matrix Deposition in Sao, Drexel University Washington Permanently Differentiated and Stem Cell Poster B037 Poster B044 Breakfast Cultures, Dimitrios Zeugolis, NUI Galway Location: Veranda 5:45pm Senescence Diminishes the Responsiveness 2:30pm Functionalized PEDOT Neuroelectrode Coatings 4:00-4:30pm of Primary Human Mesenchymal Stem Cells Using Heparan Sulphate Mimetics, Manus Biggs, to Substrate Stiffness, Venkatesh Mallikarjun, 8:30-9:30am NUI Galway Coffee Break Wellcome Centre for Cell-Matrix Research, University of Location: Veranda Plenary III: Signaling From the Matrix 3:00pm Systemically Administered Wound-Homing Manchester * Session Sponsored by the Journal of Histochemistry & Peptide Accelerates Wound Healing By Poster B045 Cytochemistry Modulating Syndecan-4 Function, Tero Jarvinen, 4:30-6:00pm Location: Summerlin E-F University of Tampere Concurrent Sessions Concurrent 11: Cardiovascular ECM Chair: Jean Schwarzbauer, Princeton University Location: Summerlin D 8:30am Milieu Molecules and Localized TGF-Beta Concurrent 12: Skin BM, Wound Healing and Disease Concurrent 9: Tumor Microenvironment Chair: Luisa Iruela-Arispe, University of California Los Angeles Location: Summerlin D Signaling, Timothy Springer, Harvard University Location: Summerlin E Chair: Cyrus Ghajar, Fred Hutchinson Cancer Research 4:30pm Vascular Regeneration in Adult Arteries, Luisa 9:00am Human Genetics Aided Discovery of a New Chair: Peter Marinkovich, Stanford University School of Center Iruela-Arispe, University of California Los Angeles Metabolic Hormone, Atul Chopra Baylor College Medicine 4:30pm Cell Cycle Independent Protection of Dormant 5:00pm The Discoidin Domain Receptor-1 Acts as a of Medicine 2:00pm Molecular Therapies for Epidermolysis Bullosa, Tumor Cells by the Perivascular Niche, Cyrus Mechanotransducer in Vascular Smooth Muscle Peter Marinkovich, Stanford University School of Cells to Promote Vascular Calcification,David Medicine Ghajar, Fred Hutchinson Cancer Research Center 9:30-10:15am Ngai, University of Toronto and Ted Rogers Centre for 2:30pm A Novel Disease-modifying Treatment for RDEB: 5:00pm DDR1 Regulates the Construction of a Dormancy- Heart Research ISMB Distinguished Investigator Award Presentation Supportive Niche By Coordinating the Assembly A Pre-clinical Study Targeting the Anti-fibrotic Poster B046 Location: Summerlin E-F AT2 and MAS Receptors, Rocco Bernasconi Uniklinik of a Pro-Quiescence ECM Proteome, Jose Javier Introduction by: Liliana Schaefer, ISMB President Bravo-Cordero, The Tisch Cancer Institute, Icahn 5:15pm 4-Phenylbutyrate Promotes Vascular Smooth Freiburg School of Medicine at Mount Sinai Muscle Cell Recruitment and Reduces The Collagen Triple Helix at the Evolutionary Poster B050 Poster B038 Intracerebral Hemorrhage Severity in Col4a1 Dawn of the Animal Kingdom, Billy Hudson, 2:45pm The Different Roles of Laminin-332 and -511 in Mutant Mice, Genki Hayashi, University of California Vanderbilt University 5:15pm Stromal PTEN Regulates Extracellular Matrix Keratinocyte Behaviors, Jun Sasaki, Nippi, Inc. San Francisco Poster B051 Organization in the Mammary Gland, Caitlin Jones, Poster B047 The Ohio State University 10:15-10:30am 3:00pm The Versican G1 Fragment, Serum-Derived 5:30pm Point Mutation in the Copper Binding Domain of Poster B039 Coffee Break Hyaluronan-Associated Proteins, Hyaluronan Lysyl Oxidase Causes Aortic Dilation Modified By (VG1F-SHAP-HA) Complex Acts as a Mediator 5:30pm Targeting CD47 as a Therapeutic Strategy for Genetic and Environmental Influences,Beth Kozel, Location: Veranda Breast Cancer Prevention, Tiffany M. Newman, Between Wound Surface and Ointment Base in National Heart, Lung, and Blood Institute, National the Treatment of Pressure Ulcer, Zenzo Isogai, Wake Forest School of Medicine Institutes of Health Poster B040 10:30-12:00pm National Center for Geriatrics and Gerontology, Japan Poster B048 Poster B052 5:45pm Exploiting the ECM for Noninvasive Imaging of Plenary IV: Genetic Disorders Affecting Connective Tissue 5:45pm Lysyl Oxidase Insufficiency Exacerbates the Location: Summerlin E-F 3:15pm Matrix Composition in 3-D Collagenous Tumor Progression and Metastases, Noor Jailkhani, Vascular Disease Caused by Fibulin-4 Mutations, Howard Hughes Medical Institute, Koch Institute for Chair: Enid Neptune, Johns Hopkins Medical Institute Bioscaffolds Modulates the Survival and Michelle Lin, Washington University School of Medicine Angiogenic Phenotype of Human Chronic Wound Integrative Cancer Research, Massachusetts Institute Poster B049 10:30am Heritable Disorders of Bone and Cartilage, of Technology Deborah Krakow, UCLA Dermal Fibroblasts, Pascal Morissette Martin, Poster B041 FREE EVENING University of Western Ontario 11:00am New Strategies to Identify Signaling Pathways Poster B053 Associated with Aneurysmal Disease in Mice with Concurrent 10: ECM of Aging Marfan Syndrome, Francesco Ramirez, Icahn School Location: Summerlin E of Medicine at Mount Sinai SIS 2: Trainee Led Session: Emerging Non-Canonical Chair: William Parks, Cedars-Sinai Tuesday, October 16th Intracellular Roles of Extracellular Matrix Proteins 11:30am The Role of Activin A in Tissue Homeostasis and Location: Summerlin F 4:30pm Macrophage Function in Fibrosis, William Parks, in Fibrodysplasia Ossificans Progressiva,Aris Chair: Davy Vanhoutte, Cincinnati Children’s Hospital Cedars-Sinai Medical Center Economides, Regeneron 7:15-8:30am Medical Center 5:00pm Alterations in Protein Composition of Aging, 2:00pm Deciphering Intracellular Roles of Photoaging, and Anti-Inflammatory Aging Models Women Mentoring Women Breakfast (Pre-registration Required) Discussion begins at 7:30am 12:00-2:00pm Thrombospondins During Heart and Skeletal of the Skin with a Focus on the Extracellular Muscle Disease, Davy Vanhoutte, Cincinnati Location: Veranda C Poster Session II Matrix, Ryan C Hill, University of Colorado-Denver Children’s Hospital Medical Center Poster B042 Location: Summerlin A-B-C Even Number Boards Present 2:30pm Distinct Intracellular Localization and Functions 5:15pm Circulating Fibrillin-1 Among Older US Men 7:30am-5:30pm for Full Length MMP-2 and NTT-MMP-2 in Heart Without Diabetes: Associations with Angina, Registration and Exhibits and Kidney Disease, David Lovett, University of Obesity and High Density Lipoprotein, Lynn M. Location: Summerlin Foyer 2:00-3:30pm California, San Francisco. Marshall, Oregon Health and Science University Concurrent Sessions Poster B043 2:50pm Function of Secreted Protein Acidic and Rich in Guest Symposium IV: Matrix Biology Ireland Cysteine (SPARC) as a Matricellular Chaperone., Location: Summerlin F Alexandre Chlenski, University of Chicago Chair: Dimitrios Zeugolis, NUI Galway Poster B054

15 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 16 Scientific Program Scientific Program

3:10pm MT-COMP Compromises Ligaments, Tendons 5:15pm Resetting Dysregulated Collagen-I Proteostasis 11:45am In Situ Detection of Degraded and Denatured and Joint Function, Francoise Coustry, McGovern in Osteogenesis Imperfecta, Ngoc-Duc Doan, 9:00-10:30am Collagen Via Triple Helical Hybridization: New Medical School at UTHealth Massachusetts Institute of Technology Tool in Histopathology, Yang Li, University of Utah Poster B055 Poster B065 Plenary V: Therapeutic Strategies for ECM Diseases Poster B075 Location: Summerlin E-F Chair: Beth Kozel, National Institutes of Health 12:00pm Intracellular MMP12 Increases Breast Cancer 3:30-4:00pm Concurrent 15: ECM in Musculoskeletal Biomechanics Metastasis, Pirjo Astrom, University of British and Regeneration 9:00am Inhibiting Fibronectin Assembly to Modify Tumor Columbia, and University of Oulu Coffee Break Location: Summerlin F Microenvironment, Weilan Ye, Genentech Inc. Poster B076 Location: Veranda Chair: Farshid Guilak, Washington University St. Louis 9:30am Targeting Regeneration Through Proteoglycans, 12:15pm Cigarette Smoking Induces Overexpression of 4:00pm Engineering New Biologic Therapies for Arthritis, Jeffrey D. Esko, University of California, San Diego Elastinolytic Cathepsin S, Pierre-Marie Andrault, 4:00-5:30pm Farshid Guilak, Washington University 10:00am Targeting Matrix Receptors in Fibrotic Diseases, Tours University Concurrent Sessions 4:30pm Discovery of Potential Therapeutic Targets for Ambra Pozzi, Vanderbilt University Medical Center Poster: B077 Concurrent 13: Growth Factors and ECM Post-Traumatic Osteoarthritis Using a Mechanical Location: Summerlin D Injury Platform, Farzad Yousefi, University of 10:30-11:00am SIS 3: Trainee Led Session: The Development and Use of Pennsylvania Translational Musculoskeletal Research Chair: Karen Lyons, University of California Los Angeles Coffee Break 3D Systems to Investigate Biological Function Center Location: Summerlin F 4:00pm CCN Proteins in Bone Formation and Poster B066 Location: Veranda Mechanotransduction, Karen Lyons, University of Chair: Reut Shainer, National Institutes of Dental and California Los Angeles 4:45pm RHAMM and CD44 Both Mediate the Influence of Craniofacial Research, NIH Hyaluronic Acid on Embryonic Myoblast Behavior, 11:00am-12:30pm 4:30pm Latency and Antagonism in the Extracellular 11:00am 3D Organoids of Skeletal Stem Cell in Vitro and Yue Leng, Purdue University Concurrent Sessions In Vivo, Pam Robey, National Institutes of Dental and Regulation of TGFbeta and BMP Family Growth Poster B067 Factors, Clair Baldock, University of Manchester Concurrent 16: ECM in Fibrosis Craniofacial Research, NIH Posters B057 and B058 5:00pm Development of Tissue-Specific Matrix-Derived Location: Summerlin D 11:30am Periosteal Cells Derived from Long Bone Are Microcarriers as a Platform for Adipose-Derived Chair: Kota Saito, Akita University Unique from Those Derived from Calvaria, Reut 4:45pm LEMD3 Desensitizes Fibroblasts to Stiffness- Stem/Stromal Cell Differentiation, Anna Kornmuller, driven TGF-beta Signaling, Dwight M. Chambers, 11:00am Mechanisms of Secretion in Fibrosis, Kota Saito, Shainer, National Institutes of Dental and Craniofacial The University of Western Ontario Research, NIH Emory University and Georgia Institute of Technology Poster B068 Akita University Poster B059 Poster B078 5:15pm Nitric Oxide Releasing Composite Hydrogels 11:30am Targeting Matrix-Mediated Signaling in Fibrosis, 5:00pm TGF and Aortic Disease Severity in MFS, Marjolijn Masha Poyurovsky, Kadmon Corporation, LLC. 11:50pm A Systems Biology Approach to Studying for Tendon Repair via Matrix Metalloproteinase Melanoma Invasion in a 3D Tumor Renard, Ghent University Controlled Pathways, Kaylee Meyers, Michigan Poster B070 Poster B060 Microenvironment, Amanpreet Kaur, University of Technological University 11:45am Calreticulin Is Important for the Development Pennsylvania 5:15pm Individual Smad2 Linker Region Poster B069 of Renal Fibrosis and Dysfunction in Diabetic Poster B079 Residues Regulate the Genes Involved in Nephropathy, Ailing Lu, University of Alabama at Glycosaminoglycan Chain Initiation and Birmingham 12:10pm Extracellular Matrix Components Isolated from Elongation on Proteoglycan, Biglycan, Kamato 7:00-11:00pm Poster B071 Diabetic Mice Alters Ccardiac Fibroblast Function Through the AGE/RAGE Signaling Cascade, Danielle, University of Queensland Banquet – Crimson 12:00pm Fibronectin-Rich ECMs Store Disease-Relevant Poster B061 (Advanced ticket purchase required.) Stephanie Burr, The University of Mississippi Memories that Drive Altered Fibroblast Signaling Poster B080 and Phenotype Through Integrin Switching, Concurrent 14: Heritable Disorders of Connective Tissue Victoria Stefanelli, Georgia Institute of Technology Session Sponsored by The Marfan Foundation Poster B072 Location: Summerlin E Wednesday, October 17th 12:15pm A Serological Biomarker Measuring True Chair: Shireen Lamande, Murdoch Children’s Research Formation of Collagen Type III (PRO-C3) is Institute Related to Histological Parameters of Non- 4:00pm Modelling Cartilage and Bone Disorders Using 8:00am-12:00pm Alcoholic Steatohepatitis, Signe Holm Nielsen, Human iPSCs, Shireen Lamande, Murdoch Children’s Nordic Bioscience & Technical University of Denmark Registration Poster B073 Research Institute Location: Summerlin Foyer 4:30pm Phenotypic Analysis of a Mouse Model for Marfanoid-Progeroid-Lipodystrophy Syndrome, Concurrent 17: Proteases and ECM Remodeling Silvia Smaldone, Regeneron Pharmaceutical Inc. 8:00am-11:00am Location: Summerlin E Poster B062 Exhibits Chair: Dirk Hubmacher, Icahn School of Medicine at Mt. Sinai 4:45pm Mouse and Human Genomic Studies Identify Location: Summerlin Foyer 11:00am ADAMTS17: Its Substrates and Its Biological Modifiers of Blood Pressure and Supravalvar Function, Dirk Hubmacher, Icahn School of Medicine Aortic Stenosis in Elastin Insufficiency and 8:00-9:00am at Mt. Sinai Williams Beuren Syndrome, Phoebe Parrish, 11:30am Fibrillin-2 Proteolysis by Adamts6 is Essential for National Institutes of Health Breakfast Location: Veranda Cardiac and Limb Development, Timothy Mead, Poster B063 Cleveland Clinic Lerner Research Institute 5:00pm Pain-related Phenotypes in A Murine Model for Poster B074 Classical Ehlers-Danlos Syndrome, Fransiska Malfait, Ghent University Hospital Poster B064 17 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 18 Poster Program Poster Program

