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PRESS RELEASE National Academies and the Law Collaborate
The Royal Society of Edinburgh, Scotland's National Academy, is Scottish Charity No. SC000470 PRESS RELEASE For Immediate Release: 11 April 2016 National academies and the law collaborate to provide better understanding of science to the courts The Lord Chief Justice, The Royal Society and Royal Society of Edinburgh today (11 April 2016) announce the launch of a project to develop a series of guides or ‘primers’ on scientific topics which is designed to assist the judiciary, legal teams and juries when handling scientific evidence in the courtroom. The first primer document to be developed will cover DNA analysis. The purpose of the primer documents is to present, in plain English, an easily understood and accurate position on the scientific topic in question. The primers will also cover the limitations of the science, challenges associated with its application and an explanation of how the scientific area is used within the judicial system. An editorial board, drawn from the judicial and scientific communities, will develop each individual primer. Before publication, the primers will be peer reviewed by practitioners, including forensic scientists and the judiciary, as well as the public. Lord Thomas, Lord Chief Justice for England and Wales says, “The launch of this project is the realisation of an idea the judiciary has been seeking to achieve. The involvement of the Royal Society and Royal Society of Edinburgh will ensure scientific rigour and I look forward to watching primers develop under the stewardship of leading experts in the fields of law and science.” Dr Julie Maxton, Executive Director of the Royal Society, says, “This project had its beginnings in our 2011 Brain Waves report on Neuroscience and the Law, which highlighted the lack of a forum in the UK for scientists, lawyers and judges to explore areas of mutual interest. -
Jeffreys Alec
Alec Jeffreys Personal Details Name Alec Jeffreys Dates 09/01/1950 Place of Birth UK (Oxford) Main work places Leicester Principal field of work Human Molecular Genetics Short biography To follow Interview Recorded interview made Yes Interviewer Peter Harper Date of Interview 16/02/2010 Edited transcript available See below Personal Scientific Records Significant Record sets exists Records catalogued Permanent place of archive Summary of archive Interview with Professor Alec Jeffreys, Tuesday 16 th February, 2010 PSH. It’s Tuesday 16 th February, 2010 and I am talking with Professor Alec Jeffreys at the Genetics Department in Leicester. Alec, can I start at the beginning and ask when you were born and where? AJ. I was born on the 9 th January 1950, in Oxford, in the Radcliffe Infirmary and spent the first six years of my life in a council house in Headington estate in Oxford. PSH. Were you schooled in Oxford then? AJ. Up until infant’s school and then my father, who worked at the time in the car industry, he got a job at Vauxhall’s in Luton so then we moved off to Luton. So that was my true formative years, from 6 to 18, spent in Luton. PSH. Can I ask in terms of your family and your parents in particular, was there anything in the way of a scientific background, had either of them or any other people in the family been to university before. Or were you the first? AJ. I was the first to University, so we had no tradition whatsoever of going to University. -
Development of a Genetic Multicolor Cell Labeling Approach for Neural
Development of a genetic multicolor cell labeling approach for neural circuit analysis in Drosophila Dafni Hadjieconomou January 2013 Division of Molecular Neurobiology MRC National Institute for Medical Research The Ridgeway Mill Hill, London NW7 1AA U.K. Department of Cell and Developmental Biology University College London A thesis submitted to the University College London for the degree of Doctor of Philosophy Declaration of authenticity This work has been completed in the laboratory of Iris Salecker, in the Division of Molecular Neurobiology at the MRC National Institute for Medical Research. I, Dafni Hadjieconomou, declare that the work presented in this thesis is the result of my own independent work. Any collaborative work or data provided by others have been indicated at respective chapters. Chapters 3 and 5 include data generated and kindly provided by Shay Rotkopf and Iris Salecker as indicated. 2 Acknowledgements I would like to express my utmost gratitude to my supervisor, Iris Salecker, for her valuable guidance and support throughout the entire course of this PhD. Working with you taught me to work with determination and channel my enthusiasm in a productive manner. Thank you for sharing your passion for science and for introducing me to the colourful world of Drosophilists. Finally, I must particularly express my appreciation for you being very understanding when times were difficult, and for your trust in my successful achieving. Many thanks to my thesis committee, Alex Gould, James Briscoe and Vassilis Pachnis for their quidance during this the course of this PhD. I am greatly thankful to all my colleagues and friends in the lab. -
