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Cocaine Use in Ireland: an Exploratory Study
Cocaine Use In Ireland: An Exploratory Study Chapter 3 Cocaine Use In Ireland: An Exploratory Study Paula Mayock 3.1 Introduction In Ireland the heroin epidemic of the 1980s, coupled with the public health crisis of HIV transmission through unsafe injecting practices, resulted in a concentration of attention on 'high-risk' drug use categories, most notably heroin and other intravenous drug use. The major focus in the domains of drug policy, treatment and research centred on the 'threats' posed by enduring patterns of drug use, unsafe methods of drug administration and associated risk behaviours. Heroin, being a dominant drug of misuse among individuals receiving treatment, certainly in the greater Dublin area (O'Brien, Moran, Kelleher & Cahill, 2000), has attracted by far the greatest level of interest and attention. This situation is by no means unique to Ireland. As Egginton & Parker (2000) have remarked, 'so distinctive is the impact of this drug that heroin has its own epidemiology' (Egginton & Parker, 2000: 7). In practice, prevalence studies and other empirical research focus on groups, such as opiate users or injectors, who are of concern at a particular time (Frischer & Taylor, 1999). Put differently, attention to particular forms of drug use is very much a function of the drug- political situation in any given jurisdiction (Cohen, 1996). Despite heroin's prominence, publicity and official concern, the past decade has witnessed increased recognition of the pervasiveness of drug use in society generally. Drug use, traditionally associated with social and economic disadvantage, is increasingly recognised as a widespread social phenomenon and is clearly no longer confined to marginalised communities. -
Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected]
Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 4-25-2018 Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected] DOI: 10.25148/etd.FIDC006565 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Chemistry Commons Recommended Citation Seither, Joshua Zolton, "Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances" (2018). FIU Electronic Theses and Dissertations. 3823. https://digitalcommons.fiu.edu/etd/3823 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida APPLICATION OF HIGH RESOLUTION MASS SPECTROMETRY FOR THE SCREENING AND CONFIRMATION OF NOVEL PSYCHOACTIVE SUBSTANCES A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in CHEMISTRY by Joshua Zolton Seither 2018 To: Dean Michael R. Heithaus College of Arts, Sciences and Education This dissertation, written by Joshua Zolton Seither, and entitled Application of High- Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved. _______________________________________ Piero Gardinali _______________________________________ Bruce McCord _______________________________________ DeEtta Mills _______________________________________ Stanislaw Wnuk _______________________________________ Anthony DeCaprio, Major Professor Date of Defense: April 25, 2018 The dissertation of Joshua Zolton Seither is approved. -
Searchable Shulgin Pharmacology Notes, Book 9
The Shulgin Lab Books Pharmacology Lab Notes #9 (1986-1994) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the ninth of the “Pharmacology” series, represents mostly active dose work-ups of various substances. It covers the end of 1986 through half of 1994. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. (ATS is Sasha and AP is Ann) Words highlighted in yellow are words that the transcription team could not decipher. -
National Report the Netherlands 2005 Final Version Version…