Research, Norway, 2National Institute of Biological Sciences, Beijing, China Guest Symposium III: B006 Poster Session II Concurrent Session 3: Sponsored by the Alport Collagens SPARC Produced by Bone-Marrow Syndrome Foundation Derived Cells Contributes to Myocardial Fibrosis B011 Poster Session I B001 Poster Session I Hannah Riley1, Ryan Kelly1, Lindsay VPS33b is essential for collagen 1 1 1 Modelling Alport syndrome using McDonald , An Van Laer , Catalin Baicu , homeostasis 1 2 1 2 patient-derived kidney organoids Amanda LaRue , , Michael Zile , , Amy Joan Chang1,2,, Adam Pickard1,2, Antony Bradshaw1,2, 1MUSC, 2Ralph H. Johnson Poster Presentations...... Summerlin A-B-C 1 1 Adamson1,2, Karl E Kadler1,2,3, 1Wellcome Pinyuan Tian , Susan J. Kimber , Daniel Veterans Affairs Medical Center P. Gale2, Rachel Lennon1, 1University of Centre for Cell-Matrix Research, All posters will be on display throughout the entire conference Manchester, 2University College London 2University of Manchester, 3Manchester but will be presented in two separate sessions. Academic Health Science Centre B002 Poster Session II Concurrent Session 2: Box lunches are provided in the Veranda room. B012 Poster Session II Collagen Hybridizing Peptide: New Proteoglycans Please grab a lunch and enjoy the poster presentations. Molecular Probe for In Vitro and Zebrafish round mutations reveal a In Vivo Detection of Degraded and novel post-Golgi collagen secretory B007 Poster Session I Denatured Collagen pathway linked to a developmental Versican is required for primary TICCA syndrome Michael Yu, University of Utah hematopoiesis and yolk sac Gokhan Unlu1, Kinsey Qi2, Amy Rushing2, Poster Session I: Odd Numbers Present vasculogenesis in the mouse Eric Gamazon3, Nisha Patel4, Mais embryo Hashem4, Abdullah AlFaifi5, Fowzan Monday, October 15th...... 12:30 – 2:30 PM Concurrent Session 1: Sumeda Nandadasa, Anna O’Donnell, Alkuraya4, Nancy Cox3, Ela Knapik3, Suneel S. Apte, Cleveland Clinic Lerner 1Vanderbilt University, 2Vanderbilt Matricellular Proteins Research Institute University Medical Center, 3Vanderbilt 4 Genetics Institute, King Faisal Specialist B003 Poster Session I B008 Poster Session II Hospital and Research Center, 5Security Forces Hospital in Riyadh Activation of cancer-associated Endorepellin evokes a pro- Poster Session II: Even Numbers Present fibroblasts is required for metastasis mitophagic transcriptomic signature Tuesday, October 16th...... 12:00 – 2:00 PM in a murine model of melanoma and regulates mitochondrial B013 Poster Session I Andrew Leask1, Krista Vincent2, David homeostasis in endothelial cells A fibronectin matrix-based Holdsworth1, Lynne-Marie Postovit2, Thomas, Neill, Renato V. Iozzo, Thomas mechanism for proteolytic James Hutchenreuther1, 1University of Jefferson University processing of procollagen I 2 Western Ontario, University of Alberta Jared Saunders, Jean Schwarzbauer, B009 Poster Session I Princeton University Set-up and breakdown for ALL poster boards is as follows: B004 Poster Session II ADAMTS5 is coupled with Dysregulation of matricellular protein mechanical load during mandibular B014 Poster Session II Set-up posters starting Monday, October 15th at 7:30 AM thrombospondin-2 in diabetes, TSP2 condylar development Structural insights into collagen lysyl deficient hydrogel derived from hydroxylases extracellular matrix accelerates Alexandra Rogers, Sarah Cisewski, 1 2 Remove posters by Wednesday, October 17th at 2:00PM diabetic wound healing. Ashton Lancaster, Alura Luck, Christine Hou-Fu Guo , Chi-Lin Tsai , Masahiko Kern, Medical University of South Terajima3, Xiaochao Tan1, Priyam Britta Kunkemoeller, Aaron H. Morris, Carolina Banerjee1, Mitchell D. Miller4, Xin Liu1, Tara Bancroft, Hudson Lee, Danielle K. Jiang Yu1, Jovita Byemerwa1, Sarah Stamer, Jason Wu, Marina Tan, Kevan 4 5,6, B010 Poster Session II Alvarado , Tamer Kaoud Kevin N. Herold, Carlos Fernandez-Hernando, Dalby5,6, Neus Bota-Rabassedas1, Yulong Themis R. Kyriakides, Yale University Biofabrication of an ideal ECM Chen1, Mitsuo Yamauchi3, John A. mimetic to function as a small Tainer2, George N. Phillips, Jr.4, Jonathan B005 Poster Session I diameter artery M. Kurie1, 1Department of Thoracic/ Connective Tissue Growth Factor William D. Wagner, Harleigh J. Warner, Head and Neck Medical Oncology, The Is Secreted as A Preproprotein that Wake Forest University School of University of Texas MD Anderson Cancer 2 Requires Proteolytic Activation Medicine Center, Department of Molecular and Cellular Oncology, The University of Texas 1 1 Ole J. Kaasboell , Ashish K Gadicherla , MD Anderson Cancer Center, 3North 2 1 Jian-Hua Wang , Vivi Talstad Monsen , Carolina Oral Health Institute, School of 1 Else Marie Valbjørn Hagelin , Meng- Dentistry, University of North Carolina at 2 1 1 Qiu Dong , Håvard Attramadal , Oslo Chapel Hill, 4Department of Biosciences, University Hospital, Institute for Surgical

19 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 20 Poster Program Poster Program