Science in Court
www.nature.com/nature Vol 464 | Issue no. 7287 | 18 March 2010 Science in court Academics are too often at loggerheads with forensic scientists. A new framework for certification, accreditation and research could help to heal the breach. o the millions of people who watch television dramas such as face more legal challenges to their results as the academic critiques CSI: Crime Scene Investigation, forensic science is an unerring mount. And judges will increasingly find themselves refereeing Tguide to ferreting out the guilty and exonerating the inno- arguments over arcane new technologies and trying to rule on the cent. It is a robust, high-tech methodology that has all the preci- admissibility of the evidence they produce — a struggle that can sion, rigour and, yes, glamour of science at its best. lead to a body of inconsistent and sometimes ill-advised case law, The reality is rather different. Forensics has developed largely which muddies the picture further. in isolation from academic science, and has been shaped more A welcome approach to mend- by the practical needs of the criminal-justice system than by the ing this rift between communities is “National leadership canons of peer-reviewed research. This difference in perspective offered in a report last year from the is particularly has sometimes led to misunderstanding and even rancour. For US National Academy of Sciences important example, many academics look at techniques such as fingerprint (see go.nature.com/WkDBmY). Its given the highly analysis or hair- and fibre-matching and see a disturbing degree central recommendation is that the interdisciplinary of methodological sloppiness. -
Metal-Organic Frameworks: the New All-Rounders in Chemistry Research
Issue 2 | January 2019 | Half-Yearly | Bangalore RNI No. KARENG/2018/76650 Rediscovering School Science Page 8 Metal-organic frameworks: The new all-rounders in chemistry research A publication from Azim Premji University i wonder No. 134, Doddakannelli Next to Wipro Corporate Office Sarjapur Road, Bangalore — 560 035. India Tel: +91 80 6614 9000/01/02 Fax: +91 806614 4903 www.azimpremjifoundation.org Also visit the Azim Premji University website at www.azimpremjiuniversity.edu.in A soft copy of this issue can be downloaded from http://azimpremjiuniversity.edu.in/SitePages/resources-iwonder.aspx i wonder is a science magazine for school teachers. Our aim is to feature writings that engage teachers (as well as parents, researchers and other interested adults) in a gentle, and hopefully reflective, dialogue about the many dimensions of teaching and learning of science in class and outside it. We welcome articles that share critical perspectives on science and science education, provide a broader and deeper understanding of foundational concepts (the hows, whys and what nexts), and engage with examples of practice that encourage the learning of science in more experiential and meaningful ways. i wonder is also a great read for students and science enthusiasts. Editors Ramgopal (RamG) Vallath Chitra Ravi Editorial Committee REDISCOVERING SCHOOL SCIENCE Anand Narayanan Hridaykant Dewan Jayalekshmy Ayyer Navodita Jain Editorial Radha Gopalan As a child growing up in rural Kerala, my chief entertainment was reading: mostly Rajaram Nityananda science, history of science and, also, biographies of scientists. To me, science Richard Fernandes seemed pure and uncluttered by politicking. I thought of scientists as completely Sushil Joshi rational beings, driven only by a desire to uncover the mysteries of the universe. -
Mala Radhakrishnan an Interview by Mindy Levine
DED UN 18 O 98 F http://www.nesacs.org N Y O T R E I T H C E N O A E S S S L T A E A C R C I th N S M 90 Anniversary Issue of The NUCLEUS S E E H C C TI N November 2011 Vol. XC, No. 3 O CA N • AMERI Monthly Meeting 2011 James Flack Norris Award to Prof. Peter Mahaffy Meeting at Astra-Zeneca, Waltham Mala Radhakrishnan An Interview by Mindy Levine ACS Governance A Summary from the Fall ACS Meeting Arno Heyn Award 2011 Award to Harvey C. Steiner 2 The Nucleus November 2011 The Northeastern Section of the American Chemical Society, Inc. Contents Office: Anna Singer, 12 Corcoran Road, Burlington, MA 01803 (Voice or FAX) 781-272-1966. Mala Radhakrishnan ____________________________________4 e-mail: secretary(at)nesacs.org NESACS Homepage: An interview by Mindy Levine http://www.NESACS.org Officers 2011 Monthly Meeting _______________________________________5 Chair: 2011 James Flack Norris Award to Prof. Peter Mahaffy Patrick M. Gordon 1 Brae Circle Meeting at Astra-Zeneca, Waltham Woburn, MA 01801 [email protected] ACS Awards to NESACS Members _________________________6 Chair-Elect Ruth Tanner To be presented at the 243rd ACS National Meeting, San Diego, CA Olney Hall 415B March 27, 2012 Lowell, MA 01854 University of Mass Lowell Ruth_Tanner(at)uml.edu Report from Denver ____________________________________6 978-934-3662 Revamping the MCAT Exams. By Morton Z. Hoffman Immediate Past Chair: John McKew Historical Notes 7 John.McKew(at)gmail.com _______________________________________ Secretary: Virginia C. -
Linearity in Cell Signaling Pathways
