Introduction to the Local Theory of Curves and Surfaces
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Toponogov.V.A.Differential.Geometry
Victor Andreevich Toponogov with the editorial assistance of Vladimir Y. Rovenski Differential Geometry of Curves and Surfaces A Concise Guide Birkhauser¨ Boston • Basel • Berlin Victor A. Toponogov (deceased) With the editorial assistance of: Department of Analysis and Geometry Vladimir Y. Rovenski Sobolev Institute of Mathematics Department of Mathematics Siberian Branch of the Russian Academy University of Haifa of Sciences Haifa, Israel Novosibirsk-90, 630090 Russia Cover design by Alex Gerasev. AMS Subject Classification: 53-01, 53Axx, 53A04, 53A05, 53A55, 53B20, 53B21, 53C20, 53C21 Library of Congress Control Number: 2005048111 ISBN-10 0-8176-4384-2 eISBN 0-8176-4402-4 ISBN-13 978-0-8176-4384-3 Printed on acid-free paper. c 2006 Birkhauser¨ Boston All rights reserved. This work may not be translated or copied in whole or in part without the writ- ten permission of the publisher (Birkhauser¨ Boston, c/o Springer Science+Business Media Inc., 233 Spring Street, New York, NY 10013, USA) and the author, except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and re- trieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. (TXQ/EB) 987654321 www.birkhauser.com Contents Preface ....................................................... vii About the Author ............................................. -
Geometry of Curves
Appendix A Geometry of Curves “Arc, amplitude, and curvature sustain a similar relation to each other as time, motion and velocity, or as volume, mass and density.” Carl Friedrich Gauss The rest of this lecture notes is about geometry of curves and surfaces in R2 and R3. It will not be covered during lectures in MATH 4033 and is not essential to the course. However, it is recommended for readers who want to acquire workable knowledge on Differential Geometry. A.1. Curvature and Torsion A.1.1. Regular Curves. A curve in the Euclidean space Rn is regarded as a function r(t) from an interval I to Rn. The interval I can be finite, infinite, open, closed n n or half-open. Denote the coordinates of R by (x1, x2, ... , xn), then a curve r(t) in R can be written in coordinate form as: r(t) = (x1(t), x2(t),..., xn(t)). One easy way to make sense of a curve is to regard it as the trajectory of a particle. At any time t, the functions x1(t), x2(t), ... , xn(t) give the coordinates of the particle in n R . Assuming all xi(t), where 1 ≤ i ≤ n, are at least twice differentiable, then the first derivative r0(t) represents the velocity of the particle, its magnitude jr0(t)j is the speed of the particle, and the second derivative r00(t) represents the acceleration of the particle. As a course on Differential Manifolds/Geometry, we will mostly study those curves which are infinitely differentiable (i.e. -
ON the CURVATURES of a CURVE in RIEMANN SPACE*F
ON THE CURVATURES OF A CURVE IN RIEMANN SPACE*f BY E,. H. CUTLER Introduction. The curvature and torsion of a curve in ordinary space have three properties which it is the purpose of this paper to attempt to extend to the curvatures of a curve in Riemann space. First, if the curvature vanishes identically the curve is a straight line ; if the torsion vanishes identically the curve lies in a plane. Second, the distances of a point of the curve from the tangent line and the osculating plane at a nearby point are given approxi- mately by formulas involving the curvature and torsion. Third, the curva- ture of a curve at a point is the curvature of its projection on the osculating plane at the point. In extending to Riemann space we take as the Riemannian analogue of the line or plane, a geodesic space generated by geodesies through a point. Such a space possesses the property of the line or plane of being de- termined by the proper number of directions given at a point, but it will not in general have the three properties given above. On the other hand, if we take as the analogue of line or plane only totally geodesic spaces, then, if such osculating "planes" exist, the three properties will hold. Curves with a vanishing curvature. Given a curve C: xi = x'(s), i = l, •••,«, in a Riemann space Vn with fundamental tensor g,-,-(assumed defi- nite). Following BlaschkeJ we write the Frenet formulas for the curve. The « associate vectors are given by ¿x* dx' (1) Éi|' = —> fcl'./T" = &-i|4 ('=1. -