Rice University, 5Division of Medicinal 1Erasmus Medical Center, 2University of B024 Poster Session II Nicole Eter2 and Maged Alnawaiseh2, 1 cytokine elaboration after neonatal B037 Poster Session I Chemistry, Targeted Therapeutic Drug Tsukuba ADAMTS9 and ADAMTS20 have a Institute for Musculoskeletal Medicine, hyperoxia exposure Myosin II Governs Intracellular 2 Discovery and Development Program, dual function in ECM remodeling and University Hospital Muenster, Rashmin C. Savani, John Ibrahim, Pressure and Traction Stress by College of Pharmacy, The University of biogenesis of the primary cilium Department of Ophthalmology, Jie Liao, Naeun Cheong, Christopher Distinct Mechanisms Texas at Austin, 6Division of Chemical B019 Poster Session I University of Muenster Medical Center, Longoria, University of Texas 1 1 Biology & Medicinal Chemistry, College of Molecular interaction between Sumeda Nandadasa, Lauren W. Wang, 3 Department of Gynecology and Kimheak Sao , Tia Jones , Andrew Southwestern Medical Center 2 3 3 Pharmacy, The University of Texas elastogenic proteins impacting Anna O’Donnell, Caroline M. Kraft, Obstetrics, University Hospital Muenster Doye , Galina Schevzov , Peter Gunning , 1 1 2 at Austin. matrix assembly and function Rushabh Patel, Heon Yung Gee, Kay B033 Poster Session I Ryan Petrie , Drexel University, National Grobe, Timothy C. Cox, Friedhelm Institutes of Health, 3University of New Heena Kumra*, Valentin Nelea*, Dieter B028 Poster Session II Distinct sorting of subsets of Hildebrandt, and Suneel S. Apte, extracellular vesicles expressing South Wales P. Reinhardt, McGill University *Co-First Cleveland Clinic Lerner Research Institute Hyaluronic Acid-Mediated Authors CD63, MHC class 1, and CD47 in cell- Special Interest Session I: Macromolecular Crowding to cell communication Stimulate Human Cell-Derived Matrix Extracellular Vesicles- The B025 Poster Session I 1 1 B020 Poster Session II Deposition Sukhbir Kaur , David D. Roberts , Abdel Next SMALL Thing Mouse B3glct knockout: a model G. Elkahloun2, Weiwei Wu2, Arakelyan, Concurrent Session 9: 1 2 Smooth muscle and endothelial for congenital hydrocephaly Dalia Shendi , Julia Marzi , Will Anush3, Leonid Margolis3, Satya P. Tumor Microenvironment 1 1 1 cell contributions to arterial elastin and craniofacial and skeletal Linthicum , David M. Dolivo , Qi Wen , Singh 4, 1Laboratory of Pathology, Poster Session I 1 2 B015 deposition dysmorphology Tanja Dominko , Katja Schenke-Laylan , Center for Cancer Research, National Marsha W. Rolle1, 1Worcester Polytechnic B038 Poster Session II Tumor Exosomes: From Mediators of M. Catalin Staiculescu, Chien-Jung Lin, 1 Cancer Institute, National Institutes Bernadette C. Holdener , Richard C. 2 Institute, University of Tubingen 2 DDR1 regulates the construction Systemic Disease to Biomarkers of Robert P. Mecham, Jessica E. Wagenseil, Grady1, Daniel Cameron1, Christopher of Health, Cancer Genetics Branch, Metastatic Spread Washington University 1 1 National Human Genome Research of a dormancy-supportive niche by J. Percival , Javier C Jimenez-Vega , coordinating the assembly of a pro- Irina Matei, Weill Cornell Medicine David E. Komatsu1, Sardar Uddin1, B029 Poster Session I Institute, National Institutes of Health, 3 quiescence ECM proteome June Goto2, Natalia Peunova1, Helene Proteomic analysis of extracellular Section of Intercellular Interactions, B021 Poster Session I 1 1 2 3 Benveniste3, Hedok Lee3, Takashi matrix dynamics during mouse Eunice Kennedy-Shriver National Julie Di Martino , Rita Nobre , , , 1 1 B016 Poster Session II Aortic Smooth Muscle Cell Sato4, Hisashi Narimatsu4, Steven forelimb development Institute of Child Health and Human Eduardo Farias , Chandrani Mondal , 4 4 Chemoexosomes secreted by Elastogenesis Driven by Adipose- J. Bernardinelli5, Ao Zhang5, and Development, National Institutes of Robert Morabito , Ben Martin , David Kathryn R. Jacobson, Alexander R. 4 4 5 6 myeloma cells enhance osteoclast Derived Mesenchymal Stem Cell Robert S. Haltiwanger1,5, 1Stony Health, Inflammation Biology Section, Matus , Elana Fertig , Alexandra Naba , Ocken, Alita F. Miller, Tamara L. Kinzer- 1 2 formation and promote aggressive Secreted Factors Brook University, 2Cincinnati Children’s National Institute of Allergy and Infectious Julio Aguirre-Ghiso , , Jose Javier Bravo- Ursem, Sarah Calve, Purdue University 1 bone disease Aneesh K. Ramaswamy, Rachel E. Sides, Hospital,3Yale University, 4National Diseases, National Institutes of Health. Cordero Shyam Kumar Bandari, Rada Amin, David A. Vorp, Justin S. Weinbaum, Institute of Advanced Industrial Science 1Department of Medicine, Division of 5 Kauslendra Tripathi, Zhengi Shi, Xu University of Pittsburgh and Technology in Japan, University of Hematology and Oncology, The Tisch Feng, Elezabeth E. Brown, Ralph D. Georgia Concurrent Session 7: ECM Cancer Institute, Icahn School of Concurrent Session 8: Medicine at Mount Sinai, 2Department Sanderson, University of Alabama at of Inflamation, Infection Birmingham Mechanosensing of Otolaryngology, Department of and Immunity Oncological Sciences, Black Family Concurrent Session 5: Stem Cell Institute, Mount Sinai School B017 Poster Session I Matrix in Morphogenesis Concurrent Session 6: B034 Poster Session II of Medicine; 3Abel Salazar School Structure & Assembly of B030 Poster Session II Inflaming the Masses: Glioma EVs ECM Non-Coding Mechanogenomic of Biomedicine, Porto University, Promote Inflammatory, Degradative, B022 Poster Session II ADAMTS7 and influenza virus Regulation Identified In Human PT; 4 Biochemistry and Cell Biology and Metabolic Responses in Normal immunity Dystroglycan regulates signaling Cardiomyocytes Department, Stonybrook University, Brain Cells 1 1 5 pathways critical to postnatal brain B026 Poster Session II John Stambas , Meagan McMahon , Adam J. Engler, UC San Diego Department of Oncology, Sidney Kimmel Michael Graner, Mary Wang, Anthony development Siying Ye1, Daniel Dlugolenski1, Ralph Comprehensive Cancer Center, Johns Collagen IV scaffolds are coated 6 Fringuello, Andrew Bubak, Maria Nagel, Tripp2, Daniel McCulloch1, 1Deakin Hopkins University, Department of Holly Colognato, Freyja McClenahan, with agrin/perlecan: a unique B035 Poster Session I Petr Pauckek, University of Colorado University, 2University of Georgia Physiology & Biophysics, University of Himanshu Sharma, Andrea Arreguin, organizational feature of a model Anschutz Medical Campus Mechanical cell communication Illinois at Chicago Azeez Aranmolate, Stony Brook basement membrane and its influence on organization of University Elena Pokidysheva1, Chetyrkin S1, B031 Poster Session I cellular structures B039 Poster Session I Boudko SP1, Colon S1, Bhave G1, Zientek Thrombospondin-4 Produced by Daniel Rüdiger, Angelika Vollmar, Stefan K2, Rafi 1M , Lennon R3, UK, Hudson Stromal PTEN regulates extracellular B023 Poster Session I Pro-inflammatory Macrophages Zahler, Ludwig-Maximilians University Concurrent Session 4: BG1, 1Vanderbilt University Medical matrix organization in the mammary ECM omics identifies signature Promotes Inflammation Munich Department of Pharmacy Elastic Fiber Proteins Center, 2Shriners Hospital for Children, gland ECMs for the sites of inter-tissue 3 Mohammed Tanjimur Rahman, Santoshi University of Manchester Caitlin Jones1, Anisha Hammer1, YouJin interactions in mouse hair follicles Muppala, Irene Krukovets, Jasmine B036 Poster Session II Cho1, Gina Sizemore1, Edna Cukierman2, B018 Poster Session II 1 1 Ko Tsutsui , Hiroki Machida , Asako Gajeton, Dmitriy Verbovetskiy, Edward 3 1 B027 Poster Session I Mechanotransduction of the Lisa Yee , Samir Ghadiali , Michael 1 1 F. Plow, Olga Stenina-Adognravi, Lerner Fibulin-4 deficiency differentially Nakagawa , Chun-Chun Cheng , Sean endothelial glycocalyx mediates Ostrowski4, Jennifer Leight1, 1The Ohio 1 1 Formation of lamellae in the Research Institute Cleveland Clinic affects TGF signaling as well as D. Keeley , Chiharu Tanegashima , nitric oxide production through State University, 2Fox Chase Cancer 2 3 corneal stroma: New insights in cytoskeleton structure and dynamics Yasuko Tomono , Kiyotoshi Sekiguchi , activation of TRP channels Center, 3City of Hope, 4Medical University 1 1 Kisa Kakiguchi1, Shigenobu Yonemura1, the underlying pathomechanism of B032 Poster Session II Joyce Burger , Paula van Heijningen , X. Frank Zhang1, Matthew A. Dragovich1, of South Carolina 1 1 Hironobu Fujiwara1, 1Riken Center for keratoconus Gert-Jan Kremers , Gert van Cappellen , Extracellular Superoxide Dismutase Daniel Chester1, Bing-mei Fu2, 1Lehigh 2 1 Biosystems Dynamics Research, 2Shigei Uwe Hansen1, Melanie Timmen1, Martin Hiromi Yanagisawa , Roland Kanaar , (EC-SOD) knockout mice have worse University, 2The City University of New 1 1 MRI, 3Osaka University Götte3, Richard Stange1, Thomas Pap1, Ingrid van der Pluijm , Jeroen Essers , alveolarization, inflammation and York

21 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 22 Poster Program Poster Program

B040 Poster Session II May J. Reed1, Mamatha Anderson Watson1, Amanda Wardlaw1, B053 Poster Session I B058 Poster Session II Phoebe Parrish, Russell Knutsen, 1 1 3 Targeting CD47 as a therapeutic Damodarasamy , Jasmine Pathan , Frederick T. Greenaway , Juergen Matrix composition in 3-D The Structure and Regulation of Angela Troia, Amanda Wardlaw, Charles 2 1 3 4 1 strategy for breast cancer prevention. Christina K Chan , Charles Spiekerman , Brinckman , , and Beth A. Kozel , collagenous bioscaffolds modulates latent TGF by LTBP1 and Fibrillin Billington, Delong Liu, Yi Ping Fu, and 2 1 3 1 Thomas N Wight , William A. Banks , , Laboratory of Vascular and Matrix the survival and angiogenic Beth Kozel, National Institutes of Health Tiffany M. Newman, Elizabeth R. Stirling, 4 2 Clair Baldock, Michael P. Lockhart- Anthony J Day , Robert B. Vernon , C Genetics, National Heart, Lung, and phenotype of human chronic wound Adam Wilson, Katherine L. Cook, David 1 1 Cairns, Jennifer Thomson, Rana Dajani, Dirk Keene , University of Washington, Blood Institute, National Institutes of dermal fibroblasts B064 Poster Session II R. Soto-Pantoja, Wake Forest School of 2Benaroya Research Institute, 3VA Puget Health, 2Institute of Virology and Cell University of Manchester Medicine Sound Health Care System, 4Wellcome Biology, University of Luebeck, 3Clark Pascal Morissette Martin, Aaron Grant, B059 Poster Session I Pain-related phenotypes in a murine Trust Centre for Cell-Matrix Research, University, 4Department of Dermatology Douglas W. Hamilton, and Lauren E. model for classical Ehlers-Danlos Flynn, University of Western Ontario LEMD3 Desensitizes Fibroblasts to syndrome B041 Poster Session I University of Manchester and Institute of Virology and Cell Biology, Stiffness-driven TGF-beta Signaling University of Luebeck Fransiska Malfait1, Delfien Syx1, Rachel Exploiting the ECM for noninvasive 1 2 Dwight M. Chambers , , Leandro E. Miller2, Alia M. Obeidat2, Phuong imaging of tumor progression and B045 Poster Session I 3 3 1 Moretti , Thomas H. Barker , Emory B. Tran2, Anne-Marie Malfait2, 1Ghent metastases B049 Poster Session I 2 Senescence diminishes the Special Interest Session II: University, Georgia Institute of University Hospital, Ghent Belgium, 1 2 3 Noor Jailkhani , Jessica R Ingram , responsiveness of primary human Lysyl oxidase insufficiency Technology, University of Virginia 2Rush University Medical Center 3 1 Emerging Non-Canonical Mohammad Rashidian , Steffen Rickelt , mesenchymal stem cells to substrate exacerbates the vascular disease 1 3 Intracellular Roles of Chenxi Tian , Hidde L Ploegh and stiffness caused by Fibulin-4 mutations B060 Poster Session II 1 4 1 B065 Poster Session I Richard O Hynes , , David H Koch 1 1 Extracellular Matrix Venkatesh Mallikarjun , Oana Dobre , Michelle Lin, Thomas J. Broekelmann, TGF and aortic disease severity in Institute for Integrative Cancer Research, 1 1 Proteins Resetting Dysregulated Collagen-I Mark R. Jackson , Hamish T.J. Gilbert , Robert P. Mecham, Carmen M. Halabi, MFS Massachusetts Institute of Technology Stephen M. Richardson2, Joe Swift1, Washington University School of Medicine Proteostasis in Osteogenesis 2 1 2 Department of Cancer Immunology and 1Wellcome Centre for Cell-Matrix Marjolijn Renard , Elise C. Manalo , Imperfecta B054 Poster Session II 2 2 Virology, Dana Farber Cancer Institute, Research, University of Manchester, Sara Tufa , Douglas R. Keene , Julie Ngoc-Duc Doan, Andrew S. DiChiara, 3 1 2 1 Program in Cellular and Molecular 2University of Manchester Function of Secreted Protein Acidic De Backer , Lynn Y. Sakai , Ghent Agata Bikovtseva, and Matthew D. 2 Medicine, Boston Children’s Hospital, Concurrent Session 12: and Rich in Cysteine (SPARC) as a University, Shriners Hospital for Children Shoulders, Massachusetts Institute of 4Howard Hughes Medical Institute matricellular chaperone Portland Skin BM, Wound Healing Technology and Disease Alexandre Chlenski, Marija Dobratic, Concurrent Session 11: Helen R. Salwen, Mark A. Applebaum, B061 Poster Session I Emma Wilkinson, Susan L. Cohn, Concurrent Session 10: Cardiovascular ECM Individual Smad2 linker region Concurrent Session 15: B050 Poster Session II University of Chicago residues regulate the genes involved ECM of Aging ECM in Musculoskeletal A novel disease-modifying treatment in glycosaminoglycan chain initiation B046 Poster Session II for RDEB: a pre-clinical study B055 Poster Session I and elongation on proteoglycan, Biomechanics and B042 Poster Session II The Discoidin Domain Receptor-1 targeting the anti-fibrotic AT2 and MT-COMP compromises ligaments, biglycan. Regeneration Acts as a Mechanotransducer in MAS receptors 1 1 2 Alterations in Protein Composition tendons and joint function Kamato Danielle , Osman Narin , , Little Vascular Smooth Muscle Cells to 1 1 2 Rocco Bernasconi1, Christine 1 1 Peter , University of Queensland, RMIT of Aging, Photoaging, and Anti- Promote Vascular Calcification Francoise Coustry , Karen L. Posey , B066 Poster Session II Gretzmeier1, Tobias Kühl1, Thomas Tristan Maerz2, Kevin Baker3, Alka C. University inflammatory Aging models of Discovery of potential therapeutic David Ngai, Michelle Bendeck, University Walther2, Leena Bruckner-Tuderman1, Veerisetty1, Mohammad G. Hossain1, the Skin with a Focus on the targets for post-traumatic of Toronto Department of Laboratory Alexander Nyström1, 1Uniklinik Freiburg, Frankie Chiu1, Jacqueline T. Hecht1,4, Extracellular Matrix osteoarthritis using a mechanical Medicine and Pathobiology, Translational 2University College Cork 1 Ryan C Hill1, Taihao Quan2, Kelly Higa1, McGovern Medical School at UTHealth Biology and Engineering Program 2 injury platform 1 2 Department of Pediatrics, University of Concurrent Session 14: James DeGregori , Gary J Fisher , Kirk C (TBEP), and Ted Rogers Centre for Heart Farzad Yousefi, Madison Tanis, Hansen1, 1University of Colorado-Denver, B051 Poster Session I Michigan Department of Orthopaedic Heritable Disorders of Research Surgery and MedSport, 3Beaumont Robert L. Mauck, George R. Dodge, 2University of Michigan The different roles of laminin-332 Connective Tissue Hospital – Royal Oak Department of Department of Orthopaedic Surgery, and -511 in keratinocyte behaviors B047 Poster Session I Orthopaedic Surgery, 4UTHealth School University of Pennsylvania Translational B043 Poster Session I Jun Sasaki, Chisei Shimono, Yuji of Dentistry B062 Poster Session II Musculoskeletal Research Center, 4-phenylbutyrate promotes vascular Atsuzawa, Shunji Hattori, Kazunori Crescenz VA Medical Center Circulating fibrillin-1 among older US smooth muscle cell recruitment and Phenotypic analysis of a mouse Mizuno, Nippi Research Institute of men without diabetes: associations reduces intracerebral hemorrhage model for Marfanoid-Progeroid- Biomatrix with angina, obesity and high density severity in Col4a1 mutant mice Lipodystrophy syndrome B067 Poster Session I lipoprotein Concurrent Session 13: Genki Hayashi, Cassandre Labelle- Silvia Smaldone, Erika Troy, Lawrence RHAMM and CD44 both mediate 1 2 B052 Poster Session II Lynn M Marshall , Eric J Carlson , Dumais, Mao Mao, Rebekah Aldrich, Growth Factors and ECM Miloscio, Trikaldarshi Persaud, Giusy Della the influence of hyaluronic acid on 1 3 Carrie M Nielson , Elsa S Strotmeyer , Douglas B Gould, University of California The Versican G1 Fragment, Serum- Gatta, Guochon Gong, Brian Zambrowicz, embryonic myoblast behavior 1 1 Cherrie Z Abraham , Amir F Azarbal , San Francisco Derived Hyaluronan-Associated Aris N. Economides, Chris Schoenherr, Yue Leng, Sarah Calve, Purdue University 4 1 B057 Poster Session I William S Evans , Eric S Orwoll , Lynn Proteins, Hyaluronan (VG1F-SHAP- Regeneron Pharmaceutical Inc. Y Sakai1,2, 1Oregon Health and Science Internal cleavage and synergy with HA) Complex Acts as a Mediator University, 2Shriners Hospital for Children, B048 Poster Session II twisted gastrulation enhance BMP B068 Poster Session II between Wound Surface and B063 Poster Session I 3University of Pittsburgh, 4Duke University Point mutation in the copper binding Ointment Base in the Treatment of inhibition by BMPER Development of tissue-specific Mouse and human genomic studies domain of lysyl oxidase causes aortic Pressure Ulcer Clair Baldock1, Michael P Lockhart- matrix-derived microcarriers as a dilation modified by genetic and 1 1 identify modifiers of blood pressure platform for adipose-derived stem/ B044 Poster Session II Yusuke Murasawa, Hiroyuki Nakamura, Cairns , Karen Tzia Wei Lim , Alan RF environmental influences Godwin1, Alexandra Zuk2, Gerhard and supravalvar aortic stenosis in stromal cell differentiation Hyaluronan and TSG-6 in Alzheimer’s Ken Watanabe, Zenzo Isogai, National elastin insufficiency and Williams Kit Man Tsang1, Russell H Knutsen1, Sengle2, 1University of Manchester, Anna Kornmuller, Ammi Jani, Lauren E. Disease Neuropathology Center for Geriatrics and Gerontology, Beuren syndrome Charles J. Billington1, Heiko Steenbock2, bu, Aichi, Japan 2University of Cologne Flynn, The University of Western Ontario