Linearity in Cell Signaling Pathways Thesis by Harry Nunns In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California 2019 Defended January 11, 2019 ii © 2019 Harry Nunns ORCID: 0000-0002-9669-0039 All rights reserved iii ABSTRACT Accurate cellular communication is of paramount importance for the development, growth, and maintenance of multi-cellular organisms. Communication between cells is carried out by a highly conserved set of signaling pathways, whose dysregu- lation can lead to many diseases. The molecular details of these signaling pathways are now well-characterized, allowing researchers to investigate the emergent prop- erties that arise from the complex signaling networks. These properties often arise from counter-intuitive or paradoxical mechanisms, meaning that systems-level anal- ysis is necessary. Importantly, mathematical models have been constructed for many pathways that capture measured reaction rates and protein levels. These mathemat- ical models successfully recapitulate dynamic responses of each pathway. Here, I investigated the input-output response of the Wnt, MAPK/ERK, and Tgfβ pathways using analytical and numerical treatment of mathematical models. Using this ap- proach, I found that the distinct architectures of the three signaling pathways lead to a convergent behavior, linear input-output response. Specifically, mathematical analysis reveals that a futile cycle in the Wnt pathway, a kinase cascade coupled to feedback in the ERK pathway, and nucleocytoplasmic shuttling in the Tgfβ path- ways all yield linear signal transmission. I then verified this finding experimentally in the Wnt and ERK pathways. For the Wnt pathway, direct measurements of the input-output response reveal that β-catenin is linear with respect to Wnt co- receptor LRP5/6 activity up until receptor saturation. -
Forensic DNA Analysis
FOCUS: FORENSIC SCIENCE Forensic DNA Analysis JESSICA MCDONALD, DONALD C. LEHMAN LEARNING OBJECTIVES: Television shows such as CSI: Crime Scene 1. Discuss the important developments in the history Investigation, Law and Order, Criminal Minds, and of DNA profiling. many others portray DNA analysis as a quick and 2. Compare and contrast restriction fragment length simple process. However, these portrayals are not polymorphism and short tandem repeat analyses in accurate. Since the discovery of DNA as the genetic the area of DNA profiling. material in 1953, much progress has been made in the Downloaded from 3. Describe the structure of short tandem repeats and area of forensic DNA analysis. Despite how much we their alleles. have learned about DNA and DNA analysis (Table 1), 4. Identify the source of DNA in a blood sample. our knowledge of DNA profiling can be enhanced 5. Discuss the importance of the amelogenin gene in leading to better and faster results. This article will DNA profiling. discuss the history of forensic DNA testing, the current 6. Describe the advantages and disadvantages of science, and what the future might hold. http://hwmaint.clsjournal.ascls.org/ mitochondrial DNA analysis in DNA profiling. 7. Describe the type of DNA profiles used in the Table 1. History of DNA Profiling Combined DNA Index System. 8. Compare the discriminating power of DNA 1953 Franklin, Watson, and Crick discover structure of DNA 1983 Kary Mullis develops PCR procedure, ultimately winning profiling and blood typing. Nobel Prize in Science in 1993 -
Dnai DVD and the Dnai Teacher Guide Dnai
DNAi DVD 1 DNAi DVD and the DNAi Teacher Guide The DNA Interactive (DNAi) DVD carries approximately four hours of video interviews with 11 Nobel Laureates and more than 50 other scientists, clinicians, and patients. It also holds the complete set of 3-dimensional animations produced for the DNA TV series and DNAi project. The following pages list video clips and animations from the DVD that would be appropriate to show with specific activities in the DNAi Teacher Guide. The clips and animations are listed under “themes” and “additional animations.” The “themes” listing includes relevant interviews and animations that can be accessed from the “themes” section of the DVD. The “additional animations” are best accessed from “animations” button in the DVD main menu. You can access the DNAi Teacher Guide by registering at www.dnai.org/teacher. Activity 1: DNAi Timeline: a scavenger hunt THEMES • DNA MOLECULE • Discovery of DNA A pre-1953 notion _ biology prior to discovery of the double helix . François Jacob DNA is the genetic material _ the experiment that identified DNA as the genetic material . Maclyn McCarty Chargaff's ratios _ the DNA base ratio rules . Erwin Chargaff The answer _ the X-ray diffraction picture that revealed the helix . Maurice Wilkins DNA: the key to understanding _ why the discovery of DNA's structure was so important . Francis Crick Structure of DNA The correct model _ Meselson and Franklin Stahl's experiment to determine the correct DNA replication mode . Matthew Meselson • DNA IN ACTION • The genetic code Defining the gene _ matching the gene to protein sequence . -
Final Report