Appendix Computer Formulas ▼
▲ Appendix Computer Formulas ▼ The computer commands most useful in this book are given in both the Mathematica and Maple systems. More specialized commands appear in the answers to several computer exercises. For each system, we assume a famil- iarity with how to access the system and type into it. In recent versions of Mathematica, the core commands have generally remained the same. By contrast, Maple has made several fundamental changes; however most older versions are still recognized. For both systems, users should be prepared to adjust for minor changes. Mathematica 1. Fundamentals Basic features of Mathematica are as follows: (a) There are no prompts or termination symbols—except that a final semicolon suppresses display of the output. Input (new or old) is acti- vated by the command Shift-return (or Shift-enter), and the input and resulting output are numbered. (b) Parentheses (. .) for algebraic grouping, brackets [. .] for arguments of functions, and braces {. .} for lists. (c) Built-in commands typically spelled in full—with initials capitalized— and then compressed into a single word. Thus it is preferable for user- defined commands to avoid initial capitals. (d) Multiplication indicated by either * or a blank space; exponents indi- cated by a caret, e.g., x^2. For an integer n only, nX = n*X,where X is not an integer. 451 452 Appendix: Computer Formulas (e) Single equal sign for assignments, e.g., x = 2; colon-equal (:=) for deferred assignments (evaluated only when needed); double equal signs for mathematical equations, e.g., x + y == 1. (f) Previous outputs are called up by either names assigned by the user or %n for the nth output. -
Lecture Note on Elementary Differential Geometry
Lecture Note on Elementary Differential Geometry Ling-Wei Luo* Institute of Physics, Academia Sinica July 20, 2019 Abstract This is a note based on a course of elementary differential geometry as I gave the lectures in the NCTU-Yau Journal Club: Interplay of Physics and Geometry at Department of Electrophysics in National Chiao Tung University (NCTU) in Spring semester 2017. The contents of remarks, supplements and examples are highlighted in the red, green and blue frame boxes respectively. The supplements can be omitted at first reading. The basic knowledge of the differential forms can be found in the lecture notes given by Dr. Sheng-Hong Lai (NCTU) and Prof. Jen-Chi Lee (NCTU) on the website. The website address of Interplay of Physics and Geometry is http: //web.it.nctu.edu.tw/~string/journalclub.htm or http://web.it.nctu. edu.tw/~string/ipg/. Contents 1 Curve on E2 ......................................... 1 2 Curve in E3 .......................................... 6 3 Surface theory in E3 ..................................... 9 4 Cartan’s moving frame and exterior differentiation methods .............. 31 1 Curve on E2 We define n-dimensional Euclidean space En as a n-dimensional real space Rn equipped a dot product defined n-dimensional vector space. Tangent vector In 2-dimensional Euclidean space, an( E2 plane,) we parametrize a curve p(t) = x(t); y(t) by one parameter t with re- spect to a reference point o with a fixed Cartesian coordinate frame. The( velocity) vector at point p is given by p_ (t) = x_(t); y_(t) with the norm Figure 1: A curve. p p jp_ (t)j = p_ · p_ = x_ 2 +y _2 ; (1) *Electronic address: [email protected] 1 where x_ := dx/dt. -
Eukaryotic Genome Annotation