23 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 24 Poster Program Poster Program

B069 Poster Session I B073 Poster Session I B076 Poster Session II B079 Poster Session I B084 Poster Session II B090 Poster Session II Nitric Oxide Releasing Composite A Serological Biomarker Measuring Intracellular MMP12 Increases Breast A systems biology approach to Role of the CCN1-Hippo-YAP A novel mutation in the NPXY motif of Hydrogels for Tendon Repair via True Formation of Collagen Type III Cancer Metastasis studying melanoma invasion in a 3D regulatory axis in sprouting β integrin reveals unique phenotypes Matrix Metalloproteinase Controlled (PRO-C3) is Related to Histological Pirjo Astrom1,2, Antoine Dufour1, Maria tumor microenvironment angiogenesis linked to him-4/hemicentin in males Pathways Parameters of Non-alcoholic Villalba Esparza3, Yuanmei Lou2,4, Reinhild Amanpreet Kaur, Benjamin Emert, Ian Sangmi Lee, Afruja Ahad, Michele Luu, of Caenorhrabditis elegans Kaylee Meyers, Rupak Rajachar, Steatohepatitis Kappelhoff1, Nikolaus Fortelny1, Paul Mellis, Arjun Raj Brahim Chaqour, SUNY Downstate Myeongwoo Lee, Zhongqiang Qiu, Peter Carly Joseph, Bruce Lee, Michigan Signe Holm Nielsen1,2, Diana J. MacDonald1,4, Vincent Dive5, Enrique Medical Center Sheesley, Baylor University Technological University Leeming1, Jane I Grove3,4,5, Philip Lerma6, Shoukat Dedhar1,4, Alfonso Kaye3,4, Stuart Astbury3,4,5, Mette Juul Calvo3, Christopher M. Overall1, 1University B080 Poster Session II Nielsen1, Morten A. Karsdal1, Indra of British Columbia, 2University of Oulu, Extracellular matrix components B085 Poster Session I B091 Poster Session I Neil Guha3, Guruprasad P. Aithal3,4,5, Finland, 3CIMA of the University of Navarra, isolated from diabetic mice alters Thrombospondin-1-mediated TGF Analyzing the stabilizing effects of Concurrent Session 16: 1Nordic Bioscience, Fibrosis Biology and Pamplona, Spain, 4Integrative Oncology cardiac fibroblast function through signaling in myofibers causes muscle glycan modifications in ADAMTS13 2 Biomarkers, Herlev, DK, Department BC Cancer Research Centre Vancouver, the AGE/RAGE signaling cascade atrophy via the PERK-eIF2 -ATF4 Rajashri Manjunath, Steven J. ECM in Fibrosis 5 of Biotechnology and Bioengineering, British Columbia, Canada, Atomic Energy Stephanie Burr, James A. Stewart, The ER-stress pathway and regulates Berardinelli, Robert S. Haltiwanger, Technical University of Denmark, Lyngby, and Alternative Energies Commission, Gif/ University of Mississippi body adiposity by inducing FGF21 University of Georgia 3 6 B070 Poster Session II DK, NIHR Nottingham Biomedical Yvette, France, Hospital de la Santa Creu Davy Vanhoutte, Tobias Schips, Matthew Research Centre, Nottingham University I Sant Pau, Barcelona, Spain Targeting Matrix-mediated Signaling J. Brody, Jeffery D. Molkentin, Cincinnati Hospitals NHS trust and University Children’s Hospital Medical Center, B092 Poster Session II in Fibrosis 4 of Nottingham, UK, MRC/EPSRC Department of Pediatrics, University of Thrombospondin-4 mediates TGF- Rigen Mo, Sarah Lucas, Rafael Depetris, Nottingham Molecular Pathology B077 Poster Session I Matricellular Proteins Ji-In Kim, Kevin G. Liu, Ed Skucas, Cincinnati and Howard Hughes Medical beta1-induced cancer growth Node, University of Nottingham, UK, Cigarette smoking induces Institute, Cincinnati Children’s Hospital Xiao-Jiang Feng, Jack Gaffney, Jeegar 5 Santoshi Muppala, Irene Krukovets, Nottingham Digestive Diseases Centre, overexpression of elastinolytic B081 Poster Session I Medical Center P. Patel, Masha V. Poyurovsky, Kadmon School of Medicine, University of cathepsin S Dmitriy Verbovetskiy, Edward F Plow, The Role of Peroxidases in Renal Olga Stenina-Adognravi*, Cleveland Corporation, LLC Nottingham, UK 1 Pierre-Marie Andrault ,Andrea C. Injury Clinic Foundation B071 Poster Session I 2 1 B086 Poster Session II Schamberger ,Thibault Chazeirat , 1 2 1 1 3 1 Selene Colon , Haiyan Luan , Yan Liu , B093 Poster Session I Calreticulin is important for the Damien Sizaret , , Justine Renault , 1 1 The laminin-binding integrins 1 1 Cameron Meyer , Leslie Gewin , Gautam development of renal fibrosis and Agnès Petit , Mylène Wartenberg , 1 1 regulate cell-cell interactions and Glycosylation of ADAMTS/TSL Concurrent Session 1 1 Bhave , Vanderbilt University Medical dysfunction in diabetic nephropathy Ahlame Saidi , Thomas Baranek , 2 the inflammatory status of the kidney Proteins is Essential for TSR Serge Guyetant1,3, Yves Courty1,Oliver Center, Jiamusi University Ailing Lu, Manuel A. Pallero, Benjamin 17: Proteases and EMC collecting duct epithelium Stabilization and Proper Secretion Eickelberg2,4, Gilles Lalmanach1,Fabien Owusu, Anton Borovjagin, Paul Sanders, Remodeling Eugenia M. Yazlovitskaya, Erin Plosa, Steven J. Berardinelli, Robert S. Lecaille1, 1INSERM, UMR 1100, Centre Joanne E. Murphy-Ullrich, University of B082 Poster Session II Olga Viquez, Ambra Pozzi, Roy Zent, Haltiwanger, Complex Carbohydrate d’Etude des Pathologies Respiratoires, Alabama at Birmingham Vanderbilt University Medical Center Research Center, University of Georgia B074 Poster Session II University of Tours, 2Comprehensive Determining the Roles of a Novel Cysteine-Rich Secretory Protein Fibrillin-2 proteolysis by Adamts6 Pneumology Center, Ludwig-Maximilians- B072 Poster Session II (CRISP) LON-1 in BMP Signaling in C. is essential for cardiac and limb University and Helmholtz Zentrum B087 Poster Session I B094 Poster Session II München,, 3Service d’Anatomie et elegans Fibronectin-rich ECMs store disease- development Identifying Growth Factors Elevated CCN1 promotes relevant memories that drive altered Cytologie Pathologique, 4Division of Anthony Nzessi, Zhiyu Liu, Herong Shi, Timothy Mead1, Cagri Gulec2, Dieter Associated with the ECM in the extracellular matrix degeneration and fibroblast signaling and phenotype Pulmonary and Critical Care Medicine, Frances Clark, Ines Muravin, Jun (Kelly) Reinhardt3, Cecilia W. Lo2, Suneel S. Tumor Microenvironment skin cancer in aged human skin through integrin switching University of Colorado Liu, Department of Molecular Biology and Apte1, 1Cleveland Clinic Lerner Research Genevieve Abbruzzese1, Eric Kuhn2, Taihao Quan, Yaping Xiang, Zhaoping 1 3 Genetics, Cornell University Victoria Stefanelli , Wei Li , Shilpa Institute, 2University of Pittsburgh School Steven A. Carr2, Richard O. Hynes1, 1MIT, Qin, Andrzej A. Dlugosz, George Bou- 1 3 Choudhury , Ping Hu , Vincent of Medicine, 3McGill University 2Broad Institute Gharios, John J. Voorhees, Gary J. 3 3 Yeh , Leandro Moretti , Dwight M. B083 Poster Session I Fisher, 1Department of Dermatology, 1 2 1 Special Interest Session Chambers , , Kelly Pesson , Matthew University of Michigan, 2Department of 1 3 1 B075 Poster Session I ADAMTSL2 Secretion Requires Torres , Thomas H. Barker , Georgia III, The Development B088 Poster Session II Dermatology, Third Xiangya Hospital, 2 O-Fucosylation and Is Affected by Institute of Technology, Emory University, In situ detection of degraded and Use of 3D Systems CD47 is positively correlated with Central South University, Changsha, 3 Geleophysic Dysplasia-causing University of Virginia 3 and denatured collagen via triple to Investigate Biological Mutations in the TSRs intraflagellar transport protein 57 in China, Institute of Ageing and Chronic helical hybridization: new tool in Function 1 1 papillary thyroid cancer Disease, University of Liverpool histopathology Ao Zhang , Steven J. Berardinelli , Christina Leonhard-Melief2,3, Deepika Kun Dong, Sukhbir Kaur, David Roberts, 1 1 Yang Li , Jeongmin Hwang , Yufeng Vasudevan2,4, Andrew Taibi2,5, Sharee National Cancer Institute, National 1 2 B078 Poster Session II B095 Poster Session I Huang , Timothy Burwell , Norman Giannone2, Suneel S. Apte6, Bernadette Institute of Health 2 2 Mural cell-derived laminin Peterson , Jane Connor , Stephen Periosteal Cells Derived from Long C. Holdener2, Robert S. Haltiwanger7,2, 3 1 1 5 plays a detrimental role in Weiss , Michael Yu , University of Utah, Bone are Unique from those Derived 1University of Georgia, 2Stony Brook 2 3 B089 Poster Session I ischemic stroke MedImmune, University of Michigan from Calvaria University, 3Center To CureTM, 4NYU Reut Shainer¹, Vardit Kram¹, Tina M. Langone Medical Center, 5University The secreted modular calcium Abhijit Nirwane1, Benjamin Nguyen1, Kilts¹, Li Li¹, Carl G. Simon Jr², Marian F. of Utah, 6Lerner Research Institute, binding protein SMOC-1 positively Jeffrey Miner2, Yao Yao1, 1University of Young¹, ¹Molecular Biology of Bones and 7University of Georgia regulates BMP signaling in a dose- Georgia, 2Washington University Teeth Section, NIDCR, NIH, ² Biosystems dependent manner and Biomaterials Division, National Melisa DeGroot, Herong Shi, Alice Institute of Standards and Technology Eastman, Alexandra McKillop, Jun Kelly Liu, Cornell University