REPORT TO THE EMCDDA by the Reitox National Focal Point THE NETHERLANDS DRUG SITUATION 2005 FINAL VERSION REITOX REPORT ON THE DRUG SITUATION 2005 Margriet van Laar1 André van Gageldonk1 Toine Ketelaars1 Marianne van Ooyen2 Guus Cruts1 Esther Croes1 1Trimbos Institute, Netherlands Institute of Mental Health and Addiction 2WODC, Scientific Research and Documentation Centre, Ministry of Justice As approved on 06-02-2006 by the Scientific Committee of the NDM © NDM/Netherlands Focal Point 2005 Trimbos Institute NDM/Netherlands Focal Point PO Box 725 3500 AS Utrecht The Netherlands article number: AF0658 phone: +31-30-2971100 fax: +31-30-2971111 The Report on the Drug Situation in the Netherlands 2005 has been written for the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Each year, national centres of expertise on drug-related issues in the member states of the European Union (‘Focal Points’) draw up a report on the national drugs situation, according to guidelines provided by the EMCDDA. These reports form the basis of the “Annual Report on the State of the Drug Problem in the European Union” compiled by the EMCDDA. In line with the guidelines, the report focuses on new developments in the reporting year. This 2005 national report was written by the staff of the Bureau of the National Drug Monitor (NDM) at the Trimbos Institute and staff of the Scientific Research and Documentation Centre (WODC) of the Ministry of Justice. The NDM was established in 1999 on the initiative of the Ministry of Health, Welfare and Sports. The Ministry of Justice also participates in the NDM. -
Taking the Profit out of Drug Trafficking
Select Committee Into the Misuse of Drugs Act 1981 TAKING THE PROFIT OUT OF DRUG TRAFFICKING AN AGENDA FOR LEGAL AND ADMINISTRATIVE REFORMS IN WESTERN AUSTRALIA TO PROTECT THE COMMUNITY FROM ILLICIT DRUGS Interim Report - November 1997 Select Committee into Misuse of Drugs Act 1981 Select Committee Into the Misuse of Drugs Act 1981 TAKING THE PROFIT OUT OF DRUG TRAFFICKING AN AGENDA FOR LEGAL AND ADMINISTRATIVE REFORMS IN WESTERN AUSTRALIA TO PROTECT THE COMMUNITY FROM ILLICIT DRUGS Presented by Mr Christopher Baker MLA, Chairman Laid on the Table of the Legislative Assembly on 27 November 1997 ORDERED TO BE PRINTED Chapter 1: Extent of inquiries Chapter 1: Extent of inquiries 1.1 Establishment of the Committee The Legislative Assembly of the Parliament of Western Australia agreed to the establishment of the Select Committee into the Misuse of Drugs Act 1981 as a result of a motion that was moved by the Member for Joondalup, which was passed on 26 June 1997. The motion as passed reflects a bi- partisan consensus on the need to: · examine mechanisms to prevent and ameliorate illicit drug problems through the application of effective legal sanctions; and · to provide educational, health services and community support structures to assist those who are affected by the use or abuse of illicit drugs. When it was accepted that it would not be possible to comprehensively deal with the large range of issues encompassed by the two terms of reference, particularly the second term of reference, it was agreed to produce a number of reports seriatum. As the first such report this publication primarily deals with the first term of reference, which has been generally referred to as the “law and order” term of reference. -
The Netherlands Drug Situation 2004
REPORT TO THE EMCDDA by the Reitox National Focal Point THE NETHERLANDS DRUG SITUATION 2004 FINAL VERSION REITOX 2 REPORT ON THE DRUG SITUATION 2004 Margriet van Laar1 André van Gageldonk1 Toine Ketelaars1 Marianne van Ooyen2 Guus Cruts1 Paul van Gelder1 1Trimbos Institute, Netherlands Institute of Mental Health and Addiction 2WODC, Scientific Research and Documentation Centre, Ministry of Justice as approved on 19-01-2005 by the Scientific Committee of the NDM © NDM/Netherlands Focal Point 2004 Trimbos Institute NDM/Netherlands Focal Point PO Box 725 3500 AS Utrecht The Netherlands phone: +31-30-2971100 fax: +31-30-2971111 3 The Report on the Drug Situation in the Netherlands 2004 has been written for the European Monitoring Centre of Drugs and Drug Addiction (EMCDDA). Each year, national centres of expertise on drug-related issues in the member states of the European Union (‘Focal Points’) draw up a report on the national drugs situation, according to guidelines provided by the EMCDDA. These reports form the basis of the “Annual Report on the State of the Drug Problem in the European Union” compiled by the EMCDDA. This 2004 national report was written by the staff of the Bureau of the National Drug Monitor (NDM) located at the Trimbos Institute and staff of the Scientific Research and Documentation Centre (WODC) of the Ministry of Justice. The NDM was established in 1999 on the initiative of the Ministry of Health, Welfare and Sports. The Ministry of Justice also participates in the NDM. The NDM carries out the functions of the Focal Point. The NDM relies on the contribution of a multitude of experts and input from registration systems and monitors in the Netherlands. -