Comparative Features of Multicellular Eukaryotic Genomes (2017) (First three statistics from www.ensembl.org; other from original papers) C. elegans A. thaliana D. melanogaster M. musculus H. sapiens Species name Nematode Thale Cress Fruit Fly Mouse Human Size (Mb) 103 136 143 3,482 3,555 # Protein-coding genes 20,362 27,655 13,918 22,598 20,338 (25,498 (13,601 original (30,000 (30,000 original est.) original est.) original est.) est.) Transcripts 58,941 55,157 34,749 131,195 200,310 Gene density (#/kb) 1/5 1/4.5 1/8.8 1/83 1/97 LINE/SINE (%) 0.4 0.5 0.7 27.4 33.6 LTR (%) 0.0 4.8 1.5 9.9 8.6 DNA Elements 5.3 5.1 0.7 0.9 3.1 Total repeats 6.5 10.5 3.1 38.6 46.4 Exons % genome size 27 28.8 24.0 per gene 4.0 5.4 4.1 8.4 8.7 average size (bp) 250 506 Introns % genome size 15.6 average size (bp) 168 Arabidopsis Chromosome Structures Sorghum Whole Genome Details Characterizing the Proteome The Protein World • Sequencing has defined o Many, many proteins • How can we use this data to: o Define genes in new genomes o Look for evolutionarily related genes o Follow evolution of genes ▪ Mixing of domains to create new proteins o Uncover important subsets of genes that ▪ That deep phylogenies • Plants vs. animals • Placental vs. non-placental animals • Monocots vs. dicots plants • Common nomenclature needed o Ensure consistency of interpretations InterPro (http://www.ebi.ac.uk/interpro/) Classification of Protein Families • Intergrated documentation resource for protein super families, families, domains and functional sites o Mitchell AL, Attwood TK, Babbitt PC, et al. -
STACK: a Toolkit for Analysing Β-Helix Proteins
STACK: a toolkit for analysing ¯-helix proteins Master of Science Thesis (20 points) Salvatore Cappadona, Lars Diestelhorst Abstract ¯-helix proteins contain a solenoid fold consisting of repeated coils forming parallel ¯-sheets. Our goal is to formalise the intuitive notion of a ¯-helix in an objective algorithm. Our approach is based on first identifying residues stacks — linear spatial arrangements of residues with similar conformations — and then combining these elementary patterns to form ¯-coils and ¯-helices. Our algorithm has been implemented within STACK, a toolkit for analyzing ¯-helix proteins. STACK distinguishes aromatic, aliphatic and amidic stacks such as the asparagine ladder. Geometrical features are computed and stored in a relational database. These features include the axis of the ¯-helix, the stacks, the cross-sectional shape, the area of the coils and related packing information. An interface between STACK and a molecular visualisation program enables structural features to be highlighted automatically. i Contents 1 Introduction 1 2 Biological Background 2 2.1 Basic Concepts of Protein Structure ....................... 2 2.2 Secondary Structure ................................ 2 2.3 The ¯-Helix Fold .................................. 3 3 Parallel ¯-Helices 6 3.1 Introduction ..................................... 6 3.2 Nomenclature .................................... 6 3.2.1 Parallel ¯-Helix and its ¯-Sheets ..................... 6 3.2.2 Stacks ................................... 8 3.2.3 Coils ..................................... 8 3.2.4 The Core Region .............................. 8 3.3 Description of Known Structures ......................... 8 3.3.1 Helix Handedness .............................. 8 3.3.2 Right-Handed Parallel ¯-Helices ..................... 13 3.3.3 Left-Handed Parallel ¯-Helices ...................... 19 3.4 Amyloidosis .................................... 20 4 The STACK Toolkit 24 4.1 Identification of Structural Elements ....................... 24 4.1.1 Stacks ................................... -
Calculating the Structure-Based Phylogenetic Relationship
CALCULATING THE STRUCTURE-BASED PHYLOGENETIC RELATIONSHIP OF DISTANTLY RELATED HOMOLOGOUS PROTEINS UTILIZING MAXIMUM LIKELIHOOD STRUCTURAL ALIGNMENT COMBINATORICS AND A NOVEL STRUCTURAL MOLECULAR CLOCK HYPOTHESIS A DISSERTATION IN Molecular Biology and Biochemistry and Cell Biology and Biophysics Presented to the Faculty of the University of Missouri-Kansas City in partial fulfillment of the requirements for the degree Doctor of Philosophy by SCOTT GARRETT FOY B.S., Southwest Baptist University, 2005 B.A., Truman State University, 2007 M.S., University of Missouri-Kansas City, 2009 Kansas City, Missouri 2013 © 2013 SCOTT GARRETT FOY ALL RIGHTS RESERVED CALCULATING THE STRUCTURE-BASED PHYLOGENETIC RELATIONSHIP OF DISTANTLY