25 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 26 Poster Program Poster Program

LB01 Poster Session I B099 Poster Session I B105 Poster Session I B110 Poster Session II B116 Poster Session II Proteomic Analysis of Detergent Inhibition of Transglutaminase Identification of major collagen 7S Dodecamer of Collagen IV as Chloride ions play both a signaling Elastic Fiber Proteins Soluble Proteins Suggests Activity in a Murine Model of producing cells in adult mouse heart Substrate of Lysyl Oxidase like-2 and a structural role in the assembly Cooperative, Non-redundant Periodontal Disease Induces Altered during disease for the Screening of Anti-fibrotic of collagen IV scaffolds B119 Poster Session I Functions For TSP1 and TSP2 in Collagen Fiber Morphology Hadi, Khalil,, Bryan D Maliken, Onur Compounds Ryan Bauer1,2, Billy Hudson1,2,3,4,5,6,7,8, Cortical Bone Emilie A. Rosset1, Jessica Trombetta- Kanisicak, Robert N. Correll, Jeffery D Mark G. Athanason, Alberto López Sergey Budko1,2, 1Center for Matrix Cutis Laxa Mutations in Fibulin-5 Andrea I. Alford, Venkatesha Basrur, eSilva1, Dylan Brown1, Glenn Hepfer2, Molkentin, Cincinnati Children’s Hospital Jiménez, Rafi Mohamed, Roberto M. Biology, 2Department of Medicine, Decrease Elastin Deposition, GPCR Anita B. Reddy, University of Michigan Peng Chen2, Hai Yao1,2, Amy D. Medical Center Vanacore, Vanderbilt University Medical Division of Nephrology and Hypertension, and TGF- Signaling Bradshaw1,3, 1Medical University of South Center Vanderbilt University Medical Center, Erika Dreikorn, Zsolt Urban, University Carolina, 2Clemson University, 3Ralph H. 3Department of Pathology, Microbiology, of Pittsburgh Graduate School of Public B106 Poster Session II 4 Johnson Veterans Affairs Medical Center and Immunology, Department of Health Proteoglycans Type I Collagen binding to B111 Poster Session I Medical Education and Administration, Fibronectin, Defining the high affinity Collagen XI Is a Critical Regulator in 5Department of Cell and Developmental B100 Poster Session II interactive sites Tendon Fibrillogenesis Biology, 6Department of Biochemistry, B120 Poster Session II B096 Poster Session II 7 Acetyltransferase p300 inhibitor, Jonathan Picker, Wen Liu, Xiaowen Mei Sun1,22, Eric Y. Luo1, Sheila M. Vanderbilt-Ingram Cancer Center, Gene targeting of ADAMTSL3, 8 Nascent laminin- 1 synthesis L002 reverses hypertension-induced Liang, Magnus Hook, Texas A&M Health Adams1, Thomas Adams1, Louis J. Vanderbilt Institute of Chemical Biology, a novel participant in the regulates the steady-state adult bone cardiac hypertrophy and fibrosis Science Center - Institute of Bioscience Soslowsky3, David E. Birk1, 1University Vanderbilt University Medical Center musculoskeletal system marrow hematopoietic niche Tianjiao Sun, Rahul Rai, Veronica and Technology, Department of of South Florida, 2Morsani College of Deborah Hoelting, Suneel Apte, 3 Karen Carlson1,2, Sreemanti Basu2, Ramirez, Elizabeth Lux, Mesut Eren, Biochemistry and Biophysics, Texas A&M Medicine, University of Pennsylvania B117 Poster Session I Cleveland Clinic Lerner Research Institute Pouneh Kermani3, Irene Hernandez2, Douglas Vaughan, Asish Ghosh, Feinberg University Heterogeneity of posttranslational Mark Zogg2, Jennifer May2, British Cardiovascular and Renal Research B112 Poster Session II modification in type I collagen from Fields2, Hartmut Weiler2, 1Medical College Institute, Feinberg School of Medicine, B121 Poster Session I B107 Poster Session I different tissues of Wisconsin, 2Blood Research Institute Northwestern University Regulation of the Sar1 GTPase cycle Upregulation of Fibulin-3 in human 1 1 part of Versiti, 3Weill Cornell College of The first crystal structure of native is necessary for collagen secretion Shinomi Yagi , Keisuke Tanaka , Yuki ovarian cancer: understanding the 1 2 2 Medicine collagen: A multiplexin-like domain from the endoplasmic reticulum Taga , Shugo Tohyama , Eiji Kobayashi , role of Fibulin-3 in normal oviductal B101 Poster Session I 1 1 1 present in prokaryotic hyaluronidase Miharu Maeda, Kota Saito, Akita Kazunori Mizuno , Shunji Hattori , Nippi biology in young and aged mice 2 3D Printing Networks of Type 1 Research Institute of Biomatrix, Keio Joo Hyoung Lee , Kanagalaghatta R. University, Graduate School of Medicine Yazmin Brown1, M Fairuz B Jamaluddin1, B097 Poster Session I I Collagen with Tunable Fiber 2 1 University School of Medicine Rajashankar , Norbert Shormann , Arnab Ghosh1, Manish Kumar1, Ayesha Alignment and Geometry 1 Chemotherapy induces secretion of Selvarangan Ponnazhagan , Champion Ali1, Albert S. Mellick2 Lucy Murtha3 exosomes loaded with heparanase 1 1 B113 Poster Session I 3 1 Bryan Nerger, Pierre-Thomas Brun, Deivanayagam , The University of B118 Poster Session II Andrew Boyle , Pradeep S. Tanwar , that degrades extracellular matrix Celeste Nelson, Princeton University Alabama at Birmingham, 2Cornell Scar-in-a-Jar, a novel in vitro 1University of Newcastle (Australia), Bacterial modulation of ECM and and impacts tumor and host cell University and NE-CAT Advanced Photon screening tool for antifibrotics 2Ingham Institute, University of New contribution to tumor growth – a behavior Source 1 South Wales, Sydney, Australia, 3Hunter B102 Poster Session II Natasja S. Gudmann , Sarah R. novel mechanism Shyam Kumar Bandari1, Anurag Rønnow1, Sarah Brockbank2, Simon Medical Research Institute, Newcastle, Purushothaman1, Vishnu C. Ramani1, Abnormal collagen post-translational 2 1 Ritesh Kumar, John Taylor, Juan Xu, Yi Australia B108 Poster Session II Cruwys , Morten A. Karsal , Diana J. Garrett J. Brinkley1, Darshan S. chemistry and cross-linking causing Leeming1, Jannie M. B. Sand1, 1Nordic Xu, Texas A&M University Chandrashekar1, Sooryanarayana bone fragility in Bruck Syndrome The role of COL27A1 in skeletal Bioscience, 2Innovative Medicines Unit, Varambally1, James A. Mobley1, Yi caused by compound heterozygous development: mouse modeling of the LB04 Poster Session II Grünenthal Group LB02 Poster Session II Zhang2, Elizabeth E. Brown1, Israel PLOD2 mutations Steel syndrome Puerto Rican founder Zebrafish Elastin is Required for Vlodavsky3, Ralph D. Sanderson1, Charlotte Gistelinck, MaryAnn Weis, allele and additional pathogenic Determining the fates of misfolded Cardiac Valve Development and 1University of Alabama at Birmingham, Jyoti Rai, Peter H. Byers, David R. Eyre, variants from Turkish kindreds B114 Poster Session II type-I collagen C-propeptide variants Function 2 3 1 associated with osteogenesis Eli Lilly and Company, Cancer and University of Washington Harikiran Nistala , Claudia Gonzaga- A Cysteine-Based Molecular Code Michelle Zorrilla1, Jerome P. Givi1, Simon 1 1 imperfecta (OI) Vascular Biology Research Center, The Jauregui , Kalyan Nannuru , Johanna Guides Collagen C-Propeptide C. Watkins2, Beth L. Roman1, Kang Kim3, Bruce Rappaport Faculty of Medicine, Jimenez1, John Dronzek1, Saathyaki Assembly Michelle Huang, Azade S. Hosseini, Zsolt Urban1, 1University of Pittsburgh Technion, Haifa, Israel B103 Poster Session I 1 1 Rajamani , Silvia Smaldone , Richard Rasia Li1, Andrew DiChiara1, Azade Andrew S. DiChiara, Ngoc-Duc Doan, Department of Human Genetics, 2 2 Glycation targets the same type I A. Gibbs , James R. Lupski , Aris N. Hosseini1, Darrell McCaslin2, Matthew Amanda Del Rosario, Matthew D. 2Center for Biologic Imaging, 3Center 1 collagen helical domain sites as lysyl Economides, Regeneron Genetics Shoulders, 1MIT, 2UW-Madison Shoulders, MIT for Ultrasound Molecular Imaging and oxidase-mediated cross-linking Center, Regeneron Pharmaceuticals Inc., Therapeutics 2 Collagens 1 1 Baylor College of Medicine David Hudson , Marilyn Archer , Karen LB03 Poster Session I B. King2, David R. Eyre, 1University of B115 Poster Session I 2 The Zebrafish crusher Mutation B098 Poster Session II Washington, University of Colorado B109 Poster Session I Species-specific collagen deposition School of Medicine in a xenograft model of the human Disrupts Collagen Secretion and Evolutionary origin of collagen IV in a Coordinate roles for collagen VI and digit Cartilage Growth unicellular relative of animals Bgn in regulating tendon collagen 1 1 Amy R. Rushing, Gokhan Unlu, and Ela B104 Poster Session II fibril structure Russell Fernandes , Mary Ann Weis , Aaron Fidler, Sergei Chetyrkin, Sergei David Hudson1, David Eyre1, William W. Knapik, Vanderbilt University Medical 1 1 Boudko, Favour Akabogu, Justin Visible Light Crosslinking of Type I Hai Pham , Marian Young , Sheila M. Landis2, 1University of Washington, Center 2 3 1 2 Cartaillier, Ly Hoang, Julie Hudson, Billy Collagen 3D Bioprinted Tissues Adams , David E. Birk , NIH, University Seattle, 2University of California, San 3 Hudson, Vanderbilt University Medical David Bagley, Bowman Bagley, Joshua of South Florida, Morsani College of Francisco Center Valdez, Advanced BioMatrix Medicine, Tampa, FL