Eyewitness Identification Task Force Report to the Judiciary Committee of the Connecticut General Assembly February 8, 2012 February 8, 2012 Dear Members of the Judiciary Committee: The Eyewitness Identification Task Force is pleased to submit this report summarizing its activities and recommendations for policy reform. In 2011, Public Act No. 11-252, Section 2, created the Connecticut Eyewitness Identification Task Force, and mandated that it focus its efforts on: “The science of sequential methods of conducting a live lineup and a photo lineup, (2) the use of sequential lineups in other states, (3) the practical implications of a state law mandating sequential lineups, and (4) other topics as the task force deems appropriate relating to eyewitness identification and the provision of sequential lineups.” The Task Force membership consists of all of the relevant stakeholders and the entire spectrum of critical interests, including: the Co-Chairs and Ranking Members of the Judiciary Committee; a retired judge; representatives of the Offices of the Chief State’s Attorney and Chief Public Defender; representatives of state and local police departments; legal scholars; social scientists; the State Victim Advocate; a representative of the Connecticut Innocence Project; representatives of the public; and representatives of the Bar. The work of the Task Force was greatly facilitated by the collaborative efforts and cooperation of relevant stake-holders, in particular, police and law enforcement. The entire law enforcement community is keenly aware of the risks of erroneous identifications by eye-witnesses. Police and prosecutors are on the front-line of arrests and prosecutions, and understand the critical need to establish reliable identification procedures, while preserving a viable investigative tool in eye-witness identifications. -
Australian Biochemist the Magazine of the Australian Society for Biochemistry and Molecular Biology Inc
ISSN 1443-0193 Australian Biochemist The Magazine of the Australian Society for Biochemistry and Molecular Biology Inc. Volume 47 AUGUST 2016 No.2 SHOWCASE ON RESEARCH Protein Misfolding and Proteostasis THIS ISSUE INCLUDES Showcase on Research Regular Departments A Short History of Amyloid SDS (Students) Page Molecular Chaperones: The Cutting Edge Guardians of the Proteome Off the Beaten Track When Proteostasis Goes Bad: Intellectual Property Protein Aggregation in the Cell Our Sustaining Members Extracellular Chaperones and Forthcoming Meetings Proteostasis Directory INSIDE ComBio2016 International Speaker Profiles Vol 47 No 2 August 2016 AUSTRALIAN BIOCHEMIST Page 1 ‘OSE’ Fill-in Puzzle We have another competition for the readers of the Australian Biochemist. All correct entries received by the Editor (email [email protected]) before 3 October 2016 will enter the draw to receive a gift voucher. With thanks to Rebecca Lew. The purpOSE is to choOSE from thOSE words listed and transpOSE them into the grid. So, clOSE your door, repOSE in a chair, and diagnOSE the answers – you don’t want to lOSE! 6 letters 8 letters ALDOSE FRUCTOSE FUCOSE FURANOSE HEXOSE PYRANOSE KETOSE RIBOSE 9 letters XYLOSE CELLULOSE GALACTOSE 7 letters RAFFINOSE AMYLOSE TREHALOSE GLUCOSE LACTOSE 11 letters MALTOSE DEOXYRIBOSE PENTOSE Australian Biochemist – Editor Chu Kong Liew, Editorial Officer Liana Friedman © 2016 Australian Society for Biochemistry and Molecular Biology Inc. All rights reserved. Page 2 AUSTRALIAN BIOCHEMIST Vol 47 No 2 August 2016 SHOWCASE ON RESEARCH EDITORIAL Molecular Origami: the Importance of Managing Protein Folding In my humble opinion, the most important biological transcription, RNA processing and transport, translation, molecule is the protein. -
Postmaster & the Merton Record 2020
Postmaster & The Merton Record 2020 Merton College Oxford OX1 4JD Telephone +44 (0)1865 276310 Contents www.merton.ox.ac.uk College News From the Warden ..................................................................................4 Edited by Emily Bruce, Philippa Logan, Milos Martinov, JCR News .................................................................................................8 Professor Irene Tracey (1985) MCR News .............................................................................................10 Front cover image Merton Sport .........................................................................................12 Wick Willett and Emma Ball (both 2017) in Fellows' Women’s Rowing, Men’s Rowing, Football, Squash, Hockey, Rugby, Garden, Michaelmas 2019. Photograph by John Cairns. Sports Overview, Blues & Haigh Ties Additional images (unless credited) Clubs & Societies ................................................................................24 4: © Ian Wallman History Society, Roger Bacon Society, Neave Society, Christian 13: Maria Salaru (St Antony’s, 2011) Union, Bodley Club, Mathematics Society, Quiz Society, Art Society, 22: Elina Cotterill Music Society, Poetry Society, Halsbury Society, 1980 Society, 24, 60, 128, 236: © John Cairns Tinbergen Society, Chalcenterics 40: Jessica Voicu (St Anne's, 2015) 44: © William Campbell-Gibson Interdisciplinary Groups ...................................................................40 58, 117, 118, 120, 130: Huw James Ockham Lectures, History of the Book