RELATED HOMOLOGOUS PROTEINS UTILIZING MAXIMUM LIKELIHOOD STRUCTURAL ALIGNMENT COMBINATORICS AND A NOVEL STRUCTURAL MOLECULAR CLOCK HYPOTHESIS Scott Garrett Foy, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2013 ABSTRACT Dendrograms establish the evolutionary relationships and homology of species, proteins, or genes. Homology modeling, ligand binding, and pharmaceutical testing all depend upon the homology ascertained by dendrograms. Regardless of the specific algorithm, all dendrograms that ascertain protein evolutionary homology are generated utilizing polypeptide sequences. However, because protein structures superiorly conserve homology and contain more biochemical information than their associated protein sequences, I hypothesize that utilizing the structure of a protein instead -
And Beta-Helical Protein Motifs
Soft Matter Mechanical Unfolding of Alpha- and Beta-helical Protein Motifs Journal: Soft Matter Manuscript ID SM-ART-10-2018-002046.R1 Article Type: Paper Date Submitted by the 28-Nov-2018 Author: Complete List of Authors: DeBenedictis, Elizabeth; Northwestern University Keten, Sinan; Northwestern University, Mechanical Engineering Page 1 of 10 Please doSoft not Matter adjust margins Soft Matter ARTICLE Mechanical Unfolding of Alpha- and Beta-helical Protein Motifs E. P. DeBenedictis and S. Keten* Received 24th September 2018, Alpha helices and beta sheets are the two most common secondary structure motifs in proteins. Beta-helical structures Accepted 00th January 20xx merge features of the two motifs, containing two or three beta-sheet faces connected by loops or turns in a single protein. Beta-helical structures form the basis of proteins with diverse mechanical functions such as bacterial adhesins, phage cell- DOI: 10.1039/x0xx00000x puncture devices, antifreeze proteins, and extracellular matrices. Alpha helices are commonly found in cellular and extracellular matrix components, whereas beta-helices such as curli fibrils are more common as bacterial and biofilm matrix www.rsc.org/ components. It is currently not known whether it may be advantageous to use one helical motif over the other for different structural and mechanical functions. To better understand the mechanical implications of using different helix motifs in networks, here we use Steered Molecular Dynamics (SMD) simulations to mechanically unfold multiple alpha- and beta- helical proteins at constant velocity at the single molecule scale. We focus on the energy dissipated during unfolding as a means of comparison between proteins and work normalized by protein characteristics (initial and final length, # H-bonds, # residues, etc.). -
Chern-Simons-Higgs Model As a Theory of Protein Molecules
ITEP-TH-12/19 Chern-Simons-Higgs Model as a Theory of Protein Molecules Dmitry Melnikov and Alyson B. F. Neves November 13, 2019 Abstract In this paper we discuss a one-dimensional Abelian Higgs model with Chern-Simons interaction as an effective theory of one-dimensional curves embedded in three-dimensional space. We demonstrate how this effective model is compatible with the geometry of protein molecules. Using standard field theory techniques we analyze phenomenologically interesting static configurations of the model and discuss their stability. This simple model predicts some characteristic relations for the geometry of secondary structure motifs of proteins, and we show how this is consistent with the experimental data. After using the data to universally fix basic local geometric parameters, such as the curvature and torsion of the helical motifs, we are left with a single free parameter. We explain how this parameter controls the abundance and shape of the principal motifs (alpha helices, beta strands and loops connecting them). 1 Introduction Proteins are very complex objects, but in the meantime there is an impressive underlying regularity beyond their structure. This regularity is captured in part by the famous Ramachandran plots that map the correlation of the dihedral (torsion) angles of consecutive bonds in the protein backbone (see for example [1, 2, 3]). The example on figure 1 shows an analogous data of about hundred of proteins, illustrating the localization of the pairs of angles around two regions.1 These two most densely populated regions, labeled α and β, correspond to the most common secondary structure elements in proteins: (right) alpha helices and beta strands. -