National Report on the Drug Situation in the Netherlands 2001
National Report on the Drug Situation in The Netherlands 2001 Draft Final version December 2001 © Netherlands Focal Point Part I (Henk Rigter, Toine Ketelaars) Part II (Margriet van Laar) Part III (André van Gageldonk) Part IV (André van Gageldonk, Margriet van Laar) 2001 Trimbos Institute Netherlands Focal Point PO Box 725 3500 AS Utrecht The Netherlands phone: +31-30-2971100 fax: +31-30-2971111 2 LIST OF ABBREVIATIONS 2C-B 4-bromo-2,5-dimethoxyphenethylamine 4-MTA 4-methylthioamphetamine ADAM Arrestee Drug Abuse Monitoring system ADHD Attention-Deficit/Hyperactivity Disorder AIAR Amsterdam Institute for Addiction Research AIDS Acquired Immune Deficiency Syndrome APZ General Psychiatric Hospital AWBZ General Act on Special Disease Management CAD Consultation Agency for Alcohol and Drugs CAM Coordination Centre for the Assessment and Monitoring of NewDrugs CBS Statistics Netherlands CEDRO Centre for Drug Research CIDI Composite International Diagnostic Interview CIT Community Intervention Trial CMR Central Methadone Registration CVS Client Monitoring System CVZ Health Insurance Board DIMS Drugs Information and Monitoring System DMS Drugs Monitoring System DOB 2,5-dimethoxy-4-bromoamphetamine DSM Diagnostic and Statistical Manual of Mental Disorders EMCDDA European Monitoring Centre for Drugs and Drug Addiction EU European Union GGD Municipal Health Service GG&GD Area Health Authority GGZ Nederland Netherlands Association for Mental Health Care GHB Gamma-hydroxy-butyrate GMR General Mortality Register HBV Hepatitis B HCV Hepatitis C HIV -
Us 2019 / 0142851 A1
US 20190142851A1 ( 19) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0142851 A1 CHADEAYNE (43 ) Pub. Date : May 16 , 2019 ( 54 ) COMPOSITIONS COMPRISING A 2017 , provisional application No. 62/ 587, 410 , filed PSILOCYBIN DERIVATIVE AND A on Nov. 16 , 2017 , provisional application No . 62 /587 , CANNABINOID 395 , filed on Nov . 16 , 2017 . (71 ) Applicant: CaaMTech , LLC , Issaquah , WA (US ) Publication Classification (51 ) Int . Ci. ( 72 ) Inventor: Andrew R . CHADEAYNE , Issaquah , A61K 31/ 675 ( 2006 .01 ) WA (US ) A61K 31 / 4045 (2006 . 01 ) A61K 31/ 4406 ( 2006 .01 ) (21 ) Appl. No. : 16 / 192, 736 A61K 31/ 05 (2006 . 01) A61K 31 / 192 (2006 .01 ) ( 22 ) Filed : Nov . 15 , 2018 A61K 31 /353 ( 2006 . 01) (52 ) U . S . CI. Related U . S . Application Data CPC .. A61K 31/ 675 ( 2013 .01 ) ; A61K 31/ 4045 (60 ) Provisional application No . 62/ 613 , 360 , filed on Jan . (2013 . 01 ) ; A61K 31/ 353 (2013 .01 ) ; ACIK 3 , 2018 , provisional application No. 62 /609 , 115 , filed 31/ 05 (2013 . 01 ) ; A61K 31/ 192 (2013 . 01 ) ; on Dec . 21 , 2017 , provisional application No . 62/ 598 , A61K 31 /4406 ( 2013 . 01 ) 767, filed on Dec . 14 , 2017 , provisional application No . 62 /595 ,336 , filed on Dec . 6 , 2017 , provisional ( 57 ) ABSTRACT application No . 62 / 595 , 321 , filed on Dec . 6 , 2017 , This disclosure pertains to new compositions and methods provisional application No . 62 /593 ,021 , filed on Nov . comprising a psilocybin derivative . In one embodiment, the 30 , 2017 , provisional application No . 62 / 592, 320 , compositions disclosed herein are used for a method of filed on Nov . 29 , 2017 , provisional application No . -
Pharmacology Notebook 4 PDF (Searchable)
The Shulgin Lab Books Pharmacology Lab Notes #4 (1981 - 1982) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the fourth of the “Pharmacology” series, represents mostly subjective responses by Shulgin and his research group and active dose work-ups of various substances. It covers the time frame of 1981 to 1982. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. (ATS is Sasha and AP is Ann) Words highlighted in yellow are words that the transcription team could not decipher. -