27 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 28 Poster Program Poster Program

Rabelink2, Clemens van Blitterswijk1, B131 Poster Session I B136 Poster Session II B141 Poster Session I B146 Poster Session II 1 1 Matrix in Morphogenesis Vanessa LaPointe , MERLN Institute Investigation of fibronectin- Halogenation of renal collagen IV Kidney cell response to Examining the biochemical for Technology - Inspired Regenerative heparan sulfate interactions during scaffold in vivo decellularized extracellular matrix properties of the novel ECM Medicine, Maastricht University, extracellular matrix assembly with modified mechanical properties glycoprotein SNED1 to decipher its 2 Paul Voziyan, Kyle Brown, Billy Hudson, B122 Poster Session II Maastricht, The Netherlands, Leiden role in breast cancer metastasis University Medical Center, Leiden, The Katherine Hill, Irene Raitman, Jean Vanderbilt University Medical Center Snehal Sant, Nicholas Ferrell, Vanderbilt Sned1 knockout causes neonatal Netherlands Schwarzbauer, Princeton University University Medical Center Alexandra M. Socovich, Martin N. lethality and craniofacial defects in Davis, Morgan C. Win, Alexandra Naba, mice B137 Poster Session I University of Illinois at Chicago B132 Poster Session II B142 Poster Session II Anna Barque1, Martin N. Davis1, Kyleen B126 Poster Session II Ex-vivo evaluation of mesenchymal Mechanical stress attenuated Jan1, Christina L. Nicholas1, Richard O. Unicellular ancestry and role of ECM biodynamics by cross- Identification of Two Novel Protein inflammatory cytokines induced B147 Poster Session I Hynes2, Alexandra Naba1, 1University the Goodpasture Antigen Binding disciplinary approaches in mouse O-Glucosyltransferases That Modify matrix degradative enzymes of Illinois at Chicago, 2David H Koch Protein in the transition to animal models of GI pathologies Proteomic profiling of the Fibrillin-1 EGF Repeats expression in chondrocyte by Institute for Integrative Cancer Research, mutlicellularity extracellular matrix in pancreatic Daniel Williamson1, Hideyuki Takeuchi1, Véronique Pomerleau, Vilcy Reyes inhibition of NF-kB translocation 1 2 ductal adenocarcinoma reveals Massachusetts Institute of Technology 1 2 1 Carl Darris , Francisco Revert , Roberto Nicolas, Raphaëlle Servant, François- Robert S. Haltiwanger , , University of 1 1 2 1 Takashi Ohtsuki , Omer Faruk Hatipoglu , promoters of PDAC progression and 2 Gozalbo-Rovira , Andrew Fiegley , Michel Boisvert, Michel Grandbois, Georgia, Stony Brook University 1 2 Juan Saus2, Billy Hudson1, 1 Vanderbilt Nathalie Perreault, Université de Guole Liu , Akira Shinaoka Keiichi metastasis B123 Poster Session I 3 1 University and Vanderbilt University Sherbrooke Asano , Takuto Nishimura , Junko Chenxi Tian1, Karl Clauser2, Daniel 4 2 Laminin- 1 cessary for Adult Murine B127 Poster Session I Medical Center, 2 FibroStatin S.L., Parc Inagaki , Keiichiro Nishida , Toshitaka Öhlund3, Steffen Rickelt1, Ying Huang1, 3 1 1 Intestinal Epithelial–Mesenchymal Oohashi , Satoshi Hirohata , Department 3 4 The Role of Matrix Assembly Site Cientific Universitat de València Tommy Lidström , Mala Gupta , Steven Homeostasis of Medical Technology, Okayama 2 Distribution in Aligned Fibronectin A. Carr , David A. Tuveson5, Richard O. University Graduate School of Health 1 1 2 3 1 2 2 Hynes , MIT, Broad Institute, Umeå Karen Carlson , , British Fields , Jennifer Fibril Formation ECM of Inflamation 2 B133 Poster Session I Sciences, Department of Human 4 May2, Irene Hernandez2, Mark Zogg2, University, New York University Winthrop Carly Garrison, Jean Schwarzbauer, Infection and Immunity Morphology, 3Molecular Biology and Anne DeLaForest1, Hartmut Weiler2, Neonatal Fibrin Polymerization Hospital, 5CSHL Princeton University Biochemistry, 4Cell Chemistry, Graduate Michelle Battle1, 1Medical College of Dynamics School of Medicine Wisconsin, 2Blood Research Institute part 1 1 B138 Poster Session II Kimberly Nellenbach , A. Kyu , B148 Poster Session II of Versiti B128 Poster Session II N. Guzzetta2, A.C. Brown1, 1Joint Inflammatory Cytokines Promote Targeting Thrombospondin-1/ Perlecan knockdown significantly Department of Biomedical Engineering, Pro-Fibrotic Phenotype in Lung North Carolina State University and The Fibroblast Subpopulations CD47 signaling axis regulates B124 Poster Session II alters ECM composition during Tumor Microenvironment hypoxia & metabolism in the tumor cartilage development University of North Carolina at Chapel Daniel Abebayehu, Thomas Barker, ECM remodeling and focal adhesion Hill, 2Emory University School of Medicine microenvironment to enhance anti- Alexander R. Ocken, Madeline Ku, Sarah University of Virginia tumor immune responses activation direct airway epithelial and Children’s Healthcare of Atlanta B143 Poster Session I branching morphogenesis Calve, Purdue University Elizabeth R. Stirling, Adam Wilson, Dietary-regulated microbiota impact B139 Poster Session I Tiffany M. Newman, Liliya Yamaleyeva, James Spurlin, Michael J. Siedlik, Mei breast tumorigenesis and regulates B134 Poster Session II Pierre L. Triozzi, David R. Soto-Pantoja, Fong Pang, Sahana Jayaraman Celeste B129 Poster Session I Revealing silent pathological tissue the tumor stroma Wake Forest School of Medicine M. Nelson, Princeton University In-silico definition of the matrisomes states through extracellular matrix Abnormal collagen fibril ultrastructure Akiko Chiba, David R. Soto-Pantoja, of three model organisms: Danio composition-to-structure translation in abdominal aortic aneurysms rerio, Caenorhabditis elegans, and Adam S. Wilson, Kenysha Y.J. Clear, 1 1 LB05 Session I Blain Jones1, Anna Debski1, Jeff R. Drosophila melanogaster Elee Shimshoni , Ran Afik , Anjana Katherine L. Cook, Wake Forest B149 Poster Session I 2 1 3 1 1 1 Shenoy , Miri Adler , Luca Puricelli , Tonniges , Ben Albert , David Yeung , Ed 1 2 University School of Medicine Extracellular Vesicle Heterogeneity Palate Development: Review of ECM Martin N. Davis , Alina Teuscher , 4 4 1 1 2 Odelia Mouhadeb , Nathan Gluck , P. Calomeni , Michael Go , A. Mahajan , 2 3 Profiling using High Resolution Flow Properties, Genes, Cell Movement. Elisabeth Jongsma , Jan Gebauer , 4 2 1 1 Sigal Fishman , Lael Werner5, Dror Chetan Hans , Gunjan Agarwal , The 2 1 Cytometry and Imaging What’s Next? Collin Y. Ewald , Sally Horne-Badovinac , 4 2 S. Shouval5, Chen Varol , Alessandro B144 Poster Session II Ohio State University, University of Alexandra Naba1, 1University of Illinois at Hyun-ji Kim, Samuel Yunga, Fehmi Kathy K. H. Svoboda, L. Bruno Ruest, Podestà3, Tamar Geiger2, Paolo Milani3, Defining the Perlecan/HSPG2- Missouri Chicago, 2Eidgenössische Technische Civitci, Matthew Rames, Justin Plaut, Shaun Logan, M. Douglas Benson, Texas Uri Alon1, Irit Sagi1, 1Weizmann Institute of Semaphorin Receptor Complex to Hochschule (ETH) Zürich, 3University of Dennis Duran, Xiaolin Nan, *Thuy Ngo, A&M College of Dentistry Science, 2Tel-Aviv University, 3University Understand Cohesive Behavior of Cologne Oregon Health and Science University, B130 Poster Session II of Milan, 4Tel Aviv Sourasky Medical Metastatic Prostate Cancer Center, 5Sheba Medical Center *corresponding author Label-free Raman imaging of elastic Tristen V. Tellman1, Brian J. Grindel2, fibers in disease and healthy mouse B135 Poster Session I 1 1 Structure and Assembly of Mary C. Farach-Carson , University of aortic tissues Classification of the collagen ECM in Texas Health Science Center at Houston, B150 Poster Session II ECM Kaori Sugiyama1, Julia Marzi2, Eva normal human tissue as a biomarker School of Dentistry, 2The University of ECM Atlas 2.0: Integrating 50+ Brauchlec2,3, Yoshito Yamashiro1, for future breast cancer incidence Mechanosensing Texas MD Anderson Cancer Center Proteomic ECM Profiles of Normal, 2 3 4 B125 Poster Session I Katja Schenke-Layland , , , Hiromi Ryan Gigstad, Tianjie Wang, Yifei Fibrotic, and Tumor Tissues 1 1 Yanagisawa , University of Tsukuba, Liu, Menggang Yu, Yuming Liu, Adib B140 Poster Session II Karl Clauser1,2, Huiming Ding3, Charles Unraveling the role of the 2 B145 Poster Session I Japan, Eberhard Karls University, Keikhosravi, Kevin W. Eliceiri, Patricia J. A. Whittaker3, Steven A. Carr1,2, extracellular matrix during kidney 3 Matrix Stiffness and Viscoelasticity Dynamically Stiffening Niche Tübingen, Germany, NMI Natural Keely, Matthew W. Conklin, University of Richard O. Hynes3, Alexandra Naba4, organoid maturation. Direct Fibroblast Spreading and Promote Malignant Transformation and Medical Sciences Institute at the Wisconsin 1Broad Institute of MIT, 2Harvard, 1 1 Modes of Migration via Collective Mechanical Signaling Thomas Geuens , Anika Schumacher , University of Tübingen, Reutlingen, 3Massachusetts Institute of Technology, 1 4 Timo Rademakers , Cathelijne van Germany, Cardiovascular Research Daniel Chester, Jeremy Nortey, Roni Lee, Adam J. Engler, University of California 4University of Illinois at Chicago 2 2 den Berg , Loes Wiersma , Ton Laboratories, University of California Ashley C. Brown, North Carolina State San Diego University

29 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 30 Poster Program Poster Program