Computational Genomics
COMPUTATIONAL GENOMICS: GROUP MEMBERS: Anshul Kundaje (EE) [email protected] Daita Domnica Nicolae (Bio) [email protected] Deniz Sarioz (CS) [email protected] Joseph Gagliano (CS) [email protected] Predicting the Beta-helix fold from Protein sequence data Abstract: This project involves the study and implementation of Betawrap, an algorithm used to predict Beta-helix supersecondary structural motifs using protein sequence data. We begin with a biochemical view of proteins and their structural features. This is followed by a general discussion of the various methods of protein structural prediction. A structural viewpoint of the Beta-Helix is highlighted followed by a detailed discussion of Betawrap. We include the design and implementation details alongside. PERL was the programming language used for the implementation. The alpha helical filter was implemented with the help of pre-existing software known as Pred2ary. The implementation was run on a positive and negative test set, a total of 59 proteins. These tests sets were generated from the SCOP database by checking predictions made by the original Betawrap software and by directly looking at the structures in the PDB. Our program can be downloaded from betawrap.tar.gz. The archive contains a readme with necessary instructions. The program has been commented extensively. Some debugging statements have also be left as comments. The predictions made by our program are very accurate and we had a only 2 misclassifications in a set of 59 proteins. Basic Biochemistry of Protein Structure: Proteins are polymers of 20 different amino acids joined by peptide bonds. At physiological temperatures in aqueous solution, the polypeptide chains of proteins fold into a structure that in most cases is globular. -
Prediction of Certain Well-Characterized Domains of Known Functions Within the PE and PPE Proteins of Mycobacteria
RESEARCH ARTICLE Prediction of Certain Well-Characterized Domains of Known Functions within the PE and PPE Proteins of Mycobacteria Rafiya Sultana, Karunakar Tanneeru, Ashwin B. R. Kumar, Lalitha Guruprasad* School of Chemistry, University of Hyderabad, Hyderabad, 500046, India * [email protected] Abstract The PE and PPE protein family are unique to mycobacteria. Though the complete genome sequences for over 500 M. tuberculosis strains and mycobacterial species are available, few PE and PPE proteins have been structurally and functionally characterized. We have therefore used bioinformatics tools to characterize the structure and function of these pro- OPEN ACCESS teins. We selected representative members of the PE and PPE protein family by phylogeny Citation: Sultana R, Tanneeru K, Kumar ABR, analysis and using structure-based sequence annotation identified ten well-characterized Guruprasad L (2016) Prediction of Certain Well- protein domains of known function. Some of these domains were observed to be common Characterized Domains of Known Functions within the PE and PPE Proteins of Mycobacteria. PLoS to all mycobacterial species and some were species specific. ONE 11(2): e0146786. doi:10.1371/journal. pone.0146786 Editor: Bostjan Kobe, University of Queensland, AUSTRALIA Received: September 22, 2015 Introduction Accepted: December 22, 2015 Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb), remains a major global health Published: February 18, 2016 problem and one of the main causes of death around the world [1]. About one third of the world’s population has latent TB infection. TB kills about two million people annually and is Copyright: © 2016 Sultana et al. This is an open the second leading cause of death from an infectious disease worldwide, after the human access article distributed under the terms of the Creative Commons Attribution License, which permits immunodeficiency virus (HIV) [2,3].