The Frontier Orbital Phase Angles: Novel QSAR Descriptors for Benzene Derivatives, Applied to Phenylalkylamine Hallucinogens
The Frontier Orbital Phase Angles: Novel QSAR Descriptors for Benzene Derivatives, Applied to Phenylalkylamine Hallucinogens Brian W. Clare* Division of Science, Murdoch University, Murdoch, W.A. 6150, Australia Received March 9, 1998 A new empirical electronic descriptor, obtained from a molecular orbital calculation and applicable to benzene derivatives, is proposed. It is shown that this descriptor, the frontier orbital phase angle, correlates very strongly with the pharmacological activity in humans of a large series of hallucinogenic phenethylamines. In the largest QSAR study on such hal- lucinogens yet reported, it is demonstrated that the phase of mixing of degenerate frontier orbitals of benzene to form the frontier orbitals of the drug results in the best electronic descriptor yet found for hallucinogenic activity in phenylalkylamines. Introduction In the course of investigations of the quantitative structure-activity relationships (QSAR) of phenylalkyl- amine hallucinogen activity with data produced by quantum chemical calculations1 on the drug molecules, schematic diagrams of the frontier orbitals of the molecules were made. Figure 1 shows a pair of such diagrams for two hallucinogens: mescaline, a drug of relatively low activity, and the much more potent drug known as DOM. A plot is made for both the highest occupied (HOMO) and lowest unoccupied (LUMO) mo- lecular orbitals by running a molecular orbital calcula- tion with the molecule oriented with the Z axis normal to the plane of the benzene ring. The molecule is then sketched in the X-Y plane, and circles are drawn on each atom, with a radius proportional to the coefficient of the atomic pz orbital in the molecular orbital expan- sion. -
Drug Misuse Research Division
A collection of papers on drug issues in Ireland Item Type Report Authors Moran, Rosalyn;Dillon, Lucy;O'Brien, Mary;Mayock, Paula;Farrell, Eimear;Pike, Brigid Citation Moran, R. et al., 2001. A collection of papers on drug issues in Ireland. Dublin: Health Research Board. Publisher Health Research Board, Drug Misuse Research Division. Download date 04/10/2021 03:48:06 Link to Item http://hdl.handle.net/10147/338538 Find this and similar works at - http://www.lenus.ie/hse Drug Misuse Research Division The Health Research Board ~-~:~~,:: -: ~',:,-;~~~~::: - -"--'1 17:5f>: [.:. (o • ....Lll.1! I • .:. r.• '..J j ! : ',,:,. t_.; '.:1 : !)",.;., I :....-~ .•• ',·0 15050 ;i I -----.• ---....•. -.----.-... -- . i 0 5 SE P ~nl" . ~ .~'. "';~ :: $ • '. , " ',.: I ",_":"', A Collection Of Bap.ers-'-~~~~~;: ,)~~.' On Drug Issues In Ireliiria--"-- .-... -.. - with Brigid Pike Drug Misuse Research Division The Health Research Board, Dublin 2001 Citation: Moran, R., Dillon, L., O'Brien, M., Mayock, P. & Farrell, E. with Pike, B. (2001). A Collection of Papers on Drug Issues in Ireland. Dublin: The Health Research Board. Published by: The Health Research Board An Bord Taighde Siainte 73 Lower Baggot Street Dublin 2 Ireland Tel: 00-353-(0)1-6761176 Fax: 00-353-(0)1-6611856 Email: [email protected] Web: www.hrb.ie ISBN: 1-903669-02-2 © The Health Research Board, 2001 Contents List of Tables vii List of Abbreviations ix Acknowledgements xi Introduction by Rosalyn Moran xiii Chapter 1 National Drugs Strategy and Structural Mechanisms Rosalyn Moran and Brigid -
Shulgin Lab Book 5
The Shulgin Lab Books Pharmacology Lab Notes #5 (1982 - 1983) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the fifth of the “Pharmacology” series, represents mostly subjective responses by Shulgin and his research group and active dose work-ups of various substances. It covers the time frame of 1982 to 1983. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. (ATS is Sasha and AP is Ann) Words highlighted in yellow are words that the transcription team could not decipher.