B151 Poster Session I Shunsuke Iriyama, Saori Nishikawa, Peter, School of Pharmacy, University of Unnati M Pandya, Ana Tellechea, Miguel B169 Poster Session I Schuitema, Genki Hayashi, Kendall Potential Association of Expression Eisuke Takai, Junichi Hosoi and Satoshi Queensland, Woolloongabba, Australia A. Manzanares, Chinaza Egbuta, Julien Assessment of the effect of a pro- Hoff, Wenhui Gong, Dang Q Dao, Peter of CD133 and CD44 with Distant Amano, Shiseido Global Innovation Center Daubriac, Cougar Jaramillo, Marek growth extracellular matrix protein, Oishi, Marta Margeta, Douglas B. Gould, Michalak, Feres Samra, and Leslie I Gold, Univeristy of California, San Francisco Metastatic Relapse and Tumor B161 Poster Session I matrilin-2, on axonal sprouting in the Growth in Advanced Prostate Cancer New York University School of Medicine post-stroke brain Fibrillin-1-mediated regulation of Meenakshi A. Chellaiah, Sunipa Cardiovascular ECM microRNA signaling and cell function Samuel Bridges, Michal Machnicki, S. B174 Poster Session II Majumdar, Renty B. Franklin, University LB06 Poster Session II Thomas Carmichael, UCLA Circulating fibrillin-1 fragments of Maryland School of Dentistry Rongmo Zhang, Karina A. Zeyer, Heena Kumra, Dieter P. Reinhardt, McGill Recombinant elastonectin in children and young adults with B156 Poster Session II University accelerates epidermal neogenesis Marfan syndrome B152 Poster Session II Homeostatic-like Cardiac Fibroblasts and reinstates epidermal integrity in Heritable Disorders of Lynn M. Marshall1, Eric J Carlson2, Turn off Angiogenesis Following skin wound healing 1 3 4 Non-neoplastic extracellular matrix Connective Tissue Kathryn W. Holmes , Luciana T. Young , , Myocardial Infarction Wound Healing B162 Poster Session II Won Bae Jeon, Jin-Kyu Park, KNU; Shaine A. Morris5,6 Jacqueline T. components abrogate primary B170 Poster Session II human glioma cell malignancy Alan Mouton1, Elizabeth R. Flynn1, Mechanoresponse to Periodic Seong-Kyoon Choi, DGIST; Kyeong-Min Hecht5, Mary J. Roman7, Angela T. 1 Hydrostatic Pressure Enables Lee, DGIST; Bo Hyung Park, DGIST; A mutation in the fibronectin Yetman8, Lynn Y Sakai1,2, 1Oregon 1 1 Yonggang Ma , Kristine Y. DeLeon- Mark Murdock , Jordan Chang , George 2 1 1 Fabrication of Human Arterial Graft Kyu-Shik Jeong, KNU assembly domain impacts both Health and Science University, Shriners 1 2 Pennell , Michael R. Garret , Tom C. Hussey , Nduka Amankulor , Johnathan 3 2 1 1 1 1 fibronectin and collagen matrix Hospital for Children, University of 2 1 Freeman , Merry L. Lindsey , University Junichi Saito , Utako Yokoyama , Engh , Stephen Badylak , 1McGowan 4 of Mississippi Medical Center, 2The Roslin 2 2 assembly by fibroblast cells Washington, Seattle Children’s Hospital, Institute for Regenerative Medicine, Toshio Takayama , Mitsuhiro Horade , ‑ Institute, University of Edinburgh 2 3 1 1 5University of Texas, 6Texas Children’s 2UPMC Hillman Cancer Center Hiroaki Ito , Yoshinobu Sugo , Kentaro Eli B. Cadoff , Ashley Drengler , Ruth Kurasawa3, Miyuki Ogawa3, Etsuko Sheffer2, Vardiella Meiner2, Jean E. Hospital Houston, 7Weill Cornell Medical Miyagi3, Makoto Kaneko2, Yoshihiro Growth Factors and ECM Schwarzbauer1, 1Princeton University, Center, 8University of Nebraska and B157 Poster Session I B153 Poster Session I Ishikawa1, 1 Cardiovascular Research 2Hadassah-Hebrew University Medical Children’s Hospital & Medical Center Investigating the Effects of Type VIII Internalization of CD239, a laminin Institute, Yokohama City University, Center Collagen Deficiency in Advanced 2 B166 Poster Session II 5 receptor, in human breast cancer: Yokohama, Japan, Department B175 Poster Session I Atherosclerosis A versatile salt-based method to a novel antigen for antibody-drug of Mechanical Engineering, Osaka 3 B171 Poster Session I A zebrafish platform to study Cameron Harper1,2, Joshua Lopes1, University, Suita, Japan, Department of immobilize glycosaminoglycans conjugates new treatment options for Marfan Guangpei Hou1,2, Michelle Bendeck1,2, Obstetrics and Gynecology, Yokohama and create gradients of Zebrafish type I collagen mutants Yamato Kikkawa1, Yurie Enomoto- syndrome 1University of Toronto, 2Ted Rogers City University, Yokohama, Japan glycosaminoglycans and growth faithfully recapitulate human type I Okawa2, Aiko Fujiyama2, Takeshi Centre For Heart Research factors collagenopathies Patrick Sips, Petra Vermassen, Hanna Fukuhara1, Nozomi Harashima1, Danique Hof, Elly Versteeg, Willeke Charlotte Gistelinck1, Ronald Y Kwon1, De Saffel, Marjolijn Renard, Andy Willaert, 1 1 B163 Poster Session I Yumika Sugawara , Kazuki Ikari , Yoichi Daamen, Toin Van Kuppevelt, Radboud Fransiska Malfait2, Sofie Symoens2, Anne De Paepe, Paul Coucke, Julie De 1 1 B158 Poster Session II Negishi , Fumihiko Katagiri , Kentaro Role of Fibronectin’s extra domains University Medical Center, RIMLS, Matthew P. Harris3, Katrin Henke3, Backer, Ghent University 1 1 2 Hozumi , Motoyoshi Nomizu , Yuji Ito , The role of type VIII collagen in EIIIA and EIIIB in early vascular Dept. of Biochemistry, Nijmegen, The Michael B. Hawkins3, Shannon Fisher4, 1 Tokyo University of Pharmacy and Life arterial vessel stiffening development Netherlands Patrick Sips2, Brecht Guillemyn2, Jan Science, 2Kagoshima University B176 Poster Session II Amanda Mohabeer1,2, Guangpei Hou1,2, Thao Nguyen, Amanda Del Rosario, Willem Bek2, Petra Vermassen2, Hanna A new mouse model of chronic Hangjun Zhang1,2, Jeffery Kroetsch1,2, Richard Hynes, Massachusetts Institute De Saffel2, Paul Eckhard Witten2, B167 Poster Session I proteinuria due to a glomerular Steffen Sebastian Bolz1,2, Scott of Technology MaryAnn Weis1, Anne De Paepe2, David basement membrane laminin-521 Heximer1,2, Richard Assoian3, Michelle Conformational change of fibronectin R Eyre1, Andy Willaert2, Paul J Coucke2, polymerization defect ECM of Aging Bendeck1,2, 1University of Toronto, 2Ted during stretch influences growth 1Univeristy of Washington, 2Ghent B164 Poster Session II 3 1 1 Rogers Centre For Heart Research, factor binding domain availability Univeristy, Harvard Medical School, Steven Funk , Raymond H. Bayer , 3 Effects of sulforaphane, a plant- 4Boston University Karen K. McKee2, Kazushi Odaka3, B154 Poster Session II University of Pennsylvania Emily Sevcik, Adam Feinberg, Carnegie derived isothiocyanate, on cardiac Mellon University Hiroshi Nishimune3, Peter D. Yurchenco2, Protective effects of neohesperidin fibroblast activation and extracellular Jeffrey H. Miner1, 1Washington University, dihydrochalcone against epidermal B159 Poster Session I matrix expression B172 Poster Session II 2Rutgers University, 3University of Kansas basement membrane damage B168 Poster Session II Vascular Aggrecan and Versican Charity Fix, Amanda Carver, Mrinmay Angiotensin II Type 2 Receptor Medical Center through the inhibition of cathepsin S Assays for the Evaluation of Aortic Chakrabarti, Mohamad Azhar, Wayne Gastric hormone regulation Partially Mediates Hypertension in Justine Renault1, Juliette Sage2, Ahlame Tissue and Serum in Thoracic Aortic of osteoblast lysyl oxidase is Elastin Insufficiency Carver, University of South Carolina B177 Poster Session I Saidi1, Emmanuelle Leblanc2, Sylvianne Aneurysm and Dissection. School of Medicine dysregulated in diabetes, leads Michelle Lin1, Beth A. Kozel2, Robert 2 2 An atomistic view of collagen Schnebert , Carine Nizard , Robin Christopher Koch1,2, Ling Li1, Belinda to osteopenia, and is a potnetial P. Mecham1, Carmen M. Halabi1, 2 1 degradation in alkaptonuria cartilage Kurfurst , Gilles Lalmanach , Fabien Willard1, Suneel Apte1, 1Cleveland Clinic therapeutic target 1Washington University School of 1 1 by solid-state NMR Lecaille , INSERM, UMR 1100, Centre Lerner Research Institute, 2Cleveland Philip Trackman1, Eileen Daley1, Sayon Medicine, 2National Institutes of Health d’Etude des Pathologies Respiratoires, State University Roy2, Neha Shrestha1, 1Boston University Wing Ying Chow1, Brendan Norman2, 2 Skin BM-Wound Healing University of Tours, LVMH-Recherche, Henry M Goldman School of Dental University of Liverpool, Hartmut and Disease B173 Poster Session I 1 2 1 Hélios Centre, St Jean de Braye, France Medicine, 2Boston University School of Oschkinat , James Gallagher , Leibniz- B160 Poster Session II Medicine COL4A1 mutations cause Institut für Molekulare Pharmakologie B165 Poster Session I neuromuscular disease with tissue- (FMP Berlin), 2University of Liverpool B155 Poster Session I Periodontal derived lipopolysaccharide stimulates Calreticulin Exploits TGF- for specific mechanistic heterogeneity. Laminin-511 is a key component of glycosaminoglycan chain elongation Extracellular Matrix Induction Cassandre Labelle-Dumais, Vera epidermal basement membrane to in vascular smooth muscle cells Engineering A Tissue Regenerative maintain epidermal homeostasis Kamato Danielle, Afroz Rizwana, Little Process

31 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 32 Poster Program Poster Program

LB07 Poster Session I Joe Swift5, Martin Schwartz5, Craig A Keisuke Tanaka1, Naoko Teramura1, B191 Poster Session I 1 1 1 Somatic Activating Mutations in Henke6, Peter B Bitterman6, Wellcome Osamu Hayashida , Katsumasa Iijima , A cleavage-resistant mouse knock-in ECM in Fibrosis 2 1 MAP2K1 Cause Melorheostosis Centre for Cell-Matrix Research, Teru Okitsu , Kazunori Mizuno , Nippi mutant demonstrates that versican Univeristy of Manchester, 2University Research Institute of Biomatrix, Shunji 1 1 proteolysis is indispensable for Heeseog Kang , Smita Jha , Zuoming of Minnesota, Clinical and Translational Hattori1, 1Nippi Research Institute of 1 2 B181 Poster Session I interdigital web regression Deng , Nadja Fratzl-Zelman Wayne A. Medicine Institute, 3University of Biomatrix, 2Institute of Industrial Science, 1 1 Therapeutic peptides based on CCN3 Cabral , Aleksandra Ivovic , Françoise Minnesota Informatics Institute, University The University of Tokyo Sumeda Nandadasa, Jacob Knorr, 1 1 1 treat systemic sclerosis in a mouse Meylan , Eric P. Hanson , Eileen Lange , of Minnesota, 4Wythenshawe University Christopher Koch, Maria Dours- 1 2 model of the disease James Katz , Paul Roschger , Klaus Hospital, Department of Histopathology, Zimmermann, Karin Tran-Lundmark, 2 1 Klaushofer Edward W. Cowen , Richard Alex Peidl1, Katherine Quesnel1, Bruce Manchester, UK, 5Wellcome Centre B190 Poster Session II Dieter Zimmermann, Sophie Valleix, 1 1 M. Siegel , Timothy Bhattacharyya , Joan Riser2,3, and Science, Andrew Leask1, for Cell-Matrix Research, Univeristy of Vascular dimorphism via regulated Suneel S. Apte, Cleveland Clinic Lerner 1 1 C. Marini , National Institutes of Health 1Western University, 2BLR Bio LLC, Manchester, 6University of Minnesota, extracellular matrix dynamics Research Institute 2 (NIH), Ludwig Boltzmann Institute of 3Rosalind Franklin University of Medicine Department of Medicine ensures rapid and selective umbilical LB08 Poster Session II Osteology artery occlusion at birth Role of progesterone and protease B182 Poster Session II B186 Poster Session II Sumeda Nandadasa, Vai Pathak, ADAMTS 1 on migration and invasion Caroline M Kraft, Anna O’Donnell, of ovarian tumor cells A High Content Imaging Screen Elevated glucose alters expression of Clare Hughes, Bruce Caterson, Karin For Modulators of Corticosteroid Maira de Assis Lima, Suely Viera da ECM in Musculoskeletal ECM- and cell adhesion-associated Tran Lundmark, Martina Veigl, David Mediated Extracellular Matrix Silva, Vanessa Morais Freitas, University Biomechanics and genes in a diabetic nephropathy cell Sedwick, Miriam S. Domowicz, Nancy Deposition of Sao Paulo Regeneration model B. Schwartz, Elliot Philipson and Suneel Christopher Wilson, Louis Yang, Chian Maria E. Vega*, John B. Finlay*, Jean S Apte Cleveland Clinic Lerner Research Yang, Martin Henault, Thomas Vollmer, E. Schwarzbauer, *equal contributors, Institute B178 Poster Session II Megan Jabour, Yuan Wang, Erik Princeton University Osteopontin/integrin v 3 Signaling Meredith, Heather MacLeod, Ganesh Regulates Membrane Localization of Prasanna, Amy Chen, Novartis Institutes CD44 and Migration of Osteoclasts for Biomedical Research B187 Poster Session I by ERM-Actin Interaction with CD44 Fibronectin o,o’-Dityrosine Crosslinking Attenuates Adhesion Meenakshi A. Chellaiah, University of B183 Poster Session I Maryland Signaling and Confers Protease Global alignment of extracellular Resistance matrix by keloid fibroblasts Morgan Locy1, Sunad Rangarajan, Sufen B179 Poster Session I Fiona Kenny, Rachel Bell, Tanya Shaw, Yang, Mark Johnson, Karen Bernard, Pegvorhyaluronidase Alfa-mediated Brian Stramer, King’s College London Ashish Kurundkar, Jaeman Byun2, degradation of hyaluronan in skeletal Subramaniam Pennathur2, Yong Zhou1, muscle results in changes consistent Victor Thannickal1, 1University of Alabama with metabolic stress B184 Poster Session II at Birmingham, 2University of Michigan Li Ma, Kevin Kwok, Curtis B. Thompson, A CRISPR/Cas9 in vitro human induced pluripotent stem cell (hiPSC) Daniel Maneval, Rudolph D. Paladini., B188 Poster Session II Halozyme Therapeutics Inc. model to investigate the role of perlecan in cardiovascular fibrotic Novel Tacrolimus (FK506) Analogue disease. Inhibits FKBP10:Lysyl-Hydroxylase-2 B180 Poster Session II James Smith1, Kate S. Dowding1, Jamie (LH2) Collagen Processing in Molecular level detection of L. Thompson1, Cathy L. R .Merry1, Idiopathic Pulmonary Fibrosis (IPF) mechanical damage in collagen Megan Lord2, Chris Denning1, John Fibroblasts enabled by collagen hybridizing Whitelock1,2, 1Wolfson Centre for Stem Sarah Bui1, Young-Ok You1, Steven peptides Cells, Tissue Engineering and Modelling, D Nathan2, Geraldine Grant1, George 1 1 Yang Li1, Jared Zitnay1, Matthew University of Nottingham, Nottingham, Mason University, Mikell Paige , George 2 2 Converse1, Zhao Qin2, Julian Kessler1, United Kingdom, Graduate School of Mason University, Inova Fairfax Hospital Markus Buehler2, Kenneth Monson1, S. Biomedical Engineering, University of Michael Yu1, Jeffrey Weiss1, 1University of New South Wales, Sydney, Australia Utah, 2MIT B185 Poster Session I Proteases and ECM Remodeling Idiopathic Pulmonary Fibrosis: Registration of extracellular matrix components comprising the B189 Poster Session I fibroblastic focus Identification of a novel collagen- Jeremy Herrera1, Colleen Forster2, binding domain from Grimontia Thomas Pengo3, Angeles Monteres4, hollisae collagenase

33 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 34 ADVERTISEMENT

Affiliated with the:  Journal Impact Factor* Affiliated with the:  . Journal Impact Factor* *Journal Citation Reports® (Clarivate . Analytics, ) American Society International Society *Journal Citation Reports® for Matrix Biology for Matrix Biology (Clarivate Analytics, ) American Society International Society 2017 for Matrix Biology for Matrix Biology Editor-in-Chief 6.472017 Editor-in-ChiefRenato Iozzo 6.47 RenatoThomas Jefferson Iozzo University, Philadelphia, USA Thomas Jefferson University, Philadelphia, USA Supports open access

Supports open access Reasons to submit your next “Matrix Biology is now positioned as one of the best cell biology journals, so I think if we have a “Matrix Biology is now positioned as one of the Reasonsarticle to toMatrix submit Biology: your next compelling story about the matrix this will really best cell biology journals, so I think if we have a • It is the premier journal in matrix biology; published articles be our go-to journal, and people outside the field article to Matrix Biology: compelling story about the matrix this will really have a universal appeal, value, and utility to the researcher are also reading it” • Itcommunity is the premier worldwide. journal in matrix biology; published articles be our go-to journal, and people outside the field have a universal appeal, value, and utility to the researcher Dr. Alexandra Naba, Rupert Timpl awardee • High impact metrics in 2017: are also reading it” community worldwide. CiteScore 6.47 (powered by Scopus) and Dr. Alexandra Naba, Rupert Timpl awardee • HighJournal impact Impact metrics Factor in 8.136 2017: (Clarivate Analytics). CiteScore 6.47 (powered by Scopus) and Recent Special Issues: • An international board of key researchers in the field. Journal Impact Factor 8.136 (Clarivate Analytics). Fibrosis – Mechanisms and • Rigorous, fair and efficient peer review process. Recent Special Issues: • An international board of key researchers in the field. Translational Aspects August 2018 • Your paper your way: no unnecessary formatting requests. FibrosisEdited by – LilianaMechanisms Schaefer and • Rigorous, fair and efficient peer review process. Translational Aspects August 2018 • Flexible publication: you can choose to publish open access. • Your paper your way: no unnecessary formatting requests. EditedProvisional by Liliana Matrix Schaefer July 2017 • Rapid publication: your article available online within a week • Flexible publication: you can choose to publish open access. Edited by Thomas Barker and Adam Engler after acceptance. Provisional Matrix July 2017 • Rapid publication: your article available online within a week Basement Membranes in • No page charges. Edited by Thomas Barker and Adam Engler after acceptance. Health and Disease January 2017 • No color charges for online version. Basement Membranes in • No page charges. Edited by Ambra Pozzi • Option of co-submitting a data article to Data in Brief. Health and Disease January 2017 • No color charges for online version. Edited by Ambra Pozzi 35 • AmericanOption Society of co-submitting for Matrix Biology a data 2018 article BIENNEAL to Data MEETING in Brief . ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 36 In Memoriam

Celebrating the Life and Memory Editor-in-Chief: Renato V. Iozzo, Thomas Je erson University of Our Matrix Biology Colleagues Philadelphia, USA Announcement J. Frederick Woessner, Jr. Prof. Renato V. Iozzo, Editor-in-Chief of 1928-2017 University of Miami, Florida Matrix Biology, together with the entire editorial board and Elsevier are proud to announce the birth of Matrix Biology Plus! Open Access

Matrix Biology Plus is the new, online only, open access Five reasons to publish peer reviewed journal in matrix biology research, Your next article in Matrix Biology Plus (discover more complementary to Matrix Biology. It o ers the quality, bene­ ts on the Matrix Biology Plus webpage…) visibility and impact that you would expect from Matrix • Designated – the best home for comparative and Patricia Keely Biology, combined with the convenience and reach of translational research in the ­ eld of matrix biology. open access. • Quality – our trusted international board of experienced 1963-2017 key researchers in the ­ eld, that is also responsible for University of Wisconsin -Madison To be considered for publication, submitted articles Matrix Biology, guarantee a rigorous, fair and e† cient must provide substantial advances in the eld of matrix peer review process. biology without a strict requirement for novel biological • Accessibility – Open access provides immediate and free mechanisms. online access to articles for anyone, anywhere in the world. No subscription needed. Matrix Biology Plus welcomes: • Readership – No subscriptions and no paywalls means • Comparative and correlative studies more people can read and access an open access article, • New methods increasing author readership and usage. • Proteomics datasets • Speed – Articles are published online, quickly aŠ er • Translational studies acceptance. Articles are published constantly so there • Detailed descriptions of novel transgenic animal models are no print delays or long waits for the next issue to • Signal transduction and genomics/transcriptomic studies be published. Liselotte (Lisa) Isabella Fessler 1924-2016 University of California Los Angeles Join the cover competition YOUR image could be the cover of Matrix Biology Plus! Join our cover image competition, download the template from the journal homepage and submit your entry before 31 December 2018!

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37 American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net American Society for Matrix Biology 2018 BIENNEAL MEETING ASMB.net 38 For more Agenda at a Glance information, ECM Microenvironments in Disease, Aging, and Regeneration visit www.asmb.net

10:00–10:30am Coffee Break 2:00–3:30pm Concurrent Sessions Sunday, October 14th LOCATION: Veranda Guest Symposium IV: Matrix Biology Ireland 10:00am–12:00pm LOCATION: Summerlin F Guest Symposium I 10:30–12:00pm Plenary II: ECM in Disease, Concurrent 12: Skin BM, Wound Healing and Tissue Engineering Regenerative Medicine Aging and Regeneration Disease International Society (TERMIS) LOCATION: Summerlin E–F LOCATION: Summerlin E LOCATION: Summerlin D SIS 2: Trainee Led Session: Emerging Non– Guest Symposium II 12:00–12:30pm ASMB Business Meeting Canonical Intracellular Roles of Extracellular The Histochemical Society LOCATION: Summerlin E–F Matrix Proteins LOCATION: Summerlin E LOCATION: Summerlin F Guest Symposium III 12:30–2:30pm Poster Session I Alport Syndrome Foundation LOCATION: Summerlin A–B–C 3:30–4:00pm Coffee Break LOCATION: Summerlin F Odd Number Boards Present LOCATION: Veranda

12:00–1:00pm Break – Lunch on Your Own 2:30–4:00pm Concurrent Sessions 4:00–5:30pm Concurrent Sessions Concurrent 6: Structure &Assembly of ECM Concurrent 13: Growth Factors and ECM 1:00–2:30pm Concurrent Sessions LOCATION: Summerlin D LOCATION: Summerlin D Concurrent 1: Matricellular Proteins Concurrent 7: ECM of Inflamation, Infection Concurrent 14: Heritable Disorders of LOCATION: Summerlin D and Immunity Connective Tissue Concurrent 2: Proteoglycans LOCATION: Summerlin E LOCATION: Summerlin E LOCATION: Summerlin E Concurrent 8: Mechanosensing Concurrent 15: ECM in Musculoskeletal Concurrent 3: Collagens LOCATION: Summerlin F Biomechanics and Regeneration LOCATION: Summerlin F LOCATION: Summerlin F 4:00–4:30pm Coffee Break 2:30–2:45pm Break LOCATION: Veranda 7:00–11:00pm Banquet–Crimson (Advanced ticket purchase required.) 2:45–4:15pm Concurrent Sessions 4:30–6:00pm Concurrent Sessions SIS 1: Trainee Led Session: Extracellular Concurrent 9: Tumor Microenvironment Vesicles– The Next SMALL Thing LOCATION: Summerlin D LOCATION: Summerlin D Concurrent 10: ECM of Aging Wednesday, October 17th Concurrent 4: Elastic Fiber Proteins LOCATION: Summerlin E 8:00–9:00am Breakfast LOCATION: Summerlin E Concurrent 11: Cardiovascular ECM LOCATION: Veranda Concurrent 5: Matrix in Morphogenesis LOCATION: Summerlin D LOCATION: Summerlin F 9:00–10:30am Plenary V: Therapeutic Strategies for ECM Diseases 4:15–4:30pm Break LOCATION: Summerlin E–F Tuesday, October 16th 4:30–6:00pm President’s Welcome 7:15–8:30am Women Mentoring Women 10:30–11:00am Coffee Break & Award Talks Breakfast (Pre–registration Required) LOCATION: Veranda LOCATION: Summerlin E–F LOCATION: Veranda C 11:00am –12:30pm Concurrent Sessions 6:00–7:00pm Opening Reception 7:30–8:30am Breakfast Concurrent 16: ECM in Fibrosis LOCATION: Veranda LOCATION: Veranda LOCATION: Summerlin D Concurrent 17: Proteases and ECM 7:00–7:15pm Founders Award Talk 8:30–9:30am Plenary III: Signaling From the Remodeling LOCATION: Summerlin E–F Matrix LOCATION: Summerlin E LOCATION: Summerlin E–F SIS 3: Trainee Led Session: 7:15–8:00pm Keynote Lecture The Development and Use of LOCATION: Summerlin E–F 9:30–10:15am ISMB Distinguished 3D Systems to Investigate Investigator Award Presentation Biological Function LOCATION: Summerlin E–F LOCATION: Summerlin F Monday, October 15th 10:15–10:30am Coffee Break 7:15–8:30am Career Mentoring Breakfast LOCATION: Veranda (Pre-registration Required) LOCATION: Veranda C 10:30–12:00pm Plenary IV: Genetic Disorders Affecting Connective Tissue 7:30–8:30am Breakfast LOCATION: Summerlin E–F LOCATION: Veranda 8:30–10:00am Plenary I: Novel Approaches 12:00–2:00pm Poster Session II and Technologies to Investigate the LOCATION: Summerlin A–B–C Extracellular Matrix Even Number Boards Present LOCATION: Summerlin E–F